Daniele Zacchetti
Molecular mechanisms in neurodegeneration
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Degeneration of neurons is a common hallmark of several neurological diseases. The study of the mechanisms underlying neuronal death is needed for the comprehension of the neuronal physiology and the development of strategies for disease prevention and therapy. While the etiology of these diseases is multifarious, several events in the pathogenetic process are shared such as inflammation, oxidative stress, synaptic failure and apoptosis. We investigate the steps in the neurodegenerative process by working with primary neuronal/glial cultures and cell lines. With cellular and molecular approaches we aim at dissecting the pathogenetic events of neurodegenerative diseases and to understand the role of astrocyte and microglia activation in neuronal survival.
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