Comai Stefano Ricercatore a tempo determinatoMedicinaBIO/14

Biografia

Pubblicazioni

English version

Biografia

Data di nascita:

November 30, 1979

POSIZIONE ATTUALE:

Ricercatore a tempo determinato SSD BIO/14 – Farmacologia, Università Vita-Salute San Raffaele.

EDUCAZIONE e ESPERIENZE DI RICERCA:
2012-2015 Research Associate
Neurobiological Psychiatry Unit (Prof. G. Gobbi)
Department of Psychiatry, McGill University and McGill University Health Center

2009-2012 Postdoctoral fellow
Neurobiological Psychiatry Unit (Prof. G. Gobbi)
Department of Psychiatry
McGill University, Montréal, Canada

2008-2009 Assegnista di ricerca

Dipartimento di Scienze Farmaceutiche (Supervisore: Prof. C.V.L. Costa/Prof. A. Bertazzo)
Universitá degli Studi di Padova, Padova, Italia
Progetto: Metabolismo del triptofano via serotonina in pazienti con HCV e depressione e trattati con interferone alpha e ribavirina

2007 Assegnista di ricerca
Dipartimento di Scienze Farmaceutiche (Supervisore: Prof. G. Innocenti)
Universitá degli Studi di Padova, Padova, Italia
Progetto: Studio di piante medicinali di origine Nepalese

2007 Dottorato di Ricerca in Scienze Farmaceutiche

Dipartimento di Scienze Farmaceutiche (Supervisore: Prof. A. Bertazzo)
Universitá degli Studi di Padova, Padova, Italia
Tesi: Ruolo del triptofano in processi fisiologici e patologici

2003 Laurea magistrale in Farmacia
Universitá degli Studi di Padova, Padova, Italia
110/110 “Maxima cum laude”
Tesi: Metabolismo del triptofano via serotonina nel liquido cerebrospinale

Premi
2015 New Investigator Award
American Society of Clinical Psychopharmacology

REVISORE DI PROGETTI SCIENTIFICI
2014-ad oggi Ministero dell’Istruzione, dell’Universitá e della Ricerca (MIUR)
SIR 2014

2014 Netherlands Organisation for Scientific Research
Innovational Research Incentives Scheme Vidi

2011-ad oggi Ministero della Salute, Governo Italiano
Bando ricerca finalizzata

ORGANIZZAZIONE E CHAIRMAN DI CONGRESSI
Simposio: Serotonin and melatonin in neurobiology and pharmacology.
In: 13th Meeting of the International Society for Tryptophan Research (ISTRY)
Sydney, Australia, November 7-9, 2012.

REVIEWER PER RIVISTE SCIENTIFICHE INTERNAZIONALI
International Journal of Tryptophan Research; Progress in Neuro-Psychopharmacology & Biological Psychiatry; Clinical and Experimental Pharmacology and Physiology; British Journal of Pharmacology; Plos ONE; Journal of Natural Product; International Journal of Molecular Sciences; Current Medicinal Chemistry; European Neuropsychopharmacology; Frontiers in Neuropharmacology; African Journal of Pharmacy and Pharmacology; Behavioural Brain Research; Molecular Nutrition and Food Research.

PRESENTAZIONI ORALI A CONFERENZE INTERNAZIONALI
Invited speaker a numerose conferenze internazionali tra cui il 2nd EBBS-EBPS Joint Meeting (Settembre 2015), 29th International College of Neuropsychopharmacology (CINP) World Congress (Giugno 2014), Meeting of the International Society for Tryptophan Research (ISTRY) (Novembre 2012, Luglio 2009, Luglio 2006), e la Gordon Research Conference on Pineal Cell Biology (Febbraio 2010).

Pubblicazioni

PUBBLICAZIONI SU RIVISTE INTERNAZIONALI
Autore di più di 40 pubblicazioni su riviste scientifiche internazionali, più di 50 abstracts a conferenze nazionali e internazionali e di 7 capitoli di libro.

Articoli peer reviewed pubblicati negli ultimi 3 anni:
1.     M.F. Ghabrash, S. Comai, J. Tabaka, M. Saint-Laurent, L. Booij, and G. Gobbi.
Valproic acid augmentation in a subgroup of treatment-resistant unipolar depression patients.
The World Journal of Biological Psychiatry, in press
2.     M. Lopez-Canul#, S. Comai#, S. Dominguez-Lopez, V. Granados-Soto, G. Gobbi
Antinoceptive and anti-inflammatory properties of selective Melatonin MT2 receptor partial agonists
European Journal of Pharmacology 764, 424-32, 2015. # These authors have equally contributed.
3.     S. Comai, R. Ochoa-Sanchez, S. Dominguez-Lopez, F. R. Bambico, G. Gobbi.
Melancholic-like behaviors and circadian neurobiological abnormalities in melatonin MT1 receptor knockout mice.
The International Journal of Neuropsychopharmacology, pyu075, 2015.
4.     D. Checknita, G. Maussion, B. Labonté, S. Comai, R.E. Tremblay, F. Vitaro, N. Tureki, A. Bertazzo, G. Gobbi, G. Côté, G. Turecki.
Monoamine oxidase A gene promoter methylation and transcriptional downregulation in an offender population with antisocial personality disorder.
British Journal of Psychiatry 206, 216–222, 2015.
5.     M. Lopez-Canul, E. Palazzo, S. Dominguez-Lopez, L. Luongo, B. Lacoste, S. Comai, D. Angeloni, F. Fraschini, G. Spadoni, A. Bedini, G. Tarzia, S. Maione, V. Granados-Soto, G. Gobbi.
Selective Melatonin MT2 receptor ligands relieve neuropathic pain through modulation of brainstem descending antinociceptive pathways.
Pain 156(2), 305-317, 2015.
6.     S. Comai, R. Ochoa-Sanchez, G. Gobbi.
Distinct role of melatonin MT1 and MT2 receptors in sleep and anxiety: insights from melatonin receptor knockout mice.
European Neuropsychopharmacology, 24(Suppl 2), S268, 2014.
7.     G. Gobbi, S. Comai, R. Ochoa-Sanchez.
Novel selective melatonin MT2 receptor agonist in the treatment of insomnia.
European Neuropsychopharmacology, 24(Suppl 2), S144, 2014.
8.     G. Gobbi, S. Comai, G. Debonnel.
Effects of quetiapine and olanzapine in patients with psychosis and violent behavior:
A pilot randomized, open label, comparative study.
Neuropsychiatric Disease and Treatment, 10, 757-765, 2014.
9.     R. Ochoa-Sanchez#, S. Comai#, G. Spadoni, A. Bedini, S. Rivara, M. Mor, G. Tarzia, G. Gobbi.
Melatonin, selective and non-selective MT1/MT2 receptors agonists: differential effects on the 24-hr vigilance states.
Neuroscience Letters, 561, 156-61, 2014. # These authors have equally contributed.
10.   S. Comai, G. Gobbi.
Unveiling the role of melatonin MT2 receptors in sleep, anxiety and other neuropsychiatric diseases: a novel target in psychopharmacology.
Journal of Psychiatry & Neuroscience 39, 6-21, 2014.
11.   S. Comai, R. Ochoa-Sanchez, G. Gobbi.
Sleep-wake cycle in Melatonin MT1, MT2 and MT1/MT2 receptor knockout mice.
Behavioural Brain Research 243, 231-8, 2013.
12.   R. Ochoa-Sanchez, Q. Rainer, S. Comai, G. Spadoni, A. Bedini, S. Rivara, F. Fraschini, M. Mor, G. Tarzia, G. Gobbi.
Anxiolytic effects of the melatonin MT(2) receptor partial agonist UCM765: Comparison with melatonin and diazepam.
Progress in Neuro-Psychopharmacology & Biological Psychiatry, 39, 318-25, 2012.
13.   S. Comai, M. Tau, Z. Pavlovic, G. Gobbi.
The Psychopharmacology of Aggressive Behavior: A Translational Approach. Part 2: atypical antipsychotics, anticonvulsants and lithium.
Journal of Clinical Psychopharmacology, 32, 237-60, 2012. Review article.
14.   S. Comai, M. Tau, G. Gobbi.
The Psychopharmacology of Aggressive Behavior: A Translational Approach. Part 1: Neurobiology.
Journal of Clinical Psychopharmacology, 32, 83-94, 2012. Review article.
15.   S. Dall’Acqua, P. Minesso, B.B. Shresta, S. Comai, P.K. Jha, M.B. Gewali, E. Greco, R. Cervellati, G. Innocenti.
Phytochemical and antioxidant-related investigations on bark of Abies spectabilis (D. Don) Spach. from Nepal.
Molecules, 17,1686-97, 2012.

English version

Date of birth:

November 30, 1979

CURRENT POSITION:

Assistant Professor of Pharmacology, Vita-Salute San Raffaele University.

EDUCATION and RESEARCH EXPERIENCES:
2012-2015 Research Associate
Neurobiological Psychiatry Unit (Prof. G. Gobbi)
Department of Psychiatry, McGill University and McGill University Health Center

2009-2012 Postdoctoral fellow
Neurobiological Psychiatry Unit (Prof. G. Gobbi)
Department of Psychiatry
McGill University, Montréal, Canada

2009-2010 Postdoctoral fellow

Department of Pharmaceutical Sciences (Supervisor: Prof. CVL Costa)
University of Padova, Padova, Italy
Project: Tryptophan metabolism via serotonin in patients with HCV and depression treate
with interferon-alpha plus ribavirin

2008 Postdoctoral fellow

Department of Pharmaceutical Sciences (Supervisor: Prof. G. Innocenti)
University of Padova, Padova, Italy
Project: Study of medicinal plants from Nepal

2007 Ph.D. in Pharmaceutical Sciences

Department of Pharmaceutical Sciences (Supervisor: Prof. A. Bertazzo)
University of Padova, Italy
Thesis: “Role of Tryptophan in Physiological and Pathological Processes”

2003 Pharm.D.

University of Padova, Italy
110/110 “Maxima cum laude”
Thesis : ” Tryptophan Metabolism along the Serotonin Pathway in the Cerebrospinal Fluid ”

Honorific Awards

2015 New Investigator Award
American Society of Clinical Psychopharmacology

MEMBERSHIPS ON ANY FEDERAL GOVERNMENT PUBLIC ADVISORY COMMITTEE

2014 Italian Ministry for Education, University and Research (MIUR): Grant reviewer
2014 Netherlands Organisation for Scientific Research: Grant reviewer

2011-present Ministry of Health

Italy government. Grant Reviewer

ORGANIZATION OF MEETINGS

Organization of Symposium: Serotonin and melatonin in neurobiology and pharmacology.
In: 13th Meeting of the International Society for Tryptophan Research (ISTRY)
Sydney, Australia, November 7-9, 2012.

REVIEWER FOR SCIENTIFIC JOURNALS

International Journal of Tryptophan Research; Progress in Neuro-Psychopharmacology & Biological Psychiatry; Clinical and Experimental Pharmacology and Physiology; British Journal of Pharmacology; Plos ONE; Journal of Natural Product; International Journal of Molecular Sciences; Current Medicinal Chemistry; European Neuropsychopharmacology; Frontiers in Neuropharmacology; African Journal of Pharmacy and Pharmacology; Behavioural Brain Research; Molecular Nutrition and Food Research.

INVITED CONFERENCES

Invited speaker at several international conferences among which 2nd EBBS-EBPS Joint Meeting (September 2015), 29th International College of Neuropsychopharmacology (CINP) World Congress (June 2014), Meeting of the International Society for Tryptophan Research (ISTRY) (November 2012, July 2009, July 2006), and Gordon Research Conference on Pineal Cell Biology (February 2010).

PUBLICATIONS

Author of more than 40 publications in international peer-reviewed journals and 50 abstracts at national and international conferences, and 7 book chpaters.

Peer reviewed articles last 3 years:
1.     M.F. Ghabrash, S. Comai, J. Tabaka, M. Saint-Laurent, L. Booij, and G. Gobbi.
Valproic acid augmentation in a subgroup of treatment-resistant unipolar depression patients.
The World Journal of Biological Psychiatry, in press
2.     M. Lopez-Canul#, S. Comai#, S. Dominguez-Lopez, V. Granados-Soto, G. Gobbi
Antinoceptive and anti-inflammatory properties of selective Melatonin MT2 receptor partial agonists
European Journal of Pharmacology 764, 424-32, 2015. # These authors have equally contributed.
3.     S. Comai, R. Ochoa-Sanchez, S. Dominguez-Lopez, F. R. Bambico, G. Gobbi.
Melancholic-like behaviors and circadian neurobiological abnormalities in melatonin MT1 receptor knockout mice.
The International Journal of Neuropsychopharmacology, pyu075, 2015.
4.     D. Checknita, G. Maussion, B. Labonté, S. Comai, R.E. Tremblay, F. Vitaro, N. Tureki, A. Bertazzo, G. Gobbi, G. Côté, G. Turecki.
Monoamine oxidase A gene promoter methylation and transcriptional downregulation in an offender population with antisocial personality disorder.
British Journal of Psychiatry 206, 216–222, 2015.
5.     M. Lopez-Canul, E. Palazzo, S. Dominguez-Lopez, L. Luongo, B. Lacoste, S. Comai, D. Angeloni, F. Fraschini, G. Spadoni, A. Bedini, G. Tarzia, S. Maione, V. Granados-Soto, G. Gobbi.
Selective Melatonin MT2 receptor ligands relieve neuropathic pain through modulation of brainstem descending antinociceptive pathways.
Pain 156(2), 305-317, 2015.
6.     S. Comai, R. Ochoa-Sanchez, G. Gobbi.
Distinct role of melatonin MT1 and MT2 receptors in sleep and anxiety: insights from melatonin receptor knockout mice.
European Neuropsychopharmacology, 24(Suppl 2), S268, 2014.
7.     G. Gobbi, S. Comai, R. Ochoa-Sanchez.
Novel selective melatonin MT2 receptor agonist in the treatment of insomnia.
European Neuropsychopharmacology, 24(Suppl 2), S144, 2014.
8.     G. Gobbi, S. Comai, G. Debonnel.
Effects of quetiapine and olanzapine in patients with psychosis and violent behavior:
A pilot randomized, open label, comparative study.
Neuropsychiatric Disease and Treatment, 10, 757-765, 2014.
9.     R. Ochoa-Sanchez#, S. Comai#, G. Spadoni, A. Bedini, S. Rivara, M. Mor, G. Tarzia, G. Gobbi.
Melatonin, selective and non-selective MT1/MT2 receptors agonists: differential effects on the 24-hr vigilance states.
Neuroscience Letters, 561, 156-61, 2014. # These authors have equally contributed.
10.   S. Comai, G. Gobbi.
Unveiling the role of melatonin MT2 receptors in sleep, anxiety and other neuropsychiatric diseases: a novel target in psychopharmacology.
Journal of Psychiatry & Neuroscience 39, 6-21, 2014.
11.   S. Comai, R. Ochoa-Sanchez, G. Gobbi.
Sleep-wake cycle in Melatonin MT1, MT2 and MT1/MT2 receptor knockout mice.
Behavioural Brain Research 243, 231-8, 2013.
12.   R. Ochoa-Sanchez, Q. Rainer, S. Comai, G. Spadoni, A. Bedini, S. Rivara, F. Fraschini, M. Mor, G. Tarzia, G. Gobbi.
Anxiolytic effects of the melatonin MT(2) receptor partial agonist UCM765: Comparison with melatonin and diazepam.
Progress in Neuro-Psychopharmacology & Biological Psychiatry, 39, 318-25, 2012.
13.   S. Comai, M. Tau, Z. Pavlovic, G. Gobbi.
The Psychopharmacology of Aggressive Behavior: A Translational Approach. Part 2: atypical antipsychotics, anticonvulsants and lithium.
Journal of Clinical Psychopharmacology, 32, 237-60, 2012. Review article.
14.   S. Comai, M. Tau, G. Gobbi.
The Psychopharmacology of Aggressive Behavior: A Translational Approach. Part 1: Neurobiology.
Journal of Clinical Psychopharmacology, 32, 83-94, 2012. Review article.
15.   S. Dall’Acqua, P. Minesso, B.B. Shresta, S. Comai, P.K. Jha, M.B. Gewali, E. Greco, R. Cervellati, G. Innocenti.
Phytochemical and antioxidant-related investigations on bark of Abies spectabilis (D. Don) Spach. from Nepal.
Molecules, 17,1686-97, 2012

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