Manfredi Angelo Andrea Maria Professore associatoMedicinaMED/16

Professore Associato di Reumatologia

Responsabile dell’Unità di Autoimmunita’ e Flogosi Vascolare, Divisione di Medicina Rigenerativa, Cellule staminali e Terapia Genica, Istituto Scientifico San Raffaele, Milano

Coordinatore d’Area Assistenziale Reumatologia, UO Medicina a Indirizzo Immunologico Clinico, Dipartimento di Medicina Interna e Specialistica, Istituto Scientifico San Raffaele, Milano

Scheda biografica

Nato il 4 luglio 1961 a Milano. Tre figli.

Laurea in Medicina e Chirurgia con lode presso l’Università di Milano nel 1985

Specializzazione in Allergologia e Immunologia Clinica con lode presso l’Università di Milano nel 1989

Curriculum

1985-1986: medico interno presso la Divisione di Medicina e il laboratorio di Immunologia dell’Istituto Scientifico Ospedale S. Raffaele, Milano (Prof. C. Rugarli).

1988-1992: post-doctoral associate, University of Minnesota, St. Paul 55108, USA.

1992-2003: assistente ricercatore, poi dirigente medico di I° livello, Laboratorio di Immunologia dei Tumori e Divisione di Medicina, Istituto Scientifico San Raffaele, Milano.

1996: Visiting Scientist, Centre d’Immunologie INSERM-CNRS de Marseille-Luminy, Marseille

1998 ad oggi: principal investigator, PIBIC Istituto Scientifico H. Raffaele, Milano.

2003 ad oggi: responsabile dell’Unità di Autoimmunità e Flogosi Vascolare, Istituto Scientifico H. Raffaele – DIBIT, Milano

2004 ad oggi: Professore Associato, Facoltà di Medicina e Chirurgia, Università Vita-Salute San Raffaele, Milano

Associate Editor per Infiammazione e Reumatologia di Clinical & Experimental Immunology, official organ of the British Society of Immunology

imm@immunology.org. Guest and Topic Editor per Antioxidant & Redox Signalling e Frontiers in Immunology. Board dei reviewers di: American Journal of Pathology, Annals of Rheumatic Diseases, Apoptosis, Arthritis & Rheumatism, Arthritis Care& Research, Autoimmunity, Biochemistry, Blood, British Journal of Pharmacology, Cancer Research, Cell Death & Differentiation, Experimental Cell Research, European Journal of Histochemistry, European Journal of Immunology, Immunology, International Journal of Cancer, Journal of Autoimmunity, Journal of Biological Chemistry, Journal of Immunology, Journal of Immunological Methods, Journal of Infectious Diseases, Journal of Investigative Dermatology, Journal of Leukocyte Biology, Journal of Neurochemistry, Journal of Neuroimmunology, Molecular Cancer Therapeutics, Nature Medicine, Reproductive Sciences,  Signal Transduction, Trends in Immunology.

E’ inoltre membro dell’INCa-Scientific Evaluation Committee (Parigi), referente scientifico per lo studio delle malattie rare della Fondazione Ceschina (Lugano), revisore per Ministero dell’Istruzione, dell’Universita’ e della Ricerca (MIUR), ANVUR, Istituto Superiore di Sanità,  Ministero della Salute, for the Comitato di Indirizzo per la Valutazione della Ricerca (CIVR),  Università degli studi di Padova, Università degli studi di Verona,  Arthritis Research Campaign (U.K.), Association for International Cancer Research (U.K.), MRC (U.K.), Welcome Trust (U.K.), French National Cancer Institute (INCa, France), United States-Israel Binational Science Foundation (Jerusalem-Bethesda), EMBO fellowship organization, Austrian Science Fund (FWF, Austria), The Icelandic Research Fund (IRF, Reykjavìk, Iceland)

Aree di ricerca

1. Ruolo dei segnali associati alla morte cellulare nella patogenesi di malattie autoimmuni sistemiche e nell’immunità dei tumori.
2. Risposta innata a segnali di danno tessutale.
3. Presentazione dell’antigene e rottura della tolleranza in corso di malattie autoimmuni e vasculiti sistemiche

Autore o coautore di >160 articoli con > 5800 citazioni dal 1995 e un h index pari a 40 (dati aggiornati al 2013). Suoi lavori sono stati citati come “papers of outstanding interest” e “papers of special interest” nella  Bibliography of the Current World Literature, Current Opinion in Immunology (1993, 1999, 2000, 2005, 2006, 2008), Current Opinion in Microbiology (1999), Current Opinion in Nephrology and Hypertension (1999 and 2007), Current Opinion in Rheumatology (2000).

Pubblicazioni selezionate (2008-2013)

 

Reviews e Commentaries:

Valle A, Maugeri N, Manfredi AA, Battaglia M. Standardization in flow cytometry: correct sample handling as a priority. Nat Rev Immunol. 2012 Dec;12(12):864. doi: 10.1038/nri3158-c3.

Maugeri N, Baldini M, Ramirez GA, Rovere-Querini P, Manfredi AA. Platelet-leukocyte deregulated interactions foster sterile inflammation and tissue damage in immune-mediated vessel diseases. Thromb Res. 2012 Mar;129(3):267-73. doi: 10.1016/j.thromres.2011.12.001. Epub 2012 Jan 14

Castiglioni A, Canti V, Rovere-Querini P, Manfredi AA. High-mobility group box 1 (HMGB1) as a master regulator of innate immunity. Cell Tissue Res. 2011 Jan;343(1):189-99. doi: 10.1007/s00441-010-1033-1

Manfredi AA, Rovere-Querini P. The mitochondrion – A Trojan horse that kicks off inflammation?New England Journal of Medicine, 2010; 362, 2132-2134.

 

Munoz L, Lauber L, Schiller M, Manfredi AA, Herrmann M. The role of defective clearance of apoptotic cells in systemic autoimmunity. Nature Rev. Rheumatology, 2010, 6:280-289

 

Muñoz LE, Lauber K, Schiller M, Manfredi AA, Schett G, Voll RE, Herrmann M. Die Bedeutung einer unvollständigen Beseitigung apoptotischer Zellen für Ätiologie und Pathogenese des SLE. Zeitschrift für Rheumatologie 2010, 69:152-156.

 

Manfredi AA, Rovere-Querini P, Maugeri N. Dangerous connections: neutrophils and the phagocytic clearance of activated platelets. Curr Opin Hematol. 2010, 17:3-8.

 

Bianchi ME, Manfredi AA. Immunology. Dangers in and out. Science. 2009; 323 (5922) :1683-4.

 

Manfredi AA, Capobianco A, Bianchi ME, Rovere-Querini P. Regulation of dendritic- and T-cell fate by injury-associated endogenous signals. Crit Rev Immunol 2009;29(1):69-86.

 

Maugeri N, Rovere-Querini P, Baldini M, Sabbadini MG, Manfredi AA. Translational mini-review series on immunology of vascular disease: mechanisms of vascular inflammation and remodelling in systemic vasculitis. Clin Exp Immunol. 2009;156(3):395-404.

 

Clementi E, Manfredi AA. The immune system facing injured tissues and stem cells: more of a healer or a fighter? Pharmacol Res. 2008;58(2):87.

 

Manfredi AA, Rovere-Querini P, Bottazzi B, Garlanda C, Mantovani A. Pentraxins, humoral innate immunity and tissue injury. Curr Opin Immunol. 2008 Oct;20(5):538-44.6.

Articoli in extenso

 

Maugeri N, Franchini S, Campana L, Baldini M, Ramirez GA, Sabbadini MG, Rovere-Querini P, Manfredi AA. Circulating platelets as a source of the damage-associated molecular pattern HMGB1 in patients with systemic sclerosis.

Autoimmunity. 2012 Dec;45(8):584-7. doi: 10.3109/08916934.2012.719946.

 

Ammirati E, Cannistraci CV, Cristell NA, Vecchio V, Palini AG, Tornvall P, Paganoni AM, Miendlarzewska EA, Sangalli LM, Monello A, Pernow J, Björnstedt Bennermo M, Marenzi G, Hu D, Uren NG, Cianflone D, Ravasi T, Manfredi AA, Maseri A. Identification and predictive value of interleukin-6+ interleukin-10+ and interleukin-6- interleukin-10+ cytokine patterns in ST-elevation acute myocardial infarction. Circ Res. 2012 Oct 26;111(10):1336-48. doi: 10.1161/CIRCRESAHA.111.262477

 

Sarter K, Janko C, André S, Muñoz LE, Schorn C, Winkler S, Rech J, Kaltner H, Lorenz HM, Schiller M, Andreoli L, Manfredi AA, Isenberg DA, Schett G, Herrmann M, Gabius HJ. Autoantibodies against galectins are associated with antiphospholipid syndrome in patients with systemic lupus erythematosus. Glycobiology. 2013 Jan;23(1):12-22. doi: 10.1093/glycob/cws120.

 

Baldini M, Maugeri N, Ramirez GA, Giacomassi C, Castiglioni A, Prieto-González S, Corbera-Bellalta M, Comite GD, Papa I, Dell’antonio G, Ammirati E, Cuccovillo I, Vecchio V, Mantovani A, Rovere-Querini P, Sabbadini MG, Cid MC, Manfredi AA.

Selective up-regulation of the soluble pattern-recognition receptor pentraxin 3 and of vascular endothelial growth factor in giant cell arteritis: relevance for recent optic nerve ischemia. Arthritis Rheum. 2012 Mar;64(3):854-65. doi: 10.1002/art.33411. Erratum in: Arthritis Rheum. 2012 May;64(5):1487.

 

Canti V, Castiglioni MT, Rosa S, Franchini S, Sabbadini MG, Manfredi AA, Rovere-Querini P Pregnancy outcomes in patients with systemic autoimmunity. Autoimmunity. 2012 Mar;45(2):169-75. doi: 10.3109/08916934.2011.593600.

 

Maugeri N, Rovere-Querini P, Evangelista V, Godino C, Demetrio M, Baldini M, Figini F, Coppi G, Slavich M, Camera M, Bartorelli A, Marenzi G, Campana L, Baldissera E, Sabbadini MG, Cianflone D, Tremoli E, D’Angelo A, Manfredi AA, Maseri A. An intense and short-lasting burst of neutrophil activation differentiates early acute myocardial infarction from systemic inflammatory syndromes.

PLoS One. 2012;7(6):e39484. doi: 10.1371/journal.pone.0039484.

 

Dagna L, Salvo F, Tiraboschi M, Bozzolo EP, Franchini S, Doglioni C, Manfredi AA, Baldissera E, Sabbadini MG. Pentraxin-3 as a marker of disease activity in Takayasu arteritis. Ann Intern Med. 2011 Oct 4;155(7):425-33. doi: 10.7326/0003-4819-155-7-201110040-00005.

 

Maugeri N, Malato S, Femia EA, Pugliano M, Campana L, Lunghi F, Rovere-Querini P, Lussana F, Podda G, Cattaneo M, Ciceri F, Manfredi AA. Clearance of circulating activated platelets in polycythemia vera and essential thrombocythemia. Blood. 2011 Sep 22;118(12):3359-66. doi: 10.1182/blood-2011-02-337337.

 

Maugeri N, Rovere-Querini P, Slavich M, Coppi G, Doni A, Bottazzi B, Garlanda C, Cianflone D, Maseri A, Mantovani A, Manfredi AA. Early and transient release of leukocyte pentraxin 3 during acute myocardial infarction. J Immunol. 2011 Jul 15;187(2):970-9. doi: 10.4049/jimmunol.1100261. Epub 2011 Jun 15. Erratum in: J Immunol. 2011 Dec 15;187(12):6582.

 

Maroso M, Balosso S, Ravizza T, Liu J, Aronica E, Iyer AM, Rossetti C, Molteni M, Manfredi AA, Bianchi ME, Vezzani A. A causative role of Toll-Like Receptor 4 (TLR4) activation by High Mobility Group Box 1 (HMGB1) protein in ictogenesis. Nature Medicine, 2010, 16:413-419

 

Pluchino S, Zanotti L, Brambilla E, Rovere-Querini P, Capobianco A, Alfaro-Cervello C, Salani G, Cossetti C, Borsellino G, Battistini L, Ponzoni M, Doglioni C, Garcia-Verdugo JM, Comi G, Manfredi AA, Martino G. Immune regulatory neural stem/precursor cells protect from central nervous system autoimmunity by restraining dendritic cell function. PLoS One. 2009 ;4(6):e5959.

 

Ferri LA, Maugeri N, Rovere-Querini P, Calabrese A, Ammirati E, Cianflone D, Maseri A, Manfredi AA. Antiinflamamtory action of apoptotic cells in patients with acute coronary syndromes. Atherosclerosis. 2009 Aug;205(2):391-5.

 

Campana L, Bosurgi L, Bianchi ME, Manfredi AA, Rovere-Querini P. Requirement of HMGB1 for stromal cell-derived factor-1/CXCL12-dependent migration of macrophages and dendritic cells. J Leukoc Biol. 2009 Sep;86(3):609-15.

 

Maugeri N, Rovere-Querini P, Evangelista V, Covino C, Capobianco A, Bertilaccio MT, Piccoli A, Totani L, Cianflone D, Maseri A, Manfredi AA Neutrophils phagocytose activated platelets in vivo: a phosphatidylserine, P-selectin, and beta2 integrin-dependent cell clearance program. Blood. 2009 21;113(21):5254-65.

Di Comite G, Rossi CM, Marinosci A, Lolmede K, Baldissera E, Aiello P, Mueller RB, Herrmann M, Voll RE, Rovere-Querini P, Sabbadini MG, Corti A, Manfredi AA. Circulating chromogranin A reveals extra-articular involvement in patients with rheumatoid arthritis and curbs TNF-alpha-elicited endothelial activation. J Leukoc Biol. 2009;85(1):81-7.

 

Di Comite G, Previtali P, Rossi CM, Dell’Antonio G, Rovere-Querini P, Praderio L, Dagna L, Corti A, Doglioni C, Maseri A, Sabbadini MG, Manfredi AA. High blood levels of chromogranin A in giant cell arteritis identify patients refractory to corticosteroid treatment. Ann Rheum Dis. 2009;68(2):293-

 

Urbonaviciute V, Fürnrohr BG, Meister S, Munoz L, Heyder P, De Marchis F, Bianchi ME, Kirschning C, Wagner H, Manfredi AA, Kalden JR, Schett G, Rovere-Querini P, Herrmann M, Voll RE. Induction of inflammatory and immune responses by HMGB1-nucleosome complexes: implications for the pathogenesis of SLE. J Exp Med. 2008 22;205(13):3007-18.

 

Manfredi AA, Capobianco A, Esposito A, De Cobelli F,  Canu T, Monno A, Sanvito F, Raucci A, Doglioni C,  Nawroth PP,  Bierhaus A, Rovere-Querini P,  Del Maschio A, Maturing Dendritic Cells Depend on RAGE for In Vivo Homing to Lymph Nodes. J Immunol 2008 180(4):2270-5.