Curriculum Vitae

  • 1982:        degree in Biological Science, Dept. of Genetics, Biophysics and Biochemistry of the University of Pisa, Pisa
  • 1983-86: Ph.D. fellow of the School of Pharmacology at the Mario Negri Institute Pharmacological Research, Milano
  • 1986-90: post-doctoral fellow at the Dept. of Cellular and Molecular Physiology (Lewis C. Cantley group), Tufts University Medical School, Boston, USA 1990-1995:
  • 1991-95   Research Associate, Dept. of Biomedicine and Oncology (Paolo Comoglio group), University of Torino Medical School, Torino.
  • 1996-99:  Ricercatore Universitario of Biochemistry, Dept. of Genetics, Biology and Biochemistry (Federico Bussolino group), University of Torino Medical School.
  • 2000-06: Associate Professor of Biochemistry, Dept. of Medical Sciences, University of Piemonte Orientale Medical School, Novara
  • 2006-14 Full professor of Biochemistry, Dept. of Clinical and Experimental Medicine, of the University of Piemonte Orientale Medical School, Novara
  • 2015-       Full professor of Biochemistry, Medical School, University Vita-Salute San Raffaele, Milan and Division of Experimental Oncology, Ospedale San Raffaele, Milano.

 

Awards and Financial Support:

  • 1982            Magna cum laude graduation in Biological Sciences, University of Pisa
  • 1986-87:      EEC (European Economic Community) post-doctoral fellow.
  • 1987-89:      American Heart Association post-doctoral fellow.
  • 1989-90:    EORTC-NCI post-doctoral fellow(European Organization for Research and Treatment  of Cancer- National Cancer Institute)

 

Recent and Current Competitive Grants

  • 2016-17, AIRC (Italian Association for Cancer Research): Role of tumor-induced PI3-kinase-gamma in promoting skeletal muscle ghrelin resistance in cancer cachexia
  • 2014-16, TelethonRole of SAP-mediated inhibition of DGKa in regulating restimulation induced cell death (RICD): does DGKa targeting rescue RICD in XLP patients?”
  • 2014-16, Muscle Dystrophy Association (USA): Exploring the therapeutic potential of unacylated ghrelin for muscular dystrophy
  • 2013-15, AFM-Telethon (France), Ghrelin peptides as novel anti-atrophic factors acting directly in the skeletal muscle: identification of their molecular mechanisms and of their role in cancer cachexia
  • 2013-15, Compagnia San PaoloRole of Ghrelin in cancer cachexia
  • 2013-2015, AIRC (Italian Association for Cancer Research) Role of Diacylglycerol kinase alpha in the transduction of oncogenic signaling

Publications

Bibliometrics Author of more than 60 publications Total citations: 6.910; H index: 30, i-10 index: 46,

Selected Recent Publications (since 2010):

– Ruffo E et al. Inhibition of diacylglycerol kinase α restores restimulation-induced cell death and reduces immunopathology in XLP-1. Sci Transl Med. 2016 Jan 13;8(321):321ra7.

– Gortan Capellari GG et al., Unacylated Ghrelin Reduces Skeletal Muscle Reactive Oxygen Species Generation and Inflammation and Prevents  High-Fat Diet Induced Hyperglycemia and Whole-Body Insulin Resistance in Rodents. Diabetes. 2016 Jan 28. pii: db151019,

– Ruozi G., AAV-mediated in vivo functional selection of tissue-protective factors against ischaemia.  Nat Commun. 2015 Jun 11;6:7388.

– Rainero E. et alThe Diacylglycerol Kinase α/atypicalPKCs/β1-Integrin Pathway in SDF-1α Mammary Carcinoma Invasiveness Plos One, 2014, 9 (6), e97144

– Porporato PE et al. Acylated and unacylated ghrelin impair skeletal muscle atrophy in mice J. Clin. Invest. 2013, Feb 1;123(2):611-22.

– Rainero E, et al. Diacylglycerol kinase-α controls RCP-dependent integrin trafficking to promote invasive migration. J Cell Biol. 2012 Jan 23;196(2):277-95.

– Baldanzi G et al.  SAP-mediated inhibition of diacylglycerol kinase α regulates TCR-induced diacylglycerol signaling.  J Immunol. 2011 Dec 1;187(11):5941-51.

– Chianale F et al  Diacylglycerol kinase alpha mediates HGF-induced Rac activation and membrane ruffling by regulating atypical PKC and RhoGDI. Proc Natl Acad Sci U S A. 2010 Mar 2;107:4182-7

– Baldanzi G, et al. Negative regulation of diacylglycerol kinase theta mediates adenosine-dependent hepatocyte preconditioning. Cell Death Differ. 2010 Jun;17(6):1059-68

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