Pappalardo Federico Professore AssociatoMedicinaMED/41 – Anestesiologia

Biografia

Pubblicazioni

English version

Biografia

Titoli di studio:
Maturità Classica Liceo Ginnasio “N. Spedalieri” di Catania.
Laureato in Medicina e Chirurgia presso l’ Università di Catania
Specializzazione con lode in Anestesiologia e Rianimazione presso Università Cattolica del Sacro Cuore, Policlinico “A. Gemelli” di Roma

Attività professionale:
Responsabile Unità Funzionale Terapia Intensiva Cardiochirurgica, Ospedale San Raffaele di Milano.
Responsabile clinico dell’attività di supporto meccanico del circolo ed insufficienza respiratoria acuta. Ha eseguito come primo operatore, o come tutor, impianti di ECMO (Veno-arterioso e veno-venoso) in tutti i contesti clinici (eCPR, Mobile Ecmo, Postcardiotomy, Bilume, supporto periprocedurale). Ha inoltre eseguito impianti di Impella. in questo contesto, ha sviluppato una tecnica originale per l’inserimento del dispositivo senza fluoroscopia ed è l’unico operatore certificato in Italia per l’assistenza ventricolare destra.
Svolge attività di selezione del paziente, cure post-operatorie e follow up a lungo termine di pazienti con LVAD (Left Ventricular Assist Device).

Responsabile dei corsi Teorico-Pratici in “Assistenza meccanica al circolo: IABP, ECMO, LVAD” dell’Ospedale San Raffaele di Milano. In questo ambito, ad oggi, ho formato medici, perfusionisti, infermieri provenienti sia dall’Italia che da paesi esteri.

Responsabile Unità di Ricerca presso INSTM (Consorzio Interuniversitario Nazionale per la Scienza e la Tecnologia dei Materiali) Ospedale San Raffaele di Milano, nel progetto “BIOSUOVAD – Studio di superfici bioattive per l’ottimizzazione degli LVAD (Left Ventricular Assist Device): Bioactive Surfaces for Optimized LVAD” in collaborazione con il Dipartimento di Chimica Organica dell’Università di Catania.

Responsabile programmi Dottorato di Ricerca Politecnico di Milano, XXIV Cycle “Multi-Perspective Investigation of the Effectiveness of Anti-Thrombotic Treatments in Association with Shear-Mediated Paltelet Activation”- Dipartimento di Elettronica, Informazione e Bioingegneria (Prof. A. Redaelli) presso Ospedale San Raffaele di Milano.

Attività di ricerca:

L’attività di ricerca ha come principali campi di interesse le tecnologie artificiali per il supporto circolatorio e respiratorio, con particolare riferimento alla biocompatibilità.
In questo ambito, l’interesse si è focalizzato sugli anticoaugulanti alternativi, sulle superfici biocompatibli e sulle interazioni biologiche piastriniche – superficie estranea. L’attività scientifica ha sempre avuto connotati di interdisciplinarietà, traslazionalità e internazionalizzazione.

Attività di docenza:
Da giugno 2017: Professore Associato presso Università Vita-Salute San Raffaele di Milano

Dal 2009 al 2016:
Tutore e correlatore di Tesi di laurea in Medicina e Chirurgia e Specializzazione in Anestesiologia e Rianimazione, Cardiologia, Cardiochirurgia, Ingegneria Biomedica presso il Politecnico di Milano.

Correlatore della redazione di Tesi di Laurea Magistrale in Ingegneria Biomedica “Valutazione dello stato di attivazione piastrinica in pazienti portatori di LVAD: il Platelet Activity State Assay come strumento di analisi del rischio di complicanze trombotiche post-impianto”, presso il Politecnico di Milano.

Docente nell’ambito del Corso integrato di Emergency Medicine presso l’Università Vita Salute San Raffaele di Milano.

Tutore nella Scuola di Specializzazione in Medicina di Emergenza-Urgenza dell’Università Vita-Salute San Raffaele di Milano.

Tutore della Scuola di Specialità in Anestesiologia e Rianimazione dell’Università Vita-Salute San Raffaele di Milano per la preparazione teorico/pratica degli Specializzandi, nei seguenti settori: Anestesia e Rianimazione, Cardiologia, Pneumologia, Medicina d’Urgenza, Nefrologia e Cardiochirurgia.

Professore a contratto presso la Scuola di Specializzazione in Malattie dell’Apparato Cardiovascolare dell’Università Vita-Salute San Raffaele di Milano.

Professore a contratto presso la Scuola di Specializzazione Anestesia e Rianimazione, Terapia Intensiva e del Dolore dell’Università Vita-Salute San Raffaele di Milano.

Co-direttore del Master in Anestesia e Rianimazione Cardio-Toraco-Vascolare presso l’Università Vita-Salute San Raffaele di Milano.

Docente per “1st Ecmo Course” presso Russian Ecmo School, Società di Anestesia e Rianimazione Russa, Mosca.

Docente per corsi ECMO sul trattamento dell’insufficienza respiratoria acuta mediante supporto extracorporeo, nell’ambito del programma EcmoNet/Ministero della Salute “Rete nazionale per la gestione della sindrome da insufficienza respiratoria acuta grave da polmoniti da virus A(H1N1) e l’eventuale utilizzo della terapia ECMO”.

Docente corsi: ANMCO “Assistenza ventricolare meccanica nei pazienti con scompenso cardiaco avanzato LVAD” e Convegno “Centri Scompenso Lombardia, up date scientifico–organizzativo.”

Docente corso: “Interventional EP Curriculum 13 VT, Introductory session”.

Onorificenze:
Membro dell’Innovation Commettee di EuroELSO.

Membro della Commissione Scientifica Rete Nazionale Insufficienza Respiratoria RESPIRA.

Membro della Roland Hetzer International Society.

Membro del Gruppo di Studio del Centro Nazionale Trapianti su HTA, VAD Cuore Artificiale, Registro Itamacs.

Ha sviluppato le metodiche di donazione DCD presso l’Ospedale San Raffaele di Milano ed è membro della Commissione Tecnica CNT che si occupa di questa tematica.

Membro del GIROC (Gruppo Italiano Ricerca in Cardiochirurgia).

Pubblicazioni

PUBBLICAZIONI

Malfertheiner MV, Broman LM, Belliato M, Venti A, Bader A, Taccone FS, Nardo MD, Maj G, Pappalardo F. Management strategies in venovenous extracorporeal membrane oxygenation: a retrospective comparison from five European centres. Crit Care Resusc. 2017 Oct;19(Suppl 1):76-81

Schulte C, Schrage B, Pappalardo F, Westermann D. De-escalation of support with veno-arterial extracorporeal membrane oxygenation and Impella for cardiogenic shock: reply. Eur J Heart Fail. 2017 Sep 25

Scandroglio AM, Bove T, Calabrò MG, Votta CD, Pappalardo F, Giacomello R, Landoni G, Zangrillo A. Extracorporeal membrane oxygenation to resuscitate a 14-year-old boy after 43min drowning. Med Intensiva. 2017 Sep 4. pii: S0210-5691(17)30204-8

Spartera M, Jabbour RJ, Chiarito M, De Bonis M, Pappalardo F. Stepwise use of circulatory support devices in a patient refractory to cardiopulmonary resuscitation. Cardiovasc Revasc Med. 2017 Sep;18(6):447-449

Giannini F, Montorfano M, Jabbour RJ, Latib A, Ruparelia N, Azzalini L, Magni V, Romano V, De Bonis M, Pappalardo F, Colombo A. Use of a parallel stiff wire to facilitate percutaneous Impella RP ventricular assist device positioning. Cardiovasc Revasc Med. 2017 Sep;18(6S1):54-55

Pappalardo F, Ancona MB, Giannini F, Regazzoli D, Mangieri A, Montorfano M, De Bonis M, Alfieri O, Zangrillo A, Scandroglio AM, Colombo A, Latib A. First in man prolonged pressure-controlled intermittent coronary sinus occlusion to treat refractory left ventricular dysfunction and ischemia with patent epicardial coronary arteries. Int J Cardiol. 2017 Aug 15;241:138-141

De Bonis M, Lapenna E, Del Forno B, Di Sanzo S, Giacomini A, Schiavi D, Vicentini L, Latib A, Pozzoli A, Pappalardo F, La Canna G, Alfieri O. Minimally invasive or conventional edge-to-edge repair for severe mitral regurgitation due to bileaflet prolapse in Barlow’s disease: does the surgical approach have an impact on the long-term results? Eur J Cardiothorac Surg. 2017 Jul 1;52(1):131-136

Consolo F, Sheriff J, Gorla S, Magri N, Bluestein D, Pappalardo F, Slepian MJ, Fiore GB, Redaelli A. High Frequency Components of Hemodynamic Shear Stress Profiles are a Major Determinant of Shear-Mediated Platelet Activation in Therapeutic Blood Recirculating Devices. Sci Rep. 2017 Jul 10;7(1):4994

Taccone FS, Malfertheiner MV, Ferrari F, Di Nardo M, Swol J, Broman LM, Vercaemst L, Barrett N, Pappalardo F, Belohlavek J, Mueller T, Lorusso R, Belliato M; EuroELSO Workgroup “Innovation on ECMO and ECLS”. Extracorporeal CO2 removal in critically ill patients: a systematic review. Minerva Anestesiol. 2017 Jul;83(7):762-772

De Bonis M, Lapenna E, Di Sanzo S, Del Forno B, Pappalardo F, Castiglioni A, Vicentini L, Pozzoli A, Giambuzzi I, Latib A, Schiavi D, La Canna G, Alfieri O. Long-term results (up to 14 years) of the clover technique for the treatment of complex tricuspid valve regurgitation. Eur J Cardiothorac Surg. 2017 Jul 1;52(1):125-130

Pappalardo F, Montisci A. What is extracorporeal cardiopulmonary resuscitation? J Thorac Dis. 2017 Jun;9(6):1415-1419

Scandroglio AM, Pieri M, Pappalardo F, Landoni G. Intra-aortic balloon pump during venoarterial extracorporeal membrane oxygenation: still a matter of debate? Contemporary multi-device pproach to cardiogenic shock. J Thorac Dis. 2017 May;9(5):E522-E524

Landoni G, Lomivorotov VV, Alvaro G, Lobreglio R, Pisano A, Guarracino F, Calabrò MG, Grigoryev EV, Likhvantsev VV, Salgado-Filho MF, Bianchi A, Pasyuga VV, Baiocchi M, Pappalardo F, Monaco F, Boboshko VA, Abubakirov MN, Amantea B, Lembo R, Brazzi L, Verniero L, Bertini P, Scandroglio AM, Bove T, Belletti A, Michienzi MG, Shukevich DL, Zabelina TS, Bellomo R, Zangrillo A; CHEETAH Study Group. Levosimendan for Hemodynamic Support after Cardiac Surgery. N Engl J Med. 2017 May 25;376(21):2021-2031

Meani P, Gelsomino S, Natour E, Johnson DM, Rocca HB, Pappalardo F, Bidar E, Makhoul M, Raffa G, Heuts S, Lozekoot P, Kats S, Sluijpers N, Schreurs R, Delnoij T, Montalti A, Sels JW, van de Poll M, Roekaerts P, Poels T, Korver E, Babar Z, Maessen J, Lorusso R. Modalities and Effects of Left Ventricle Unloading on Extracorporeal Life support: a Review of the Current Literature. Eur J Heart Fail. 2017 May;19 Suppl 2:84-91

De Bonis M, Lapenna E, Buzzatti N, La Canna G, Denti P, Pappalardo F, Schiavi D, Pozzoli A, Cioni M, Di Giannuario G, Alfieri O. Corrigendum to ‘Optimal results immediately after MitraClip therapy or surgical edge-to-edge repair for functional mitral regurgitation: are they really stable at 4 years?’ [Eur J Cardiothorac Surg 2016;50:488-494]. Eur J Cardiothorac Surg. 2017 Apr 1;51(4):807

Pappalardo F, Montisci A, Scandroglio A, Belliato M, Malfertheiner M, Broman M, David P, Lorusso R, Taccone F, Broccati F, Di Nardo M. Veno-Venous ECMO in Europe: are we all speaking the same language? Minerva Anestesiol. 2017 Apr;83(4):424-425

Ruggeri L, Evangelista M, Consolo F, Montisci A, Zangrillo A, Pappalardo F. Peripheral VA-ECMO venous cannulation: which side for the femoral cannula? Intensive Care Med. 2017 Mar;43(3):468-469

Pappalardo F, Schulte C, Pieri M, Schrage B, Contri R, Soeffker G, Greco T, Lembo R, Müllerleile K, Colombo A, Sydow K, De Bonis M, Wagner F, Reichenspurner H, Blankenberg S, Zangrillo A, Westermann D. Concomitant implantation of Impella® on top of veno-arterial extracorporeal membrane oxygenation may improve survival of patients with cardiogenic shock. Eur J Heart Fail. 2017 Mar;19(3):404-412.

De Bonis M, Lapenna E, Buzzatti N, La Canna G, Denti P, Pappalardo F, Schiavi D, Pozzoli A, Cioni M, Di Giannuario G, Alfieri O. Optimal results immediately after MitraClip therapy or surgical edge-to-edge repair for functional mitral regurgitation: are they really stable at 4 years? Eur J Cardiothorac Surg. 2016 Sep;50(3):488-94

Pappalardo F, Montisci A. Is there light at the end of the tunnel? – new perspectives in ECMO survival. J Thorac Dis. 2016 Aug;8(8):E765-71

Cavalli G, Pappalardo F, Mangieri A, Dinarello CA, Dagna L, Tresoldi M. Treating Life-Threatening Myocarditis by Blocking Interleukin-1. Crit Care Med. 2016 Aug;44(8):e751-4

Pappalardo F, Crivellari M, Di Prima AL, Agracheva N, Celinska-Spodar M, Lembo R, Taddeo D, Landoni G, Zangrillo A. Protein C zymogen in severe sepsis: a double-blinded, placebo-controlled, randomized study. Intensive Care Med. 2016 Jun 25. [Epub ahead of print]

Consolo F, Dimasi A, Rasponi M, Valerio L, Pappalardo F, Bluestein D, Slepian MJ, Fiore GB, Redaelli A. Microfluidic approaches for the assessment of blood cell trauma: a focus on thrombotic risk in mechanical circulatory support devices. Int J Artif Organs. 2016 Jun 15;39(4):184-93

Slavich M, Ballarotto C, Margonato D, Peretto G, Giannini F, Spoladore R, Benincasa S, Cera M, Maranta F, Pappalardo F, Oppizzi M, Margonato A. Coronary reactivity testing in vasospastic angina leading to cardiac arrest and coronary dissection. Int J Cardiol. 2016 May 1;210:10-3

Valerio L, Tran PL, Sheriff J, Brengle W, Ghosh R, Chiu WC, Redaelli A, Fiore GB, Pappalardo F, Bluestein D, Slepian MJ. Aspirin has limited ability to modulate shear-mediated platelet activation associated with elevated shear stress of ventricular assist devices. Thromb Res. 2016 Apr;140:110-7

De Bonis M, Lapenna E, Barili F, Nisi T, Calabrese M, Pappalardo F, La Canna G, Pozzoli A, Buzzatti N, Giacomini A, Alati E, Alfieri O. Long-term results of mitral repair in patients with severe left ventricular dysfunction and secondary mitral regurgitation: does the technique matter? Eur J Cardiothorac Surg. 2016 Apr 28

Lorusso R, Centofanti P, Gelsomino S, Barili F, Di Mauro M, Orlando P, Botta L, Milazzo F, Actis Dato G, Casabona R, Casali G, Musumeci F, De Bonis M, Zangrillo A, Alfieri O, Pellegrini C, Mazzola S, Coletti G, Vizzardi E, Bianco R, Gerosa G, Massetti M, Caldaroni F, Pilato E, Pacini D, Di Bartolomeo R, Marinelli G, Sponga S, Livi U, Mauro R, Mariscalco G, Beghi C, Miceli A, Glauber M, Pappalardo F, Russo CF; GIROC Investigators. Venoarterial Extracorporeal Membrane Oxygenation for Acute Fulminant Myocarditis in Adult Patients: A 5-Year Multi-Institutional Experience. Ann Thorac Surg. 2016 Mar;101(3):919-26

Grimaldi A, Vermi AC, Cammalleri V, Castiglioni A, Pappalardo F, Taramasso M, Baratto F, Alfieri O. Heart surgery for immigrants in Italy: burden of cardiovascular disease, adherence to treatment and outcomes. J Cardiovasc Med (Hagerstown). 2016 Feb;17(2):105-12

De Bonis M, Taramasso M, Lapenna E, Denti P, La Canna G, Buzzatti N, Pappalardo F, Di Giannuario G, Cioni M, Giacomini A, Alfieri O. MitraClip therapy and surgical edge-to-edge repair in patients with severe left ventricular dysfunction and secondary mitral regurgitation: mid-term results of a single-centre experience. Eur J Cardiothorac Surg. 2016 Jan;49(1):255-62

Pappalardo F, Regazzoli D, Mangieri A, Ajello S, Melisurgo G, Agricola E, Baratto F, Ruparelia N, Oppizzi M, De Bonis M, Colombo A, Zangrillo A, Della Bella P. Hemodynamic and echocardiographic effects of aortic regurgitation on femoro-femoral veno-arterial ECMO. Int J Cardiol. 2016 Jan 1;202:760-2

De Bonis M, Lapenna E, Pozzoli A, Nisi T, Giacomini A, Calabrese M, La Canna G, Pappalardo F, Miceli A, Glauber M, Barili F, Alfieri O Mitral Valve Repair Without Repair of Moderate Tricuspid Regurgitation. Ann Thorac Surg. 2015 Dec;100(6):2206-12

Nobile L, Lamanna I, Fontana V, Donadello K, Dell’anna AM, Creteur J, Vincent JL, Pappalardo F, Taccone FS. Greater temperature variability is not associated with a worse neurological outcome after cardiac arrest. Resuscitation. 2015 Nov;96:268-74

Pieri M, Contri R, Winterton D, Montorfano M, Colombo A, Zangrillo A, De Bonis M, Pappalardo F. The contemporary role of Impella in a comprehensive mechanical circulatory support program: a single institutional experience. BMC Cardiovasc Disord. 2015 Oct 14;15:126

Melisurgo G, Ajello S, Pappalardo F. Echocardiographic Evaluation of LVAD Flow During Intra-Aortic Balloon Pump Support. J Cardiothorac Vasc Anesth. 2015 Oct;29(5):1305-7

Pasin L, Frati E, Cabrini L, Giovanni L, Nardelli P, Bove T, Calabro MG, Scandroglio AM, Pappalardo F, Zangrillo A. Percutaneous tracheostomy in patients on anticoagulants. Ann Card Anaesth. 2015 Jul-Sep;18(3):329-3

Pappalardo F, Pieri M, Arnaez Corada, B, Ajello S, Melisurgo G, De Bonis M, Zangrillo A. Timing and Strategy for Weaning from Venoarterial ECMO are Complex Issues. Journal of Cardiothoracic and Vascular Anesthesia 2015 Aug;29(4):906-11

Valerio L, Consolo F, Bluestein D, Tran P, Slepian M, Redaelli A, Pappalardo F. Shear-mediated platelet activation in patients implanted with continuous flow LVADs: A preliminary study utilizing the platelet activity state (PAS) assay. Conf Proc IEEE Eng Med Biol Soc. 2015 Aug;2015:1255-8

Montisci A, Maj G, Zangrillo A, Winterton D, Pappalardo F. Management of refractory hypoxemia during venovenous extracorporeal membrane oxygenation for ARDS. ASAIO J. 2015 May-Jun;61(3):227-36

Pappalardo F, Ruggeri L, Pieri M, Maj G, de Bonis M, Zangrillo A. Dual lumen catheter cannulation for venovenous ECMO. Intensive Care Med. 2015 May;41(5):941

Pappalardo F, Cristaldi DA, Fragalà IL, Millesi S, De Bonis M, Gulino A. Spectroscopic and morphological characterization of inflow cannulas of left ventricular assist devices. ASAIO J. 2015 Mar-Apr;61(2):150-5

Silvetti S, Koster A, Pappalardo F. Do we need heparin coating for extracorporeal membrane oxygenation? New concepts and controversial positions about coating surfaces of extracorporeal circuits. Artif Organs. 2015 Feb;39(2):176-9

Panoulas VF, Montorfano M, Contri R, Spagnolo P, Agricola E, Pappalardo F, Latib A, Colombo A. Acute heart failure management in a young patient requiring complex left main percutaneous coronary intervention, Impella 2.5 and transcatheter aortic valve implantation. Int J Cardiol. 2015 Feb 1;180:199-202

Pappalardo F, Contri R, Pieri M, Colombo A, Zangrillo A. Fluoroless placement of Impella: a single center experience. Int J Cardiol. 2015 Jan 20;179:491-2

Zangrillo A, Pappalardo F, Dossi R, Di Prima AL, Sassone ME, Greco T, Monaco F, Musu M, Finco G, Landoni G. Preoperative intra-aortic balloon pump to reduce mortality in coronary artery bypass graft: a meta-analysis of randomized controlled trials. Crit Care 2015 Jan 14;19:10

Di Prima AL, Covello DR, Franco A, Gerli C, Lembo R, Denti P, Godino C, Taramasso M, Maisano F, Pappalardo F. Do patients undergoing MitraClip implantation require routine ICU admission? J Cardiothorac Vasc Anesth. 2014 Dec;28(6):1479-83

Bove T, Zangrillo A, Guarracino F, Alvaro G, Persi B, Maglioni E, Galdieri N, Comis M, Caramelli F, Pasero DC, Pala G, Renzini M, Conte M, Paternoster G, Martinez B, Pinelli F, Frontini M, Zucchetti MC, Pappalardo F, Amantea B, Camata A, Pisano A, Verdecchia C, Dal Checco E, Cariello C, Faita L, Baldassarri R, Scandroglio AM, Saleh O, Lembo R, Calabrò MG, Bellomo R, Landoni G. Effect of fenoldopam on use of renal replacement therapy among patients with acute kidney injury after cardiac surgery: a randomized clinical trial. JAMA. 2014 Dec 3;312(21):2244-53

De Bonis M, Lapenna E, Taramasso M, La Canna G, Buzzatti N, Pappalardo F, Alfieri O. Very long-term durability of the edge-to-edge repair for isolated anterior mitral leaflet prolapse: up to 21 years of clinical and echocardiographic results. J Thorac Cardiovasc Surg. 2014 Nov;148(5):2027-32

Pappalardo F. Veno-arterial extracorporeal membrane oxygenation system: “leave the chest closed!”.G Ital Cardiol (Rome). 2014 Oct;15(10):588-9

Maj G, Melisurgo G, De Bonis M, Pappalardo F. ECLS management in pulmonary embolism with cardiac arrest: which strategy is better? Resuscitation. 2014 Oct;85(10):e175-6

De Bonis M, Lapenna E, Maisano F, Barili F, La Canna G, Buzzatti N, Pappalardo F, Calabrese M, Nisi T, Alfieri O. Long-term results (?18 years) of the edge-to-edge mitral valve repair without annuloplasty in degenerative mitral regurgitation: implications for the percutaneous approach. Circulation. 2014 Sep 9;130(11 Suppl 1):S19-24

Pappalardo F, Agracheva N, Covello RD, Pieri M, De Bonis M, Calabrò MG, Koster A, Zangrillo A. Anticoagulation for critically ill cardiac surgery patients: is primary bivalirudin the next step? J Cardiothorac Vasc Anesth. 2014 Aug;28(4):1025-9

Crivellari M, Silvetti S, Gerli C, Landoni G, Franco A, Bove T, Pappalardo F, Zangrillo A. Protein C zymogen in adults with severe sepsis or septic shock. Med Intensiva. 2014 Jun-Jul;38(5):278-82

Melisurgo G, Ajello S, Pappalardo F, Guidotti A, Agricola E, Kawaguchi M, Latib A, Covello RD, Denti P, Zangrillo A, Alfieri O, Maisano F. Afterload mismatch after MitraClip insertion for functional mitral regurgitation. Am J Cardiol. 2014 Jun 1;113(11):1844-50

Pieri M, Agracheva N, Di Prima AL, Nisi T, De Bonis M, Isella F, Zangrillo A, Pappalardo F. Primary anticoagulation with bivalirudin for patients with implantable ventricular assist devices. Artif Organs. 2014 Apr;38(4):342-6

Silvetti S, Meroni R, Bignami E, Bove T, Landoni G, Zangrillo A, Bellomo R, Pappalardo F. Preoperative urinary neutrophil gelatinase-associated lipocalin and outcome in high-risk heart failure patients undergoing cardiac surgery. J Cardiothorac Vasc Anesth. 2014 Apr;28(2):323-7

Pappalardo F, Ammirati E, Ferrari S. The IABP-SHOCK II study. G Ital Cardiol (Rome). 2014 Mar;15(3):133-7

Pieri M, Agracheva N, Fumagalli L, Greco T, De Bonis M, Calabrese MC, Rossodivita A, Zangrillo A, Pappalardo F. Infections occurring in adult patients receiving mechanical circulatory support: the two-year experience of an Italian National Referral Tertiary Care Center. Med Intensiva. 2013 Oct;37(7):468-75

Koster AA, Pappalardo F, Silvetti S, Schirmer U, Lueth JU, Dummler R, Emmerich M, Schmitt M, Kirchne G, Kececioglu D, Sandica E. Cesarean section in a patient with non-compaction cardiomyopathy managed with ECMO. Heart Lung Vessel. 2013;5(3):183-6

Grimaldi A, Figini F, Maisano F, Montorfano M, Chieffo A, Latib A, Pappalardo F, Spagnolo P, Cioni M, Vermi AC, Ferrarello S, Piraino D, Cammalleri V, Ammirati E, Sacco FM, Arendar I, Collu E, La Canna G, Alfieri O, Colombo A. Clinical outcome and quality of life in octogenarians following transcatheter aortic valve implantation (TAVI) for symptomatic aortic stenosis. Int J Cardiol. 2013 Sep 20;168(1):281-6

Zangrillo A, Landoni G, Biondi-Zoccai G, Greco M, Greco T, Frati G, Patroniti N, Antonelli M, Pesenti A, Pappalardo F. A meta-analysis of complications and mortality of extracorporeal membrane oxygenation. Crit Care Resusc. 2013 Sep;15(3):172-8

Pappalardo F, Zangrillo A, Pieri M, Landoni G, Morelli A, Stefani M, Guarracino F. Esmolol administration in patients with VV ECMO: why not? J Cardiothorac Vasc Anesth. 2013 Aug;27(4):e40

Pappalardo F, Nisi T, Melisurgo G, Calabrese M, De Bonis M. Aortic cannula disruption following long-term LVAD support. J Card Surg. 2013 Jul;28(4):472-4

Pappalardo F, Pieri M, De Bonis M, Maj G, Calabrò MG, Ajello S, Melisurgo G, Zangrillo A. Cardiac support with IABP during venovenous ECMO for ARDS. Intensive Care Med. 2013 Jun;39(6):1152-3

De Bonis M, Lapenna E, Buzzatti N, Taramasso M, Calabrese MC, Nisi T, Pappalardo F, Alfieri O. Can the edge-to-edge technique provide durable results when used to rescue patients with suboptimal conventional mitral repair? Eur J Cardiothorac Surg. 2013 Jun;43(6):e173-9

Silvetti S, Pappalardo F, Melisurgo G, Nisi T, Latib A, Figini F, Colombo A. Ultrasound-accelerated thrombolysis and extracorporeal membrane oxygenation in a patient with massive pulmonary embolism and cardiac arrest. Circ Cardiovasc Interv. 2013 Jun;6(3):e34-6

Della Bella P, Baratto F, Tsiachris D, Trevisi N, Vergara P, Bisceglia C, Petracca F, Carbucicchio C, Benussi S, Maisano F, Alfieri O, Pappalardo F, Zangrillo A, Maccabelli G. Management of ventricular tachycardia in the setting of a dedicated unit for the treatment of complex ventricular arrhythmias: long-term outcome after ablation. Circulation. 2013 Apr 2;127(13):1359-68

Grimaldi A, Vermi AC, Pappalardo F, Benussi S, Fumero A, Maisano F, Colombo A, La Canna G, Alfieri O. The pivotal role of echocardiography in the assessment of multivalvular heart disease. Minerva Cardioangiol. 2013 Apr;61(2):229-42

Grimaldi A, De Gennaro L, Chiara Vermi A, Pappalardo F, Daniele Brunetti N, Di Biase M, La Canna G, Alfieri O. Cardiac valve involvement in systemic diseases: a review. Clin Cardiol. 2013 Mar;36(3):117-24

Pieri M, Turla OG, Calabrò MG, Ruggeri L, Agracheva N, Zangrillo A, Pappalardo F. A new phosphorylcholine-coated polymethylpentene oxygenator for extracorporeal membrane oxygenation: a preliminary experience. Perfusion. 2013 Mar;28(2):132-7

Pasin L, Umbrello M, Greco T, Zambon M, Pappalardo F, Crivellari M, Borghi G, Morelli A, Zangrillo A, Landoni G. Methylene blue as a vasopressor: a meta-analysis of randomised trials. Crit Care Resusc. 2013 Mar;15(1):42-8

Zangrillo A, Biondi-Zoccai G, Landoni G, Frati G, Patroniti N, Pesenti A, Pappalardo F. Extracorporeal membrane oxygenation (ECMO) in patients with H1N1 influenza infection: a systematic review and meta-analysis including 8 studies and 266 patients receiving ECMO. Crit Care. 2013 Feb 13;17(1):R30

Pieri M, Agracheva N, Bonaveglio E, Greco T, De Bonis M, Covello RD, Zangrillo A, Pappalardo F. Bivalirudin versus heparin as an anticoagulant during extracorporeal membrane oxygenation: a case-control study. J Cardiothorac Vasc Anesth. 2013 Feb;27(1):30-4

Pappalardo F, Pieri M, Greco T, Patroniti N, Pesenti A, Arcadipane A, Ranieri VM, Gattinoni L, Landoni G, Holzgraefe B, Beutel G, Zangrillo A; Predicting mortality risk in patients undergoing venovenous ECMO for ARDS due to influenza A (H1N1) pneumonia: the ECMOnet score. Intensive Care Med. 2013 Feb;39(2):275-81

Grimaldi A, Ajello S, Bove T, Scandroglio M, Melisurgo G, Calabrò MG, Zangrillo A, Pappalardo F. An unusual “swinging” biatrial mass. J Cardiothorac Vasc Anesth. 2013 Feb;27(1):194-6

Correale M, Ieva R, Pappalardo F, Santoro F, De Bonis M, Di Biase M. Gastrointestinal bleeding and coagulation disorders in a patient with left-ventricular assist device. J Cardiovasc Med (Hagerstown). 2013 Feb;14(2):173-4

Ghio FE, Serini C, Ghislanzoni L, Calini A, Monti G, Pappalardo F, Ponti A. 2012 pandemic flu. HSR Proc Intensive Care Cardiovasc Anesth. 2012;4(4):271

Melisurgo G, De Bonis M, Pieri M, Nisi T, Silvetti S, Zangrillo A, Pappalardo F. Is flow really continuous in last generation continuous flow Ventricular Assist Devices? A comparison between HeartMate II and HeartWare HVAD. HSR Proc Intensive Care Cardiovasc Anesth. 2012;4(4):268-9

Maj G, De Bonis M, Pieri M, Melisurgo G, Pappalardo F. Extracorporeal life support for refractory cardiac arrest: what is a good outcome? Intensive Care Med. 2012 Dec;38(12):2083-5

Maj G, Calabrò MG, Pieri M, Melisurgo G, Zangrillo A, Pappalardo F. Abdominal compartment syndrome during extracorporeal membrane oxygenation. J Cardiothorac Vasc Anesth. 2012 Oct;26(5):890-2

Grimaldi A, Fumero A, Taramasso M, Pappalardo F, Sanvito F, Ammirati E, Capritti E, Castiglioni A, Collu E, Pala MG, Zangrillo A, Alfieri O. Polypoid atrial myxoma. J Cardiovasc Med (Hagerstown). 2012 Aug;13(8):529-30

Grimaldi A, De Bonis M, Pappalardo F, Taramasso M, Verzini A, Calabrese MC, Maisano F, Alfieri O. Undersized annuloplasty for functional mitral regurgitation: is it responsible for clinically relevant mitral stenosis during exercise? J Heart Valve Dis. 2012 Jul;21(4):446-53

Pieri M, Greco T, De Bonis M, Maj G, Fumagalli L, Zangrillo A, Pappalardo F. Diagnosis of infection in patients undergoing extracorporeal membrane oxygenation: a case-control study. J Thorac Cardiovasc Surg. 2012 Jun;143(6):1411-6.

Grimaldi A, Olivotto I, Figini F, Pappalardo F, Capritti E, Ammirati E, Maisano F, Benussi S, Fumero A, Castiglioni A, De Bonis M, Vermi AC, Colombo A, Zangrillo A, Alfieri O. Dynamic assessment of ‘valvular reserve capacity’ in patients with rheumatic mitral stenosis. Eur Heart J Cardiovasc Imaging. 2012 Jun;13(6):476-82

Grimaldi A, Marijon E, Cammalleri V, Mirabel M, Ammirati E, Baratto F, Pappalardo F, Colombo A, Zangrillo A, Alfieri O. Severe rheumatic heart disease patterns in urban italian population in epidemiologic transiting. Circulation 2012;12(19)

Grimaldi A, Vermi AC, Montorfano M, Pappalardo F, Alfieri O, Colombo A. Multimodality imaging of iatrogenic pulmonary vein stenosis. Eur Heart J Cardiovasc Imaging. 2012 May;13(5):369

De Bonis M, Lapenna E, Taramasso M, Manca M, Calabrese MC, Buzzatti N, Rossodivita A, Pappalardo F, Dorigo E, Alfieri O. Mid-term results of tricuspid annuloplasty with a three-dimensional remodelling ring. J Card Surg. 2012 May;27(3):288-94

Grimaldi A, Vermi AC, Ho SY, Pappalardo F, Castiglioni A, Benussi S, Zangrillo A, Alfieri O. Surgical outcome of partial Shone complex. Interact Cardiovasc Thorac Surg. 2012 Apr;14(4):440-4

Grimaldi A, Ajello S, Scandroglio M, Melisurgo G, Gardini C, De Bonis M, Bove T, Calabrò MG, Maj G, Zangrillo A, Pappalardo F. Intracardiac clots masked by extracorporeal membrane oxygenation venous cannula. J Cardiothorac Vasc Anesth. 2012 Apr;26(2):e13-4

Mocavero PE, Staglianò A, Coppola M, Langella S, Conte A, Pappalardo F, Martiniello AR, Pieri M, Mattei A. An unusual cause of cardiogenic shock: tricuspid regurgitation and right ventricular perforation due to vena cava filter migration. HSR Proc Intensive Care Cardiovasc Anesth. 2012;4(1):47-50

Pappalardo F, Scandroglio AM, Potapov E, Stepanenko A, Maj G, Krabatsch T, Zangrillo A, Koster A, Hetzer R. Argatroban anticoagulation for heparin induced thrombocytopenia in patients with ventricular assist devices. Minerva Anestesiol. 2012 Mar;78(3):330-5

Guarracino F, Zangrillo A, Ruggeri L, Pieri M, Calabrò MG, Landoni G, Stefani M, Doroni L, Pappalardo F. ?-Blockers to optimize peripheral oxygenation during extracorporeal membrane oxygenation: a case series. J Cardiothorac Vasc Anesth. 2012 Feb;26(1):58-63

Brazzi L, Lissoni A, Panigada M, Bottino N, Patroniti N, Pappalardo F, Gattinoni L. Simulation-based training of extracorporeal membrane oxygenation during H1N1 influenza pandemic: the Italian experience. Simul Healthc. 2012 Feb;7(1):32-4

Grimaldi A, Capritti E, Pappalardo F, Radinovic A, Ferrarello S, Cammalleri V, Collu E, Ammirati E, Fumero A, Benussi S, De Bonis M, Zangrillo A, Alfieri O. Blood cyst of the mitral valve. J Cardiovasc Med (Hagerstown). 2012 Jan;13(1):46

Ponschab M, Landoni G, Biondi-Zoccai G, Bignami E, Frati E, Nicolotti D, Monaco F, Pappalardo F, Zangrillo A. Recombinant activated factor VII increases stroke in cardiac surgery: a meta-analysis. J Cardiothorac Vasc Anesth. 2011 Oct;25(5):804-1

Patroniti N, Zangrillo A, Pappalardo F, Peris A, Cianchi G, Braschi A, Iotti GA, Arcadipane A, Panarello G, Ranieri VM, Terragni P, Antonelli M, Gattinoni L, Oleari F, Pesenti A. The Italian ECMO network experience during the 2009 influenza A(H1N1) pandemic: preparation for severe respiratory emergency outbreaks. Intensive Care Med. 2011 Sep;37(9):1447-57

Maj G, Monaco F, Landoni G, Barile L, Nicolotti D, Pieri M, Melisurgo G, Pappalardo F, Zangrillo A. Cardiac index assessment by the pressure recording analytic method in unstable patients with atrial fibrillation. J Cardiothorac Vasc Anesth. 2011 Jun;25(3):476-80

Guarracino F, Covello RD, Landoni G, Baldassarri R, Stefani M, Cariello C, Ruggeri L, Franco A, Gerli C, Pappalardo F, Zangrillo A. Anesthetic management of transcatheter aortic valve implantation with transaxillary approach. J Cardiothorac Vasc Anesth. 2011 Jun;25(3):437-43

Pappalardo F, Grimaldi A, Melisurgo G, Scandroglio AM. Acute right ventricular failure post ascending aorta surgery. Interact Cardiovasc Thorac Surg. 2011 Feb;12(2):276-7

Silvani P, Facchini A, Bignami E, Capodanno P, Pappalardo F, Gerli C, Landoni G. Which protein C after cardiac surgery? J Cardiothorac Vasc Anesth. 2010 Aug;24(4):738-9

Pappalardo F, Della Valle P, Maj G, Franco A, Lattuada A, Landoni G, Zangrillo A, D’Angelo A. Perioperative evaluation of primary hemostasis in patients undergoing mitral valve repair. HSR Proc Intensive Care Cardiovasc Anesth. 2010;2(2):119-27

Zangrillo A, Garozzo FA, Biondi-Zoccai G, Pappalardo F, Monaco F, Crivellari M, Bignami E, Nuzzi M, Landoni G. Miniaturized cardiopulmonary bypass improves short-term outcome in cardiac surgery: a meta-analysis of randomized controlled studies. J Thorac Cardiovasc Surg. 2010 May;139(5):1162-9

Landoni G, Monti G, Facchini A, Cama F, Bignami E, Cabrini L, Pappalardo F, Zangrillo A. Human protein C concentrate in pediatric septic patients. Signa Vitae 2010 Apr;5(1):13-19

Pappalardo F, Scandroglio A, Maj G, Zangrillo A, D’Angelo A. Treatment of heparin-induced thrombocytopenia after cardiac surgery: preliminary experience with fondaparinux. J Thorac Cardiovasc Surg. 2010 Mar;139(3):790-2

Pappalardo F, Corno L, Ruggeri L, Zangrillo A. Perioperative management of chronic heart failure. HSR proceedings in Intensive Care & Cardiovascular Anesthesia 2010;2(Suppl.1):23-25

Pappalardo F, Corno L, Ruggeri L, Zangrillo A. Refractory heart failure and assist devices. HSR proceedings in Intensive Care & Cardiovascular Anesthesia 2010;2(Suppl.1):26-28

Melisurgo G, Pappalardo F, Scandoglio AM, Zangrillo A. Role of the cardiologist in intensive care unit. HSR proceedings in Intensive Care & Cardiovascular Anesthesia 2010;2(Suppl.1):29-31

Landoni G, Fochi O, Bignami E, Calabrò MG, D’Arpa MC, Moizo E, Mizzi A, Pappalardo F, Morelli A, Zangrillo A. Cardiac protection by volatile anesthetics in non-cardiac surgery? A meta-analysis of randomized controlled studies on clinically relevant endpoints. HSR Proc Intensive Care Cardiovasc Anesth. 2009;1(4):34-43

Crivellari M, Della Valle P, Landoni G, Pappalardo F, Gerli C, Bignami E, Marino G, Zangrillo A, D’Angelo A. Human protein C zymogen concentrate in patients with severe sepsis and multiple organ failure after adult cardiac surgery. Intensive Care Med. 2009 Nov;35(11):1959-63

Bignami E, Landoni G, Crescenzi G, Gonfalini M, Bruno G, Pappalardo F, Marino G, Zangrillo A, Alfieri O. Role of cardiac biomarkers (troponin I and CK-MB) as predictors of quality of life and long-term outcome after cardiac surgery. Ann Card Anaesth. 2009 Jan-Jun;12(1):22-6

Pappalardo F, Maj G, Scandroglio A, Sampietro F, Zangrillo A, Koster A. Bioline heparin-coated ECMO with bivalirudin anticoagulation in a patient with acute heparin-induced thrombocytopenia: the immune reaction appeared to continue unabated. Perfusion. 2009 Mar;24(2):135-7

Zangrillo A, Mizzi A, Biondi-Zoccai G, Bignami E, Calabrò MG, Pappalardo F, Dedola E, Tritapepe L, Marino G, Landoni G. Recombinant activated factor VII in cardiac surgery: a meta-analysis. J Cardiothorac Vasc Anesth. 2009 Feb;23(1):34-40

Crescenzi G, Landoni G, Biondi-Zoccai G, Pappalardo F, Nuzzi M, Bignami E, Fochi O, Maj G, Calabrò MG, Ranucci M, Zangrillo A. Desmopressin reduces transfusion needs after surgery: a meta-analysis of randomized clinical trials. Anesthesiology. 2008 Dec;109(6):1063-76

Crescenzi G, Pappalardo F, Rosica C, Gonfalini M, Landoni G, Zangrillo A. Tricks and pitfalls regarding the hemodynamics of patients undergoing non-transplantation surgery for heart failure. Minerva Anestesiol. 2008 Dec;74(12):715-25

Pappalardo F, Greinacher A, Selleng S. Postoperative complications after cardiac surgery and HIT: a word of caution. Ann Thorac Surg. 2008 Sep;86(3):1054-5

Pappalardo F, Corno C, Franco A, Giardina G, Scandroglio AM, Landoni G, Crescenzi G, Zangrillo A. Reduction of hemodilution in small adults undergoing open heart surgery: a prospective, randomized trial. Perfusion. 2007 Sep;22(5):317-22

Landoni G, Pappalardo F, Crescenzi G, Aletti G, Marchetti C, Poli D, Franco A, Rosica C, Zangrillo A. The outcome of patients requiring emergency conversion from off-pump to on-pump coronary artery bypass grafting. Eur J Anaesthesiol. 2007 Apr;24(4):317-22

Pappalardo F, Cristallo E, Franco A, Antonioli G, Zangrillo A. Decotrecogin alpha and anticoagulants in septic patients after cardiac surgery. European Journal of Anaesthesiology 2007;24(3):294-295

Castiglioni A, Verzini A, Pappalardo F, Colangelo N, Torracca L, Zangrillo A, Alfieri O. Minimally invasive closed circuit versus standard extracorporeal circulation for aortic valve replacement. Ann Thorac Surg. 2007 Feb;83(2):586-91

Landoni G, Pappalardo F, Calabrò MG, Boroli F, Sottocorna O, Aletti G, Crescenzi G, Zangrillo A. Myocardial necrosis biomarkers after different cardiac surgical operations. Minerva Anestesiol. 2007 Jan-Feb;73(1-2):49-56

Pappalardo F, Franco A, Crescenzi G, Poli A, Zangrillo A, Koster A. Successful use of bivalirudin for cardiopulmonary bypass in a patient with heparin allergy. Perfusion 2007 Jan;22(1):67-69

Pappalardo F, Franco A, Crescenzi G, De Simone F, Torracca L, Zangrillo A. Anticoagulation management in patients undergoing open heart surgery by activated clotting time and whole blood heparin concentration. Perfusion. 2006 Dec;21(5):285-90

Zangrillo A, Pappalardo F, Talò G, Corno C, Landoni G, Scandroglio A, Rosica C, Crescenzi G. Temperature management during off-pump coronary artery bypass graft surgery: a randomized clinical trial on the efficacy of a circulating water system versus a forced-air system. J Cardiothorac Vasc Anesth. 2006 Dec;20(6):788-92

Pappalardo F, Crescenzi G, Franco A, Zangrillo A. Early heparin-induced thrombocytopaenia (HIT) after cardiac surgery. Eur J Anaesthesiol. 2006 Sep;23(9):806-8

Pappalardo F, Della Valle P, Crescenzi G, Corno C, Franco A, Torracca L, Alfieri O, Galli L, Zangrillo A, D’Angelo A. Phosphorylcholine coating may limit thrombin formation during high-risk cardiac surgery: a randomized controlled trial. Ann Thorac Surg. 2006 Mar;81(3):886-91

Zangrillo A, Landoni G, Sparicio D, Pappalardo F, Bove T, Cerchierini E, Sottocorna O, Aletti G, Crescenzi G. Perioperative magnesium supplementation to prevent atrial fibrillation after off-pump coronary artery surgery: a randomized controlled study. J Cardiothorac Vasc Anesth. 2005 Dec;19(6):723-8

Zangrillo A, Annalisa F, Crescenzi G, Pappalardo F, Boroli F, Sottocorna O, Landoni G.Underreporting of conversion from off-pump coronary artery bypass surgery. Anesthesiology. 2005 Oct;103(4):902

Zangrillo A, Crescenzi G, Landoni G, Benussi S, Crivellari M, Pappalardo F, Dorigo E, Pappone C, Alfieri O. The effect of concomitant radiofrequency ablation and surgical technique (repair versus replacement) on release of cardiac biomarkers during mitral valve surgery. Anesth Analg. 2005 Jul;101(1):24-9

Zangrillo A, Landoni G, Pappalardo F, Oppizzi M, Torri G. Different anesthesiological management in two high risk pregnant women with heart failure undergoing emergency cesarean section. Minerva Anestesiol. 2005 May;71(5):227-36

Zangrillo A, Crescenzi G, Landoni G, Leoni A, Marino G, Calabrò MG, Corno C, Pappalardo F, Alfieri O. Off-pump coronary artery bypass grafting reduces postoperative neurologic complications. J Cardiothorac Vasc Anesth. 2005 Apr;19(2):193-6

Zangrillo A, Landoni G, Sparicio D, Benussi S, Aletti G, Pappalardo F, Fracasso G, Fano G, Crescenzi G. Predictors of atrial fibrillation after off-pump coronary artery bypass graft surgery. J Cardiothorac Vasc Anesth. 2004 Dec;18(6):704-8

Zangrillo A, Romano A, Landoni G, Sparicio D, Redaelli C, Pappalardo F, Marino G, Gulletta S, Aletti G, Alfieri O. Postoperative complications after coronary artery by pass graft surgery: a comparison between the off-pump and on-pump techniques. Eur J Anaesthesiol. 2004 Sep;21(9):745-7

Crescenzi G, Bove T, Pappalardo F, Scandroglio AM, Landoni G, Aletti G, Zangrillo A, Alfieri O. Clinical significance of a new Q wave after cardiac surgery. Eur J Cardiothorac Surg. 2004 Jun;25(6):1001-5

Pappalardo F, Franco A, Landoni G, Cardano P, Zangrillo A, Alfieri O. Long-term outcome and quality of life of patients requiring prolonged mechanical ventilation after cardiac surgery. Eur J Cardiothorac Surg. 2004 Apr;25(4):548-52

Crescenzi G, Scandroglio AM, Pappalardo F, Landoni G, Cedrati V, Bignami E, Aletti G, Zangrillo A. ECG changes after CABG: the role of the surgical technique. J Cardiothorac Vasc Anesth. 2004 Feb;18(1):38-42

Sparicio D, Landoni G, Pappalardo F, Crivellari M, Cerchierini E, Marino G, Zangrillo A. Methylene blue for lithium-induced refractory hypotension in off-pump coronary artery bypass graft: report of two cases. J Thorac Cardiovasc Surg. 2004 Feb;127(2):592-3

Landoni G, Marino G, Gerli C, Bellotti F, Bove T, Pappalardo F, Mamo D, Aletti G, Maisano F, Alfieri O, Torri G. Beating-heart coronary artery bypass graft surgery at San Raffaele Hospital: four years of experience. J Cardiothorac Vasc Anesth. 2002 Dec;16(6):691-4

Pappalardo F, Landoni G, Franco A, Monaco C, Marino G, Torri G. Prolonged refractory hypotension in cardiac surgery after institution of cardiopulmonary bypass. J Cardiothorac Vasc Anesth. 2002 Aug;16(4):477-9

English version

Education:

School Leaving Certificate Liceo Ginnasio “N. Spedalieri”, Catania.
Degree in Medicine and Surgery, University of Catania.
Residency in Anaesthesia and Intensive Care Catholic University of Sacred Heart, Policlinico “A. Gemelli”, Rome.

Work Experience:

Head of Functional Unit for Cardiac Thoracic ICU Surgery, San Raffaele Hospital, Milan.

Responsible for Circumcular Mechanical Support Activity and Acute Respiratory Failure (Anaesthesia and Resuscitation Service). During this period, ECMO (Veno-arterial and veno-venous) implants in all clinical contexts (eCPR, Mobile Ecmo, Postcardiotomy, Bilume, Periprocedural support) have been performed as first operator or tutor. He has also run Impella implants. In this context, he has developed an original technique for inserting the device without fluoroscopy and is the only certified operator in Italy for right ventricular assistance.

Undertakes patient selection, post-operative care and long-term follow-up of patients with LVAD (Left Ventricular Assist Device).

Responsible for Theoretical-Practical Courses in “Mechanical Circuit Assistance: IABP, ECMO, LVAD” at San Raffaele Hospital, Milan, and has trained physicians, perfusionists and nurses in this field from Italy and numerous other countries.

Head of Research Unit at INSTM (National Interuniversity Consortium for Materials Science and Technology) San Raffaele Hospital, Milan, in the project “BIOSUOVAD – Bioactive Surface Study for the Optimisation of Left Ventricular Assist Device (LVAD): Bioactive Surfaces for Optimised LVAD “in collaboration with the Department of Organic Chemistry at the University of Catania.

Head of the PhD Program of Politecnico, Milan, XXIV Cycle “Multi-Perspective Investigation of the Effectiveness of Anti-Thrombotic Treatments in Shear-Mediated Palltelet Activation” – Department of Electronics, Information and Bioengineering (Prof. A. Redaelli) at San Raffaele Hospital, Milan.

Research Activity
Research activity has been centred on artificial respiratory and respiratory support technologies, with particular reference to biocompatibility. More specifically, interest has focused on alternative anti-agitators, biocompatible surfaces, and platelet-like surface interactions. Scientific activity has always been characterised by interdisciplinary, transnationalism and internationalisation.

Teaching Activity
June 2017 – Present:
Associate Professor at San Raffaele University, Milan.

2009 – 2016:
Tutor and Coordinator of Bachelor’s Thesis in Medicine and Surgery and Specialisation in Anaesthesiology and Resuscitation, Cardiology, Cardiac Surgery, Biomedical Engineering at the Politecnico of Milan

Correspondent of the PhD thesis in Biomedical Engineering “Evaluation of platelet activation status in LVAD carriers”: Platelet Activity State Assay as a Therapeutic Thrombotic Post-Ventricular Risk Analysis Tool at the Politecnico of Milan

Lecturer in the Integrated Emergency Medicine Course at San Raffaele Health University, Milan

Tutor at the Emergency-Urgent Medicine School of San Raffaele University, Milan

Tutor of the Anaesthesiology and Resuscitation Specialty School at San Raffaele University, Milan for theoretical / practical training of Specialists in the following areas: Anaesthesia and Resuscitation, Cardiology, Pneumology, Urgency Medicine, Nephrology and Cardiac Surgery

Contracted Professor at the School of Specialisation in Cardiovascular Disease at the San Raffaele University of Vita-Salute, Milan

Co-director of the Master in Anaesthesia and Cardio-Thoraco-Vascular Resuscitation at the San Raffaele University, Milan

Teacher for “1st Ecmo Course” at Russian Ecmo School, Anaesthesia Society and Russian Resuscitation Society, Moscow

Teacher for ECMO courses on treatment of acute respiratory failure through extracorporeal support, under the EcmoNet program / Ministry of Health “National Network for Management of Acute Vulnerable Aperture Aperture Syndrome A (H1N1) possible use of ECMO therapy ”

Lecturer: “Interventional EP Curriculum 13 VT, Introductory session”
Honors:
Member of the Innovation Committee of EuroELSO
Member of the National Scientific Committee Network of  Respiratory  Failure  : RESPIRA
Member of the Roland Hetzer International Society
Member of the National Transplant Center ,  National Study Group on HTA, VAD Artificial Heart, Itamacs Register
Developed DCD donation methods at the San Raffaele Hospital, Milan and is a member of the CNT Technical Committee dealing with this issue
Member of the GIROC (Italian Cardiac Surgery Group)

Il titolare del presente curriculum vitae, pubblicato online sul portale www.unisr.it, è garante in via esclusiva della correttezza e della veridicità dei dati e delle informazioni in esso riportate e del loro eventuale e puntuale aggiornamento. Egli è dunque il diretto ed unico responsabile dei contenuti indicati nei propri curricula.