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Pardi Ruggero

Pardi Ruggero Versione in italiano

Professore ordinario - Facoltà di Medicina e Chirurgia

e-mail: ruggero.pardi@unisr.it
telefono: 02 2643.4763
fax: 02 2643.4723
sito: http://w3dibit.hsr.it/PhD/people/pardi.html

Scientific and Professional profile


Ruggero Pardi is an internationally recognized investigator in the field of integrin biology, and has devoted his scientific career to the study of the pathophysiology of adhesive interactions in the immune system.

He has obtained his MD and subspecialty Degree in Pneumology at the University of Milan in 1980 and 1983, respectively. In 1985 he moved as a post-doctoral fellow to the Department of Pathology, Stanford University School of Medicine, in the group led by E. G. Engleman. Between 1985 and 1988 Pardi and JR Bender (at the time a Cardiology Fellow at Stanford) pioneered the field of leukocyte-endothelial cell interactions, and were among the first to characterize the cell subsets and molecules involved in the adhesive interactions of various leukocyte subsets with primary microvascular endothelium (J. Clin. Invest. 1987. 79:1679). Between 1989 and 1991, Pardi and Bender relocated to Yale University, where Bender was appointed as Assistant Professor in the Department of Internal Medicine. Soon thereafter they showed that the leukocyte integrin LFA-1 undergoes regulated activation by engagement of the T Cell Receptor, involving the dynamic association with peripheral proteins of the actin cytoskeleton (JCB. 1992. 116:1211).

In 1991 R. Pardi was appointed as Assistant Professor at the Internal Medicine Department of the University of Milan School of Medicine. During such period he was among the first to demonstrate that ligand-engaged leukocyte integrins are competent to transduce intracellular signals (J. Immunol. 1989. 143:3157; PNAS. 1994. 91:3994; J. Cell Biol. 1995. 128:969) that involve breakdown of phosphoinositides and the establishment of transient interactions of the adhesion receptor with the actin-based cytoskeleton (J. Immunol. 1995. 155:1252) and lead to the regulation of gene expression programs in T cells (J. Clin Invest 1996. 98:1133; J. Immunol. 1999. 162: 1085; Eur J. Immunol. 2000. 30:136). His work also established that integrin turnover, entailing the regulated internalization and recycling of the adhesion receptor via defined endocytic sequences, is required to support vectorial motility of leukocytes (EMBO J. 1999. 18: 4915; Mol Biol Cell. 2003. 14:2570; Mol Biol. Cell. 2005. 16:5793)

More recently, Pardi's group has identified and fully chracterized at the genetic and functional level novel intermediates in integrin-generated signals leading to the control of gene expression programs (Nature 2000. 404:617) that are dysregulated in precancerous lesions (Oncogene 2008. 27:2401; J. Exp Med. 2008. 205:465)

In 2000 Pardi was appointed as Associate Professor of Pathology at the San Raffaele University School of Medicine and in 2007 he was promoted to Full Professor with tenure. He has appointing as full professor since 2011. He is teaching a 120 hours general pathology class to third year medical students and a 20 hours molecular oncology class to biotechnology MS students. Since 1992 he has acted as Director of Studies for over 15 graduate students in the institutional Programs of Basic & Applied immunology and Cell & Molecular Biology.

His most recent work concerns the demonstration that cooperative and concurrent signaling by chemokines and integrins is crucial to the coordination of the various steps of leukocyte extravasation (Blood. 2009. 114:1073; Blood. 2009. 113:1699; J. Cell Sci. 2009. 122: 268)

In the last 20 years Pardi has been awarded numerous grants from national and international funding agencies, and has coordinated several EU-funded networks, including a FP6 Network of Excellence (MAIN: www.main-noe.org) composed of 16 Institutes from 8 EU and associated Countries, focusing on inflammatory Cell migration.

From 2003 to 2007 he served as Dean of the Graduate School of Molecular Medicine of San Raffaele University.

In 2008 he was named Chairman of the Division of Immunology, Transplantation and Infectious Diseases of the Scientific Institute San Raffaele.

Overall, he has authored over 80 publications in international peer-reviewed journals, with a global impact factor exceeding 600 and an h index of 31. He has been invited as a speaker to over 25 international meetings in the last 15 years.


Relevant Publications

M PENZO, R MOLTENI, T SUDA, S SAMANIEGO, RR KEW, H JANG, J, LI, R PARDI, ME BIANCHI, KB MARCU (2010). Inhibitor Of NK-{Kappa}B Kinases {Alpha} And {Beta} Are Both Essential For High Mobility Group Box 1-Mediated Chemotaxis. J Immunol. 184:4497-4509.


GAVINA, M., ZA, L., MOLTENI, R., PARDI, R. AND DE CURTIS, I. (2010). The GIT/PIX Complexes Regulate The Chemotactic Response To Rat Basophilic Leukemia Cells. Biol.Cell. 102:231-234.


YOSHIDA A, YONEDA-KATO N, PANATTONI M, PARDI R, KATO JY. (2010). CSN5/Jab1 Controls Multiple Events In The Mammalian Cell Cycle. FEBS Lett. Oct 25. [Epub Ahead Of Print]


A. VERGANI, B. CLISSI, F. SANVITO, C. DOGLIONI, P. FIORINA AND R. PARDI (2010). Laser Capture Microdissection As A New Tool To Assess Graft Infiltrating Lymphocytes Gene Profile In Islet Transplantation. Cell Transplantation. 18:827-832.


ALFANO M, MARIANI SA, ELIA C, PARDI R., BLASI F, POLI G (2009). Ligand-Engaged Urokinase-Type Plasminogen Activator Receptor And Activation Of The CD11b/CD18 Integrin Inhibit Late Events Of HIV Expression In Monocytic Cells. BLOOD, Vol. 113; P. 1699-1709, ISSN: 0006-4971


CERA MR, FABBRI M, MOLENDINI C, CORADA M, ORSENIGO F, REHBERG M, REICHEL CA, KROMBACH F, PARDI R., DEJANA E (2009). JAM-APromotes Neutrophil Chemotaxis By Controlling Integrin Internalization And Recycling. JOURNAL OF CELL SCIENCE, Vol. 122; P. 268-277, ISSN: 0021-9533


MOLTENI R, CRESPO CL, FEIGELSON S, MOSER C, FABBRI M, GRABOVSKY V, KROMBACH F, LAUDANNA C, ALON R, PARDI R. (2009). Beta-Arrestin 2 Is Required For The Induction And Strengthening Of Integrin-Mediated Leukocyte Adhesion During CXCR2-Driven Extravasation. BLOOD, Vol. 114; P. 1073-1082, ISSN: 0006-4971


PANATTONI M, SANVITO F, BASSO V, DOGLIONI C, CASORATI G, MONTINI E, BENDER JR, MONDINO A, PARDI R. (2008). Targeted Inactivation Of The COP9 Signalosome Impairs Multiple Stages Of T Cell Development. JOURNAL OF EXPERIMENTAL MEDICINE, Vol. 205; P. 465-477, ISSN: 0022-1007


SAVIO MG, ROTONDO G, MAGLIE S, ROSSETTI G, BENDER JR, PARDI R. (2008). An Alternatively Spliced Constitutive Photomorphogenetic-1 (COP1) Product, Stabilizes UV Stress-Induced C-Jun Through Inhibition Of Full Length COP1. ONCOGENE, Vol. 27; P. 2401-2411, ISSN: 0950-9232


MOLTENI R, FABBRI M, BENDER JR, PARDI R. (2006). Pathophysiology Of Leukocyte-Tissue Interactions. CURRENT OPINION IN CELL BIOLOGY, Vol. 18; P. 491-498, ISSN: 0955-0674


WANG JG, COLLINGE M, RAMGOLAM V, AYALON O, FAN XC, PARDI R., BENDER JR (2006). LFA-1-Dependent Hur Nuclear Export And Cytokine Mrna Stabilization In T Cell Activation. JOURNAL OF IMMUNOLOGY, Vol. 176; P. 2105-2113, ISSN: 0022-1767


DE LA FUENTE H, MITTELBRUNN M, SANCHEZ-MARTIN L, VICENTE-MANZANARES M, LAMANA A, PARDI R., CABANAS C, SANCHEZ-MADRID F. (2005). Synaptic Clusters Of MHC Class II Molecules Induced On Dcs By Adhesion Molecule-Mediated Initial T-Cell Scanning. MOLECULAR BIOLOGY OF THE

CELL, Vol. 16; P. 3314-3322, ISSN: 1059-1524


WANG JG, COLLINGE M, PARDI R., STEITZ J, BENDER JR (2005). Costimulator-Dependent Hur Nuclear Export And Cytokine Mrna Stabilization In T Cell Activation. JOURNAL OF IMMUNOLOGY, ISSN: 0022-1767


CARRABINO S, CARMINATI E, TALARICO D, PARDI R., BIANCHI E (2004). Expression Pattern Of The JAB1 Gene During Murine Embryogenesis: Colocalization With NEDD8. MECHANISMS OF DEVELOPMENT, Vol. 4; P. 423-431, ISSN: 0925-4773


DENTI S, SIRRI A, CHELI A, ROGGE L, INNAMORATI G, PUTIGNANO S, FABBRI M, BIANCHI E, PARDI R. (2004). RANBPM Is A Phosphoprotein That Associates With The Plasma Membrane And Interacts With The Integrin LFA-1. THE JOURNAL OF BIOLOGICAL CHEMISTRY, Vol. 279; P. 13027-13034, ISSN:



BIANCHI E, DENTI S, CATENA R, ROSSETTI G, GASPARIAN S, POLO S, PUTIGNANO S, ROGGE L, PARDI R. (2003). Characterization Of HumanConstitutive Photomorphogenesis Protein 1 (Hucop1), A RING-Finger Ubiquitin Ligase That Interacts With Jun Transcription Factors And Modulates TheirTranscriptional Activity. THE JOURNAL OF BIOLOGICAL CHEMISTRY, Vol. 278; P. 19682-19690, ISSN: 0021-9258




FERRERO E, BISWAS P, VETTORETTO K, UGUCCIONI MG, PIALI L, LEONE BE, MOSER B, RUGARLI C, PARDI R. (2003). Macrophages Exposed To M.Tuberculosis Release Chemokines Able To Recruit Selected Leukocyte Subpopulations: Focus On Gamma/Delta T Cells. IMMUNOLOGY, Vol. 108; P. 1-10, ISSN: 0019-2805


TOHYAMA Y, KATAGIRI K, PARDI R., CHAFEN L, SPRINGER T, KINASHI T (2003). The Critical Cytoplasmic Regions Of Al/B2 Integrin In Rap1-Induced Adhesion And Migration. MOLECULAR BIOLOGY OF THE CELL, Vol. 14; P. 2570-2582, ISSN: 1059-1524


ROSSETTI G, MOLTENI R, COLLINGE M, BENDER JR, PARDI R. (2002). Integrin-Dependent Regulation Of Gene Expression In Leukocytes. IMMUNOLOGICAL REVIEWS, Vol. 186; P. 189-207, ISSN: 0105-2896


DRAVIAM VM, ORECCHIA S, LOWE M, PARDI R., PINES J (2001). The Localization Of Human Cyclins B1 And B2 Determines CDK1 Substrate Specificity AndNeither Enzyme Requires MEK To Disassemble The Golgi Apparatus. THE JOURNAL OF CELL BIOLOGY, Vol. 152; P. 945-958, ISSN: 0021-9525


SADEGHI MM, TIGLIO A, SADIGH K, O' DONNEL L, COLLINGE M, PARDI R., BENDER JR (2001). Inhibition Of Interferon-Gamma-MediatedMicrovascular Endothelial Cell Major Histocompatibility Complex Class II Gene Activation By HMG-Coa Reductase Inhibitors. TRANSPLANTATION, Vol. 71; P.1262-1268, ISSN: 0041-1337


BIANCHI E., DENTI S., GRANATA A., GEGINAT J., ROGGE L., PARDI R. (2000). The Integrin LFA-1 Interacts With The Transcriptional Coactivator JAB1 To Modulate AP-1 Transcriptional Activity. NATURE, Vol. 404; P. 617-621, ISSN: 0028-0836


CLISSI B., D'AMBROSIO D., COLANTONIO L., GEGINAT J, PARDI R. (2000). Chemokines Fail To Up-Regulate Beta-1 Integrin-Dependent Adhesion In HumanType 2 Helper T Lymphocytes. JOURNAL OF IMMUNOLOGY, Vol. 164; P. 3292-3230, ISSN: 0022-1767


D'AMBROSIO D, IELLEM A, COLANTONIO L, CLISSI B, PARDI R. (2000). Differential Trafficking Of Helper T Subsets: Can We Dial Th1 And Th2 Area Codes?.IMMUNOLOGY TODAY, Vol. 21; P. 183-186, ISSN: 0167-5699


FABBRI M., FUMAGALLI L., BOSSI G., BIANCHI E., BENDER J. R., PARDI R. (1999). A Tyrosine-Based Sorting Signal In The Beta-2 Integrin Cytoplasmic Domain Mediates Its Recycling To The Plasma Membrane And Is Required For Ligand-Supported Migration. EMBO JOURNAL, Vol. 18; P. 4915-4925, ISSN:



GEGINAT J., BOSSI G., BENDER JR., PARDI R. (1999). Anchorage Dependence Of Mitogen-Induced G1 To S Transition In Primary T Lymphocytes. JOURNAL

OF IMMUNOLOGY, Vol. 162; P. 5085-5093, ISSN: 0022-1767


G. J. WANG, M. COLLINGE, F. BLASI, BENDER JR, PARDI R. (1998). Post-Transcriptional Regulation Of Upar Mrna Levels By Leukocyte Integrin



BIANCHI E., BLASI F., BENDER J. R., PARDI R. (1997). Through And Beyond The Wall: Late Steps In Leukocyte Diapedesis And Invasion. IMMUNOLOGY TODAY, Vol. 18; P. 586-591, ISSN: 0167-5699


E. BIANCHI, E. FERRERO, F. FAZIOLI, F. MANGILI, G.J. WANG, J.R. BENDER, PARDI R. (1996). Integrin-Dependent Induction Of Functional Urokinase Receptors In Primary T Lymphocytes. JOURNAL OF CLINICAL INVESTIGATION, Vol. 98; P. 1133-1141, ISSN: 0021-9738


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