Bio

Posizione attuale

Ricercatrice a tempo determinato FIRB presso la Facoltà di Psicologia (Università Vita-Salute San Raffaele) e coordinatrice nazionale del progetto di ricerca FIRB 2012 (RBFR12VHR7) “Interpreting emotions: a computational tool integrating facial expressions and biosignals based on shape analysis and bayesian networks”.

Formazione
2010-2013 Assegnista di ricerca presso la Facoltà di Psicologia (Università Vita-Salute San Raffaele) e coinvolta nelle attività di ricerca e didattica del C.U.S.S.B. (University Statistical Center for Biomedical Sciences), sotto la supervisione della Prof.ssa C. Di Serio. Titolo del progetto di ricerca: “Modelli computazionali multivariati parametrici e non parametrici per gli studi longitudinali”.

2009-2010 Borsa post-doc su “Multivariate permutation methods with applications in both biomedical and management field: theoretical development and statistical software applications”. Progetto di ricerca finanziato dall’Università degli Studi di Padova CPDA088513 (Coordinatore progetto: Prof. L. Salmaso).

2006-2009 Dottorato in Scienze Statistiche presso il Dipartimento di Scienze Statistiche, Università degli Studi di Padova. Titolo della tesi “A nonparametric permutation approach to statistical shape analysis” (Supervisore: Prof. L. Salmaso). Nel corso del dottorato, visiting student, presso il Dipartimento di Antropologia, EVAN (European Virtual Anthropology Network) Centre, Vienna (Aprile-Giugno 2007) e poi presso il Dipartimento di Ecologia & Evoluzione, State University of New York, Stony Brook, NY (Marzo-Giugno 2008).

2000-2005 Laurea in Scienze Statistiche ed Economiche (Vecchio Ordinamento), presso la Facoltà di Scienze Statistiche, Università degli Studi di Padova. Titolo della tesi: “Analisi multivariate per osservazioni appaiate con dati mancanti”, relatore Prof. F. Pesarin, co-relatore Prof. G. A. Fava.

Principali interessi di ricerca

Shape Analysis

Test di permutazione
Statistica multivariata
Modelli ad effetti misti lineari e non
Survival analysis
Modelli congiunti per dati longitudinali e di sopravvivenza
Applicazione e sviluppo di tecniche statistiche in ambito biomedico

Attività didattica

Dal 2010, esercitatrice del corso di Analisi dei Dati Multidimensionali (Facoltà di Psicologia, Università Vita-Salute San Raffaele, Milano).

Dal 2011, esercitatrice del corso di Statistica-Metodologia scientifica e fisica applicata (Corso di Laurea in Odontoiatria e protesi dentaria, Università Vita-Salute San Raffaele, Milano).
2010/2011-2011/2012 Esercitatrice del corso Statistics & Bioinformatics (International MD Program).

Selezione di pubblicazioni (2009-2014)

Brombin, C., Di Serio, C., Rancoita, P. M. V. (2014) Joint modeling of HIV data in multicentre observational studies: a comparison among different approaches. Accepted for publication in Statistical Methods in Medical Research.

Cesana, D., Ranzani, M., Volpin, M., Bartholomae, C. C., Duros, C., Artus, A., Merella, S., Benedicenti, F., Sergi, L., Sanvito, F., Brombin, C., Nonis, A., Di Serio, C., Doglioni, C., von Kalle, C., Schmidt, M., Cohen-Haguenauer, O., Naldini, L., Montini, E. (2014) Uncovering and dissecting the genotoxicity of self-inactivating lentiviral vectors in vivo. Molecular Therapy. Article published online before print.

Brigida, I., Sauer, A. V., Ferrua, F., Giannelli, S., Scaramuzza, S., Pistoia, V., Castiello, M. C., Barendregt, B. H., Cicalese, M. P., Casiraghi, M., Brombin, C., Puck, J., Müller, K., Notarangelo, L. D., Montin, D., van Montfrans, J. M., Roncarolo, M. G., Traggiai, E., van Dongen, J. J.M., van der Burg, M., Aiuti, A. (2014) B-cell development and functions and therapeutic options in adenosine deaminase-deficient patients. Journal of Allergy and Clinical Immunology. Article published online before print.

Brombin, C., Salmaso, L. (2013) Permutation Tests for Shape Analysis. SpringerBriefs in Statistics, Vol. 15, ISBN 978-1-4614-8163-8.

Brombin, C., Salmaso, L. (2013) A review on combination-based tests for shape analysis. In JSM Proceedings, Section on Nonparametric Statistics. Alexandria, VA: American Statistical Association, 715-728.

Brombin, C., Midena, E., Salmaso, L. (2013) Robust non-parametric tests for complex-repeated measures problems in ophthalmology. Statistical Methods in Medical Research 22, 643-660.

Mascheretti, S., Marino, C., Simone, D., Quadrelli, E., Riva, V., Cellino, M.R., Maziade, M., Brombin, C., Battaglia, M. (2013) Putative risk factors in developmental dyslexia: a case-control study of Italian children. Journal of learning disabilities. DOI:10.1177/0022219413492853. Article published online before print.

Mizuno, H., Vergara, P., Maccabelli, G., Trevisi, N., Colombo, S., Brombin, C. Mazzone, P. and Della Bella, P. (2013) Contact Force Monitoring for cardiac Mapping in Patients with Ventricular Tachycardia. Journal of Cardiovascular Electrophysiology 24, 519-24. DOI: 10.1111/jce.12080.

Brombin, C., Diomede, L., Tudor, D., Drillet, A. S., Pastori, C., Poli, E., Riva, A., Uberti-Foppa, C., Galli, M., Di Serio, C., Bomsel, M. and Lopalco, L. (2013). A nonparametric procedure for defining a new humoral immunological profile in a pilot study on HIV infected patients. PLoS One 8:e58768. DOI: 10.1371/journal.pone.0058768.

Cantore, A., Nair, N., Della Valle, P., Di Matteo, M., Màtrai, J., Sanvito, F., Brombin, C., Di Serio, C., D’Angelo, A., Chuah, M., Naldini, L., VandenDriessche, T. (2012) Hyperfunctional coagulation factor IX improves the efficacy of gene therapy in hemophilic mice. Blood. 120, 4517-20. DOI: 10.1182/blood- 2012-05-432591.

Alfieri, R., Bonnini, S., Brombin, C., Castoro, C., Salmaso, L. (2012) Iterated combination-based paired permutation tests to determine shape effects of chemotherapy in patients with esophageal cancer. Statistical Methods in Medical Research. DOI: 10.1177/0962280212461981. Article published online before print.

Brombin, C., Di Serio, C. (2012) Evaluating treatment effect within a multivariate stochastic ordering framework: NPC methodology applied to a study on Multiple Sclerosis. Statistical Methods in Medical Research. DOI: 10.1177/0962280212454203. Article published online before print.

Brombin, C., Di Serio, C. and Crippa, M. (2012) Modeling cancer cells growth. Communications in Statistics-Theory and Methods. Special Issue-Statistics for complex problems 41, 3043-3059.

Brombin, C., Salmaso, L., Ferronato, G. and Galzignato, PF. (2011) Multi-aspect procedures for paired data with application to biometric morphing. Communications in Statistics-Simulation and Computation, 40, 1-12.

Floreani, A., Caroli, D., Variola, A., Rizzotto, E. R., Antoniazzi, S., Chiaramonte, M., Cazzagon, N., Brombin, C., Salmaso, L., Baldo, V. (2011) A 35-year follow-up of a large cohort of patients with primary biliary cirrhosis seen at a single centre. Liver international 31, 361-368.

Finos, L., Brombin, C., Salmaso, L. (2010) Adjusting stepwise p-values in generalized linear models. Communications in Statistics – Theory and Methods 39, 1832-1846.

Brombin, C., Pesarin, F. and Salmaso, L. (2010) Dealing with more variables than sample sizes: an application to Shape Analysis. NONPARAMETRIC STATISTICS AND MIXTURE MODELS A Festschrift in Honor of Thomas P. Hettmansperger, The Pennsylvania State University, USA, 23 – 24 May 2008. ISBN: 978-981- 4340-55-7 981-4340-55-3

Brombin, C. and Salmaso, L. (2009) Multi-aspect permutation tests in shape analysis with small sample size. Computational statistics and data analysis 53, 3921-3931.

Brombin, C., Mo, G., Zotti, A., Giurisato, M., Salmaso, L. and Cozzi, B. (2009) A landmark analysis-based approach to age and sex classification of the skull of the Mediterranean monk seal (Monachus monachus) (Hermann, 1779). Anatomia, Histologia, Embryologia 38, 382-386.

Current position

FIRB Researcher and national coordinator of the FIRB 2012 project (RBFR12VHR7) “Interpreting emotions: a computational tool integrating facial expressions and biosignals based on shape analysis and bayesian networks”.

 

Previous experience and education

2010-2013 Research fellowship at C.U.S.S.B. (University Centre for Statistics in the Biomedical Sciences, Vita-Salute San Raffaele University, Milan) and involved in teaching activities at Vita-Salute San Raffaele University, Milan (supervised by Prof. C. Di Serio). Research project entitled: “Parametric and non-parametric modeling of multivariate longitudinal studies”.

2009-2010 Post-doc grant in “Multivariate permutation methods with applications in both biomedical and management field: theoretical development and statistical software applications”. The research project is supported by the University of Padova CPDA088513 (Project Coordinator: Prof. L. Salmaso).

2006-2009 PhD in Statistical Sciences, at the Department of Statistical Sciences, University of Padova. Thesis on “A nonparametric permutation approach to statistical shape analysis” (Supervisor: Prof. L. Salmaso).

Visiting Ph.D. student, at the Department of Anthropology, EVAN (European Virtual Anthropology Network) Centre, Vienna, (April-June 2007) and at the Department of Ecology and Evolution, State University of New York, Stony Brook, NY (March-June 2008).

2000-2005 Laurea Degree (four years) in Statistics, at the Faculty of Statistical Sciences, University of Padova, Italy. Thesis on “Multivariate analysis with paired observations and missing values”, advisors: Prof. F. Pesarin and Prof. G. A. Fava.

 

Research interest

Shape analysis

Permutation tests

Multivariate statistics

Linear and nonlinear mixed-effect models

Survival analysis

Joint models for longitudinal and time-to-event data

Application and extension of statistical methods in biomedical research

Teaching activities

Since 2010, Teaching Assistant, Multidimensional Data Analysis, (Faculty of Psychology, Vita-Salute San Raffaele University, Milano).

Since 2011, Teaching Assistant, Statistics (Master Degree in dentistry and dental implantology,, Vita-Salute San Raffaele University, Milano)

2010/2011-2011/2012 Teaching assistant, Statistics & Bioinformatics course (International MD Program, Vita-Salute San Raffaele University, Milano).

 

Selected publications (2009-2014)

Brombin, C., Di Serio, C., Rancoita, P. M. V. (2014) Joint modeling of HIV data in multicentre observational studies: a comparison among different approaches. Accepted for publication in Statistical Methods in Medical Research.

Cesana, D., Ranzani, M., Volpin, M., Bartholomae, C. C., Duros, C., Artus, A., Merella, S., Benedicenti, F., Sergi, L., Sanvito, F., Brombin, C., Nonis, A., Di Serio, C., Doglioni, C., von Kalle, C., Schmidt, M., Cohen-Haguenauer, O., Naldini, L., Montini, E. (2014) Uncovering and dissecting the genotoxicity of self-inactivating lentiviral vectors in vivo. Molecular Therapy. Article published online before print.

Brigida, I., Sauer, A. V., Ferrua, F., Giannelli, S., Scaramuzza, S., Pistoia, V., Castiello, M. C., Barendregt, B. H., Cicalese, M. P., Casiraghi, M., Brombin, C., Puck, J., Müller, K., Notarangelo, L. D., Montin, D., van Montfrans, J. M., Roncarolo, M. G., Traggiai, E., van Dongen, J. J.M., van der Burg, M., Aiuti, A. (2014) B-cell development and functions and therapeutic options in adenosine deaminase-deficient patients. Journal of Allergy and Clinical Immunology. Article published online before print.

Brombin, C., Salmaso, L. (2013) Permutation Tests for Shape Analysis. SpringerBriefs in Statistics, Vol. 15, ISBN 978-1-4614-8163-8.

Brombin, C., Salmaso, L. (2013) A review on combination-based tests for shape analysis. In JSM Proceedings, Section on Nonparametric Statistics. Alexandria, VA: American Statistical Association, 715-728.

Brombin, C., Midena, E., Salmaso, L. (2013) Robust non-parametric tests for complex-repeated measures problems in ophthalmology. Statistical Methods in Medical Research 22, 643-660.

Mascheretti, S., Marino, C., Simone, D., Quadrelli, E., Riva, V., Cellino, M.R., Maziade, M., Brombin, C., Battaglia, M. (2013) Putative risk factors in developmental dyslexia: a case-control study of Italian children. Journal of learning disabilities. DOI:10.1177/0022219413492853. Article published online before print.

Mizuno, H., Vergara, P., Maccabelli, G., Trevisi, N., Colombo, S., Brombin, C. Mazzone, P. and Della Bella, P. (2013) Contact Force Monitoring for cardiac Mapping in Patients with Ventricular Tachycardia. Journal of Cardiovascular Electrophysiology 24, 519-24. DOI: 10.1111/jce.12080.

Brombin, C., Diomede, L., Tudor, D., Drillet, A. S., Pastori, C., Poli, E., Riva, A., Uberti-Foppa, C., Galli, M., Di Serio, C., Bomsel, M. and Lopalco, L. (2013). A nonparametric procedure for defining a new humoral immunological profile in a pilot study on HIV infected patients. PLoS One 8:e58768. DOI: 10.1371/journal.pone.0058768.

Cantore, A., Nair, N., Della Valle, P., Di Matteo, M., Màtrai, J., Sanvito, F., Brombin, C., Di Serio, C., D’Angelo, A., Chuah, M., Naldini, L., VandenDriessche, T. (2012) Hyperfunctional coagulation factor IX improves the efficacy of gene therapy in hemophilic mice. Blood. 120, 4517-20. DOI: 10.1182/blood- 2012-05-432591.

Alfieri, R., Bonnini, S., Brombin, C., Castoro, C., Salmaso, L. (2012) Iterated combination-based paired permutation tests to determine shape effects of chemotherapy in patients with esophageal cancer. Statistical Methods in Medical Research. DOI: 10.1177/0962280212461981. Article published online before print.

Brombin, C., Di Serio, C. (2012) Evaluating treatment effect within a multivariate stochastic ordering framework: NPC methodology applied to a study on Multiple Sclerosis. Statistical Methods in Medical Research. DOI: 10.1177/0962280212454203. Article published online before print.

Brombin, C., Di Serio, C. and Crippa, M. (2012) Modeling cancer cells growth. Communications in Statistics-Theory and Methods. Special Issue-Statistics for complex problems 41, 3043-3059.

Brombin, C., Salmaso, L., Ferronato, G. and Galzignato, PF. (2011) Multi-aspect procedures for paired data with application to biometric morphing. Communications in Statistics-Simulation and Computation, 40, 1-12.

Floreani, A., Caroli, D., Variola, A., Rizzotto, E. R., Antoniazzi, S., Chiaramonte, M., Cazzagon, N., Brombin, C., Salmaso, L., Baldo, V. (2011) A 35-year follow-up of a large cohort of patients with primary biliary cirrhosis seen at a single centre. Liver international 31, 361-368.

Finos, L., Brombin, C., Salmaso, L. (2010) Adjusting stepwise p-values in generalized linear models. Communications in Statistics – Theory and Methods 39, 1832-1846.

Brombin, C., Pesarin, F. and Salmaso, L. (2010) Dealing with more variables than sample sizes: an application to Shape Analysis. NONPARAMETRIC STATISTICS AND MIXTURE MODELS A Festschrift in Honor of Thomas P. Hettmansperger, The Pennsylvania State University, USA, 23 – 24 May 2008. ISBN: 978-981- 4340-55-7 981-4340-55-3

Brombin, C. and Salmaso, L. (2009) Multi-aspect permutation tests in shape analysis with small sample size. Computational statistics and data analysis 53, 3921-3931.

Brombin, C., Mo, G., Zotti, A., Giurisato, M., Salmaso, L. and Cozzi, B. (2009) A landmark analysis-based approach to age and sex classification of the skull of the Mediterranean monk seal (Monachus monachus) (Hermann, 1779). Anatomia, Histologia, Embryologia 38, 382-386.

Il titolare del presente curriculum vitae, pubblicato online sul portale www.unisr.it, è garante in via esclusiva della correttezza e della veridicità dei dati e delle informazioni in esso riportate e del loro eventuale e puntuale aggiornamento. Egli è dunque il diretto ed unico responsabile dei contenuti indicati nei propri curricula.