Meneghini Vasco Ricercatore tempo determinato tipo aMedicina
Biografia
Biografia
FORMAZIONE
2010 Ph.D. in Biotecnologie Farmaceutiche ed Alimentari - Università del Piemonte Orientale “A. Avogadro”, Novara, Italy
2006 Laurea Specialistica in Biotecnologie Industriali - Università degli studi Milano-Bicocca, Milano, Italy
2003 Laurea Triennale in Biotecnologie Molecolari - Università degli studi Milano-Bicocca, Milano, Italy
ATTIVITÀ DIDATTICA-ACCADEMICA
2022 Ricercatore t. det. (RTD-A) - BIO/17 ISTOLOGIA, 5/H2 ISTOLOGIA - Facoltà di Medicina e Chirurgia, Libera Università Vita-Salute San Raffaele, Milan, Italy
2021 Professore a contratto, - SSD BIO/14 - Corso di Laurea Magistrale in Biotecnologie Farmaceutiche, Dipartimento di Scienza del Farmaco, Università del Piemonte Orientale “A. Avogadro”, Vercelli, Italy
ATTIVITÀ DI RICERCA
2019 Project Leader, Gene and Neural Stem Cell Therapy for Lysosomal Storage Diseases Unit, San Raffaele-Telethon Institute for Gene Therapy (SR-Tiget), Milan, Italy
2014 Postdoctoral Fellow, Laboratory of Chromatin and Gene Regulation during Development - INSERM UNIT U1163 - Imagine Institute of Genetic Diseases, Hôpital Necker-Enfants maladies, Paris, France
2011 Postdoctoral Fellow, Gene and Neural Stem Cell Therapy for Lysosomal Storage Diseases Unit - San Raffaele-Telethon Institute for Gene Therapy (SR-Tiget), Milan, Italy
2006 Ph.D. student and Postdoctoral Fellow, Laboratory of Neuroplasticity and Neuropathic Pain - University of Piemonte Orientale “A. Avogadro”, Novara, Italy
PREMI e RICONOSCIMENTI
2022 NextGenerationEU-PNRR grant, Italian Ministry of University and Research
2022 BGTC AAV Biology research program (Co-PI), Foundation for the National Institutes of Health
2020 Marie Skłodowska Curie Actions (MSCA), Individual Fellowship - Horizon 2020
2019 Ricerca Finalizzata - Giovani Ricercatori 2019, Italian Ministry of Health
2019 Sanofi iAwards Europe 2019 (Co-PI)
2016 PRESTIGE COFUND European Union FP7 - Campus France
2006 National PhD Fellowship, Italian Ministry of Health and Research
PUBLICAZIONI SCIENTIFICHE
1. Cantore A., Fraldi A., Meneghini V., Gritti A. In vivo Gene Therapy to the Liver and Nervous System: Promises and Challenges. Front Med (Lausanne). 2022 Jan 18; 8:774618.
2. Ramadier S., … , Meneghini V.*, Miccio A.* Combination of lentiviral and genome editing technologies for the treatment of sickle cell disease. Mol Ther. 2022 Jan 5; 30(1):145-163. *Co-last and co-corresponding authors.
3. Meneghini V.*, Peviani M., Zambonini G., Luciani M, Gritti A. Delivery Platforms for CRISPR/Cas9 Genome Editing of Glial Cells in the Central Nervous System. Front Genome Ed. 2021 Mar 3; 3:644319. *Corresponding author. Review.
4. Luciani M, Gritti A, Meneghini V.*. Human iPSC-Based Models for the Development of Therapeutics Targeting Neurodegenerative Lysosomal Storage Diseases. Front Mol Biosci. 2020 Sep 18; 7:224. *Corresponding author. Review.
5. Romano O., Petiti L., Felix T., Meneghini V., et al. GATA factor-mediated gene regulation in human erythropoiesis. iScience 2020 Mar 30;23(4):101018.
6. Weber L, Frati G, Felix T, Hardouin G, Casini A, Wollenschlaeger C, Meneghini V, et al. Editing a gamma-globin repressor binding site restores fetal hemoglobin synthesis and corrects the sickle cell disease phenotype. Sci Adv. 2020 Feb 12;6(7): eaay9392.
7. Lattanzi A., Meneghini V., et al. Optimization of CRISPR/Cas9 Delivery to Human Hematopoietic Stem and Progenitor Cells for Therapeutic Genomic Rearrangements. Mol Ther. 2019 Jan 2;27(1):137-150.
8. Frati G., Luciani M., Meneghini V., et al. Human iPSC-based models highlight defective glial and neuronal differentiation from neural progenitor cells in metachromatic leukodystrophy. Cell Death Dis. 2018, 9(6):698.
9. Antoniani C.*, Meneghini V.*, et al. Induction of fetal hemoglobin synthesis by CRISPR/Cas9-mediated editing of the beta-globin locus. Blood. 2018 Apr 26;131(17):1960-1973. *Co-first authors.
Commentary on Blood Journal: A chance to cut (the genome) is a chance to cure. Kara E. Montbleau and Vijay G. Sankaran. Blood 2018 131:1884-1885.
10. Meneghini V.*, Frati G.*, et al. Generation of Human Induced Pluripotent Stem Cell-Derived Bona Fide Neural Stem Cells for Ex Vivo Gene Therapy of Metachromatic Leukodystrophy. Stem Cells Transl Med. 2017 Feb;6(2):352-368. *Co-first authors.
11. Meneghini V., et al. Pervasive supply of therapeutic lysosomal enzymes in the CNS of normal and Krabbe-affect non-human primates by intracerebral lentiviral gene therapy. EMBO Mol Med. 2016 May 2;8(5):489-510.
12. Meneghini V., et al. The noradrenergic component in Tapentadol action counteracts MOR-mediated adverse effects on adult neurogenesis. Mol Pharmacol. 2014 May;85(5):658-70.
13. Meneghini V., et al. High-mobility group box-1 protein and beta-amyloid oligomers promote neuronal differentiation of adult hippocampal neural progenitors via receptor for advanced glycation end products/nuclear factor-kB axis: relevance for Alzheimer's disease. J Neurosci. 2013 Apr 3;33(14):6047-59.
14. Meneghini V., et al. A novel role for the Receptor for Advanced Glycation End-products in neural progenitor cells derived from adult SubVentricular Zone. Mol Cell Neurosci. 2010, 45(2):139-50.
15. Meneghini V., Odent S., Platonova N., Egeo A., Merlo G.R. Novel TBX3 mutation data in families with Ulnar-Mammary syndrome indicate a genotype-phenotype relationship: mutations that do not disrupt the T-domain are associated with less severe limb defects. Eur J Med Genet. 2006 Mar-Apr; 49(2):151-8.
EDUCATION
2010 Ph.D. in Food and Pharmaceutical Biotechnologies - University of Piemonte Orientale “A. Avogadro”, Novara, Italy
2006 Master Degree in Industrial Biotechnology - University of Milan-Bicocca, Milano, Italy
2003 Bachelor in Molecular Biotechnology - University of Milan-Bicocca, Milano, Italy
PROFESSIONAL EXPERIENCES
2022 Fixed-term Researcher (RTD-A), “Human Histology” - SSD BIO/7, University Vita-Salute San Raffaele, Milan, Italy
2021 Fixed-term Assistant Professor, “Pharmacology of ATMP” - SSD BIO/14, University of Piemonte Orientale “A. Avogadro”, Vercelli, Italy
PROFESSIONAL ACTIVITIES
2019 Project Leader, Gene and Neural Stem Cell Therapy for Lysosomal Storage Diseases Unit, San Raffaele-Telethon Institute for Gene Therapy (SR-Tiget), Milan, Italy
2014 Postdoctoral Fellow, Laboratory of Chromatin and Gene Regulation during Development - INSERM UNIT U1163 - Imagine Institute of Genetic Diseases, Hôpital Necker-Enfants maladies, Paris, France
2011 Postdoctoral Fellow, Gene and Neural Stem Cell Therapy for Lysosomal Storage Diseases Unit - San Raffaele-Telethon Institute for Gene Therapy (SR-Tiget), Milan, Italy
2006 Ph.D. student and Postdoctoral Fellow, Laboratory of Neuroplasticity and Neuropathic Pain - University of Piemonte Orientale “A. Avogadro”, Novara, Italy
PROFESSIONAL HONORS
2022 NextGenerationEU-PNRR grant, Italian Ministry of University and Research
2022 BGTC AAV Biology research program (Co-PI), Foundation for the National Institutes of Health
2020 Marie Skłodowska-Curie actions (MSCA), Individual Fellowship - Horizon 2020
2019 Ricerca Finalizzata – Giovani Ricercatori 2019, Italian Ministry of Health
2019 Sanofi iAwards Europe 2019 (Co-PI)
2016 PRESTIGE COFUND European Union FP7 - Campus France
2006 National PhD Fellowship, Italian Ministry of Health and Research
Consulta il profilo completo, gli insegnamenti e le pubblicazioni sulla pagina docente
Il titolare del presente curriculum vitae, pubblicato online sul portale www.unisr.it, è garante in via esclusiva della correttezza e della veridicità dei dati e delle informazioni in esso riportate e del loro eventuale e puntuale aggiornamento. Egli è dunque il diretto ed unico responsabile dei contenuti indicati nei propri curricula.