Alessandra Mortellaro RicercatoreMedicina

Research Activity

Curriculum Vitae

Publications

Research Activity

Autoinflammatory diseases are rare genetic diseases characterized by recurrent inflammation caused by dysregulation of the innate immune system. One of these is the adenosine deaminase 2 deficiency (DADA2), a newly identified disease caused by autosomal recessive mutations in the ADA2 gene. The most common presentation of DADA2 is cutaneous and cerebral vasculopathy, stroke, systemic inflammation, hematological and immunological manifestations. Disease onset is usually in childhood, and, without treatment, a significant proportion of patients are deceased before the age of 30. The clinical benefit of the existing therapies is variable, and sustained disease remission is difficult to achieve. Therefore, there is a high unmet medical need for the development of targeted therapies for DADA2. However, there is a complete lack of knowledge of the immune mechanisms underlying DADA2. Our group is working towards the identification of the cellular mechanisms underlying DADA2, with the final goal to develop a gene therapy approach for this devastating disease.

Curriculum Vitae

Education

2005, Ph.D. in Cellular and Molecular Biology, Open University of London (U.K.) & Vita-Salute University San Raffaele (Italy)

1998, Bachelor and Master Degree in Biological Sciences, University of Milan (Italy)

 

Positions and Employment

2017–present: Project Leader, San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute, Milan (Italy)

2011–2017: Principal Investigator, Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore

2010–2011: Senior Research Scientist, Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore

2008–2010: Research Scientist, Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore

2006–2007: Postdoctoral Fellow, Department of Biotechnology and Bioscience, University of Milano-Bicocca, Italy

2001–2005: Ph.D. Student, San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), Italy

1998–2000: Postgraduate Fellow, San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), Italy

1995–1997: Master Thesis Student, Department of Immunology, Istituto Ricerche Farmacologiche Mario Negri, Italy.

 

Honors

2019, Recipient of a Marie Skłodowska-Curie Individual Fellowship funded under the Horizon 2020 program by the European Commission

2011, Young Investigator Award, League Associations of Rheumatology, Taiwan.

 

Teaching and Mentoring Activities

2017, Adjunct Assistant Professor, School of Biological Sciences (SBS), Nanyang Technological University (NTU), Singapore (11th in the QS World University Rankings).

2015–2017, Adjunct Assistant Professor, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore (11th in the QS World University Rankings).

2009–2010, Lecturer, Immuno-Technologies Training Course (ITTC) organized by SIgN, Singapore

2005–2008, Lecturer, Laboratory of Immunological Techniques (theoretical and practical classes), Course of Biotechnology, University of Milano-Bicocca, Milan (Italy)

2005–2008, Lecturer, Course of Integrated Biology (Immunology module), University of Milano-Bicocca, Milan (Italy)

2008–present: Supervisor of 11 Postdoctoral Fellows and 8 Ph.D. students

2002–present: Supervisor of 12 B.S. and 10 M.S. students

Publications

  • Original Articles

  • Jofra Hernández R, Calabria A, Sanvito F, De Mattia F, Farinelli G, Scala S, Visigalli I, Carriglio N, De Simone M, Vezzoli M, Cecere F, Migliavacca M, Basso-Ricci L, Omrani M, Benedicenti F, Norata R, Rancoita PMV, Di Serio C, Albertini P, Cristofori P, Naldini L, Gentner B, Montini E, Aiuti A, Mortellaro A. Hematopoietic Tumors in a Mouse Model of X-linked Chronic Granulomatous Disease after Lentiviral Vector-Mediated Gene Therapy. Mol Ther. 2020 Sep 23:S1525-0016(20)30487. PMID: 33010230.
  • Javanmard Khameneh H, Leong KWK, Mencarelli A, Vacca M, Mambwe B, Neo K, Tay A, Zolezzi F, Lee B, Mortellaro A. The Inflammasome Adaptor ASC Intrinsically Limits CD4+ T-Cell Proliferation to Help Maintain Intestinal Homeostasis. Front Immunol. 2019 Jul 15;10:1566. PMID: 31379813.
  • Mambwe B, Neo K, Khameneh HJ, Leong KWK, Colantuoni M, Vacca M, Muimo R, Mortellaro A. Tyrosine Dephosphorylation of ASC Modulates the Activation of the NLRP3 and AIM2 Inflammasomes. Front Immunol. 2019;10:1556. PMID: 31333677.
  • Pal A, Neo K, Rajamani L, Ferrer FJ, Lane DP, Verma CS, Mortellaro A. Inhibition of NLRP3 inflammasome activation by cell-permeable stapled peptides. Sci Rep. 2019; 9(1):4913. PMID: 30894604.
  • Mencarelli A, Khameneh HJ, Fric J, Vacca M, El Daker S, Janela B, Tang JP, Nabti S, Balachander A, Lim TS, Ginhoux F, Ricciardi-Castagnoli P, Mortellaro A. Calcineurin-mediated IL-2 production by CD11chighMHCII+ myeloid cells is crucial for intestinal immune homeostasis. Nat Commun. 2018;9(1):1102. PMID: 29549257.
  • Mencarelli A, Vacca M, Khameneh HJ, Acerbi E, Tay A, Zolezzi F, Poidinger M, Mortellaro A. Calcineurin B in CD4+ T Cells Prevents Autoimmune Colitis by Negatively Regulating the JAK/STAT Pathway. Front Immunol. 2018;9:261. PMID: 29515579.
  • Chaurasia SS, Lim RR, Parikh BH, Wey YS, Tun BB, Wong TY, Luu CD, Agrawal R, Ghosh A, Mortellaro A, Rackoczy E, Mohan RR, Barathi VA. The NLRP3 Inflammasome May Contribute to Pathologic Neovascularization in the Advanced Stages of Diabetic Retinopathy. Sci Rep. 2018;8(1):2847. PMID: 29434227.
  • Kale SD, Dikshit N, Kumar P, Balamuralidhar V, Khameneh HJ, Bin Abdul Malik N, Koh TH, Tan GGY, Tan TT, Mortellaro A, Sukumaran B. Nod2 is required for the early innate immune clearance of Acinetobacter baumannii from the lungs. Sci Rep. 2017;7(1):17429. PMID: 29234083.
  • Vacca M, Böhme J, Zambetti LP, Khameneh HJ, Paleja BS, Laudisi F, Ho AWS, Neo K, Leong KWK, Marzuki M, Lee B, Poidinger M, Santambrogio L, Tsenova L, Zolezzi F, De Libero G, Singhal A, Mortellaro A. NLRP10 in dendritic cells enhances IFNg production by antigen-specific T cells. Front Immunol. 2017;8:1462. PMID: 29163529.
  • Diamond CE, Leong KWK, Vacca M, Rivers-Auty J, Brough D, Mortellaro A. Salmonella Typhimurium-induced IL-1 release from primary human monocytes requires NLRP3 and occurs in the absence of pyroptosis. Sci Rep. 2017;7(1):6861. PMID: 28761045.
  • Bist P, Cheong WS, Ng A, Dikshit N, Kim BH, Pulloor NK, Khameneh HJ, Hedl M, Shenoy AR, Balamuralidhar V, Malik NBA, Hong M, Neutzner A, Chin KC, Kobayashi KS, Bertoletti A, Mortellaro A, Abraham C, MacMicking JD, Xavier RJ, Sukumaran B. E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2-signaling, and mediates induction of MDP-tolerance. Nat Commun. 2017;8:15865. PMID: 28656966.
  • Dikshit N, Kale SD, Khameneh HJ, Balamuralidhar V, Tang CY, Kumar P, Lim TP, Tan TT, Kwa AL, Mortellaro A, Sukumaran B. NLRP3 inflammasome pathway plays a critical role in the host immunity against clinically relevant Acinetobacter baumannii pulmonary infection. Mucosal Immunol. 2017;11(1):257-272. PMID: 28612844.
  • Khameneh HJ, Ho AW, Laudisi F, Derks H, Kandasamy M, Sivasankar B, Teng GG, Mortellaro A. C5a regulates IL-1β production and leukocyte recruitment in a murine model of gout. Front Pharmacol. 2017;8:10. PMID: 28167912.
  • Ho AWS, Spreafico R, Khameneh HJ, Derks H, Quek HQY, Mortellaro A. The Syk-NFAT-IL-2 pathway in dendritic cells is required for optimal sterile immunity elicited by alum adjuvants. J Immunol. 2017 Jan 1;198(1):196-204. PMID: 27895176.
  • Acerbi E, Viganò E, Poidinger M, Mortellaro A, Zelante T, Stella F. Continuous time Bayesian networks identify Prdm1 as a negative regulator of TH17 cell differentiation in humans. Sci Rep. 2016 Mar 15;6:23128. PMID: 26976045.
  • Martín-Sánchez F, Diamond C, Zeitler M, Gomez-Sanchez A, Baroja-Mazo A, Bagnall J, Spiller D, White MR, Mortellaro A, Peñalver M, Paszek P, Nickel W, Brough D, Pelegrín P. Inflammasome-dependent IL-1β release depends upon membrane permeabilization. Cell Death Differ. 2016 Jul;23(7):1219-31. PMID: 26868913.
  • Viganò E, Diamond CE, Spreafico R, Balachander A, Sobota RM, Mortellaro A. Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes. Nat Commun. 2015 Oct 28;6:8761. PMID: 26508369.
  • Zelante T, Wong A, Tang JP, Chen J, Sumatoh HRS, Elena Vigano’ E, Yu HB, Lee B, Zolezzi F, Fric J, Newell EW, Mortellaro A, Poidinger M, Puccetti P, Ricciardi-Castagnoli P. CD103+ dendritic cells control Th17 cell function in the lung. Cell Rep. 2015 Sept 22;12(11):1789-801. PMID: 26365185.
  • Andiappan AK, Melchiotti R, Poh TY, Nah M, Puan KJ, Viganò E, Haase D, Yusof N, San-Luiz B, Lum J, Kumar D, Foo S, Li L, Vasudev A, Irwanto A, Lee B, Nardin A, Liu H, Zhang F, Connolly J, Liu J, Mortellaro A, Wang DY, Poidinger M, Larbi A, Zolezzi F, Rotzschke O. Genome-wide analysis of the genetic regulation of gene expression in human neutrophils. Nat Commun. 2015 Aug 10;6:7971. PMID: 26259071.
  • Li L, Ng DS, Mah W, Almeida FF, Rahmat SA, Rao VK, Leow SC, Laudisi F, Peh MT, Goh AM, Lim JS, Wright GD, Mortellaro A, Taneja R, Ginhoux F, Lee CG, Moore PK, Lane DP. A unique role for p53 in the regulation of M2 macrophage polarization. Cell Death Differ. 2015 Jul;22(7):1081-93. PMID: 25526089.
  • Zhou Q, Ho AWS, Schlitzer A, Tang Y, Wong KHS, Wong FHS, Chua YL, Angeli V, Mortellaro A, Ginhoux F, Kemeny DM. GM-CSF-licensed CD11b+ lung DCs orchestrate Th2 immunity to Blomia tropicalis. J Immunol. 2014 July 15;193(2):496-509. PMID: 24943219.
  • Goh AX, Bertin-Maghit S, Yeo SP, Ho AWS, Derks H, Mortellaro A, Wang CI. A novel human anti-interleukin-1b neutralizing monoclonal antibody showing in vivo efficacy. MAbs. 2014 May-June;6(3):764-72. PMID: 24671001.
  • Bist P, Dikshit N, Koh TH, Mortellaro A, Tan TT, Sukumaran B. The Nod1, Nod2, and Rip2 axis contributes to host immune defense against intracellular Acinetobacter baumannii infection. Infect Immun. 2014 Mar;82(3):1112-22. PMID: 24366254.
  • Laudisi F, Spreafico R, Evrard M, Hughes TR, Mandriani B, Kandasamy M, Morgan BP, Sivasankar B, Mortellaro A. Cutting edge: The NLRP3 inflammasome links complement-mediated inflammation and IL-1b release. J Immunol. 2013 Aug 1;191(3):1006-10. [Reviewed in F1000Prime, f1000.com/prime/718046840]. PMID: 23817414.
  • Licandro G, Khor HL, Beretta O, Lai J, Derks H, Laudisi F, Conforti-Andreoni C, Qian HL, Teng GG, Ricciardi-Castagnoli P, Mortellaro A. The NLRP3 inflammasome affects DNA damage responses after oxidative and genotoxic stress in dendritic cells. Eur J Immunol. 2013 Aug;43(8):2126-37. [Selected for cover image and Editorial Commentary]. PMID: 23619996.
  • Lim TS, Goh JK, Mortellaro A, Lim CT, Hämmerling GJ, Ricciardi-Castagnoli P. CD80 and CD86 differentially regulate mechanical interactions of T-cells with antigen-presenting dendritic cells and B-cells. PLoS One. 2012;7(9):e45185. PMID: 23024807.
  • Fric J, Lim CXF, Koh EGL, Hofmann B, Chen J, Tay HS, Isa SA, Mortellaro A, Ruedl C, Ricciardi-Castagnoli P. Calcineurin/NFAT signaling inhibits myeloid hematopoiesis. EMBO Mol Med. 2012 Apr,4(4):269-85. PMID: 22311511.
  • Lin M., Isa SA, Wee NF, Siu KS, Beretta O, Mortellaro A, and Ruedl C. Synergism between curdlan and GM-CSF confers a strong inflammatory signature to dendritic cells. J Immunol. 2012 Feb;188(4):1789-98. PMID: 22250091.
  • Conforti-Andreoni C, Spreafico R, Qian HL, Riteau N, Ryffel B, Ricciardi-Castagnoli P, and Mortellaro A. Uric acid-driven Th17 differentiation requires inflammasome-derived IL-1 and IL-18. J Immunol. 2011 Dec;187(11):5842-50. PMID: 22058415.
  • Lim TS, Mortellaro A, Lim CT, Hämmerling GJ, Ricciardi-Castagnoli P. Mechanical interactions between dendritic cells and T cells correlate with T cell responsiveness. J Immunol. 2011 Jul;187(1):258-65. PMID: 21622857.
  • Conforti-Andreoni C, Beretta O, Licandro G, Qian HL, Urbano M, Vitulli F, Ricciardi-Castagnoli P, Mortellaro A. Synergism of NOD2 and NLRP3 activators promotes a unique transcriptional profile in murine dendritic cells. J Leukoc Biol. 2010 Dec; 88(6):1207-1216. PMID: 20884650.
  • Tailleux L, Waddell SJ, Pelizzola M, Mortellaro A*, Withers M, Tanne A, Castagnoli PR, Gicquel B, Stoker NG, Butcher PD, Foti M, Neyrolles O. Probing host pathogen cross-talk by transcriptional profiling of both Mycobacterium tuberculosis and infected human dendritic cells and macrophages. PLoS One. 2008 Jan;3(1):e1403. (*First co-authorship). PMID: 18167562.
  • Mortellaro A, Hernandez RJ, Guerrini MM, Carlucci F, Tabucchi A, Ponzoni M, Sanvito F, Doglioni C, Di Serio C, Biasco L, Follenzi A, Naldini L, Bordignon C, Roncarolo MG, Aiuti A. Ex vivo gene therapy with lentiviral vectors rescues adenosine deaminase (ADA)-deficient mice and corrects their immune and metabolic defects. Blood. 2006 Nov;108(9):2979-88. PMID: 16835374.
  • Guazzi V, Aiuti F, Mezzaroma I, Mazzetta F, Andolfi G, Mortellaro A, Pierdominici M, Fantini R, Marziali M, Aiuti A. Assessment of thymic output in common variable immunodeficiency patients by evaluation of T cell receptor excision circles. Clin Exp Immunol. 2002 Aug;129(2):346-53. PMID: 12165093.
  • Aiuti A, Slavin S, Aker M, Ficara F, Deola S, Mortellaro A, Morecki S, Andolfi G, Tabucchi A, Carlucci F, Marinello E, Cattaneo F, Vai S, Servida P, Miniero R, Roncarolo MG, Bordignon C. Correction of ADA-SCID by stem cell gene therapy combined with nonmyeloablative conditioning. Science. 2002 Jun;296(5577):2410-3. PMID: 12089448.
  • Aiuti A, Vai S, Mortellaro A, Casorati G, Ficara F, Andolfi G, Ferrari G, Tabucchi A, Carlucci F, Ochs HD, Notarangelo LD, Roncarolo MG, Bordignon C. Immune reconstitution in ADA-SCID after PBL gene therapy and discontinuation of enzyme replacement. Nat Med. 2002 May;8(5):423-5. PMID: 11984564.
  • Mortellaro A, Songia S, Gnocchi P, Ferrari M, Fornasiero C, D'Alessio R, Isetta A, Colotta F, Golay J. New immunosuppressive drug PNU156804 blocks IL-2-dependent proliferation and NF-kappa B and AP-1 activation. J Immunol. 1999 Jun;162(12):7102-9. PMID: 10358154.
  • Songia S, Mortellaro A, Taverna S, Fornasiero C, Scheiber EA, Erba E, Colotta F, Mantovani A, Isetta AM, Golay J. Characterization of the new immunosuppressive drug undecylprodigiosin in human lymphocytes: retinoblastoma protein, cyclin-dependent kinase-2, and cyclin-dependent kinase-4 as molecular targets. J Immunol. 1997 Apr;158(8):3987-95. PMID: 9103470.

 

 

 

 

Reviews, Commentaries and Book Chapters

Tucci F, Scaramuzza S, Aiuti A, Mortellaro A. Update on Clinical Ex Vivo Hematopoietic Stem Cell Gene Therapy for Inherited Monogenic Diseases. Mol Ther. 2021 Feb 3;29(2):489-504. PMID: 33221437. Diamond C, Bagnall J, Spiller DG, White MR, Mortellaro A, Paszek P, Brough D. Investigating IL-1β Secretion Using Real-Time Single-Cell Imaging. Methods Mol Biol. 2016;1417:75-88. PMID: 27221482. Diamond CE, Khameneh HJ, Mortellaro A. Novel perspectives on non-canonical inflammasome activation. ImmunoTargets and Therapy. 2015;4:131. PMID: 27471719. Khameneh HJ, Mortellaro A. NLRC4 gets out of control. Nat Genet. 2014;46(10):1048. PMID: 25257084. Zambetti LP, Mortellaro A. NLRPs, microbiota and gut homeostasis: unraveling the connection. J Pathol. 2014;233(4):321. PMID: 24740681. Laudisi F, Viganò E, Mortellaro A. Tyrosine kinases: the molecular switch for inflammasome activation. Cell Mol Immunol. 2014;11(2):129. PMID: 24509443. Viganò E, Mortellaro A. Caspase-11: the driving factor for non-canonical inflammasomes. Eur J Immunol. 2013;43(9):2240. PMID: 24037676. Zambetti LP, Laudisi F, Licandro G, Ricciardi-Castagnoli P, Mortellaro A. The rhapsody of NLRPs: master players of inflammation … and a lot more. Immunol Res. 2012;53(1-3):78. PMID: 22427013. Mortellaro A & Ricciardi-Castagnoli P. From vaccine practice to vaccine science: the contribution of human immunology to the prevention of infectious disease. Immunol Cell Biol. 2011;89(3):332. PMID: 21301476. Conforti-Andreoni C, Ricciardi-Castagnoli P, Mortellaro A. The inflammasomes in health and disease: from genetics to molecular mechanisms of autoinflammation and beyond. Cell Mol Immunol. 2011;8(2):135. PMID: 21258359. Spreafico R, Ricciardi-Castagnoli P, Mortellaro A. The controversial relationship between NLRP3, alum, danger signals and the next-generation adjuvants. Eur J Immunol. 2010;40(3):638. PMID: 20201020. Mortellaro A, Robinson L, Ricciardi-Castagnoli P. Spotlight on Mycobacteria and dendritic cells: will novel targets to fight tuberculosis emerge? EMBO Mol Med. 2009;1(1):19. PMID: 20049700. Mortellaro A, Wong SC, Fric J, Ricciardi-Castagnoli P. The need to identify myeloid dendritic cell progenitors in human blood. Trends Immunol. 2010;31(1):18. PMID: 19836307. Mortellaro A, Urbano M, Citterio S, Foti M, Granucci F, Ricciardi-Castagnoli P. Generation of murine growth factor-dependent long-term dendritic cell lines to investigate host-parasite interactions. Methods Mol Biol. 2009;531:17. PMID: 19347308. Mortellaro A, Granucci F, Foti M, Ricciardi-Castagnoli P. Dendritic cells in their tissue microenvironments during exposure to pathogens. Editors: David G. Russell and Siamon Gordon, 2009;51-68. ASM Press. PMID: 18672083. Mortellaro A, Conforti-Andreoni C, Fric J, Ricciardi-Castagnoli P. Dendritic cells as sensors of environmental perturbations. Microbes Infect. 2008;10(9):990.2.

Original Articles

  1. Jofra Hernández R, Calabria A, Sanvito F, De Mattia F, Farinelli G, Scala S, Visigalli I, Carriglio N, De Simone M, Vezzoli M, Cecere F, Migliavacca M, Basso-Ricci L, Omrani M, Benedicenti F, Norata R, Rancoita PMV, Di Serio C, Albertini P, Cristofori P, Naldini L, Gentner B, Montini E, Aiuti A, Mortellaro A. Hematopoietic Tumors in a Mouse Model of X-linked Chronic Granulomatous Disease after Lentiviral Vector-Mediated Gene Therapy. Mol Ther. 2020 Sep 23:S1525-0016(20)30487. PMID: 33010230.
  2. Javanmard Khameneh H, Leong KWK, Mencarelli A, Vacca M, Mambwe B, Neo K, Tay A, Zolezzi F, Lee B, Mortellaro A. The Inflammasome Adaptor ASC Intrinsically Limits CD4+ T-Cell Proliferation to Help Maintain Intestinal Homeostasis. Front Immunol. 2019 Jul 15;10:1566. PMID: 31379813.
  3. Mambwe B, Neo K, Khameneh HJ, Leong KWK, Colantuoni M, Vacca M, Muimo R, Mortellaro A. Tyrosine Dephosphorylation of ASC Modulates the Activation of the NLRP3 and AIM2 Inflammasomes. Front Immunol. 2019;10:1556. PMID: 31333677.
  4. Pal A, Neo K, Rajamani L, Ferrer FJ, Lane DP, Verma CS, Mortellaro A. Inhibition of NLRP3 inflammasome activation by cell-permeable stapled peptides. Sci Rep. 2019; 9(1):4913. PMID: 30894604.
  5. Mencarelli A, Khameneh HJ, Fric J, Vacca M, El Daker S, Janela B, Tang JP, Nabti S, Balachander A, Lim TS, Ginhoux F, Ricciardi-Castagnoli P, Mortellaro A. Calcineurin-mediated IL-2 production by CD11chighMHCII+ myeloid cells is crucial for intestinal immune homeostasis. Nat Commun. 2018;9(1):1102. PMID: 29549257.
  6. Mencarelli A, Vacca M, Khameneh HJ, Acerbi E, Tay A, Zolezzi F, Poidinger M, Mortellaro A. Calcineurin B in CD4+ T Cells Prevents Autoimmune Colitis by Negatively Regulating the JAK/STAT Pathway. Front Immunol. 2018;9:261. PMID: 29515579.
  7. Chaurasia SS, Lim RR, Parikh BH, Wey YS, Tun BB, Wong TY, Luu CD, Agrawal R, Ghosh A, Mortellaro A, Rackoczy E, Mohan RR, Barathi VA. The NLRP3 Inflammasome May Contribute to Pathologic Neovascularization in the Advanced Stages of Diabetic Retinopathy. Sci Rep. 2018;8(1):2847. PMID: 29434227.
  8. Kale SD, Dikshit N, Kumar P, Balamuralidhar V, Khameneh HJ, Bin Abdul Malik N, Koh TH, Tan GGY, Tan TT, Mortellaro A, Sukumaran B. Nod2 is required for the early innate immune clearance of Acinetobacter baumannii from the lungs. Sci Rep. 2017;7(1):17429. PMID: 29234083.
  9. Vacca M, Böhme J, Zambetti LP, Khameneh HJ, Paleja BS, Laudisi F, Ho AWS, Neo K, Leong KWK, Marzuki M, Lee B, Poidinger M, Santambrogio L, Tsenova L, Zolezzi F, De Libero G, Singhal A, Mortellaro A. NLRP10 in dendritic cells enhances IFNg production by antigen-specific T cells. Front Immunol. 2017;8:1462. PMID: 29163529.
  10. Diamond CE, Leong KWK, Vacca M, Rivers-Auty J, Brough D, Mortellaro A. Salmonella Typhimurium-induced IL-1 release from primary human monocytes requires NLRP3 and occurs in the absence of pyroptosis. Sci Rep. 2017;7(1):6861. PMID: 28761045.
  11. Bist P, Cheong WS, Ng A, Dikshit N, Kim BH, Pulloor NK, Khameneh HJ, Hedl M, Shenoy AR, Balamuralidhar V, Malik NBA, Hong M, Neutzner A, Chin KC, Kobayashi KS, Bertoletti A, Mortellaro A, Abraham C, MacMicking JD, Xavier RJ, Sukumaran B. E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2-signaling, and mediates induction of MDP-tolerance. Nat Commun. 2017;8:15865. PMID: 28656966.
  12. Dikshit N, Kale SD, Khameneh HJ, Balamuralidhar V, Tang CY, Kumar P, Lim TP, Tan TT, Kwa AL, Mortellaro A, Sukumaran B. NLRP3 inflammasome pathway plays a critical role in the host immunity against clinically relevant Acinetobacter baumannii pulmonary infection. Mucosal Immunol. 2017;11(1):257-272. PMID: 28612844.
  13. Khameneh HJ, Ho AW, Laudisi F, Derks H, Kandasamy M, Sivasankar B, Teng GG, Mortellaro A. C5a regulates IL-1β production and leukocyte recruitment in a murine model of gout. Front Pharmacol. 2017;8:10. PMID: 28167912.
  14. Ho AWS, Spreafico R, Khameneh HJ, Derks H, Quek HQY, Mortellaro A. The Syk-NFAT-IL-2 pathway in dendritic cells is required for optimal sterile immunity elicited by alum adjuvants. J Immunol. 2017 Jan 1;198(1):196-204. PMID: 27895176.
  15. Acerbi E, Viganò E, Poidinger M, Mortellaro A, Zelante T, Stella F. Continuous time Bayesian networks identify Prdm1 as a negative regulator of TH17 cell differentiation in humans. Sci Rep. 2016 Mar 15;6:23128. PMID: 26976045.
  16. Martín-Sánchez F, Diamond C, Zeitler M, Gomez-Sanchez A, Baroja-Mazo A, Bagnall J, Spiller D, White MR, Mortellaro A, Peñalver M, Paszek P, Nickel W, Brough D, Pelegrín P. Inflammasome-dependent IL-1β release depends upon membrane permeabilization. Cell Death Differ. 2016 Jul;23(7):1219-31. PMID: 26868913.
  17. Viganò E, Diamond CE, Spreafico R, Balachander A, Sobota RM, Mortellaro A. Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes. Nat Commun. 2015 Oct 28;6:8761. PMID: 26508369.
  18. Zelante T, Wong A, Tang JP, Chen J, Sumatoh HRS, Elena Vigano’ E, Yu HB, Lee B, Zolezzi F, Fric J, Newell EW, Mortellaro A, Poidinger M, Puccetti P, Ricciardi-Castagnoli P. CD103+ dendritic cells control Th17 cell function in the lung. Cell Rep. 2015 Sept 22;12(11):1789-801. PMID: 26365185.
  19. Andiappan AK, Melchiotti R, Poh TY, Nah M, Puan KJ, Viganò E, Haase D, Yusof N, San-Luiz B, Lum J, Kumar D, Foo S, Li L, Vasudev A, Irwanto A, Lee B, Nardin A, Liu H, Zhang F, Connolly J, Liu J, Mortellaro A, Wang DY, Poidinger M, Larbi A, Zolezzi F, Rotzschke O. Genome-wide analysis of the genetic regulation of gene expression in human neutrophils. Nat Commun. 2015 Aug 10;6:7971. PMID: 26259071.
  20. Li L, Ng DS, Mah W, Almeida FF, Rahmat SA, Rao VK, Leow SC, Laudisi F, Peh MT, Goh AM, Lim JS, Wright GD, Mortellaro A, Taneja R, Ginhoux F, Lee CG, Moore PK, Lane DP. A unique role for p53 in the regulation of M2 macrophage polarization. Cell Death Differ. 2015 Jul;22(7):1081-93. PMID: 25526089.
  21. Zhou Q, Ho AWS, Schlitzer A, Tang Y, Wong KHS, Wong FHS, Chua YL, Angeli V, Mortellaro A, Ginhoux F, Kemeny DM. GM-CSF-licensed CD11b+ lung DCs orchestrate Th2 immunity to Blomia tropicalis. J Immunol. 2014 July 15;193(2):496-509. PMID: 24943219.
  22. Goh AX, Bertin-Maghit S, Yeo SP, Ho AWS, Derks H, Mortellaro A, Wang CI. A novel human anti-interleukin-1b neutralizing monoclonal antibody showing in vivo efficacy. MAbs. 2014 May-June;6(3):764-72. PMID: 24671001.
  23. Bist P, Dikshit N, Koh TH, Mortellaro A, Tan TT, Sukumaran B. The Nod1, Nod2, and Rip2 axis contributes to host immune defense against intracellular Acinetobacter baumannii infection. Infect Immun. 2014 Mar;82(3):1112-22. PMID: 24366254.
  24. Laudisi F, Spreafico R, Evrard M, Hughes TR, Mandriani B, Kandasamy M, Morgan BP, Sivasankar B, Mortellaro A. Cutting edge: The NLRP3 inflammasome links complement-mediated inflammation and IL-1b release. J Immunol. 2013 Aug 1;191(3):1006-10. [Reviewed in F1000Prime, f1000.com/prime/718046840]. PMID: 23817414.
  25. Licandro G, Khor HL, Beretta O, Lai J, Derks H, Laudisi F, Conforti-Andreoni C, Qian HL, Teng GG, Ricciardi-Castagnoli P, Mortellaro A. The NLRP3 inflammasome affects DNA damage responses after oxidative and genotoxic stress in dendritic cells. Eur J Immunol. 2013 Aug;43(8):2126-37. [Selected for cover image and Editorial Commentary]. PMID: 23619996.
  26. Lim TS, Goh JK, Mortellaro A, Lim CT, Hämmerling GJ, Ricciardi-Castagnoli P. CD80 and CD86 differentially regulate mechanical interactions of T-cells with antigen-presenting dendritic cells and B-cells. PLoS One. 2012;7(9):e45185. PMID: 23024807.
  27. Fric J, Lim CXF, Koh EGL, Hofmann B, Chen J, Tay HS, Isa SA, Mortellaro A, Ruedl C, Ricciardi-Castagnoli P. Calcineurin/NFAT signaling inhibits myeloid hematopoiesis. EMBO Mol Med. 2012 Apr,4(4):269-85. PMID: 22311511.
  28. Lin M., Isa SA, Wee NF, Siu KS, Beretta O, Mortellaro A, and Ruedl C. Synergism between curdlan and GM-CSF confers a strong inflammatory signature to dendritic cells. J Immunol. 2012 Feb;188(4):1789-98. PMID: 22250091.
  29. Conforti-Andreoni C, Spreafico R, Qian HL, Riteau N, Ryffel B, Ricciardi-Castagnoli P, and Mortellaro A. Uric acid-driven Th17 differentiation requires inflammasome-derived IL-1 and IL-18. J Immunol. 2011 Dec;187(11):5842-50. PMID: 22058415.
  30. Lim TS, Mortellaro A, Lim CT, Hämmerling GJ, Ricciardi-Castagnoli P. Mechanical interactions between dendritic cells and T cells correlate with T cell responsiveness. J Immunol. 2011 Jul;187(1):258-65. PMID: 21622857.
  31. Conforti-Andreoni C, Beretta O, Licandro G, Qian HL, Urbano M, Vitulli F, Ricciardi-Castagnoli P, Mortellaro A. Synergism of NOD2 and NLRP3 activators promotes a unique transcriptional profile in murine dendritic cells. J Leukoc Biol. 2010 Dec; 88(6):1207-1216. PMID: 20884650.
  32. Tailleux L, Waddell SJ, Pelizzola M, Mortellaro A*, Withers M, Tanne A, Castagnoli PR, Gicquel B, Stoker NG, Butcher PD, Foti M, Neyrolles O. Probing host pathogen cross-talk by transcriptional profiling of both Mycobacterium tuberculosis and infected human dendritic cells and macrophages. PLoS One. 2008 Jan;3(1):e1403. (*First co-authorship). PMID: 18167562.
  33. Mortellaro A, Hernandez RJ, Guerrini MM, Carlucci F, Tabucchi A, Ponzoni M, Sanvito F, Doglioni C, Di Serio C, Biasco L, Follenzi A, Naldini L, Bordignon C, Roncarolo MG, Aiuti A. Ex vivo gene therapy with lentiviral vectors rescues adenosine deaminase (ADA)-deficient mice and corrects their immune and metabolic defects. Blood. 2006 Nov;108(9):2979-88. PMID: 16835374.
  34. Guazzi V, Aiuti F, Mezzaroma I, Mazzetta F, Andolfi G, Mortellaro A, Pierdominici M, Fantini R, Marziali M, Aiuti A. Assessment of thymic output in common variable immunodeficiency patients by evaluation of T cell receptor excision circles. Clin Exp Immunol. 2002 Aug;129(2):346-53. PMID: 12165093.
  35. Aiuti A, Slavin S, Aker M, Ficara F, Deola S, Mortellaro A, Morecki S, Andolfi G, Tabucchi A, Carlucci F, Marinello E, Cattaneo F, Vai S, Servida P, Miniero R, Roncarolo MG, Bordignon C. Correction of ADA-SCID by stem cell gene therapy combined with nonmyeloablative conditioning. Science. 2002 Jun;296(5577):2410-3. PMID: 12089448.
  36. Aiuti A, Vai S, Mortellaro A, Casorati G, Ficara F, Andolfi G, Ferrari G, Tabucchi A, Carlucci F, Ochs HD, Notarangelo LD, Roncarolo MG, Bordignon C. Immune reconstitution in ADA-SCID after PBL gene therapy and discontinuation of enzyme replacement. Nat Med. 2002 May;8(5):423-5. PMID: 11984564.
  37. Mortellaro A, Songia S, Gnocchi P, Ferrari M, Fornasiero C, D'Alessio R, Isetta A, Colotta F, Golay J. New immunosuppressive drug PNU156804 blocks IL-2-dependent proliferation and NF-kappa B and AP-1 activation. J Immunol. 1999 Jun;162(12):7102-9. PMID: 10358154.
  38. Songia S, Mortellaro A, Taverna S, Fornasiero C, Scheiber EA, Erba E, Colotta F, Mantovani A, Isetta AM, Golay J. Characterization of the new immunosuppressive drug undecylprodigiosin in human lymphocytes: retinoblastoma protein, cyclin-dependent kinase-2, and cyclin-dependent kinase-4 as molecular targets. J Immunol. 1997 Apr;158(8):3987-95. PMID: 9103470.

 

Reviews, Commentaries and Book Chapters

  1. Tucci F, Scaramuzza S, Aiuti A, Mortellaro A. Update on Clinical Ex Vivo Hematopoietic Stem Cell Gene Therapy for Inherited Monogenic Diseases. Mol Ther. 2021 Feb 3;29(2):489-504. PMID: 33221437.
  2. Diamond C, Bagnall J, Spiller DG, White MR, Mortellaro A, Paszek P, Brough D. Investigating IL-1β Secretion Using Real-Time Single-Cell Imaging. Methods Mol Biol. 2016;1417:75-88. PMID: 27221482.
  3. Diamond CE, Khameneh HJ, Mortellaro A. Novel perspectives on non-canonical inflammasome activation. ImmunoTargets and Therapy. 2015;4:131. PMID: 27471719.
  4. Khameneh HJ, Mortellaro A. NLRC4 gets out of control. Nat Genet. 2014;46(10):1048. PMID: 25257084.
  5. Zambetti LP, Mortellaro A. NLRPs, microbiota and gut homeostasis: unraveling the connection. J Pathol. 2014;233(4):321. PMID: 24740681.
  6. Laudisi F, Viganò E, Mortellaro A. Tyrosine kinases: the molecular switch for inflammasome activation. Cell Mol Immunol. 2014;11(2):129. PMID: 24509443.
  7. Viganò E, Mortellaro A. Caspase-11: the driving factor for non-canonical inflammasomes. Eur J Immunol. 2013;43(9):2240. PMID: 24037676.
  8. Zambetti LP, Laudisi F, Licandro G, Ricciardi-Castagnoli P, Mortellaro A. The rhapsody of NLRPs: master players of inflammation … and a lot more. Immunol Res. 2012;53(1-3):78. PMID: 22427013.
  9. Mortellaro A & Ricciardi-Castagnoli P. From vaccine practice to vaccine science: the contribution of human immunology to the prevention of infectious disease. Immunol Cell Biol. 2011;89(3):332. PMID: 21301476.
  10. Conforti-Andreoni C, Ricciardi-Castagnoli P, Mortellaro A. The inflammasomes in health and disease: from genetics to molecular mechanisms of autoinflammation and beyond. Cell Mol Immunol. 2011;8(2):135. PMID: 21258359.
  11. Spreafico R, Ricciardi-Castagnoli P, Mortellaro A. The controversial relationship between NLRP3, alum, danger signals and the next-generation adjuvants. Eur J Immunol. 2010;40(3):638. PMID: 20201020.
  12. Mortellaro A, Robinson L, Ricciardi-Castagnoli P. Spotlight on Mycobacteria and dendritic cells: will novel targets to fight tuberculosis emerge? EMBO Mol Med. 2009;1(1):19. PMID: 20049700.
  13. Mortellaro A, Wong SC, Fric J, Ricciardi-Castagnoli P. The need to identify myeloid dendritic cell progenitors in human blood. Trends Immunol. 2010;31(1):18. PMID: 19836307.
  14. Mortellaro A, Urbano M, Citterio S, Foti M, Granucci F, Ricciardi-Castagnoli P. Generation of murine growth factor-dependent long-term dendritic cell lines to investigate host-parasite interactions. Methods Mol Biol. 2009;531:17. PMID: 19347308.
  15. Mortellaro A, Granucci F, Foti M, Ricciardi-Castagnoli P. Dendritic cells in their tissue microenvironments during exposure to pathogens. Editors: David G. Russell and Siamon Gordon, 2009;51-68. ASM Press. PMID: 18672083.
  16. Mortellaro A, Conforti-Andreoni C, Fric J, Ricciardi-Castagnoli P. Dendritic cells as sensors of environmental perturbations. Microbes Infect. 2008;10(9):990.2.

 

 

Il titolare del presente curriculum vitae, pubblicato online sul portale www.unisr.it, è garante in via esclusiva della correttezza e della veridicità dei dati e delle informazioni in esso riportate e del loro eventuale e puntuale aggiornamento. Egli è dunque il diretto ed unico responsabile dei contenuti indicati nei propri curricula.