Bio

BIOGRAPHICAL SKETCH


POSITION TITLE

Professor of Molecular Biology

Università Vita Salute San Raffaele,

Director, Division of Genetics and Cell Biology

San Raffaele Scientific Institute Milano

 

 

EDUCATION/TRAINING

(Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)

INSTITUTION AND LOCATION     DEGREE

University of Genoa, Italy                                 MD                1977             Medicine (cum laude)

University of Genoa, Italy                                 Specialist        1980             Hematology (cum laude)

Memorial Sloan Kettering Cancer Center              Post Doc         1979             Immunochemistry

 

 

  1. Positions and Honors

Positions and Employment

1978-1979

Post Doctorate Fellow, Immunochemistry, Memorial Sloan Kettering Cancer Center, New York

1980-1982

Assistant Professor, Immunology and Transplantation, University of Genoa, Italy

1982-1986

Assistant Professor, Molecular Biology, National Cancer Center, Genoa Italy

1986-1987

Visiting Investigator, Laboratory of Molecular Biology, Cambridge, UK

1987-1990

Associate Professor, Immunogenetics, National Cancer Center, Genoa Italy

1990-present

Group leader, San Raffaele Scientific Institute, Milano

1998-2007

Deputy Director, Department of Functional Genomics and Molecular Biology,

San Raffaele Scientific Institute, Milano

1999   (Jan-Mar)

Visiting professor, New South Wales University (Australia)

2000-present

Professor of Molecular Biology, Università Vita Salute San Raffaele. Milano

2005-2007

Dean of the School of Medicine, Università Vita Salute San Raffaele. Milano

2006 (Oct-Nov)

Visiting professor, Tokyo University (Japan)

2008 (Mar-Dec)

Visiting professor, Institut Curie, Paris (FR)

2008-present

Director, Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano

 

 

Honors and Professional Memberships

1980-

Italian Association of Immunologists

1983-

Italian Association of Cell Biologists

1992-

Elected Member of European Molecular Biology Organisation (EMBO)

1993-1996

EMBO Course and Workshop Committee

1996

American Society of Cell Biology

2001

American Society of Biochemistry and Molecular Biology

1994-1998

Scientific Advisory Board, Enciclopedia Italiana Treccani

1998-

Founder of European Life Science Organisation (ELSO)

1998-2010

Editor, EMBO Reports

1998-2010

Editor, The EMBO Journal

1998-present

ELSO Steering Committee

2001-2006

Editor, The Journal of Biological Chemistry

2002-2007

Chair, EMBO Science and Society Committee

2008-2011

Editor, Pathogenetics

2010-present

Editor, Antioxidant Redox Signaling

  • Selected peer-reviewed publications

 

Wang L, Zhang L, Niu Y, Sitia R, Wang CC. (2014) Glutathione Peroxidase 7 Utilizes Hydrogen Peroxide Generated by Ero1α to Promote Oxidative Protein Folding. Antioxid Redox Signal. 20(4):545-56.

 

van Anken E, Orsi A, Sitia R A RIDDle solved: why an intact IRE1/XBP1 signaling relay is key for humoral immune responses. Eur J Immunol. 2014 Feb 4. doi: 10.1002/eji.201444461

 

Benasciutti E, Mariani E, Oliva L, Scolari M, Perilli E, Barras E, Milan E, Orfanelli U, Fazzalari NL, Campana L, Capobianco A, Otten L, Particelli F, Acha-Orbea H, Baruffaldi F, Faccio R, Sitia R, Reith W, Cenci S.MHC Class II Transactivator Is an In Vivo Regulator of Osteoclast Differentiation and Bone Homeostasis Co-opted From Adaptive Immunity. J Bone Miner Res. 2014 Feb;29(2):290-303.

 

Kakihana T, Araki K, Vavassori S, Iemura SI, Cortini M, Fagioli C, Natsume T, Sitia R, Nagata K. (2013) Dynamic regulation of Ero1α and Prx4 localization in the secretory pathway. J Biol Chem. 288(41):29586-94 joint last authors

 

Vavassori S, Cortini M. Masui S, Sannino S. Anelli T. Caserta I, Fagioli C, Mossuto MF, Fornili A. van Anken E, Degano M, Inaba K and Sitia R A pH-Regulated Quality Control Cycle for Surveillance of Secretory Protein Assembly. Molecular Cell 50:783-92

 

Bertolotti M, Bestetti S, García-Manteiga JM, Medraño-Fernandez I, Dal Mas A, Maria Luisa Malosio ML, and Sitia R (2013) Tyrosine kinase signal modulation: a matter of H2O2 membrane permeability? Antiox. Redox Signal., 19(13):1447-51

 

Benham A, van Lith M, Sitia R & Braakman I (2013) Ero1-PDI interactions, the response to redox flux and the implications for disulfide bond formation in the mammalian endoplasmic reticulum. Phil Trans R Soc B, Mar 25;368(1617):20110403.

 

Pengo N, Scolari M, Oliva L, Milan E, Mainoldi F, Raimondi A, Fagioli C, Merlini A, Mariani E, Pasqualetto E, Orfanelli U, Ponzoni M, Sitia R, Casola S, Cenci S Plasma cells require autophagy for sustainable immunoglobulin production. (2013) Nature Immunol. 14:298-305.

 

Campanella A, Santambrogio P, Fontana F, Frenquelli M, Cenci S, Marcatti M, Sitia R, Tonon G, Camaschella C. (2013) Iron increases the susceptibility of multiple myeloma cells to bortezomib. Haematologica. 98:971-9.

 

Cenci S, Oliva L, Cerruti F, Milan E, Bianchi G, Raule M, Mezghrani A, Pasqualetto E, Sitia R, Cascio (2012) Pivotal Advance: Protein synthesis modulates responsiveness of differentiating and malignant plasma cells to proteasome inhibitors. J Leukoc Biol. 92:921-31.

 

Margittai É, Löw P, Stiller I, Greco A, Garcia-Manteiga JM, Pengo N, Benedetti A, Sitia R, Bánhegyi G. (2012) Production of H2O2 in the endoplasmic reticulum promotes in vivo disulfide bond formation Antioxid Redox Signal 15;16(10):1088-99

 

Bertolotti M, Sitia R, Rubartelli A. (2012) On the redox control of B lymphocyte differentiation and function. Antioxid Redox Signal 15;16(10):1139-49 joint last authors

 

Kakihana T, Nagata K, Sitia R (2012) Peroxides and peroxidases in the endoplasmic reticulum: integrating redox homeostasis and oxidative folding Antioxid Redox Signal 15;16(8):763-71. doi: 10.1089/ars.2011.4238.

 

Anelli T, Bergamelli L, Rimessi A, Fagioli C, Malgaroli A, Pinton P, Ripamonti M, Rizzuto R and Sitia R (2012) Ero1a Regulates Ca2+ Fluxes at the Endoplasmic Reticulum-Mitochondria Interface (MAM). Antioxid. Redox Signal 16, 1007-87

 

Garcia-Manteiga JM, Mari S, Godejohann M, Spraul M, Napoli C, Cenci S, Musco G, Sitia R (2011) Metabolomics of B to plasma cell differentiation. J Proteome Res 2;10(9):4165-76

 

Cenci S, Van Anken E and Sitia R. (2011) Proteostenosis and plasma cell pathophysiology. Curr. Opin. Cell Biol. 23, 216-222

 

Margittai E and Sitia R. (2011). Oxidative protein folding in the secretory pathway and redox-signaling across compartments and cells. Traffic, 12, 1-8.

 

Quaglio E, Restelli E, Garofoli A, Dossena S, De Luigi A, Tagliavacca L, Imperiale D, Migheli A, Salmona M, Sitia R, Forloni G, Chiesa R. (2011) Expression of Mutant or Cytosolic PrP in Transgenic Mice and Cells Is Not Associated with Endoplasmic Reticulum Stress or Proteasome Dysfunction. PLoS One. Apr 29;6(4):e19339

 

Masui S, Vavassori S, Fagioli C, Sitia R, Inaba K. (2011) Molecular bases of cyclic and specific disulfide interchange between human Ero1{alpha} and PDI. J Biol Chem. 286(18):16261-71.

 

Bertolotti M, Yim SH, Garcia-Manteiga JM, Masciarelli S, Kim YJ, Kang MH, Iuchi Y, Fuji J, Venè R, Rubartelli I A, Rhee SG, Sitia R. (2010). B- to plasma-cell terminal differentiation entails oxidative stress and profound reshaping of the antioxidant responses. Antioxid. Redox Signal., 13:1133-44

 

Inaba K, Masui S, IidaH, Vavassori S, Sitia R*., Suzuki M* (2010). Crystal structures of human Ero1α reveal the mechanisms of regulated and targeted oxidation of PDI. EMBO J 29:3330-43 * joint last authors

 

Bertolotti M, Yim SH, Garcia-Manteiga JM, Masciarelli S, Kim YJ, Kang MH, Iuchi Y, Fuji J, Venè R, Rubartelli I A, Rhee SG, Sitia R. (2010). B- to plasma-cell terminal differentiation entails oxidative stress and profound reshaping of the antioxidant responses. Antioxid. Redox Signal., 13:1133-44

 

Inaba K, Masui S, IidaH, Vavassori S, Sitia R*, Suzuki M* (2010). Crystal structures of human Ero1α reveal the mechanisms of regulated and targeted oxidation of PDI. EMBO J 29:3330-43 * joint last authors

Cortini M and Sitia R. (2010). From antibodies to adiponectin: role of ERp44 in sizing and timing protein secretion. Diab. Obes. And Metab. 12, 39-47

 

Margittai E and Sitia R. (2010). Oxidative protein folding in the secretory pathway and redox-signaling across compartments and cells. Traffic, aug 12, doi: 10.1111/j.1600-0854.2010.01108.

 

Ronzoni R. Anelli T, Brunati M, Cortini M, Fagioli C and Sitia R. 2010. Pathogenesis of ER Storage Disorders:modulating Russell Body biogenesis by altering proximal and distal quality control Traffic, 11(7):947-57

 

Anelli T and Sitia R. 2010 Physiology and pathology of proteostasis in the early secretory compartment. Semin Cell Dev Biol. 21:520-5

 

Cortini M and Sitia R. 2010. ERp44 and ERGIC-53 synergize in coupling efficiency and fidelity of IgM polymerization and secretion. Traffic, 11; 651-659

 

Masciarelli S, Fra AM, Pengo N, Bertolotti M, Cenci S, Fagioli C, Ron D, Hendershot L and Sitia R 2010. CHOP-independent apoptosis and pathway-selective induction of the UPR in developing plasma cells Molec. Immunol. 47:1356-65.

 

Rubartelli A and Sitia R. 2009 Chemo-metabolic regulation of immune responses by Tregs.

Nature Chem- Biol. 10, 709-1

 

Bianchi G, Oliva L, Cascio P, Pengo N, Fontana F, Cerruti F, Orsi A, Pasqualetto E, Mezghrani A, Calbi V, Palladini G, Giuliani N, Anderson KC, Sitia R°, Cenci S°. 2009 The proteasome load vs. capacity balance determines apoptotic sensitivity of multiple myeloma cells to proteasome inhibition. Blood. 113, 3040-9. °joint last authors

 

Rubartelli A and Sitia R. 2009 Stress as an intercellular signal: the emergence of stress associated molecular patterns (SAMP). Antioxid Redox Signal. 11, 2621-9

 

Wang L°, Wang L°, Vavassori S°, Li S, Ke H, Anelli T, Degano M, Ronzoni R, Sitia R§, Sun F§ & Wang CC§ 2008. Crystal structure of human ERp44 reveals a dynamic functional modulation by its C-terminal tail.   EMBO Rep. 9, 642-7. §/°joint last/first authors

 

Fraldi A°, Zito E°, Annunziata F, Lombardi A, Cozzolino M, Monti M, Spampanato C, Ballabio A, Pucci P, Sitia R§ and Cosma P § 2008. Multistep, sequential control of the trafficking and function of the multiple sulfatase deficiency gene product, SUMF1 by PDI, ERGIC-53 and ERp44. Hum. Molec. Gen. 17, 2610-2 §/°joint last/first authors

 

Nerini-Molteni S, Ferrarini M, Cozza S, Caligaris-Cappio F and Sitia R. 2008. Redox homeostasis modulates the sensitivity of myeloma cells to proteasome inhibitors. Brit. J. Haemat., 41, 494-503.

 

Masciarelli S and Sitia R. 2008. Building and operating an antibody factory: Redox control during B to plasma cell terminal differentiation. Biochim Biophys Acta. 783, 578-88

 

Anelli T and Sitia R. 2008. Protein quality control in the early secretory pathway.

EMBO J. 27, 315-27.

 

Anelli T, Ceppi S, Bergamelli L, Cortini M, Masciarelli S, Valetti C and Sitia R. 2007 Sequential steps and checkpoints in the early exocytic compartment during secretory IgM biogenesis. EMBO J. 26, 4177-88

 

Cenci S and Sitia R. 2007. Managing and exploiting stress in the antibody factory.

FEBS Lett. 581, 3652-7.

Cenci, S., Mezghrani, A., Cascio, P., Bianchi, G., Cerruti, F., Fra, A., Lelouard, H., Masciarelli, S., Mattioli, L., Oliva, L., Orsi, A., Pasqualetto, E., Pierre, P., Ruffato, E., Tagliavacca, L. and Sitia, R. (2006) Progressively impaired proteasomal capacity during terminal plasma cell differentiation. EMBO J, 25, 1104-1113.

 

Mattioli L , Anelli T, Fagioli C , Tacchetti C, Sitia R§, Valetti C§. 2006 Endoplasmic Reticulum Storage Diseases: A Role for ERGIC- 53 in Controlling the Formation and Shape of Russell Bodies. J. Cell Sci. 119 2532-41 §joint last authors

Orsi A, Fioriti L, Chiesa R, Sitia R 2006 Conditions of endoplasmic reticulum stress favor the accumulation of cytosolic prion protein. J Biol Chem 281, 30431-8

Sitia R, Nerini-Molteni SN. 2004 Stress, protein (mis)folding, and signaling: the redox connection. Science STKE. 239, 27.

Nerini-Molteni SN, Fassio A, Ciriolo MR, Filomeni G, Pasqualetto E, Fagioli C, Sitia R. 2004 Glutathione limits Ero1-dependent oxidation in the endoplasmic reticulum. J Biol Chem. 279, 32667-73.

Sitia R and Braakman I. (2003). Quality control in the endoplasmic reticulum protein factory. Nature 426, 891-4.

 

VanAnken E, Romijn EP, Maggioni C, Mezghrani A, Sitia R§, Braakman I§, and Heck AJR§ (2003) Sequential waves of functionally related proteins are expressed when B cells prepare for antibody secretion. Immunity 18, 243-53. §joint last authors

 

Anelli T., Alessio M., Mezghrani A., Simmen T., Talamo F., Bachi A., Sitia R. (2002) ERp44, a novel endoplasmic reticulum folding assistant of the thioredoxin family. EMBO J. 21, 835.

 

Mezghrani A., Fassio A., Benham A., Simmen T., Braakman I., Sitia R. (2001). Manipulation of Oxidative Protein Folding and PDI Redox State in Mammalian Cells. EMBO J. 20, 6288.

 

Pagani M., Fabbri M., Fassio A., Pilati S., Benedetti C., Bulleid N.J., Cabibbo A., Sitia R. (2000) ERO1-Lbeta: a novel ER protein induced during the Unfolded Protein Response in mammalian cells. J. Biol. Chem. 275, 23685-23692.

 

Reddy P., Sparvoli A., Fagioli C., Fassina G. and Sitia R. (1996). Formation of reversible disulfide bonds with the protein matrix of the endoplasmic reticulum correlates with the retention of unassembled Ig-light chains. EMBO J. 15, 2077-2085.

 

Rubartelli A., Bajetto A., Allavena G., Wollman E. and Sitia R. (1992). Secretion of thioredoxin by normal and neoplastic cells through a leaderless secretory pathway. J. Biol. Chem. 267, 24161-24164.

 

Valetti C., Grossi C.E., Milstein C. and Sitia R. (1991). Russell bodies: a general response of secretory cells to synthesis of a mutant immunoglobulin which can neither exit from, nor be degraded in, the endoplasmic reticulum. J. Cell Biol. 115, 983-994.

 

Sitia R., Neuberger M.S., Alberini C., Bet P., Fra A.M., Valetti C., Williams G. and Milstein C. (1990). Developmental regulation of IgM secretion: the role of the carboxy-terminal cysteine. Cell 60, 781-790.

 

Klausner R.D., and Sitia R. (1990). Protein degradation in the endoplasmic reticulum. Cell 62, 611-614

BIOGRAPHICAL SKETCH


POSITION TITLE

Professor of Molecular Biology

Università Vita Salute San Raffaele,

Director, Division of Genetics and Cell Biology

San Raffaele Scientific Institute Milano

 

 

EDUCATION/TRAINING

(Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)

INSTITUTION AND LOCATION     DEGREE

University of Genoa, Italy                                 MD                1977             Medicine (cum laude)

University of Genoa, Italy                                 Specialist        1980             Hematology (cum laude)

Memorial Sloan Kettering Cancer Center              Post Doc         1979             Immunochemistry

 

 

  1. Positions and Honors

Positions and Employment

1978-1979

Post Doctorate Fellow, Immunochemistry, Memorial Sloan Kettering Cancer Center, New York

1980-1982

Assistant Professor, Immunology and Transplantation, University of Genoa, Italy

1982-1986

Assistant Professor, Molecular Biology, National Cancer Center, Genoa Italy

1986-1987

Visiting Investigator, Laboratory of Molecular Biology, Cambridge, UK

1987-1990

Associate Professor, Immunogenetics, National Cancer Center, Genoa Italy

1990-present

Group leader, San Raffaele Scientific Institute, Milano

1998-2007

Deputy Director, Department of Functional Genomics and Molecular Biology,

San Raffaele Scientific Institute, Milano

1999   (Jan-Mar)

Visiting professor, New South Wales University (Australia)

2000-present

Professor of Molecular Biology, Università Vita Salute San Raffaele. Milano

2005-2007

Dean of the School of Medicine, Università Vita Salute San Raffaele. Milano

2006 (Oct-Nov)

Visiting professor, Tokyo University (Japan)

2008 (Mar-Dec)

Visiting professor, Institut Curie, Paris (FR)

2008-present

Director, Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano

 

 

 

Honors and Professional Memberships

1980-

Italian Association of Immunologists

1983-

Italian Association of Cell Biologists

1992-

Elected Member of European Molecular Biology Organisation (EMBO)

1993-1996

EMBO Course and Workshop Committee

1996

American Society of Cell Biology

2001

American Society of Biochemistry and Molecular Biology

1994-1998

Scientific Advisory Board, Enciclopedia Italiana Treccani

1998-

Founder of European Life Science Organisation (ELSO)

1998-2010

Editor, EMBO Reports

1998-2010

Editor, The EMBO Journal

1998-present

ELSO Steering Committee

2001-2006

Editor, The Journal of Biological Chemistry

2002-2007

Chair, EMBO Science and Society Committee

2008-2011

Editor, Pathogenetics

2010-present

Editor, Antioxidant Redox Signaling

 

  1. Selected peer-reviewed publications

 

Wang L, Zhang L, Niu Y, Sitia R, Wang CC. (2014)

Glutathione Peroxidase 7 Utilizes Hydrogen Peroxide Generated by Ero1α to Promote Oxidative Protein Folding. Antioxid Redox Signal. 20(4):545-56.

 

van Anken E, Orsi A, Sitia R

A RIDDle solved: why an intact IRE1/XBP1 signaling relay is key for humoral immune responses. Eur J Immunol. 2014 Feb 4. doi: 10.1002/eji.201444461

 

Benasciutti E, Mariani E, Oliva L, Scolari M, Perilli E, Barras E, Milan E, Orfanelli U, Fazzalari NL, Campana L, Capobianco A, Otten L, Particelli F, Acha-Orbea H, Baruffaldi F, Faccio R, Sitia R, Reith W, Cenci S.

MHC Class II Transactivator Is an In Vivo Regulator of Osteoclast Differentiation and Bone Homeostasis Co-opted From Adaptive Immunity. J Bone Miner Res. 2014 Feb;29(2):290-303.

 

Kakihana T, Araki K, Vavassori S, Iemura SI, Cortini M, Fagioli C, Natsume T, Sitia R, Nagata K. (2013)

Dynamic regulation of Ero1α and Prx4 localization in the secretory pathway. J Biol Chem. 288(41):29586-94 joint last authors

 

Vavassori S, Cortini M. Masui S, Sannino S. Anelli T. Caserta I, Fagioli C, Mossuto MF, Fornili A. van Anken E, Degano M, Inaba K and Sitia R A pH-Regulated Quality Control Cycle for Surveillance of Secretory Protein Assembly. Molecular Cell 50:783-92

 

Bertolotti M, Bestetti S, García-Manteiga JM, Medraño-Fernandez I, Dal Mas A, Maria Luisa Malosio ML, and Sitia R (2013) Tyrosine kinase signal modulation: a matter of H2O2 membrane permeability? Antiox. Redox Signal., 19(13):1447-51

 

Benham A, van Lith M, Sitia R & Braakman I (2013) Ero1-PDI interactions, the response to redox flux and the implications for disulfide bond formation in the mammalian endoplasmic reticulum. Phil Trans R Soc B, Mar 25;368(1617):20110403.

 

Pengo N, Scolari M, Oliva L, Milan E, Mainoldi F, Raimondi A, Fagioli C, Merlini A, Mariani E, Pasqualetto E, Orfanelli U, Ponzoni M, Sitia R, Casola S, Cenci S

Plasma cells require autophagy for sustainable immunoglobulin production. (2013) Nature Immunol. 14:298-305.

 

Campanella A, Santambrogio P, Fontana F, Frenquelli M, Cenci S, Marcatti M, Sitia R, Tonon G, Camaschella C. (2013)

Iron increases the susceptibility of multiple myeloma cells to bortezomib. Haematologica. 98:971-9.

 

Cenci S, Oliva L, Cerruti F, Milan E, Bianchi G, Raule M, Mezghrani A, Pasqualetto E, Sitia R, Cascio (2012) Pivotal Advance: Protein synthesis modulates responsiveness of differentiating and malignant plasma cells to proteasome inhibitors. J Leukoc Biol. 92:921-31.

 

Margittai É, Löw P, Stiller I, Greco A, Garcia-Manteiga JM, Pengo N, Benedetti A, Sitia R, Bánhegyi G. (2012) Production of H2O2 in the endoplasmic reticulum promotes in vivo disulfide bond formation Antioxid Redox Signal 15;16(10):1088-99

 

Bertolotti M, Sitia R, Rubartelli A. (2012) On the redox control of B lymphocyte differentiation and function. Antioxid Redox Signal 15;16(10):1139-49 joint last authors

 

Kakihana T, Nagata K, Sitia R (2012) Peroxides and peroxidases in the endoplasmic reticulum: integrating redox homeostasis and oxidative folding Antioxid Redox Signal 15;16(8):763-71. doi: 10.1089/ars.2011.4238.

 

Anelli T, Bergamelli L, Rimessi A, Fagioli C, Malgaroli A, Pinton P, Ripamonti M, Rizzuto R and Sitia R (2012) Ero1a Regulates Ca2+ Fluxes at the Endoplasmic Reticulum-Mitochondria Interface (MAM). Antioxid. Redox Signal 16, 1007-87

 

Garcia-Manteiga JM, Mari S, Godejohann M, Spraul M, Napoli C, Cenci S, Musco G, Sitia R (2011) Metabolomics of B to plasma cell differentiation. J Proteome Res 2;10(9):4165-76

 

Cenci S, Van Anken E and Sitia R. (2011) Proteostenosis and plasma cell pathophysiology. Curr. Opin. Cell Biol. 23, 216-222

 

Margittai E and Sitia R. (2011). Oxidative protein folding in the secretory pathway and redox-signaling across compartments and cells. Traffic, 12, 1-8.

 

Quaglio E, Restelli E, Garofoli A, Dossena S, De Luigi A, Tagliavacca L, Imperiale D, Migheli A, Salmona M, Sitia R, Forloni G, Chiesa R. (2011)

Expression of Mutant or Cytosolic PrP in Transgenic Mice and Cells Is Not Associated with Endoplasmic Reticulum Stress or Proteasome Dysfunction. PLoS One. Apr 29;6(4):e19339

 

Masui S, Vavassori S, Fagioli C, Sitia R, Inaba K. (2011)

Molecular bases of cyclic and specific disulfide interchange between human Ero1{alpha} and PDI. J Biol Chem. 286(18):16261-71.

 

Bertolotti M, Yim SH, Garcia-Manteiga JM, Masciarelli S, Kim YJ, Kang MH, Iuchi Y, Fuji J, Venè R, Rubartelli I A, Rhee SG, Sitia R. (2010). B- to plasma-cell terminal differentiation entails oxidative stress and profound reshaping of the antioxidant responses. Antioxid. Redox Signal., 13:1133-44

 

Inaba K, Masui S, IidaH, Vavassori S, Sitia R*., Suzuki M* (2010). Crystal structures of human Ero1α reveal the mechanisms of regulated and targeted oxidation of PDI. EMBO J 29:3330-43 * joint last authors

 

Bertolotti M, Yim SH, Garcia-Manteiga JM, Masciarelli S, Kim YJ, Kang MH, Iuchi Y, Fuji J, Venè R, Rubartelli I A, Rhee SG, Sitia R. (2010). B- to plasma-cell terminal differentiation entails oxidative stress and profound reshaping of the antioxidant responses. Antioxid. Redox Signal., 13:1133-44

 

Inaba K, Masui S, IidaH, Vavassori S, Sitia R*, Suzuki M* (2010). Crystal structures of human Ero1α reveal the mechanisms of regulated and targeted oxidation of PDI. EMBO J 29:3330-43 * joint last authors

Cortini M and Sitia R. (2010). From antibodies to adiponectin: role of ERp44 in sizing and timing protein secretion. Diab. Obes. And Metab. 12, 39-47

 

Margittai E and Sitia R. (2010). Oxidative protein folding in the secretory pathway and redox-signaling across compartments and cells. Traffic, aug 12, doi: 10.1111/j.1600-0854.2010.01108.

 

Ronzoni R. Anelli T, Brunati M, Cortini M, Fagioli C and Sitia R. 2010. Pathogenesis of ER Storage Disorders:modulating Russell Body biogenesis by altering proximal and distal quality control Traffic, 11(7):947-57

 

Anelli T and Sitia R. 2010

Physiology and pathology of proteostasis in the early secretory compartment. Semin Cell Dev Biol. 21:520-5

 

Cortini M and Sitia R. 2010. ERp44 and ERGIC-53 synergize in coupling efficiency and fidelity of IgM polymerization and secretion. Traffic, 11; 651-659

 

Masciarelli S, Fra AM, Pengo N, Bertolotti M, Cenci S, Fagioli C, Ron D, Hendershot L and Sitia R 2010. CHOP-independent apoptosis and pathway-selective induction of the UPR in developing plasma cells Molec. Immunol. 47:1356-65.

 

Rubartelli A and Sitia R. 2009 Chemo-metabolic regulation of immune responses by Tregs.

Nature Chem- Biol. 10, 709-1

 

Bianchi G, Oliva L, Cascio P, Pengo N, Fontana F, Cerruti F, Orsi A, Pasqualetto E, Mezghrani A, Calbi V, Palladini G, Giuliani N, Anderson KC, Sitia R°, Cenci S°. 2009

The proteasome load vs. capacity balance determines apoptotic sensitivity of multiple myeloma cells to proteasome inhibition. Blood. 113, 3040-9. °joint last authors

 

Rubartelli A and Sitia R. 2009

Stress as an intercellular signal: the emergence of stress associated molecular patterns (SAMP). Antioxid Redox Signal. 11, 2621-9

 

Wang L°, Wang L°, Vavassori S°, Li S, Ke H, Anelli T, Degano M, Ronzoni R, Sitia R§, Sun F§ & Wang CC§ 2008. Crystal structure of human ERp44 reveals a dynamic functional modulation by its C-terminal tail.   EMBO Rep. 9, 642-7. §/°joint last/first authors

 

Fraldi A°, Zito E°, Annunziata F, Lombardi A, Cozzolino M, Monti M, Spampanato C, Ballabio A, Pucci P, Sitia R§ and Cosma P § 2008. Multistep, sequential control of the trafficking and function of the multiple sulfatase deficiency gene product, SUMF1 by PDI, ERGIC-53 and ERp44. Hum. Molec. Gen. 17, 2610-2 §/°joint last/first authors

 

Nerini-Molteni S, Ferrarini M, Cozza S, Caligaris-Cappio F and Sitia R. 2008. Redox homeostasis modulates the sensitivity of myeloma cells to proteasome inhibitors. Brit. J. Haemat., 41, 494-503.

 

Masciarelli S and Sitia R. 2008. Building and operating an antibody factory: Redox control during B to plasma cell terminal differentiation. Biochim Biophys Acta. 783, 578-88

 

Anelli T and Sitia R. 2008. Protein quality control in the early secretory pathway.

EMBO J. 27, 315-27.

 

Anelli T, Ceppi S, Bergamelli L, Cortini M, Masciarelli S, Valetti C and Sitia R. 2007 Sequential steps and checkpoints in the early exocytic compartment during secretory IgM biogenesis. EMBO J. 26, 4177-88

 

Cenci S and Sitia R. 2007. Managing and exploiting stress in the antibody factory.

FEBS Lett. 581, 3652-7.

Cenci, S., Mezghrani, A., Cascio, P., Bianchi, G., Cerruti, F., Fra, A., Lelouard, H., Masciarelli, S., Mattioli, L., Oliva, L., Orsi, A., Pasqualetto, E., Pierre, P., Ruffato, E., Tagliavacca, L. and Sitia, R. (2006) Progressively impaired proteasomal capacity during terminal plasma cell differentiation. EMBO J, 25, 1104-1113.

 

Mattioli L , Anelli T, Fagioli C , Tacchetti C, Sitia R§, Valetti C§. 2006 Endoplasmic Reticulum Storage Diseases: A Role for ERGIC- 53 in Controlling the Formation and Shape of Russell Bodies. J. Cell Sci. 119 2532-41 §joint last authors

Orsi A, Fioriti L, Chiesa R, Sitia R 2006 Conditions of endoplasmic reticulum stress favor the accumulation of cytosolic prion protein. J Biol Chem 281, 30431-8

Sitia R, Nerini-Molteni SN. 2004 Stress, protein (mis)folding, and signaling: the redox connection. Science STKE. 239, 27.

Nerini-Molteni SN, Fassio A, Ciriolo MR, Filomeni G, Pasqualetto E, Fagioli C, Sitia R. 2004 Glutathione limits Ero1-dependent oxidation in the endoplasmic reticulum. J Biol Chem. 279, 32667-73.

Sitia R and Braakman I. (2003). Quality control in the endoplasmic reticulum protein factory. Nature 426, 891-4.

 

VanAnken E, Romijn EP, Maggioni C, Mezghrani A, Sitia R§, Braakman I§, and Heck AJR§ (2003) Sequential waves of functionally related proteins are expressed when B cells prepare for antibody secretion. Immunity 18, 243-53. §joint last authors

 

Anelli T., Alessio M., Mezghrani A., Simmen T., Talamo F., Bachi A., Sitia R. (2002) ERp44, a novel endoplasmic reticulum folding assistant of the thioredoxin family. EMBO J. 21, 835.

 

Mezghrani A., Fassio A., Benham A., Simmen T., Braakman I., Sitia R. (2001). Manipulation of Oxidative Protein Folding and PDI Redox State in Mammalian Cells. EMBO J. 20, 6288.

 

Pagani M., Fabbri M., Fassio A., Pilati S., Benedetti C., Bulleid N.J., Cabibbo A., Sitia R. (2000) ERO1-Lbeta: a novel ER protein induced during the Unfolded Protein Response in mammalian cells. J. Biol. Chem. 275, 23685-23692.

 

Reddy P., Sparvoli A., Fagioli C., Fassina G. and Sitia R. (1996). Formation of reversible disulfide bonds with the protein matrix of the endoplasmic reticulum correlates with the retention of unassembled Ig-light chains. EMBO J. 15, 2077-2085.

 

Rubartelli A., Bajetto A., Allavena G., Wollman E. and Sitia R. (1992). Secretion of thioredoxin by normal and neoplastic cells through a leaderless secretory pathway. J. Biol. Chem. 267, 24161-24164.

 

Valetti C., Grossi C.E., Milstein C. and Sitia R. (1991). Russell bodies: a general response of secretory cells to synthesis of a mutant immunoglobulin which can neither exit from, nor be degraded in, the endoplasmic reticulum. J. Cell Biol. 115, 983-994.

 

Sitia R., Neuberger M.S., Alberini C., Bet P., Fra A.M., Valetti C., Williams G. and Milstein C. (1990). Developmental regulation of IgM secretion: the role of the carboxy-terminal cysteine. Cell 60, 781-790.

 

Klausner R.D., and Sitia R. (1990). Protein degradation in the endoplasmic reticulum. Cell 62, 611-614

Il titolare del presente curriculum vitae, pubblicato online sul portale www.unisr.it, è garante in via esclusiva della correttezza e della veridicità dei dati e delle informazioni in esso riportate e del loro eventuale e puntuale aggiornamento. Egli è dunque il diretto ed unico responsabile dei contenuti indicati nei propri curricula.