Luisa Roveri RicercatoreMedicina

Research Activity

Curriculum Vitae

Publications

Research Activity

The goal of the Cerebrovascular Disease Unit is to provide the highest quality, evidenced-based care for patients dealing with stroke, transient ischemic attack, and other cerebrovascular conditions. Critical to achieving this goal was to provide an organized structure of dedicated neurologists that operate as the hospital’s acute stroke team in order to guarantee a timely evaluation and treatment of stroke patients. Inpatient care is based in the Department of Neurology, which includes an eight-bed Stroke Unit with stroke-trained staff. Diagnostic capabilities include CT-Angiography, MRI and MRA, conventional (digital subtraction) angiography, among other diagnostic tests. The established tight collaboration with the Unit of Neuroradiology was the key to become a comprehensive center for cerebrovascular care and one of the regional "hubs" of a stroke network that improves access to high-quality and costeffective care for patients in our area. In addition to acute care, stroke management includes secondary prevention, rehabilitation, occupational  therapy and psychosocial support.
We are actively engaged in clinical research and are participating in a number of phase II, phase III and phase IV trials on stroke. Moreover, we are involved in the education of residents, medical students and nurses. Clinical research focuses on different topics amongst which we are analyzing the risk of stroke recurrence associated with different secondary prevention strategy. In collaboration with the Neuroradiology Unit we are investigating the imaging feature of carotid arterial dissection associated with stroke. In collaboration with the Neuroimaging Research Unit we are working on a project aimed to define the imaging patterns that characterize the different pathogenesis of stroke. Since the implementation of thrombectomy among the treatments of acute stroke patients, we set off a project aimed to define the histological and biochemical feature of thrombotic material and investigate the response to treatment. Other ongoing projects, also in collaboration with other stroke  centers, investigate TMS and TDCS to improve functional recovery in stroke patients.
We aim to implement international resident training and to strengthen clinical research in collaboration with Politecnico di Milano and ICFO - The Institute of Photonic Sciences. The near-infrared spectroscopy (NIRS) is a non-invasive methodology that can measure, at the bedside of the patient, with a high  temporal resolution the absolute concentration of oxygenated haemoglobin (HbO), deoxygenated haemoglobin (HbR) allowing the calculation of regional oxygen saturation (rSO2). NIRS technology exploits the capacity of the photons in the nearinfrared spectrum to penetrate deeply in the biological tissues, to be absorbed and diffused by endogenous molecules and to be detected superficially. By using specific wavelength in the absorption spectra of specific molecules, it is possible to measure the quantity and the arrival time of the photons re-emitted and to calculate absolute concentration of those molecules. The evolution of acute ischemic stroke is quite dynamic in time. Chances of favourable outcome increase with treatment strategies  applied within the right timing, when the irreversible damage has not occurred yet. The ability to monitor changes in cerebral hemodynamics may represent an important application for optical techniques that are safe, non-invasive and easily applied at the bed-side. Another diffuse optical imaging modality is the diffuse correlation spectroscopy (DCS). DCS is a non-invasive methodology complementary to NIRS being able to provide a measure of CBF without the use of any contrast medium. The DCS and NIRS modalities are based on the same principles of light transport. However, DCS exploits the movement of haemoglobin as an endogenous contrast medium. Considering the limits of the currently available diagnostic and monitoring tools, we propose to study a novel approach to perform a multimodal monitoring of relevant  neurophysiological parameters in acute, sub-acute and chronic ischemic stroke patients using advanced optical diagnostic tools (NIRS, DCS).
In addition, we collaborate to a project within the UHAE (University Hospital Alliance Europe) to establish a common ground to create a European  benchmarking platform to facilitate knowledge exchange in stroke as well as collaborate in specific projects regarding healthcare management and thereby improve pathways, outcomes and experiences for stroke patients.

Curriculum Vitae

EDUCATION
1985Università degli Studi di Milano, Laurea in Medicina e Chirurgia
1991 Università degli Studi di Milano Abilitazione di Stato
1995 Università degli Studi di Milano, Scuola di Specializzazione in Neurologia
1995 Master of Science, Loyola University Stritch School of Medicine Chicago


PROFESSIONAL EXPERIENCE
Responsabile Stroke Unit
Conduzione di clinical trials in qualità di PI
Correlatore tesi di Laurea in Medicina e Chirurgia
Correlatore tesi di Specialità in Neurologia
Certificazione BLS-D, ALS, NIHSS, mSR, BI, GCP
Interpretazione di potenziali evocati somatosensoriali, uditivi, visivi,   elettromiografia, EEG, interpretazione elettroencefalogrammi basali, da  privazione di sonno, Holter EEG, monitoraggio video EEG, mappaggio EEG, elaborazione computerizzata del segnale EEG, interpretazione  elettroretinogramma, modelli animali di retinopatie degenerative


GRANTS, FELLOWSHIP, AWARDS
1995 - Sigma Xi, the Scientific Research Society
1995 - American Academy of Clinical Neurophysiology
1996 - Retina Research Foundation
1996 Fellowship Loyola University Stritch School of Medicine Chicago
1997 – 2000 - INCAT BIOMED II
2009 – Bando Ministeriale Ricerca Clinica Finalizzata (attivazione nel dicembre 2011)

Publications

Saccadic latency does not increase as a function of eccentricity for M-scaled stimuli
M. Brigell, P.J. DeMarco, L. Roveri, G.C. Celesia
Investigative Ophthalmology & Visual Science 1995, 36- S596

Analysis of On- and OFF-pathways inputs to the human visual evoked potential
L. Roveri, P.J. DeMarco
Investigative Ophthalmology & Visual Science 1995, 36- S690


Photoreceptor degeneration associated with the expression of a G90D mutation in the opsin gene
M.I. Naash, S. Li, L. Roveri, N.S. Peachey, T. Wu
Investigative Ophthalmology & Visual Science 1996, 37- S698


Visual transmission following horizontal cell ablation
L. Roveri, N.S. Peachey, A. Messing, M.A. McCall
Investigative Ophthalmology & Visual Science 1996, 37- S699


Recent development in the assessment of visual function
G.C. Celesia, N.S. Peachey, M.Brigell, Y. Goto, L.Roveri, C. Barnes
Recent Advances in Clinical Neurophysiology, 1996, 420-425, J. Kimura and H. Shibasaki, editors


An electrophysiological metric of activity within the ON- and OFF-pathways in humans
L. Roveri, P.J. DeMarco, G.G. Celesia
Vision Research, 1997, 37 (6), 669-674


Functional consequences of oncogene-induced horizontal cell degeneration in the retina of transgenic mice
N.S. Peachey, L. Roveri, A. Messing, M.A. McCall
Visual Neuroscience, 1997, 14, 627-632


Peachey NS, Quiambao AB, Xu X, Pardue MT, Roveri L, McCall MA, Al-Ubaidi MR.
Loss of bipolar cells resulting from the expression of bcl-2 directed by the IRBP promoter.
Exp Eye Res. 2003 Oct;77(4):477-83.


Comi G, Roveri L, Swan A, Willison H, Bojar M, Illa I, Karageorgiou C, Nobile-Orazio E, van den Bergh P, Swan T, Hughes R, Aubry J, Baumann N, Hadden R, Lunn M, Knapp M, Léger JM, Bouche P, Mazanec R, Meucci N, van der Meché F, Toyka K; Inflammatory Neuropathy Cause and Treatment Group.
A randomised controlled trial of intravenous immunoglobulin in IgM paraprotein associated demyelinating neuropathy.
J Neurol. 2002 Oct;249(10):1370-7.


Comi G, Quattrini A, Fazio R, Roveri L.
Immunoglobulins in chronic inflammatory demyelinating polyneuropathy.
Neurol Sci. 2003 Oct;24 Suppl 4:S246-50


Roveri L, La Gioia S, Ghidinelli C, Anzalone N, De Filippis C, Comi G.
Wake-up stroke within 3 hours of symptom awareness: imaging and clinical  features compared to standard recombinant tissue plasminogen activator treated stroke.
J Stroke Cerebrovasc Dis. 2013 Aug; 22(6):703-8


Della-Torre E, Passerini G, Furlan R, Roveri L, Chieffo R, Anzalone N, Doglioni C, Zardini E, Sabbadini MG, Franciotta D.
Cerebrospinal fluid analysis in immunoglobulin G4-related hypertrophic  pachymeningitis.
J Rheumatol. 2013 Nov;40(11):1927-9. doi: 10.3899/jrheum.130678


Chieffo R, Bernelli C, Martinelli V, Comi G, Roveri L.
Todd's post-epileptic paresis and Takotsubo cardiomyopathy: unusual combination of neurological and cardiac disorder. Trigger or triggered?
Neurol Sci. 2015 Nov; 36(11):2157-8. DOI: 10.1007/s10072-015-2327-6.

Strambo D, Zambon AA, Roveri L, Giacalone G, Di Maggio G, Peruzzotti-Jametti L, La Gioia S, Galantucci S, Comi G, Sessa M.
Defining minor symptoms in acute ischemic stroke.
Cerebrovasc Dis. 2015; 39(3-4):209-15. DOI: 10.1159/000375151.

Campochiaro C, Ramirez GA, Bozzolo EP, Lanzillotta M, Berti A, Baldissera E, Dagna L, Praderio L, Scotti R, Tresoldi M, Roveri L, Mariani A, Balzano G, Castoldi R, Doglioni C, Sabbadini MG, Della-Torre E.
IgG4-related disease in Italy: clinical features and outcomes of a large cohort of patients.
Scand J Rheumatol. 2016;45(2):135-45. doi:  10.3109/03009742.2015.1055796


M. Vabanesi, G. Schwarz, D. Strambo, G. Comi, L. Roveri.
Low-dose versus standard-dose rtPA in acute ischemic stroke: An explorative single-centre study
Eur J Neurol 2017; 24:364-365. DOI: 10.1111/13367.


Giacalone G, Zanoletti M, Contini D, Re R, Spinelli L, Roveri L and Torricelli A.
Cerebral TD-NIRS in healthy subjects: reproducibility analysis and reference values of optical properties and hemoglobin species.
Biomed Opt Express. 2017 Oct 12;8(11):4987-5000. doi:  10.1364/BOE.8.004987


Time-Domain Near-Infrared Spectroscopy in acute ischemic stroke patients
G. Giacalone, M. Zanoletti, R. Re, B. Germinario, D. Contini, L. Spinelli, A. Torricelli, L. Roveri
Neurophotonics 2019 2019 Jan;6(1):015003. doi: 10.1117/1


Dabigatran for Prevention of Stroke after Embolic Stroke of Undetermined Source.
Diener HC, Sacco RL, Easton JD, Granger CB, Bernstein RA, Uchiyama S, Kreuzer J, Cronin L, Cotton D, Grauer C, Brueckmann M, Chernyatina M, Donnan G, Ferro JM, Grond M, Kallmünzer B, Krupinski J, Lee BC, Lemmens R, Masjuan J, Odinak M, Saver JL, Schellinger PD, Toni D, Toyoda K; RE-SPECT ESUS Steering Committee and Investigators.
N Engl J Med. 2019 May 16;380(20):1906-1917. doi:  10.1056/NEJMoa1813959.


Thrombus hallmarks reveal atherothrombotic stroke aetiology.
Semerano A, Genchi A, Callea M, Sanvito F, Simionato F, Panni P, Scomazzoni F, Doglioni C, Comi G, Falini A, Filippi M, Roveri L, Bacigaluppi M.
J Neurol. 2019 Jun;266(6):1533-1535. doi: 10.1007/s00415-019-09279-z.

Rivaroxaban or aspirin for patent foramen ovale and embolic stroke of undetermined source: a prespecified subgroup analysis from the NAVIGATE ESUS trial.
Kasner SE, Swaminathan B, Lavados P, Sharma M, Muir K, Veltkamp R, Ameriso SF, Endres M, Lutsep H, Messé SR, Spence JD, Nedeltechev K, Perera K, Santo G, Olavarria V, Lindgren A, Bangdiwala S, Shoamanesh A, Berkowitz SD, Mundl H, Connolly SJ, Hart RG; NAVIGATE ESUS Investigators.
Lancet Neurol. 2018 Dec;17(12):1053-1060. doi:  10.1016/S1474-4422(18)30319-3


Rivaroxaban for Stroke Prevention after Embolic Stroke of Undetermined Source.
Hart RG, Sharma M, Mundl H, Kasner SE, Bangdiwala SI, Berkowitz SD, Swaminathan B, Lavados P, Wang Y, Wang Y, Davalos A, Shamalov N, Mikulik R, Cunha L, Lindgren A, Arauz A, Lang W, Czlonkowska A, Eckstein J,  Gagliardi RJ, Amarenco P, Ameriso SF, Tatlisumak T, Veltkamp R, Hankey GJ, Toni D, Bereczki D, Uchiyama S, Ntaios G, Yoon BW, Brouns R, Endres M, Muir KW, Bornstein N, Ozturk S, O'Donnell MJ, De Vries Basson MM, Pare G, Pater
C, Kirsch B, Sheridan P, Peters G, Weitz JI, Peacock WF, Shoamanesh A, Benavente OR, Joyner C, Themeles E,
Connolly SJ; NAVIGATE ESUS Investigators.
N Engl J Med. 2018 Jun 7; 378(23):2191-2201. doi: 10.1056/NEJMoa1802686.

Il titolare del presente curriculum vitae, pubblicato online sul portale www.unisr.it, è garante in via esclusiva della correttezza e della veridicità dei dati e delle informazioni in esso riportate e del loro eventuale e puntuale aggiornamento. Egli è dunque il diretto ed unico responsabile dei contenuti indicati nei propri curricula.