Ischemic stroke is caused by an acute occlusion of a cerebral artery, leading to focal brain tissue injury. The brain responds to stroke with a prolonged inflammatory process characterized by rapid infiltration of blood borne immune cells and microglial cells as well as activation of resident endogenous neural stem cells, astrocytes and neuronal plasticity processes. Nonetheless these cellular responses are often insufficient to lead to the recovery of the lost neurological function.
My aim is to understand the therapeutic potential of neural stem cells and their interaction and cross-talk to inflammatory cells both resident as well as infiltrating within the central nervous system. My final, ambitious goal is to modulate, by acting on neural stem cells, the pathophysiological processes to favour neuroprotective and plasticity processes occurring after stroke.

Curriculum Vitae

EDUCATION

-2013. PhD in Molecular Medicine, Experimental Neurology, Vita-Salute San Raffaele University, Milano, Italy.

– 2009. Clinical Board in Neurology, Vita-Salute San Raffaele University, Milano, Italy.

-2004. MD Degree, Vita-Salute San Raffaele University, Milano, Italy.

 

PROFESSIONAL EXPERIENCE

– 2014- ongoing. Researcher at the Neuroimmunology Unit and Staff Neurologist in the Stroke Unit at the Neurology Department, San Raffaele Hospital.

– 2010- 2013. PhD student at the Neuroimmunology Unit, Institute of Experimental Neurology (INSPE), San Raffaele Scientific Institute.

-2004- 2009. Resident physician, at the Neurology Department of the San Raffaele Scientific Institute.

-2006– 2007. Fellowship at the Neurological Department, University Hospital, Zurig, Switzerland.

-2003. Research at the Institute of Neurology “Edinger Institut”, Frankfurt, Germany.

 

GRANTS

Ongoing. Giovani Ricercatori, from the Italian Ministery of Health, bando 2011.

Ongoing. Ricerca biomedica condotta da giovani ricercatori, bando 2015.

Research Activity

Marco Bacigaluppi (born in 1979) is currently researcher at the Neuroimmunology Unit, Institute of Experimental Neurology at the University Vita- Salute San Raffaele in Milan. Since his early degree thesis in 2004 he specialized on the study of neural progenitor cells first in multiple sclerosis and afterwards in the field of ischemic stroke. After completing his Medical Degree in 2004 he spent, during his residency in Neurology, one year at the University Clinic in Zürich learning experimental modeling of stroke in the laboratory of Professor Dirk Hermann. Back in Milan, since 2007, he continues working as clinician and as researcher on ischemic stroke with a main focus on understanding repair mechanism in cerebral ischemia and in particular the role of inflammation and of endogenous neural stem cells in stroke of the elderly.

Publications

Treatment Challenges of a Primary Vertebral Artery Aneurysm Causing Recurrent Ischemic Strokes. Strambo D, Peruzzotti-Jametti L, Semerano A, Fanelli G, Simionato F, Chiesa R, Rinaldi E, Martinelli V, Comi G, Bacigaluppi M, Sessa M. Case Rep Neurol Med. 2017;2017:2571630.

Neural Stem Cell Transplantation Induces Stroke Recovery by Upregulating Glutamate Transporter GLT-1 in Astrocytes. Bacigaluppi M, Russo GL, Peruzzotti-Jametti L, Rossi S, Sandrone S, Butti E, De Ceglia R, Bergamaschi A, Motta C, Gallizioli M, Studer V, Colombo E, Farina C, Comi G, Politi LS, Muzio L, Villani C, Invernizzi RW, Hermann DM, Centonze D, Martino G. J Neurosci. 2016 Oct 12;36(41):10529-10544.

Neurogenesis or non-neurogenesis: that is the question. Martino G, Butti E, Bacigaluppi M. J Clin Invest. 2014 Mar 3;124(3):970-3.

Neurogenic and non-neurogenic functions of endogenous neural stem cells. Butti E, Cusimano M, Bacigaluppi M and Martino G. Frontiers Neuroscience. 2014 Apr 29;8:92.

Safety and efficacy of transcranial direct current stimulation in acute experimental ischemic stroke. Peruzzotti-Jametti L, Cambiaghi M, Bacigaluppi M, Gallizioli M, Gaude E, Mari S, Sandrone S, Cursi M, Teneud L, Comi G, Musco G, Martino G, Leocani L. Stroke. 2013 Nov;44(11):3166-74.

Subventricular zone neural progenitors protect striatal neurons from glutamatergic excitotoxicity. Butti, E, Bacigaluppi M, Rossi S, Cambiaghi M, Bari M, Cebrian Silla A, Brambilla E, Musella A, De Ceglia R, Teneud L, De Chiara V, D’Adamo P, Garcia-Verdugo JM, Comi G, Muzio L, Quattrini A, Leocani L, Maccarrone M, Centonze D and Martino G. Brain. 2012 135(Pt 11): 3320-3335.

Therapeutic stem cell plasticity orchestrates tissue plasticity. Martino G, Bacigaluppi M, Peruzzotti-Jametti L. Brain. 2011 Jun;134(Pt 6):1585-7.

Post-acute delivery of erythropoietin induces stroke recovery by promoting perilesional tissue remodelling and contralesional pyramidal tract plasticity. Reitmeir R, Kilic E, Kilic U, Bacigaluppi M, ElAli A, Salani G, Pluchino S, Gassmann M, Hermann DM. Brain. 2011 Jan;134(Pt 1):84-99.

Delayed post-ischaemic neuroprotection following systemic neural stem cell transplantation involves multiple mechanisms. Bacigaluppi M, Pluchino S, Peruzzotti-Jametti L, Kilic E, Kilic U, Salani G, Brambilla E, West MJ, Comi G, Martino G, Hermann DM. Brain. 2009 Aug;132(Pt 8):2239-51.