Kuka Mirela MedicinaMED 04

Kuka Mirela

Biografia

Pubblicazioni

English version

Biografia

ISTRUZIONE

Gennaio 2010: Ph.D. in Biologia Cellulare e Molecolare
                       Scuola di Dottorato di Biologia Evoluzionistica
Università di Siena (Italia)

Luglio 2006: Laurea Specialistica in Biotecnologie Molecolari (110/110 e lode)
                    Università di Torino (Italia)

Luglio 2004: Laurea Specialistica in Biotecnologie (110/110 e lode)
                    Università di Torino (Italia)

ATTIVITÀ DI RICERCA SCIENTIFICA

2016 – oggi: Ricercatrice a tempo determinato
                   Facoltà di Medicina e Chirurgia
Università Vita-Salute San Raffaele, Milano (Italia)

2016 – oggi: Ricercatrice
                   Laboratorio di Dinamica delle Risposte Immunitarie
Divisione di Immunologia, Trapianti e Malattie Infettive
Ospedale San Raffaele, Milano (Italia)

2013 – 2016: Postdoc Senior
                     Laboratorio di Dinamica delle Risposte Immunitarie
Divisione di Immunologia, Trapianti e Malattie Infettive
Ospedale San Raffaele, Milano (Italia)

2010 – 2013: Postdoc
                     Laboratory of Immune Cell Biology
National Cancer Institute
National Institutes of Health, Bethesda, Maryland (US)

2006 – 2010: Studente di Dottorato
                     Dipartimento di Immunologia
Novartis Vaccines and Diagnostics, Siena (Italia)

2003 – 2010: Internato di Tesi Triennale e Specialistica
                     Dipartimento di Scienze Cliniche e Biologiche
Ospedale San Luigi Gonzaga
Università di Torino (Italia)

FINANZIAMENTI

 2015 –2018: Scientific Independence of Young Researchers (SIR) – MIUR
Università Vita-Salute San Raffaele (Milan, Italy)

 2013 –2016: Marie Curie Fellowship for Experienced Researchers (COFUND)
San Raffaele Scientific Institute (Milan, Italy)

2006 –2010: DC-Thera European Network Ph.D. Fellowship
Novartis Vaccines and Diagnostics (Siena, Italy)

Pubblicazioni

Fousteri G, Jofra T, Di Fonte R, Kuka M, Iannacone M, Battaglia M. PTPN22 controls virally-induced autoimmune diabetes by modulating cytotoxic T lymphocyte responses in an epitope-specific manner. 2014. Clin Immunol 156(2):98-108.

Kuka M. and M. Iannacone. The role of lymph node sinus macrophages in host defense. 2014. The Year in Immunology 1319:38-46.

Kuka M.# and J. D. Ashwell#. A method for high purity sorting of rare cell subsets applied to TDC. 2013. J Immunol Methods J Immunol 400-401: 111-116.

Kuka M.*, I. Munitic*, M.L. Giardino Torchia, and J. D. Ashwell#. 2013. CD70 is downregulated by interaction with CD27. J Immunol 191: 2282-2289.

Munitic, I.*, M. Kuka*, A. Allam*, J. P. Scoville, and J. D. Ashwell#. 2013. CD70 deficiency impairs effector CD8 T cell generation and viral clearance but is dispensable for the recall response to Lymphocytic Choriomeningitis Virus. J Immunol 190: 1169-1179.

Kuka, M., I. Munitic, and J. D. Ashwell#. 2012. Identification and characterization of polyclonal alphabeta-T cells with dendritic cell properties. Nat Commun 3: 1223.

Cavalieri, D., D. Rivero, L. Beltrame, S. I. Buschow, E. Calura, L. Rizzetto, S. Gessani, M. C. Gauzzi, W. Reith, A. Baur, R. Bonaiuti, M. Brandizi, C. De Filippo, U. D’Oro, S. Draghici, I. Dunand-Sauthier, E. Gatti, F. Granucci, M. Gundel, M. Kramer, M. Kuka, A. Lanyi, C. J. Melief, N. van Montfoort, R. Ostuni, P. Pierre, R. Popovici, E. Rajnavolgyi, S. Schierer, G. Schuler, V. Soumelis, A. Splendiani, I. Stefanini, M. G. Torcia, I. Zanoni, R. Zollinger, C. G. Figdor, and J. M. Austyn. 2010. DC-ATLAS: a systems biology resource to dissect receptor specific signal transduction in dendritic cells. Immunome Res 6: 10.

Kuka, M., R. Baronio, S. Valentini, E. Monaci, A. Muzzi, S. Aprea, E. De Gregorio, and U. D’Oro#. 2010. Src kinases are required for a balanced production of IL-12/IL-23 in human dendritic cells activated by Toll-like receptor agonists. PLoS One 5: e11491.

Rizzetto, L.*, M. Kuka*, C. De Filippo, A. Cambi, M. G. Netea, L. Beltrame, G. Napolitani, M. G. Torcia, U. D’Oro, and D. Cavalieri#. 2010. Differential IL-17 production and mannan recognition contribute to fungal pathogenicity and commensalism. J Immunol 184: 4258-4268.

Casnici, C., G. Volpe, D. Lattuada, K. Crotta, M. Kuka, C. Panuzzo, C. Mastrotto, G. Tonon, V. M. Fazio, G. Saglio, and O. Marelli. 2009. Out of frame peptides from BCR/ABL alternative splicing are immunogenic in HLA A2.1 transgenic mice. Cancer Lett 276: 61-67.

Volpe, G., A. Cignetti, C. Panuzzo, M. Kuka, K. Vitaggio, M. Brancaccio, G. Perrone, M. Rinaldi, G. Prato, M. Fava, M. Geuna, M. Pautasso, C. Casnici, E. Signori, G. Tonon, G. Tarone, O. Marelli, V. M. Fazio, and G. Saglio. 2007. Alternative BCR/ABL splice variants in Philadelphia chromosome-positive leukemias result in novel tumor-specific fusion proteins that may represent potential targets for immunotherapy approaches. Cancer Res 67: 5300-5307.

 

*These authors contributed equally                                                    #Corresponding author

English version

EDUCATION

January 2010: Ph.D. in Cellular and Molecular Biology
                       School of Evolutionary Biology
University of Siena, Siena (Italy)

July 2006: Master of Science in Molecular Biotechnologies (110/110 cum laude)
               University of Turin, Turin (Italy)

July 2004: Bachelor of Science Degree in Biotechnologies (110/110 cum laude)
               University of Turin, Turin (Italy)

 

RESEARCH EXPERIENCE

2016 – Present: Researcher/Assistant Professor
                       Faculty of Medicine and Surgery
Università Vita-Salute San Raffaele, Milan (Italy)

2016 – Present: Researcher
                         Laboratory of Dynamics of Immune Responses
Division of Immunology, Transplantation and Infectious Diseases
San Raffaele Scientific Institute, Milan (Italy)

2013 – 2016: Senior Postdoctoral Fellow
                     Laboratory of Dynamics of Immune Responses
Division of Immunology, Transplantation and Infectious Diseases
San Raffaele Scientific Institute, Milan (Italy)

2010 – 2013: Postdoctoral Fellow
                     Laboratory of Immune Cell Biology
National Cancer Institute
National Institutes of Health, Bethesda, Maryland (US)

2006 – 2010: PhD Student/Fellow Researcher
                     Department of Immunology
Novartis Vaccines and Diagnostics, Siena (Italy)

 2003 – 2010: Undergraduate Student
                     Department of Clinical and Biological Sciences
San Luigi Gonzaga Hospital
University of Turin, Turin (Italy)

 

FUNDING

 2015 – 2018: Scientific Independence of Young Researchers (SIR) – MIUR
Università Vita-Salute San Raffaele (Milan, Italy)

 2013 – 2016: Marie Curie Fellowship for Experienced Researchers (COFUND)
San Raffaele Scientific Institute (Milan, Italy)

2006 – 2010: DC-Thera European Network Ph.D. Fellowship
Novartis Vaccines and Diagnostics (Siena, Italy)

 

PUBLICATIONS

 Fousteri G, Jofra T, Di Fonte R, Kuka M, Iannacone M, Battaglia M. PTPN22 controls virally-induced autoimmune diabetes by modulating cytotoxic T lymphocyte responses in an epitope-specific manner. 2014. Clin Immunol 156(2):98-108.

Kuka M. and M. Iannacone. The role of lymph node sinus macrophages in host defense. 2014. The Year in Immunology 1319:38-46.

Kuka M.# and J. D. Ashwell#. A method for high purity sorting of rare cell subsets applied to TDC. 2013. J Immunol Methods J Immunol 400-401: 111-116.

Kuka M.*, I. Munitic*, M.L. Giardino Torchia, and J. D. Ashwell#. 2013. CD70 is downregulated by interaction with CD27. J Immunol 191: 2282-2289.

Munitic, I.*, M. Kuka*, A. Allam*, J. P. Scoville, and J. D. Ashwell#. 2013. CD70 deficiency impairs effector CD8 T cell generation and viral clearance but is dispensable for the recall response to Lymphocytic Choriomeningitis Virus. J Immunol 190: 1169-1179.

Kuka, M., I. Munitic, and J. D. Ashwell#. 2012. Identification and characterization of polyclonal alphabeta-T cells with dendritic cell properties. Nat Commun 3: 1223.

Cavalieri, D., D. Rivero, L. Beltrame, S. I. Buschow, E. Calura, L. Rizzetto, S. Gessani, M. C. Gauzzi, W. Reith, A. Baur, R. Bonaiuti, M. Brandizi, C. De Filippo, U. D’Oro, S. Draghici, I. Dunand-Sauthier, E. Gatti, F. Granucci, M. Gundel, M. Kramer, M. Kuka, A. Lanyi, C. J. Melief, N. van Montfoort, R. Ostuni, P. Pierre, R. Popovici, E. Rajnavolgyi, S. Schierer, G. Schuler, V. Soumelis, A. Splendiani, I. Stefanini, M. G. Torcia, I. Zanoni, R. Zollinger, C. G. Figdor, and J. M. Austyn. 2010. DC-ATLAS: a systems biology resource to dissect receptor specific signal transduction in dendritic cells. Immunome Res 6: 10.

Kuka, M., R. Baronio, S. Valentini, E. Monaci, A. Muzzi, S. Aprea, E. De Gregorio, and U. D’Oro#. 2010. Src kinases are required for a balanced production of IL-12/IL-23 in human dendritic cells activated by Toll-like receptor agonists. PLoS One 5: e11491.

Rizzetto, L.*, M. Kuka*, C. De Filippo, A. Cambi, M. G. Netea, L. Beltrame, G. Napolitani, M. G. Torcia, U. D’Oro, and D. Cavalieri#. 2010. Differential IL-17 production and mannan recognition contribute to fungal pathogenicity and commensalism. J Immunol 184: 4258-4268.

Casnici, C., G. Volpe, D. Lattuada, K. Crotta, M. Kuka, C. Panuzzo, C. Mastrotto, G. Tonon, V. M. Fazio, G. Saglio, and O. Marelli. 2009. Out of frame peptides from BCR/ABL alternative splicing are immunogenic in HLA A2.1 transgenic mice. Cancer Lett 276: 61-67.

Volpe, G., A. Cignetti, C. Panuzzo, M. Kuka, K. Vitaggio, M. Brancaccio, G. Perrone, M. Rinaldi, G. Prato, M. Fava, M. Geuna, M. Pautasso, C. Casnici, E. Signori, G. Tonon, G. Tarone, O. Marelli, V. M. Fazio, and G. Saglio. 2007. Alternative BCR/ABL splice variants in Philadelphia chromosome-positive leukemias result in novel tumor-specific fusion proteins that may represent potential targets for immunotherapy approaches. Cancer Res 67: 5300-5307.

 

*These authors contributed equally                                                     #Corresponding author

Il titolare del presente curriculum vitae, pubblicato online sul portale www.unisr.it, è garante in via esclusiva della correttezza e della veridicità dei dati e delle informazioni in esso riportate e del loro eventuale e puntuale aggiornamento. Egli è dunque il diretto ed unico responsabile dei contenuti indicati nei propri curricula.