Vezzoli Giuseppe Professore AssociatoMedicineMED/14

Professor of Nephrology

Director of Nephrology and Dialysis Unit

 

Educational Experience

1979: Degree in Medicine and Surgery, University of Milan.

1982: Postgraduate Speciality in Medical Nephrology, University of Milan

1985: Postgraduate Speciality in Clinical and Laboratory Hematology, University of Milan

 

Professional Experience

1982: Research Fellow, Biochemistry Section, Swiss Federal Institute of Technology (ETH), Zurich.

1/1/1983-22/7/1984: Research Fellow, Division of Clinical Medicine, Policlinico Hospital, Milan.

23/7/1984-1/3/1985: Clinical Assistant, Dialysis Unit, Division of Clinical Medicine, Policlinico Hospital, Milan.

2/3/1985-10/6/1990: Clinical Assistant, Nephrology and Dialysis Unit, Bassini Hospital, Cinisello Balsamo, Milan.

11/6/1990-31/1/1991: Clinical Assistant, Division of Clinical Medicine, San Raffaele Scientific Institute, Milan.

1/2/1991-31/12/2001: Clinical Assistant, Nephrology and Dialysis Unit, San Raffaele Scientific Institute, Milan.

1/1/2002-14/2/2019: Head of Nephrology Section, Nephrology and Dialysis Unit, San Raffaele Scientific Institute, Milan.

1997-2016: Head of Peritoneal Dialysis Service, Nephrology and Dialysis Unit, San Raffaele Scientific Institute, Milan.

1991-2019: Coordinator of Kidney Stone outpatients clinic, Nephrology and Dialysis Unit, San Raffaele Scientific Institute, Milan.

 

15/2/2019 to date:

Associate Professor of Nephrology, Università Vita Salute San Raffaele, Milan.

Director, Nephrology and Dialysis Unit, San Raffaele Scientific Institute, Milan.

 

 

Accademic experience

From 1993/94 to 1997/98: Tutor, Chair and Postgraduate School of Nephrology, University of Milan.

1999/2000: Adjunct Professor, Postgraduate School of Nephrology, University of Milan.

From 2000/01 to 2017/18: Adjunct Professor, Postgraduate School of Nephrology, Università Vita Salute San Raffaele, Milan.

From  2007/2008 to 2017/2018: Teacher, Course of Nephrology, Faculty of Medicine and Surgery, Università Vita Salute San Raffaele, Milan.

2009/2010 – 2010/2011 – 2011/2012: Teacher, Elective Course “Calcium metabolism in chronic kidney disease”, Faculty of Medicine, Università Vita Salute San Raffaele, Milan.

From 15/2/2019 – date: Associate Professor of Nephrology, Università Vita Salute San Raffaele, Milan.

 

 

Professional and Scientific Memberships

Italian Society of Nephrology (SIN),Italian Society of Mineral Metabolism (SIOMMMS),

European Renal Association and European Dialysis and Transplant Association (ERA-EDTA).

Member and founder of the “Forum in bone and mineral research”, affiliated to SIOMMMS and to Calcifed Tissue Society.

 

Member of the Editorial Board of “Clinical Cases in Bone and Mineral Metabolism”, from 2005 to date.

Member of the Editorial Board of the “Giornale di Tecniche Nefrologiche e Dialitiche” from 2011 to date.

Member of the Editorial Board of the “Giornale Italiano di Nefrologia” from 2007 to 2011

 

 

 

Clinical and Scientific expertise

• Calcium nephrolithiasis: physiopathology, genetic and nutritional predisposing factors.
• Idiopathic hypercalciuria: physiopathology, calcium transport alterations, genetic and nutritional predisposing factors, clinical characteristics.
• Hypercalcemias and hypocalcemias; physiology and regulation of cellular transport of calcium in human disorders; regulation of intestinal absorption of calcium.
• Primary and secondary hyperparathyroidism.
• Chronic kidney disease: conservative therapy, calcium and phosphate metabolism, hyperparathyroidism, metabolic bone disease and renal osteodystrophy.
• Calcium-sensing receptor: function and role in physiopathology of human disorders, in calcium nephrolithiasis and hypercalciuria.
• Obstructive nephropathy and retroperitoneal fibrosis.
• Hypophosphatemia and hypophosphatemic rickets in adults.
• Proximal and distal tubulopathies: Dent disease, Tubular acidosis, Bartter and Gitelman Syndrome, Cistinuria.

 

 

Main scientific works have been addressed to the study of nephrolithiasis and regulation of calcium excretion in humans. Findings reported in these works showed that polymorphisms of CASR gene, encoding for the calcium sensing receptor (CaSR), were involved in calcium kidney stone formation. Functional findings observed a reduction of the tubular expression of CaSR in carriers of these polymorphic variants of CASR gene. These studies also showed that variants of CASR and CLDN14 gene, this latter encoding for claudin-14, were involved in the regulation of tubular reabsorption of calcium and in idiopathic hypercalciuria. Moreover, these studies evidenced a faster intestinal absorption and tubular reabsorption of calcium after an oral load in hypercalciuric patients with kidney stones compared to hypercalciuric patients without kidney stones; these defects were associated with a decreased bone mass.

 

 

Articles indicative of his scientific activity:

1. Bianchi G, Vezzoli G, Cusi D, Cova T, Elli A, Soldati L, Tripodi G, Surian M, Ottaviano E, Rigatti P, Ortolani S. Abnormal red-cell calcium pump in patients with idiopathic hypercalciuria. New England Journal of Medicine, 319: 897-901, 1988.
2. Vezzoli G, Zerbi S, Baragetti I, Soldati L, Mora S, Dell’Antonio G, Bianchi G. Nonacidotic proximal tubulopathy transmitted as autosomal dominant trait. Am J Kidney Dis, 29: 490-495, 1997
3. Vezzoli G, Caumo A, Baragetti I, Zerbi S, Bellinzoni A, Centemero A, Rubinacci A, Moro GL, Adamo D, Bianchi G, Soldati L. Study of calcium metabolism in idiopayhic hypercalciuria by strontium oral load test. Clin Chem 45:257-261, 1999
4. Vezzoli G, Tanini A, Ferrucci L, Soldati L, Bianchin C, Franceschelli F, Malentacchi C, Porfirio B, Adamo D, Terranegra A, Falchetti A, Cusi D, Bianchi G, Brandi ML. Influence of calcium-sensing receptor gene on urinary calcium excretion in stone-forming patients. J Am Soc Nephrol 13: 2517-2523, 2002.
5. Vezzoli G, Soldati L, Arcidiacono T, Terranegra A, Biasion R, Russo CR, Lauretani F, Bandinelli S, Bartali B, Cherubini A, Cusi D, Ferrucci L. Urinary calcium is a determinant of bone mineral density in elderly men participating in the InCHIANTI study. Kidney Int 67: 2006-2014, 2005.
6. Vezzoli G, Soldati L, Jansen A, Pierro L. Choroidal calcifications in patients with Gitelman’s Syndrome. Am J Kidney Dis 855-858, 2000.
7. Vezzoli G, Caumo A, Baragetti I, Zerbi S, Bellinzoni A, Centemero A, Rubinacci A, Moro GL, Adamo D, Bianchi G, Soldati L. Study of calcium metabolism in idiopathic hypercalciuria by strontium oral load test. Clin Chem 45:257-261, 1999.
8. Gambaro G, Vezzoli G, Casari G, Rampoldi L, D’Angelo A, Borghi L. Genetics of hypercalciuria and calcium nephrolithiasis: from the rare monogenic to the common polygenic forms. Am J Kidney Dis 42: 1177-1183, 2003.
9. Vezzoli G, Terranegra A, Arcidiacono T, Biasion R, Coviello D, Syren ML, Paloschi V, Giannini S, Mignogna G, Rubinacci A, Ferraretto A, Cusi D, Bianchi G, Soldati L. R990G polymorphism of calcium-sensing receptor does produce a gain-of-function and predispose to primary hypercalciuria. Kidney Int 71: 1155-1162, 2007
10. Vezzoli G, Soldati L, Gambaro G. Update on primary hypercalciuria from a genetic perspective. J Urol 179:1676-1682, 2008.
11. Vezzoli G, Terranegra A, Arcidiacono T, Gambaro G, Milanesi L, Mosca E, Soldati L. Calcium kidney stones are associated with a haplotype of the Calcium-sensing receptor gene regulatory region. Nephrol Dial Transplant. 2010; 25: 2245-2252.
12. Nouvenne A, Meschi T, Prati B, Guerra A, Allegri F, Vezzoli G, Soldati L, Gambaro G, Maggiore U, Borghi L. Effects of a low-salt diet on idiopathic hypercalciuria in calcium-oxalate stone formers: a 3-mo randomized controlled trial. Am J Clin Nutr 91: 565-570, 2010.
13. Vezzoli G, Terranegra A, Arcidiacono T, Soldati L. Genetics and calcium nephrolithiasis. Kidney Int 2011, 80: 587-593.
14. Vezzoli G, Terramegra A, Soldati L. Calcium-sensing receptor gene polymorphisms in patients with calcium nephrolithiasis. Curr Opin Nephrol Hypertens 2012, 21:355–361
15. Vezzoli G, Terranegra A, Aloia A, Arcidiacono T, Milanesi L, Mosca E, Mingione A, J Clin Endocrinol Metab 2013; 98: 3839-3847.
16. Vezzoli G, Dogliotti E, Terranegra A, Arcidiacono T, Macrina L, Tavecchia M, Pivari F, Mingione A, Brasacchio C, Nouvenne A, Meschi T, Cusi D, Spotti D, Montanari E, Soldati L. Dietary style and acid load in an Italian population of calcium kidney stone Spotti D, Cusi D, Hou J, Hendy GN, Soldati L. Decreased transcriptional activity of Calcium-sensing receptor gene promoter 1 is associated with calcium nephrolithiasis. formers. Nutr Metab Card disease 2015; 25: 588-593.
17. Capelli AS, Donghi V, Maruca K, Vezzoli G, Corbetta S, Brandi ML, Mora S, Weber G. Clinical and molecular heterogeneity in a large series of patients with hypophosphatemic rickets. Bone 2015; 79: 143-149.
18. Vezzoli G, Macrina L, Rubinacci A, Spotti D, Arcidiacono T. Intestinal calcium absorption among hypercalciuric patients with or without calcium kidney stones. Clin J Am Soc Nephrol 2016; 11: 1450–1455.
19. Arcidiacono T, Simonini M, Lanzani C, Citterio L, Salvi E, Barlassina C, Spotti D, Cusi D, Manunta P, Vezzoli G. Claudin-14 gene polymorphisms and urine calcium excretion. Clin J Am Soc Nephrol 2018; 13:1542-1549.
20. Bellasi A, Cozzolino M, Malberti F, Cancarini G, Esposito C, Genderini A, Guastoni CM, Ondei P, Pontoriero G, Teatini U, Vezzoli G, Messa P, Locatelli F. Nuovi scenari nell’iperparatiroidismo secondario: etelcalcetide. Position paper dei Nefrologi Lombardi. G Ital Nefrol 2018; 35. pii: 2018-vol 3.

Lavori indicativi della attività scientifica:

• Bianchi G, Vezzoli G, Cusi D, Cova T, Elli A, Soldati L, Tripodi G, Surian M, Ottaviano E, Rigatti P, Ortolani S. Abnormal red-cell calcium pump in patients with idiopathic hypercalciuria. New England Journal of Medicine, 319: 897-901, 1988.

 

• Vezzoli G, Zerbi S, Baragetti I, Soldati L, Mora S, Dell’Antonio G, Bianchi G. Nonacidotic proximal tubulopathy transmitted as autosomal dominant trait. Am J Kidney Dis, 29: 490-495, 1997.

 

• Vezzoli G, Caumo A, Baragetti I, Zerbi S, Bellinzoni A, Centemero A, Rubinacci A, Moro GL, Adamo D, Bianchi G, Soldati L. Study of calcium metabolism in idiopayhic hypercalciuria by strontium oral load test. Clin Chem 45:257-261, 1999.

 

• Vezzoli G, Tanini A, Ferrucci L, Soldati L, Bianchin C, Franceschelli F, Malentacchi C, Porfirio B, Adamo D, Terranegra A, Falchetti A, Cusi D, Bianchi G, Brandi ML. Influence of calcium-sensing receptor gene on urinary calcium excretion in stone-forming patients. J Am Soc Nephrol 13: 2517-2523, 2002.

 

• Vezzoli G, Soldati L, Arcidiacono T, Terranegra A, Biasion R, Russo CR, Lauretani F, Bandinelli S, Bartali B, Cherubini A, Cusi D, Ferrucci L. Urinary calcium is a determinant of bone mineral density in elderly men participating in the InCHIANTI study. Kidney Int 67: 2006-2014, 2005.

 

• Vezzoli G, Soldati L, Jansen A, Pierro L. Choroidal calcifications in patients with Gitelman’s Syndrome. Am J Kidney Dis 855-858, 2000.

 

• Vezzoli G, Caumo A, Baragetti I, Zerbi S, Bellinzoni A, Centemero A, Rubinacci A, Moro GL, Adamo D, Bianchi G, Soldati L. Study of calcium metabolism in idiopathic hypercalciuria by strontium oral load test. Clin Chem 45:257-261, 1999.

 

• Gambaro G, Vezzoli G, Casari G, Rampoldi L, D’Angelo A, Borghi L. Genetics of hypercalciuria and calcium nephrolithiasis: from the rare monogenic to the common polygenic forms. Am J Kidney Dis 42: 1177-1183, 2003.

 

• Vezzoli G, Terranegra A, Arcidiacono T, Biasion R, Coviello D, Syren ML, Paloschi V, Giannini S, Mignogna G, Rubinacci A, Ferraretto A, Cusi D, Bianchi G, Soldati L. R990G polymorphism of calcium-sensing receptor does produce a gain-of-function and predispose to primary hypercalciuria. Kidney Int 71: 1155-1162, 2007

 

• Vezzoli G, Soldati L, Gambaro G. Update on primary hypercalciuria from a genetic perspective. J Urol 179:1676-1682, 2008.

 

• Vezzoli G, Terranegra A, Arcidiacono T, Gambaro G, Milanesi L, Mosca E, Soldati L. Calcium kidney stones are associated with a haplotype of the Calcium-sensing receptor gene regulatory region. Nephrol Dial Transplant. 2010; 25: 2245-2252.
• Nouvenne A, Meschi T, Prati B, Guerra A, Allegri F, Vezzoli G, Soldati L, Gambaro G, Maggiore U, Borghi L. Effects of a low-salt diet on idiopathic hypercalciuria in calcium-oxalate stone formers: a 3-mo randomized controlled trial. Am J Clin Nutr 91: 565-570, 2010.

 

• Vezzoli G, Terranegra A, Arcidiacono T, Soldati L. Genetics and calcium nephrolithiasis. Kidney Int 2011, 80: 587-593.

 

• Vezzoli G, Terramegra A, Soldati L. Calcium-sensing receptor gene polymorphisms in patients with calcium nephrolithiasis. Curr Opin Nephrol Hypertens 2012, 21:355–361

 

• Vezzoli G, Terranegra A, Aloia A, Arcidiacono T, Milanesi L, Mosca E, Mingione A, J Clin Endocrinol Metab 2013; 98: 3839-3847.

 

• Vezzoli G, Dogliotti E, Terranegra A, Arcidiacono T, Macrina L, Tavecchia M, Pivari F, Mingione A, Brasacchio C, Nouvenne A, Meschi T, Cusi D, Spotti D, Montanari E, Soldati L. Dietary style and acid load in an Italian population of calcium kidney stone Spotti D, Cusi D, Hou J, Hendy GN, Soldati L. Decreased transcriptional activity of Calcium-sensing receptor gene promoter 1 is associated with calcium nephrolithiasis. formers. Nutr Metab Card disease 2015; 25: 588-593.

 

• Capelli AS, Donghi V, Maruca K, Vezzoli G, Corbetta S, Brandi ML, Mora S, Weber G. Clinical and molecular heterogeneity in a large series of patients with hypophosphatemic rickets. Bone 2015; 79: 143-149.

 

• Vezzoli G, Macrina L, Rubinacci A, Spotti D, Arcidiacono T. Intestinal calcium absorption among hypercalciuric patients with or without calcium kidney stones. Clin J Am Soc Nephrol 2016; 11: 1450–1455.

 

• Arcidiacono T, Simonini M, Lanzani C, Citterio L, Salvi E, Barlassina C, Spotti D, Cusi D, Manunta P, Vezzoli G. Claudin-14 gene polymorphisms and urine calcium excretion. Clin J Am Soc Nephrol 2018; 13:1542-1549.

 

• Bellasi A, Cozzolino M, Malberti F, Cancarini G, Esposito C, Genderini A, Guastoni CM, Ondei P, Pontoriero G, Teatini U, Vezzoli G, Messa P, Locatelli F. Nuovi scenari nell’iperparatiroidismo secondario: etelcalcetide. Position paper dei Nefrologi Lombardi. G Ital Nefrol 2018; 35. pii: 2018-vol 3.