- 1982: degree in Biological Science, Dept. of Genetics, Biophysics and Biochemistry of the University of Pisa, Pisa
- 1983-86: Ph.D. fellow of the School of Pharmacology at the Mario Negri Institute Pharmacological Research, Milano
- 1986-90: post-doctoral fellow at the Dept. of Cellular and Molecular Physiology (Lewis C. Cantley group), Tufts University Medical School, Boston, USA 1990-1995:
- 1991-95 Research Associate, Dept. of Biomedicine and Oncology (Paolo Comoglio group), University of Torino Medical School, Torino.
- 1996-99: Ricercatore Universitario of Biochemistry, Dept. of Genetics, Biology and Biochemistry (Federico Bussolino group), University of Torino Medical School.
- 2000-06: Associate Professor of Biochemistry, Dept. of Medical Sciences, University of Piemonte Orientale Medical School, Novara
- 2006-14 Full professor of Biochemistry, Dept. of Clinical and Experimental Medicine, of the University of Piemonte Orientale Medical School, Novara
- 2015- Full professor of Biochemistry, Medical School, University Vita-Salute San Raffaele, Milan and Division of Experimental Oncology, Ospedale San Raffaele, Milano.
Awards and Financial Support:
- 1982 Magna cum laude graduation in Biological Sciences, University of Pisa
- 1986-87: EEC (European Economic Community) post-doctoral fellow.
- 1987-89: American Heart Association post-doctoral fellow.
- 1989-90: EORTC-NCI post-doctoral fellow(European Organization for Research and Treatment of Cancer- National Cancer Institute)
Recent and Current Competitive Grants
- 2016-17, AIRC (Italian Association for Cancer Research): Role of tumor-induced PI3-kinase-gamma in promoting skeletal muscle ghrelin resistance in cancer cachexia
- 2014-16, Telethon: Role of SAP-mediated inhibition of DGKa in regulating restimulation induced cell death (RICD): does DGKa targeting rescue RICD in XLP patients?”
- 2014-16, Muscle Dystrophy Association (USA): Exploring the therapeutic potential of unacylated ghrelin for muscular dystrophy
- 2013-15, AFM-Telethon (France), Ghrelin peptides as novel anti-atrophic factors acting directly in the skeletal muscle: identification of their molecular mechanisms and of their role in cancer cachexia
- 2013-15, Compagnia San Paolo: Role of Ghrelin in cancer cachexia
- 2013-2015, AIRC (Italian Association for Cancer Research) Role of Diacylglycerol kinase alpha in the transduction of oncogenic signaling
Bibliometrics Author of more than 60 publications Total citations: 6.910; H index: 30, i-10 index: 46,
Selected Recent Publications (since 2010):
– Ruffo E et al. Inhibition of diacylglycerol kinase α restores restimulation-induced cell death and reduces immunopathology in XLP-1. Sci Transl Med. 2016 Jan 13;8(321):321ra7.
– Gortan Capellari GG et al., Unacylated Ghrelin Reduces Skeletal Muscle Reactive Oxygen Species Generation and Inflammation and Prevents High-Fat Diet Induced Hyperglycemia and Whole-Body Insulin Resistance in Rodents. Diabetes. 2016 Jan 28. pii: db151019,
– Ruozi G., AAV-mediated in vivo functional selection of tissue-protective factors against ischaemia. Nat Commun. 2015 Jun 11;6:7388.
– Rainero E. et alThe Diacylglycerol Kinase α/atypicalPKCs/β1-Integrin Pathway in SDF-1α Mammary Carcinoma Invasiveness Plos One, 2014, 9 (6), e97144
– Porporato PE et al. Acylated and unacylated ghrelin impair skeletal muscle atrophy in mice J. Clin. Invest. 2013, Feb 1;123(2):611-22.
– Rainero E, et al. Diacylglycerol kinase-α controls RCP-dependent integrin trafficking to promote invasive migration. J Cell Biol. 2012 Jan 23;196(2):277-95.
– Baldanzi G et al. SAP-mediated inhibition of diacylglycerol kinase α regulates TCR-induced diacylglycerol signaling. J Immunol. 2011 Dec 1;187(11):5941-51.
– Chianale F et al Diacylglycerol kinase alpha mediates HGF-induced Rac activation and membrane ruffling by regulating atypical PKC and RhoGDI. Proc Natl Acad Sci U S A. 2010 Mar 2;107:4182-7
– Baldanzi G, et al. Negative regulation of diacylglycerol kinase theta mediates adenosine-dependent hepatocyte preconditioning. Cell Death Differ. 2010 Jun;17(6):1059-68
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