Bio

INFORMAZIONI PERSONALI

cittadinanza Italiana

Luogo e data di nascita Verona, Italy, October 9, 1957.

Stato civile coniugato, due figli

 

FORMAZIONE

1976 Diploma di Liceo Scientifico

1982 Laurea in Medicina e Chirurgia, Università of Ferrara: 110/110 e lode.

1985 Specialista in Oncologia, Università of Ferrara: 70/70 lode.

1985 Specialista in Ricerca Farmacologica, Regione lombardia, Istituto di Ricerche Farmacologiche “Mario Negri”, Milano.

 

ESPERIENZA PROFESSIONALE

Gennaio-giugno 1983

Internato Post-Laurea, Divisione di Medicina Generale, Ospedale Pubblico di Quistello (Mantova), USSL 48.

Settembre 1983- Settembre 1986

Ricercatore, Laboratorio d’Immunologia Umana (Capo: Dr. Alberto Mantovani), Istituto di Ricerche Farmacologiche “Mario Negri”, Milano.

Ottobre 1987- Ottobre 1993

Laboratory of Immunoregulation (capo: Dr. Anthony S. Fauci), NIAID, NIH, Bethesda, MD, USA. Ultimo ruolo occupato: Visiting Scientist.

Dal Novembre 1993

Capo, Unità d’Immunopatogenesi dell’AIDS, Istituto Scientifico San Raffaele. Milano.

Dicembre 2002- Dicembre 2015

Professore Associato di Patologia Generale, Università Vita-Salute San Raffaele, Milano.

Da gennaio 2016

Professore Ordinario di Patologia Generale, Università Vita-Salute San Raffaele, Milano.

 

LINGUE

ITALIANO                lingua madre

INGLESE                 parlato (fluente) e scritto

 

PREMI

1992                      NIH Award of Merit

1999                      European Society for Clinical Investigation (in precedenza noto come Mac Foster Award) Award.

 

ALTRE ATTIVITA’

Dal 2004

Passate o attuale Editore Associato per: The Journal of Immunology, AIDS, PlosOne.

 

Appartenenza a Network Internazionali

Dal 2011        Global Viral Network, (Chair: Robert C. Gallo, Institute of Human Virology, Baltimore, MD, USA http://gvn.org/

                        Co-Chair, Subgroup “Immunological mechanisms and compartments involved”, “TOWARDS AN HIV CURE”: GLOBAL SCIENTIFIC STRATEGY International Working Group (Chair: Francoise Barré-Sinoussi. Institut Pasteur, Paris, France. (http://www.iasociety.org/What-we-do/Towards-an-HIV-Cure/Activities/2012-International-Scientific-Working-Group)

Dal 2012       Membro, Towards an HIV Cure: Industry Collaboration

(http://www.iasociety.org/What-we-do/Towards-an-HIV-Cure/Activities/Working-Groups)

 

 

 

BIBLIOGRAFIA

(1985-2015)

Articoli Originali 155 (IF: 941,736) – IF medio: 6,07
Reviews & Capitoli di Libri 90 (IF: 229,05)
Totale   245 (IF: 1.170,886)
H-Index (ISI Web of Knowledge)

10 Pubblicazioni di rilievo

1989

  1. Poli, J. Orenstein, A. Kinter, T.M. Folks, & A.S. Fauci. Interferon alpha but not AZT suppresses HIV expression in chronically infected cell lines.  Science, 244: 575-577.

1990

  1. Poli, P. Bressler, A.L. Kinter, E. Duh, W.C. Timmer, A. Rabson,  J.S. Justement, S. Stanley, & A.S. Fauci.  Interleukin-6 induces HIV expression in chronically infected monocytic cells alone and in synergy with TNF-a by transcriptional and post-transcriptional mechanisms. J. Exp. Med., 172: 151-158.

1991

  1. Poli, A.L. Kinter, J.S. Justement, P.Bressler, J.H. Kehrl, & A.S. Fauci. Transforming growth factor-ß (TGF-ß) suppresses human immunodeficiency virus expression and replication in infected cells of the monocyte/macrophage lineage. J. Exp. Med., 173: 589-597.

1999

  1. Bovolenta, L. Camorali, A.L. Lorini, S. Ghezzi, E. Vicenzi, A. Lazzarin, & G. Poli. Constitutive activation of STATs upon in vivo HIV infection. Blood, 94: 4202-4209, 1999.

2003

  1. Poli & C. Bordignon. Unplugging the T cell receptor. Nature Immunol., 4:943-4.

2009

  1. Alfano, S.A. Mariani, C. Elia, R. Pardi, F. Blasi, & G. Poli. Ligand-engaged urokinase-type plasminogen activator receptor (uPAR) and the CD11b/CD18 (Mac1) integrin inhibit late events of HIV expression in monocytic cells. Blood, 113:1699-1709.

2009

  1. Cassol, C. Rizzi, L. Cassetta, M. Alfano, & G. Poli. M1 and M2a polarization of human monocyte-derived macrophages inhibits HIV-1 replication by distinct mechanisms. J. Immunol. 182: 6237-6246.

2012

  1. Guergnon, C. Dalmasso, P. Broet, L. Meyer, S.J. Westrop, N. Imami, E. Vicenzi, G. Morsica,
  2. Tinelli, B. Zanone Poma, C. Goujard, V. Potard, F.M. Gotch, C. Casoli, A. Cossarizza, F.

Macciardi, P. Debré, J.F. Delfraissy, M. Galli, B. Autran, D. Costagliola,

  1. Poli, I. Theodorou, & A. Riva *GISHEAL Consortium. Both Class-I and Class-III MHC genetic subregions contribute to natural long-term non progression in HIV infection.
  2. Infect. Dis., 205:718-724, 2012.

2013

  1. Saba, M. Origoni, G. Taccagni, D. Ferrari, C. Doglioni, A. Nava, A. Lisco, J.-C. Grivel,
  2. Margolis, & G. Poli. Productive HIV-1 infection of human cervical tissue ex vivo is associated with the secretory phase of the menstrual cycle. Mucosal Immunol, 6:1081-90, 2013.

2015

  1. Graziano, M. Desdouits, L. Garzetti, P. Podini, M. Alfano, A. Rubartelli,
  2. Furlan. P. Benaroch & G. Poli. Extracellular ATP induces the rapid release of HIV-1 from virus containing compartments of human macrophages. Proc. Natl. Acad. Sci. (USA), 112:E3265-73, 2015.

PERSONAL INFORMATION

Citizenship Italian

Place and date of birth Verona, Italy, October 9, 1957.

Marital Status Married, two sons

 

EDUCATION

1976 High School (Scientific Lyceum).

1982 Medical Doctor degree, University of Ferrara, Italy; final marks: 110/110 e lode (Summa cum Laude).

1985 Specialist in Oncology, University of Ferrara, Italy; final marks: 70/70 lode (Summa cum Laude).

1985 Specialist in Pharmacological Research, Lombardy Region, “Mario Negri” Institute for Pharmacological Research, Milano, Italy.

 

PROFESSIONAL EXPERIENCE

Jan-June 1983

Internship, Division of General Medicine, Public Hospital of Quistello (Mantova), USSL 48, Italy.

Sept 1983-Sept 1986

Research Fellow, Laboratory of Human Immunology (Head: Dr. Alberto Mantovani), “Mario Negri” Institute for Pharmacological Research, Milano, Italy.

Oct 1987-Oct 1993

Laboratory of Immunoregulation (Head: Dr. Anthony S. Fauci), NIAID, NIH, Bethesda, MD, USA. Final position: Visiting Scientist.

Since Nov 1993

Head, AIDS Immunopathogenesis Unit, San Raffaele Scientific Institute, Milano, Italy.

Dec 2002-Dec 2015

Associate Professor of Pathology, Vita-Salute San Raffaele University, Milano, Italy.

Since Jan 2016

Full Professor of Pathology, Vita-Salute San Raffaele University, Milano, Italy.

 

 

LANGUAGE               

ITALIAN                  Mother tongue

ENGLISH                 Spoken (fluent), written

 

AWARDS                   

1992            NIH Award of Merit.

1999            European Society for Clinical Investigation (formerly Mac Foster) Award.

 

OTHER ACTIVITIES             

SINCE 2004

Past and Current Associate Editor for: The Journal of Immunology, AIDS, PlosOne.

 

International Networks

Since 2011     Italy Vice-Director, Global Viral Network, (Chair: Robert C. Gallo, Institute of Human Virology, Baltimore, MD, USA http://gvn.org/

Since 2011      Co-Chair, Subgroup “Immunological mechanisms and compartments involved”, “TOWARDS AN HIV CURE”: GLOBAL SCIENTIFIC STRATEGY International Working Group (Chair: Francoise Barré-Sinoussi. Institut Pasteur, Paris, France. (http://www.iasociety.org/What-we-do/Towards-an-HIV-Cure/Activities/2012-International-Scientific-Working-Group)

Since 2012    Member, Towards an HIV Cure: Industry Collaboration

(http://www.iasociety.org/What-we-do/Towards-an-HIV-Cure/Activities/Working-Groups)

 

 

BIBLIOGRAPHY

(1985-2015)

Original Articles 155 (IF: 941,736) – IF medio: 6,07
Reviews & Book Chapters 90 (IF: 229,05)
Total   245 (IF: 1.170,886)
H-Index (ISI Web of Knowledge)   50

 

10 KEY PUBLICATIONS                  

1989

  1. Poli, J. Orenstein, A. Kinter, T.M. Folks, & A.S. Fauci. Interferon alpha but not AZT suppresses HIV expression in chronically infected cell lines.  Science, 244: 575-577.

1990

  1. Poli, P. Bressler, A.L. Kinter, E. Duh, W.C. Timmer, A. Rabson,  J.S. Justement, S. Stanley, & A.S. Fauci.  Interleukin-6 induces HIV expression in chronically infected monocytic cells alone and in synergy with TNF-a by transcriptional and post-transcriptional mechanisms. J. Exp. Med., 172: 151-158.

1991

  1. Poli, A.L. Kinter, J.S. Justement, P.Bressler, J.H. Kehrl, & A.S. Fauci. Transforming growth factor-ß (TGF-ß) suppresses human immunodeficiency virus expression and replication in infected cells of the monocyte/macrophage lineage. J. Exp. Med., 173: 589-597.

1999

  1. Bovolenta, L. Camorali, A.L. Lorini, S. Ghezzi, E. Vicenzi, A. Lazzarin, & G. Poli. Constitutive activation of STATs upon in vivo HIV infection. Blood, 94: 4202-4209, 1999.

2003

  1. Poli & C. Bordignon. Unplugging the T cell receptor. Nature Immunol., 4:943-4.

2009

  1. Alfano, S.A. Mariani, C. Elia, R. Pardi, F. Blasi, & G. Poli. Ligand-engaged urokinase-type plasminogen activator receptor (uPAR) and the CD11b/CD18 (Mac1) integrin inhibit late events of HIV expression in monocytic cells. Blood, 113:1699-1709.

2009

  1. Cassol, C. Rizzi, L. Cassetta, M. Alfano, & G. Poli. M1 and M2a polarization of human monocyte-derived macrophages inhibits HIV-1 replication by distinct mechanisms. J. Immunol. 182: 6237-6246.

2012

  1. Guergnon, C. Dalmasso, P. Broet, L. Meyer, S.J. Westrop, N. Imami, E. Vicenzi, G. Morsica,
  2. Tinelli, B. Zanone Poma, C. Goujard, V. Potard, F.M. Gotch, C. Casoli, A. Cossarizza, F.

Macciardi, P. Debré, J.F. Delfraissy, M. Galli, B. Autran, D. Costagliola,

  1. Poli, I. Theodorou, & A. Riva *GISHEAL Consortium. Both Class-I and Class-III MHC genetic subregions contribute to natural long-term non progression in HIV infection.
  2. Infect. Dis., 205:718-724, 2012.

2013

  1. Saba, M. Origoni, G. Taccagni, D. Ferrari, C. Doglioni, A. Nava, A. Lisco, J.-C. Grivel,
  2. Margolis, & G. Poli. Productive HIV-1 infection of human cervical tissue ex vivo is associated with the secretory phase of the menstrual cycle. Mucosal Immunol, 6:1081-90, 2013.

2015

  1. Graziano, M. Desdouits, L. Garzetti, P. Podini, M. Alfano, A. Rubartelli,
  2. Furlan. P. Benaroch & G. Poli. Extracellular ATP induces the rapid release of HIV-1 from virus containing compartments of human macrophages. Proc. Natl. Acad. Sci. (USA), 112:E3265-73, 2015.
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