Cavestro Giulia Martina Professore associatoMedicinaMED/12

Biografia

Pubblicazioni

English version

Biografia

ISTRUZIONE E FORMAZIONE

2001-2005 Dottorato di Ricerca in Fisiopatologia Epato-Digestiva conseguito presso l’Università degli Studi di Parma

1996-2000 Specializzazione in Gastroenterologia conseguita presso l’Università degli Studi di Parma.

1990-1996 Laurea in Medicina e Chirurgia conseguita presso l’Università degli Studi di Padova

ESPERIENZE PROFESSIONALI ALL’ESTERO

1995-1997 Yale University, Department of Internal Medicine, Section of Digestive Diseases, New Haven, CT, USA per attività di ricerca applicando metodologie di biologia molecolare allo studio della secrezione biliare.

CURRICULUM UNIVERSITARIO

Da Giugno 2017 Professore Associato per il settore scientifico disciplinare MED-12 (Gastroenterologia) presso la Facoltà di Medicina e Chirurgia dell’Università Vita Salute San Raffaele, Milano.

 

Da Marzo 2013 Ricercatrice Universitaria confermata in ruolo il 30/12/2005 per il settore scientifico disciplinare MED-12 (Gastroenterologia) presso la Facoltà di Medicina e Chirurgia dell’Università Vita Salute San Raffaele, Milano.

 

Da Gennaio 2011 a Febbraio 2013 Visiting Professor  a tempo pieno presso Università Vita e Salute San Raffaele Unità operativa di Gastroenterologia ed Endoscopia Digestiva

 

Dal 2002 al 2013 Ricercatrice Universitaria confermata in ruolo in Dicembre 2005, per il settore scientifico disciplinare MED-12 (Gastroenterologia) presso la Facoltà di Medicina e Chirurgia dell’Università degli Studi di Parma, Dipartimento di Scienze Cliniche, Sezione di Gastroenterologia.

2000-2002 Assegno di ricerca dell’Università degli Studi di Parma

 

1997-2001 Medico Universitario in formazione Gastroenterologica con compiti assistenziali e di cura presso l’Istituto di Semeiotica, Cattedra di Gastroenterologia dell’ Università degli Studi di Parma.

ATTIVITÀ DI RICERCA

Dal luglio 2015 responsabile ambulatorio multidisciplinare per le Sindromi Ereditarie Gastroenterologiche.

Responsabile del progetto “biobanca per lo studio di associazione tra fattori ambientali e genetici nelle patologie infiammatorie, funzionali e neoplastiche gastroenterologiche”

2001-2013: Responsabile laboratorio di ricerca molecolare in Gastroenterologia presso l’Università degli Studi di Parma, Dipartimento di Scienze Cliniche, con impiego di metodiche di biologia molecolare (amplificazione, sequenziamento, analisi mutazionale) applicate a patologie gastroenterologiche.

Collaborazioni internazionali:

– Tufts University, Frank C. Doble Professor of Engineering Department of Biomedical Engineering, Department of Physics, Dept. of Electrical Engineering, Science and Technology Center of Engineering, Silklab, Medford

– Pan-European Working Group. Progetto: Genetic Risk contribution to Alcoholic chronic Pancreatitis, Pan-European Working Group

– PANcreatic Disease ReseArch (PANDoRA) consortium

– Boston University School of Medicine and Boston Medical Center, Gastroenterology Unit, U.S.A.

– Pädiatrische Ernährungsmedizin, Technische Universität München (Heiko Witt)

– Department of Gastroenterology and Hepatology, University of Leipzig, Leipzig, Germany

– Genomic Epidemiology Group German Cancer Research Center, Heidelberg, Germany

– Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-v.-Guericke-University, Magdeburg

Partecipazione a progetti ministeriali:

1998-1999: “Colangite Sclerosante Primitiva: ruolo patogenetico delle mutazioni del gene per la fibrosi cistica”

1999-2000: “Colangite Sclerosante Primitiva ed associazione con il polimorfismo –308 del TNFα.”
2000-2001: “Pancreatite cronica Idiopatica ed associazione con particolari antigeni HLA (A, B, DR1) e con il polimorfismo –308 del TNFα.”

2001-2002: “Fattori di suscettibilità genetici nella patogenesi della Pancreatite cronica.”
2003-2004: Metabolismo dei farmaci inibitori della pompa protonica gastrica e polimorfismo dell’enzima CYP2C19

2004-2005: Ruolo delle mutazioni del gene della keratina 8 e del polimofismo del gene TNF-α nella predisposizione genetica alle malattie infiammatorie croniche intestinali

Partecipazione a progetti Nazionali di ricerca inter-universitari (Finanziamenti del Ministero della Pubblica Istruzione):

1998-2000 (Biennale): La colestasi nell’uomo e in modelli sperimentali. Biologia cellulare e molecolare della secrezione biliare e delle sue alterazioni come causa di danno epatico e progressione di malattia.

2000-2002 (Biennale): Danno cellulare, morte e proliferazione dell’epitelio biliare nella colestasi umana e sperimentale

Partecipazione a progetti di Ricerca Sanitaria Finalizzata (Finanziamenti del Ministero della salute): 2004-2006 (Biennale): “Strategie Innovative per la Diagnosi Precoce, il Follow-Up e la Terapia del Cancro dell’Esofago e del Cardias”Collaborazioni internazionali:
– Pan-European Working Group. Progetto: Genetic Risk contribution to Alcoholic chronic Pancreatitis, Pan-European Working Group.
– PANcreatic Disease ReseArch (PANDoRA) consortium.
– Boston University School of Medicine and Boston Medical Center, Gastroenterology Unit, U.S.A. (Satish K. Singh). Progetti: Clinical and molecular characteristics of inflammatory pancreatic diseases; Spectroscopic assessment of mucosal pathologies at gastrointestinal endoscopy; Detection of field effect of carcinogenesis of gastrointestinal cancers using elastic scattering spectroscopy.
– Arizona State University, School of Life Sciences, Tempe Arizona State University, U.S.A. (Douglas F. Lake). Progetto: Identification of circulating molecular markers for non-invasive diagnosis of GI cancers
– Pädiatrische Ernährungsmedizin, Technische Universität München (Heiko Witt)
– Department of Gastroenterology and Hepatology, University of Leipzig, Leipzig, Germany (Jonas Rosendahl)
– ARC-NET Research Centre for Applied Research on Cancer Department of Pathology and Diagnostics, University and Hospital Trust of Verona (Aldo Scarpa)
– Genomic Epidemiology Group German Cancer Research Center, Heidelberg, Germany (Canzian Federico). Progetto: Participation in the genome-wide association study on pancreatic
cancer risk of the Pancreatic Cancer Case Control Consortium (PanC4).
– Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-v.-Guericke-University, Magdeburg (Peter Malfertheiner)

Partecipazione a progetti ministeriali:
1998-1999: “Colangite Sclerosante Primitiva: ruolo patogenetico delle mutazioni del gene per la fibrosi cistica”
1999-2000: “Colangite Sclerosante Primitiva ed associazione con il polimorfismo –308 del TNFα.”
2000-2001: “Pancreatite cronica Idiopatica ed associazione con particolari antigeni HLA (A, B, DR1) e con il polimorfismo –308 del TNFα.”
2001-2002: “Fattori di suscettibilità genetici nella patogenesi della Pancreatite cronica.”
2003-2004: Metabolismo dei farmaci inibitori della pompa protonica gastrica e polimorfismo dell’enzima CYP2C19

2004-2005: Ruolo delle mutazioni del gene della keratina 8 e del polimofismo del gene TNF-α nella predisposizione genetica alle malattie infiammatorie croniche intestinali

Partecipazione a progetti Nazionali di ricerca inter-universitari (Finanziamenti del Ministero della Pubblica Istruzione):
1998-2000 (Biennale): La colestasi nell’uomo e in modelli sperimentali. Biologia cellulare e molecolare della secrezione biliare e delle sue alterazioni come causa di danno epatico e progressione di malattia.
2000-2002 (Biennale): Danno cellulare, morte e proliferazione dell’epitelio biliare nella colestasi umana e sperimentale

Partecipazione a progetti di Ricerca Sanitaria Finalizzata (Finanziamenti del Ministero della salute):
2004-2006 (Biennale): “Strategie Innovative per la Diagnosi Precoce, il Follow-Up e la Terapia del Cancro dell’Esofago e del Cardias”

ATTIVITÀ DIDATTICA

Università Vita Salute San Raffaele, Facoltà di Medicina e Chirurgia:

– Dall’anno Accademico 2013-2014: Titolare del corso di “Gastroenterologia”, Corso di Laurea Magistrale in Odontoiatria e Protesi Dentaria (CLMOPD) Universita’ Vita-Salute San Raffaele, Milano

– Dall’Anno Accademico 2011-2012 Titolare del corso di “Gastroenterologia”, Corso di Laurea in Igiene Dentale (CLID270) Universita’ Vita-Salute San Raffaele, Milano

– Dall’Anno Accademico 2011-2012 Affidamento insegnamento di “Digestive Disease System” nel Corso di Laurea International MD program Universita’ Vita-Salute San Raffaele, Milano

–  Dall’Anno Accademico 2015-2016 Affidamento insegnamento nel Corso di Laurea di Medicina e Chirurgia, Universita’ Vita-Salute San Raffaele, Milano

Insegnamento ufficiale di Malattie Digestive per i programmi di dottorato di ricerca (Ph.D) presso l’Università degli Studi di Firenze, Facoltà di Medicina e Chirurgia:

– Dall’anno Accademico 2013-2014: Dottorato di Ricerca in Scienze Biomediche- indirizzo scienze fisiologiche e nutrizionali.

 

Insegnamento ufficiale di Malattie Digestive per i programmi di dottorato di ricerca (Ph.D) presso l’Università degli Studi di Parma, Facoltà di Medicina e Chirurgia:

– Dall’anno Accademico 2008-2009: Dottorato di Ricerca in chirurgia epato-bilio-pancreatica e fisiopatologia epato-digestiva avanzata, Università degli Studi di Parma, Facoltà di Medicina e Chirurgia.* Tutor di 4 tesi di Dottorato in Medicina e Chirurgia

ATTIVITÀ ASSISTENZIALE

Dal luglio 2015 responsabile ambulatorio Sindromi Ereditarie Gastroenterologiche (sindrome di Lynch, poliposi familiare classica o attenuata, sindrome di Peutz–Jeghers, poliposi giovanile, cancro pancreatico familiare e gastrico familiare).

 

Da Gennaio 2011 attività di Endoscopia diagnostica e operativa delle alte (1000 EGDS/anno) e basse vie digestive (1000 Pancolonscopie/anno) presso l’U.O. complessa di Endoscopia Digestiva dell’Ospedale San Raffaele, Milano.

Dal 2007 al 2011: Dirigente medico Case Manager Esperto (Senior) presso l’Unità Operativa Complessa di Gastroenterologia ed Endoscopia Digestiva, dell’Azienda Ospedaliero-Universitaria di Parma

Membro delle Società Scientifiche/Gruppi di ricerca

– Collaborative Group of the Americas on Inherited Colorectal Cancer (C.G.A.) membro dal 2015

– Pancreas Club, inc., membro dal 2015

– Società Italiana di Gastroenterologia (S.I.G.E.) dal 1997 membro; dal 2014 membro della commissione scientifica

– American Pancreatic Association (A.P.A) dal 2007

– European Pancreatic Association (E.P.C.) dal 2010

– Associazione Italiana Studio Pancreas (A.I.S.P.) dal 2001

– Gruppo Interdisciplinare Studio Colelitiasi (G.I.S.Co.) dal 2000

– Interdisciplinary Group on Gastric Epithelial Dysplasia (I.G.G.E.D.) dal 2000

2002-2005: Dirigente Medico Case Manager presso l’Unità Operativa Complessa di Gastroenterologia ed Endoscopia Digestiva, dell’ Azienda Ospedaliero Universitaria di Parma MEMBRO DELLE SOCIETÀ SCIENTIFICHE/GRUPPI DI RICERCA
– Società Italiana di Gastroenterologia (S.I.G.E.) dal 1997 membro; dal 2014 membro della commissione scientifica
– American Pancreatic Association (A.P.A) dal 2007
– European Pancreatic Association (E.P.C.) dal 2010
– Associazione Italiana Studio Pancreas (A.I.S.P.) dal 2001
– Gruppo Interdisciplinare Studio Colelitiasi (G.I.S.Co.) dal 2000
– Interdisciplinary Group on Gastric Epithelial Dysplasia (I.G.G.E.D.) dal 2000

CONSEGUIMENTO PREMI PER L’ATTIVITÀ SCIENTIFICA

– VI Congresso della Federazione Nazionale delle Malattie Digestive premio per lo studio: “Il contributo dei geni della regione MHC delle mutazioni del CFTR nella predisposizione genetica alla colangite sclerosante primitiva”.

– Grant award, elargito dall’Associazione Europea di Gastroenterologia al X° congresso UEGW (United European Gastroenterology Week) per lo studio: “Keratin 8 mutations in patients with chronic pancreatitis”.

– Grant award elargito dall’Associazione Europea di Gastroenterologia al Congresso UEGW anno 2006 come miglior lavoro (Connections between genetics and clinical data in the setting of acute, acute recurrent, and chronic pancreatitis).

 – Premio come miglior lavoro congresso dell’American Pancreatic Association Chicago novembre 2006 (Connections between genetics and clinical data in the setting of acute, acute recurrent, and chronic pancreatitis).

– VI Congresso della Federazione Nazionale delle Malattie Digestive premio per lo studio: “Il contributo dei geni della regione MHC delle mutazioni del CFTR nella predisposizione genetica alla colangite sclerosante primitiva”.

Autrice di oltre 60 pubblicazioni in riviste scientifiche indicizzate con impact factor, h-index 25, oltre 2700 citazioni

Pubblicazioni scientifiche

Autrice di oltre 70 pubblicazioni in riviste scientifiche indicizzate con impact factor, h-index 25, oltre 2700 citazioni

Pubblicazioni

1) Okolicsanyi L, Cavestro GM, Guatti-Zuliani C; Hyperbilirubinemia: does it matter? Can J

Gastroenterol 1999;13:663-668.

2) Coruzzi G, Coppelli G, Spaggiari S, Cavestro GM, Okolicsanyi L, Lo Giudice P, Pisano C,

Tepperman B. Gastroprotective effects of amtolmetin guacil: a new non-steroidal antiinflammatory

drug that activates inducible gastric nitric oxide synthase. Dig Liver Dis

2002;34:403-410.

3) Cavestro GM, Nicola Mantovani, Paolo Coruzzi, Antonio Nouvenne, Federico Marcucci, Angelo Franzè, Francesco Di Mario, Lajos Okolicsanyi. Hypercalcemia due to ectopic

secretion of parathyriod related protein from pancreatic carcinoma: a case report. Acta

Biomed Ateneo Parmense;2002;73:37-40.

4) Ali M. Moussa, Cavestro GM, Paolo Coruzzi, Marta Maino, Gian Luigi De Angelis,

Francesco Di Mario. Macrohaematuria due to fall of protrombinic activity as clinical

presentation of celiac disease. J Clin Gastroenterol 2002;35:424-425.

5) Cavestro GM, Frulloni L, Neri TM, Cerati E, Ribeiro LA, Corrente V, Sianesi M, Franzè A, Di

Mario F. Progressive Familial Intrahepatic Cholestasis. Acta Biomed Ateneo Parmense

2002;73:53-56.

6) Del Rio P, Dell’Abate P, Soliani P, Sivelli R, Alessandri L, Cavestro GM, Sianesi M.

Gastrointestinal stromal tumours: an analysis based on personal experience. Acta Biomed

Ateneo Parmense. 2002;73:41-5.

7) Di Mario F, Dal Bò N, Aragona G, Moussa AM, Iori V, Cavestro GM, Pilotto A, Leandro G,

Franceschi M, Rugge M, Franzè A. Rabeprazole in a one week eradication therapy of H.

pylori: comparison of different dosages. J Gastroenterol Hepatol 2003;18:783-786.

8) Di Mario F, Aragona G, Dal Bò N, Ingegnoli A, Cavestro GM, Moussa AM, Iori V, Leandro

G, Pilotto A, Franzè A. Use of lactoferrin for Helicobacter pylori eradication: preliminary

results. J Clin Gastroenterol. 2003;36:396-8.

9) Cavestro GM, Frulloni L, Neri TM, Seghini P, Nouvenne A, Zanetti A, Bovo P, Di Mario F,

Okolicsanyi L, Cavallini G. Association of HLA-DRB1 *0401 Allele with chronic pancreatitis.

Pancreas 2003;26:388-391.

10) Di Mario F, Aragona G, Dal Bò N, Cavestro GM, Cavallaro LG, Iori V, Comparato G,

Leandro G, Pilotto A, Franzè A. Use of BOVINE lactoferrin for Helicobacter pylori

eradication. Dig Liv Dis 2003;35:706-10.

11) Di Mario F, Moussa AM, Caruana P, Merli R, Cavallaro LG, Cavestro GM, Dal Bò N, Iori V,

Pilotto A, Leandro G, Franze A, Rugge M. ‘Serological biopsy’ in first-degree relatives of

patients with gastric cancer affected by Helicobacter pylori infection. Scand J Gastroenterol.

2003 Dec;38:1223-7.

12) Cavestro GM, Frulloni L, Nouvenne A, Neri TM, Calore B, Ferri B, Bovo P, Okolicsanyi L, Di

Mario F, Cavallini G. Association of keratin 8 gene mutation with chronic pancreatitis. Dig

Liver Dis. 2003;35:416-20.

13) Neri TM, Cavestro GM, Seghini P, Zanelli PF, Zanetti A, Savi M, Podda M, Zuin M,

Colombo M, Floreani A, Rosina F, Bianchi Porro G, Strazzabosco M, Okolicsanyi L. Novel

association of HLA-haplotypes with primary sclerosing cholangitis (PSC) in a southern

European population. Dig Liver Dis 2003;35:571-6.

14) Cavestro GM, Comparato G, Nouvenne A, Sianesi M, Di Mario F. The race from chronic

pancreatitis to pancreatic cancer. JOP. 2003;4:165-8.

15) Di Mario F, Ingegnoli A, Dal Bo N, Cavestro GM, Moussa AM, Cavallaro LG, Aragona G,

Iori V, Pilotto A, Franze A, Rugge M. Early epigastric pain after PPI administration:

exacerbation of Helicobacter pylori corpus gastritis? Helicobacter. 2004;9:92-4.

16) Soliani P, Ziegler S, Franzini C, Dell’Abate P, Del Rio P, Di Mario F, Cavestro GM, Sianesi

  1. The size of pancreatic pseudocyst does not influence the outcome of invasive

treatments. Dig Liver Dis. 2004;36:135-40.

17) Di Mario F, Moussa AM, Cavallaro LG, Caruana P, Merli R, Bertolini S, Iori V, Cavestro

GM, Dal Bo N, Pilotto A, Franze A, Leandro G. Clinical usefulness of serum pepsinogen II

in the management of Helicobacter pylori infection. Digestion. 2004;70:167-72.

18) Soliani P, Franzini C, Ziegler S, Del Rio P, Dell’Abate P, Piccolo D, Japichino GG, Cavestro

GM, Di Mario F, Sianesi M. Pancreatic pseudocysts following acute pancreatitis: risk factors

influencing therapeutic outcomes. JOP. 2004;5:338-47.

19) Cavestro GM, Comparato G, Nouvenne A, Sereni G, Bertolini S, Frulloni L, Dalla Valle R,

Soliani P, Zanelli PF, Sianesi M, Franze A, Di Mario F. Genetics of chronic pancreatitis.

JOP. 2005;6:53-9.

20) Di Mario F, Moussa AM, Dal Bo N, Caruana P, Pilotto A, Cavallaro LG, Cavestro GM, Iori

V, Merli R, Franze A, Rugge M. Recovery of gastric function after Helicobacter pylori

eradication in subjects with body atrophic gastritis: prospective 4-year study

J Gastroenterol Hepatol. 2005;20:1661-6.

21) Pezzilli R, Morselli-Labate AM, Frulloni L, Cavestro GM, Ferri B, Comparato G, Gullo L,

Corinaldesi R.The quality of life in patients with chronic pancreatitis evaluated using the SF-

12 questionnaire: A comparative study with the SF-36 questionnaire. Dig Liver Dis.

2005;Available online 19 October 2005 Epub ahead of print.

22) Di Mario F, Ingegnoli A, Altavilla N, Cavallaro LG, Bertolini S, Merli R, Cavestro GM, Iori V,

Maino M, Leandro G, Franze A. Influence of antisecretory treatment with proton pump inhibitors on serum pepsinogen I levels. Fundam Clin Pharmacol. 2005;19:497-501.

23) Germanà B, Di Mario F, Cavallaro LG, Moussa AM, Lecis P, Liatoupolou S, Comparato G,

Carloni C, Bertiato G, Battiestel M, Papa N, Aragona G, Cavestro GM, Iori V, Merli R,

Bertolini S, Caruana P, Franzè A. Clinical usefulness of serum pepsinogens I and II,

gastrin-17 and anti-Helicobacter pylori antibodies in the management of dyspeptic patients

in primary care. Dig Liver Dis. 2005;37:501-8.

24) Pezzilli R, Morselli Labate AM, Ceciliato R, Frulloni L, Cavestro GM, Comparato G, Ferri B,

Corinaldesi R, Gullo L. Quality of life in patients with chronic pancreatitis.

Dig Liver Dis. 2005;37:181-9.

25) Di Mario F, Aragona G, Leandro G, Comparato G, Fanigliulo L, Cavallaro LG, Cavestro

GM, Iori V, Maino M, Moussa AM, Gnocchi A, Mazzocchi G, Franzè A. Efficacy of

mesalazine in the treatment of symptomatic diverticular disease. Dig Dis Sci. 2005;50:581-

6.

26) Di Mario F, Stefani N, Dal Bò N, Rugge M, Pilotto A, Cavestro GM, Cavallaro LG, Franzè

A, Leandro G. Natural course of functional dyspepsia after after helicobacter pylori

eradication a 7-year survey. Dig Dis Sci. 2005;50:2286-2295.

27) Di Mario F, Cavallaro LG, Moussa AM, Caruana P, Merli R, Maini A, Dal Bò N, Rugge M,

Cavestro GM, Bertolini S, Aragona G, Plebani M, Nervi G, Franzè A. Usefulness of serum

pepsinogens in H. pylori chronic gastritis: relationship with inflammation, activity and

density of the bacterium. Dig Dis Sci. Dig Dis Sci. 2006;51:1791-5.

28) Di Mario F, Cavallaro LG, Cavestro GM, Franzè A. Are there useful biomarkers for gastric

cancer? Dig Liver Dis. 2006;38:308-9

29) Di Mario F, Aragona G, Dal Bò N, Cavallaro L, Marcon V, Olivieri P, Benedetti E, Orzès N,

Marin R, Tafner G, Chilovi F, De Bastiani R, Fedrizzi F, Franceschi M, Heras Salvat M,

Monica F, Piazzi L, Valiante F, Vecchiati U, Cavestro GM, Comparato G, Iori V, Maino M,

Leandro G, Pilotto A, Rugge M, Franzè A. BOVINE lactoferrin for Helicobacter pylori

eradication: an open, randomised, multicenter study. Aliment Pharm Therap. 2006;23:1235-

40.

30) Witt H, Sahin-Tóth M, Landt O , Chen J-M, Kähne T, Drenth J , Kukor Z, Szepessy E,

Halangk W , Dahm S, Rohde K, Schulz HU, Le Maréchal C, Akar N, Ammann R, Truninger

K, Bargetzi M, Bhatia E, Castellani C, Cavestro GM, Cerny M, Destro-Bisol G, Eiberg H,

Jansen J, Koudova M, Macek M, Malats N, Real F, Menzel HJ, Moral P, Pignatti P,

Rickards O, Spicak J, Zarnescu N, Böck W, Gress T, Friess H, Ockenga J, Schmidt H,

Pfützer R, Löhr M, Simon P, Weiss F, Lerch M, Teich N, Keim V, Berg T, Wiedenmann B,

Luck W, Groneberg D, Serole S, Becker M, Keil T, Kage A, Bernardova, Braun M, Güldner

C, Halangk J, Rosendahl J, Witt U, Treiber M, Nickel R, Férec C. A degradation-sensitive

anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis. Nat Genet

2006;38:668-73.

31) Nervi G, Liatopoulou S, Cavallaro LG, Gnocchi A, Dal-Bo N, Rugge M, Iori V, Cavestro GM,

Maino M, Colla G, Franze A, Di Mario F. Does Helicobacter pylori infection eradication

modify pèeptic ulcer prevalence? A ten years’ endoscopical survey. World J Gastroenterol.

2006;12:2398-401

32) Di Mario F, Aragona G, Dal Bò N, Cavallaro L, Marcon V, Olivieri P, Benedetti E, Orzès N,

Marin R, Tafner G, Chilovi F, De Bastiani R, Fedrizzi F, Franceschi M, Heras Salvat M,

Monica F, Piazzi L, Valiante F, Vecchiati U, Cavestro GM, Comparato G, Iori V, Maino M,

Leandro G, Pilotto A, Rugge M, Franzè A. BOVINE lactoferrin for Helicobacter pylori

eradication: an open, randomised, multicenter study. Aliment Pharm Therap. 2006;23:1235-

40

33) Di Mario F, Cavallaro LG, Cavestro GM, Franzè A. Are there useful biomarkers for gastric

cancer? Dig Liver Dis. 2006(5):308-9.

34) Di Mario F, Stefani N, Dal Bò N, Rugge M, Pilotto A, Cavestro GM, Cavallaro LG, Franzè

A, Leandro G. Natural course of functional dyspepsia after after helicobacter pylori

eradication a 7-year survey. Dig Dis Sci. 2005;50:2286-2295.

35) Pozzoli C, Menozzi A, Grandi D, Solenghi E, Ossiprandi MC, Zullian C, Bertini S, Cavestro

GM, Coruzzi G. Protective effects of proton pump inhibitors against indomethacin-induced

lesions in the rat small intestine. Naunyn Schmiedebergs Arch Pharmacol. 2007;374:283-

91.

36) Comparato G, Fanigliulo L, Cavallaro LG, Aragona G, Cavestro GM, Iori V, Maino M,

Mazzocchi G, Muzzetto P, Colla G, Sianesi M, Franze A, Mario FD. Prevention of

Complications and Symptomatic Recurrences in Diverticular Disease with Mesalazine: A

12-Month Follow-up. Dig Dis Sci. 2007;52:2934-2941

37) Di Mario F, Cavallaro LG, Nouvenne A, Stefani N, Cavestro GM, Iori V, Maino M,

Comparato G, Fanigliulo L, Morana E, Pilotto A, Martelli L, Martelli M, Leandro G, Franze A. A curcumin-based 1-week triple therapy for eradication of Helicobacter pylori infection:

something to learn from failure? Helicobacter 2007;12:238-43.

38) Comparato G, Fanigliulo L, Aragona G, Cavestro GM, Cavallaro LG, Leandro G, Pilotto A,

Nervi G, Soliani P, Sianesi M, Franzé A, Di Mario F. Quality of life in uncomplicated

symptomatic diverticular disease: is it another good reason for treatment? Dig Dis.

2007;25:252-9.

39) de Angelis GL, Cavallaro LG, Maffini V, Moussa AM, Fornaroli F, Liatopoulou S, Bizzarri B,

Merli R, Comparato G, Caruana P, Cavestro GM, Franzé A, Di Mario F. Usefulness of a

serological panel test in the assessment of gastritis in symptomatic children. Dig Dis

2007;25:206-13.

40) Di Mario F, Cavallaro LG, Nouvenne A, Stefani N, Cavestro GM, Iori V, Maino M,

Comparato G, Fanigliulo L, Morana E, Pilotto A, Martelli L, Martelli M, Leandro G, Franzè A.

A curcumin-based 1-week triple therapy for eradication of Helicobacter pylori infection:

something to learn from failure? Helicobacter. 2007;12:238-43.

41) Comparato G, Fanigliulo L, Cavallaro LG, Aragona G, Cavestro GM, Iori V, Maino M,

Mazzocchi G, Muzzetto P, Colla G, Sianesi M, Franzé A, Mario FD. Prevention of

complications and symptomatic recurrences in diverticular disease with mesalazine: a 12-

month follow-up. Dig Dis Sci. 2007;52:2934-41.

42) Frulloni L, Scattolini C, Graziani R, Cavestro GM, Pravadelli C, Amodio A, Manfredi R,

Scarpa A, Vantini I. Clinical and radiological outcome of patients suffering from chronic

pancreatitis associated with gene mutations. Pancreas. 2008;37:371-6.

43) Frulloni L, Gabbrielli A, Pezzilli R, Zerbi A, Cavestro GM, Marotta F, Falconi M, Gaia E,

Uomo G, Maringhini A, Mutignani M, Maisonneuve P, Di Carlo V, Cavallini G;

PanCroInfAISP Study Group. Chronic pancreatitis: report from a multicenter Italian survey

(PanCroInfAISP) on 893 patients. Dig Liver Dis. 2009;41:311-7.

44) Cavestro GM, Zuppardo RA, Bertolini S, Sereni G, Frulloni L, Okolicsanyi S, Calzolari C,

Singh SK, Sianesi M, Del Rio P, Leandro G, Franzè A, Di Mario F. Connections Between

Genetics and Clinical Data: Role of MCP-1, CFTR, and SPINK-1 in the Setting of Acute,

Acute Recurrent, and Chronic Pancreatitis. Am J Gastroenterol 2010;105:199-206.

45) Frulloni L, Falconi M, Gabbrielli A, Gaia E, Graziani R, Pezzilli R, Uomo G, Andriulli A,

Balzano G, Benini L, Calculli L, Campra D, Capurso G, Cavestro GM, De Angelis C,

Ghezzo L, Manfredi R, Malesci A, Mariani A, Mutignani M, Ventrucci M, Zamboni G,

Amodio A, Vantini I; Italian Association for the Study of the Pancreas (AISP). Italian

consensus guidelines for chronic pancreatitis. Dig Liver Dis. 2010;42:381-406.

46) Gatta L, Di Mario F, Vaira D, Rugge M, Franzè A, Plebani M, Cavestro GM, Lucarini P,

Lera M, Scarpinato C. Quantification of Serum Levels of Pepsinogens and Gastrin to

Assess Eradication of Helicobacter Pylori. Clin Gastroenterol Hepatol. 2010;9:440-442.

47) Cavestro GM, Mariani A, Singh SK, Arcidiacono PG, Testoni PA. Study design biases in

pancreatic inflammatory disease. Gut 2012; 61:1778-9.

48) Banks PA, Bollen TL, Dervenis C, Gooszen HG, Johnson CD, Sarr MG, Tsiotos GG, Vege

SS; Acute Pancreatitis Classification Working Group. Classification of acute pancreatitis-

2012: revision of the Atlanta classification and definitions by international consensus. Gut.

2013;62:102-11.

49) Maria Chiara Petrone, Fulvia Terracciano, Francesco Perri, Silvia Carrara, Giulia Martina

Cavestro, Alberto Mariani, Pier Alberto Testoni, Paolo Giorgio Arcidiacono. Pancreatic

abnormalities detected by endoscopic ultrasound (EUS) in patients without clinical signs of

pancreatic disease: Any difference between standard and Rosemont classification scoring?

Pancreatology 2014;14:227-30.

50) Monique H. Derikx, Peter Kovacs MD, Emmanuelle Masson, Jian-Min Chen, Claudia

Ruffert, Peter Lichtner, Rene H.M. Morsche, Giulia Martina Cavestro, Hana Algül, Thomas

Berg, Hans Bödeker, Matthias Blüher, Marco J. Bruno, Stephan Buch, Peter Bugert, Halina

Cichoz-Lach, Andrzej Dabrowski, Antoni Farré, Josef Frank, Anita Gasiorowska, Andrea

Geisz MD, Elisabetta Goni, Johannes Grothaus, Robert Grützmann, Stephan Haas, Jochen

Hampe, Claus Hellerbrand, Peter Hegyi, Dominik Huster, Mihai Ioana, Sevastitia Iordache,

Grazyna Jurkowska, Volker Keim, Veronika Krulisova, Olfert Landt, Milena Di Leo, Markus

  1. Lerch, Philippe Lévy, Matthias Löhr, Milan Macek, Nuria Malats, Ewa Malecka-Panas,

Alberto Mariani, Davide Martorana, Julia Mayerle, Josefina Mora, Joachim Mössner,

Sebastian Müller, Johann Ockenga, Sergio Pedrazzoli, Stephen P. Pereira, Roland Pfützer

Francisco X. Real, Vinciane Rebours, Monika Ridinger, Marcella Rietschel, Kerstin Rohde,

Stephan Sack, Adrian Saftoiu, Alexander Schneider, Hans-Ulrich Schulz, Michael Soyka,

Peter Simon, James Skipworth, Felix Stickel, Michael Stumvoll, Pier Alberto Testoni, Anke

Tönjes, Matthias Treiber, Frank Ulrich Weiss, Jens Werner, Norbert Wodarz, Claude Férec,

Joost, P.H. Drenth Heiko Witt, and Jonas Rosendahl. Polymorhisms at PRSS1–PRSS2 and CLDN2–MORC4 loci associate with alcoholic and non-alcoholic chronic pancreatitis in

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51) Giulia Martina Cavestro, Gioacchino Leandro, Milena Di Leo, Raffaella Alessia Zuppardo,

Olivia B. Morrow, Chiara Notaristefano, Gemma Rossi, Sabrina Gloria Giulia Testoni,

Giorgia Mazzoleni, Matteo Alessandri, Elisabetta Goni, Satish K. Singh, Aurore Giliberti,

Margherita Bianco, Lorella Fanti, Edi Viale, Paolo Giorgio Arcidiacono, Alberto Mariani,

Maria Chiara Petrone, Pier Alberto Testoni. Single-center prospective, cohort study of the

natural history of acute pancreatitis. Dig Liver Dis (2014),

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52) Alberto Mariani, Milena Di Leo, Maria Chiara Petrone, Paolo Giorgio Arcidiacono,

Antonella Giussani, Raffaella Alessia Zuppardo, Giulia Martina Cavestro, Pier Alberto

Testoni. Outcome of endotherapy for pancreas divisum in patients with acute recurrent

pancreatitis. World J Gastroenterol. 2014;14:17468-75.

53) Childs EJ, Mocci E, Campa D, Bracci PM, Gallinger S, Goggins M, Li D, Neale RE, Olson

SH, Scelo G, Amundadottir LT, Bamlet WR, Bijlsma MF, Blackford A, Borges M, Brennan

P, Brenner H, Bueno-de-Mesquita HB, Canzian F, Capurso G, Cavestro GM, Chaffee KG,

Chanock SJ, Cleary SP, Cotterchio M, Foretova L, Fuchs C, Funel N, Gazouli M, Hassan

M, Herman JM, Holcatova I, Holly EA, Hoover RN, Hung RJ, Janout V, Key TJ, Kupcinskas

J, Kurtz RC, Landi S, Lu L, Malecka-Panas E, Mambrini A, Mohelnikova-Duchonova B,

Neoptolemos JP, Oberg AL, Orlow I, Pasquali C, Pezzilli R, Rizzato C, Saldia A, Scarpa A,

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Petersen GM, Risch HA, Klein AP. Common variation at 2p13.3, 3q29, 7p13 and 17q25.1

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Bijlsma MF, Brenner H, Burdette L, Campa D, Caporaso NE, Capurso G, Cavestro GM,

Cotterchio M, Costello E, Elena J, Boggi U, Gaziano JM, Gazouli M, Giovannucci EL,

Goggins M, Gross M, Haiman CA, Hassan M, Helzlsouer KJ, Hu N, Hunter DJ, Iskierka-

Jazdzewska E, Jenab M, Kaaks R, Key TJ, Khaw KT, Klein EA, Kogevinas M, Krogh V,

Kupcinskas J, Kurtz RC, Landi MT, Landi S, Le Marchand L, Mambrini A, Mannisto S, Milne

RL, Neale RE, Oberg AL, Panico S, Patel AV, Peeters PH, Peters U, Pezzilli R, Porta M,

Purdue M, Quiros JR, Riboli E, Rothman N, Scarpa A, Scelo G, Shu XO, Silverman DT,

Soucek P, Strobel O, Sund M, Małecka-Panas E, Taylor PR, Tavano F, Travis RC,

Thornquist M, Tjønneland A, Tobias GS, Trichopoulos D, Vashist Y, Vodicka P, Wactawski-

Wende J, Wentzensen N, Yu H, Yu K, Zeleniuch-Jacquotte A, Kooperberg C, Risch HA,

Jacobs EJ, Li D, Fuchs C, Hoover R, Hartge P, Chanock SJ, Petersen GM, Stolzenberg-

Solomon RS, Wolpin BM, Kraft P, Klein AP, Canzian F, Amundadottir LT. Three new

pancreatic cancer susceptibility signals identified on chromosomes 1q32.1, 5p15.33 and

8q24.21. Oncotarget. 201611;7:66328-66343

57) Di Leo M, Petrone MC, Zuppardo RA, Cavestro GM, Arcidiacono PG, Testoni PA, Mariani

  1. Pancreatic morpho-functional imaging as a diagnostic approach for chronic

asymptomatic pancreatic hyperenzymemia. Dig Liver Dis. 2016;48:1330-1335.

58) Di Leo M, Leandro G, Singh SK, Mariani A, Bianco M, Zuppardo RA, Goni E, Rogger TM,

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Alcohol and Cigarette Use Is Associated to the Risk of Developing Chronic Pancreatitis.

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59) Campa D, Pastore M, Gentiluomo M, Talar-Wojnarowska R, Kupcinskas J, Malecka-Panas E, Neoptolemos JP, Niesen W, Vodicka P, Delle Fave G, Bueno-de-Mesquita HB, Gazouli M, Pacetti P, Di Leo M, Ito H, Klüter H, Soucek P, Corbo V, Yamao K, Hosono S, Kaaks R, Vashist Y, Gioffreda D, Strobel O, Shimizu Y, Dijk F, Andriulli A, Ivanauskas A, Bugert P, Tavano F, Vodickova L, Zambon CF, Lovecek M, Landi S, Key TJ, Boggi U, Pezzilli R, Jamroziak K, Mohelnikova-Duchonova B, Mambrini A, Bambi F, Busch O, Pazienza V, Valente R, Theodoropoulos GE, Hackert T, Capurso G, Cavestro GM, Pasquali C, Basso D, Sperti C, Matsuo K, Büchler M, Khaw KT, Izbicki J, Costello E, Katzke V, Michalski C, Stepien A, Rizzato C, Canzian F. Functional single nucleotide polymorphisms within the cyclin-dependent kinase inhibitor 2A/2B region affect pancreatic cancer risk. Oncotarget. 2016;7:57011-57020

60) Di Leo M, Bianco M, Zuppardo RA, Guslandi M, Calabrese F, Mannucci A, Neri TM, Testoni PA, Leandro G, Cavestro GM. Meta-analysis of the impact of SPINK1 p.N34S gene variation in Caucasic patients with chronic pancreatitis. An update. Dig Liver Dis. 2017;49:847-853.

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63) Klein AP, Wolpin BM, Risch HA, Stolzenberg-Solomon RZ, Mocci E, Zhang M, Canzian F, Childs EJ, Hoskins JW, Jermusyk A, Zhong J, Chen F, Albanes D, Andreotti G, Arslan AA, Babic A, Bamlet WR, Beane-Freeman L, Berndt SI, Blackford A, Borges M, Borgida A, Bracci PM, Brais L, Brennan P, Brenner H, Bueno-de-Mesquita B, Buring J, Campa D, Capurso G, Cavestro GM, Chaffee KG, Chung CC, Cleary S, Cotterchio M, Dijk F, Duell EJ, Foretova L, Fuchs C, Funel N, Gallinger S, M Gaziano JM, Gazouli M, Giles GG, Giovannucci E, Goggins M, Goodman GE, Goodman PJ, Hackert T, Haiman C, Hartge P, Hasan M, Hegyi P, Helzlsouer KJ, Herman J, Holcatova I, Holly EA, Hoover R, Hung RJ, Jacobs EJ, Jamroziak K, Janout V, Kaaks R, Khaw KT, Klein EA, Kogevinas M, Kooperberg C, Kulke MH, Kupcinskas J, Kurtz RJ, Laheru D, Landi S, Lawlor RT, Lee IM, LeMarchand L, Lu L, Malats N, Mambrini A, Mannisto S, Milne RL, Mohelníková-Duchoňová B, Neale RE, Neoptolemos JP, Oberg AL, Olson SH, Orlow I, Pasquali C, Patel AV, Peters U, Pezzilli R, Porta M, Real FX, Rothman N, Scelo G, Sesso HD, Severi G, Shu XO, Silverman D, Smith JP, Soucek P, Sund M, Talar-Wojnarowska R, Tavano F, Thornquist MD, Tobias GS, Van Den Eeden SK, Vashist Y, Visvanathan K, Vodicka P, Wactawski-Wende J, Wang Z, Wentzensen N, White E, Yu H, Yu K, Zeleniuch-Jacquotte A, Zheng W, Kraft P, Li D, Chanock S, Obazee O, Petersen GM, Amundadottir LT. Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer. Nat Commun. 2018 Feb 8;9:556

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English version

Career/Academic Appointments:

– June 2017-present: Associate Professor of Gastroenterology, Università Vita Salute San Raffaele, Milan, Italy

– July 2015-present: Head of the Gastrointestinal Personalized Medicine (Gastro Per Me) program for Hereditary Gastrointestinal Syndromes. This is a multidisciplinary program to evaluate predisposition to hereditary GI cancer syndromes. The team includes gastroenterologists, geneticists, gastrointestinal and pancreatic surgeons, gynecologists, urologists, medical oncologists, and pathologists.

– From March 2013 to June 2017: Assistant Professor of Gastroenterology, Università Vita Salute San Raffaele, Milan, Italy

– From 17/01/2011 to 16/01/2013 Visiting Professor at  Gastroenterology and Digestive Endoscopy Unit, Università Vita Salute San Raffaele, Milan.

– From 2011 to 2017: Head of the Biobank of gastroenterological neoplastic and inflammatory diseases, Università Vita Salute San Raffaele, IRCCS Ospedale San Raffaele, Milan.

– From 31/012/2002 to 16/01/2011: Assistant professor of Gastroenterology, University of Parma, Italy, School of Medicine, Department of Clinical Science, Section of Gastroenterology and Hepatology.

– From 2002 to March 2013: Head of the Molecular Research laboratory for the study of genetics of gastrointestinal diseases, University of Parma, Italy, School of Medicine, Department of Clinical Science, Section of Gastroenterology and Hepatology.

– 2001-2005 Ph.D. “Pathophysiology of Gastrointestinal and Liver diseases” University of Parma, School of Medicine

– 1997-2001 Residency and fellowship in Gastroenterology at the University of Parma.

– 1995-1997: Basic research fellowship using molecular biology methodologies in the study of bile secretion. Yale University, School of Medicine, Section of Digestive Diseases, Department of Internal Medicine, New Haven, CT, USA.

– 1992–1996 Internship (Research) Laboratory of Hepatology University of Padova

 

International Collaborations:

– Tufts University, Frank C. Doble Professor of Engineering Department of Biomedical Engineering, Department of Physics, Dept. of Electrical Engineering, Science and Technology Center of Engineering, Silklab, Medford

– Pan-European Working Group. Progetto: Genetic Risk contribution to Alcoholic chronic Pancreatitis, Pan-European Working Group

– PANcreatic Disease ReseArch (PANDoRA) consortium

– Boston University School of Medicine and Boston Medical Center, Gastroenterology Unit, U.S.A.

– Pädiatrische Ernährungsmedizin, Technische Universität München (Heiko Witt)

– Department of Gastroenterology and Hepatology, University of Leipzig, Leipzig, Germany

– Genomic Epidemiology Group German Cancer Research Center, Heidelberg, Germany

– Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-v.-Guericke-University, Magdeburg

 

Peer Review Groups/Grant Study Sections:

– From 2015 to present: Responsible for building long term relationships with individuals, organisations, companies, and local authorities and taking responsibility for raising funds for Gastrointestinal Personalized Medicine annual gala dinner, that covered 90 percent of the annual budget.

Participation in Finalized Health Research Projects (Ministries of Health’s funding):

– 2004-2006 (Biennial): “Innovative Strategies for Early Diagnosis, Follow-up and Cancer Therapy of the Esophagus and Cardias”.

– 2004-2005: Role of Keratine 8 gene mutations and TNF-α gene polymer in genetic predisposition to chronic intestinal inflammatory diseases.

– 2003-2004: Metabolism of proton gastric pump inhibitors and CYP2C19 enzyme polymorphism

– 2001-2002: “Factors of genetic susceptibility in the pathogenesis of chronic pancreatitis”.

– 2000-2001: “Idiopathic chronic pancreatitis and association with specific HLA antigens (A, B, DR1) with TNFα -308 polymorphism”.

– 1999-2000: “Primitive Sclerosing Colangitis and Association with TNFα -308 Polymorphism”.

– 2000-2002 (Biennial): Cell death, death and proliferation of biliary epithelium in human and experimental cholestasis.

– Participation in national inter-university research projects (Ministry of Education’s funding):

– 1998-2000 (Biennial): Cholestasis in humans and experimental models. Cellular and molecular biology of biliary secretion and its alterations as a cause of liver damage and progression of disease.

– 1998-1999: “Primitive Sclerosing Colangitis: pathogenetic role of gene mutations for cystic fibrosis”.

 

Current Teaching Activities (From 2011 to date)

– Associate Professor of Gastroenterology at the Italian M.D. Program, Università Vita Salute San Raffaele, Milan

– Associate Professor of Gastroenterology at the International M.D. Program, Università Vita Salute San Raffaele, Milan

– Associate Professor of Gastroenterology at the Dental School, Università Vita Salute San Raffaele, Milan

– Associate Professor of Gastroenterology at the Bachelor’s degree in Dental Hygiene, Dental School, Università Vita Salute San Raffaele, Milan


Past Teaching Activities (From 2002 to 2011)

From 2002 to 2001 Lecturer of Diseases of the Digestive and Endocrine Systems, M.D. and PhD programs at the University of Parma, School of Medicine


Current Clinical Activities

–  Diagnostic and operative endoscopy of the upper (1000 procedures/year) and lower digestive tract (1000 procedures/year)

– Head of the program for the study, screening, prevention and surveillance of hereditary gastrointestinal cancers


Education and training

– 2001-2005: Ph.D. “Pathophysiology of Gastrointestinal and Liver diseases” University of Parma, School of Medicine

– 1996-2000: Residency and Clinical Training in Gastroenterology at the University of Parma. Thesis: “Association Study of HLA, Tumor Necrosis Factor α (TNF), Transporters Associated with antigen Processing (TAP) and CFTR in the physiopathology of primary sclerosing cholangitis (PSC) ”

– 1991-1996: M.D degree, University of Padova, School of Medicine. Thesis: “Experimental evidence of a rat Na+/H+ exchanger in the basolateral and apical plasma membranes of biliary epithelial cells.”

– 1995-1997: Basic research fellowship using molecular biology methodologies in the study of bile secretion. Yale University, School of Medicine, Section of Digestive Diseases, Department of Internal Medicine, New Haven, CT, USA.


Professional Honors & Recognition

– 2016: DDW Grant Award for the communication:” Variations of Oral and Fecal Microbiota Are Associated With Autoimmune Pancreatitis”

– 2006: UEGW Grant award for the communication: “Connections between genetics and clinical data in the setting of acute, acute recurrent, and chronic pancreatitis”.

– 2004: UEGW Grant award for “Keratin 8 mutations in patients with chronic pancreatitis”.

– 2000: SIGE Grant award for the communication VI Congresso della Federazione Nazionale delle Malattie Digestive premio per lo studio: “Il contributo dei geni della regione MHC delle mutazioni del CFTR nella predisposizione genetica alla colangite sclerosante primitiva”.- 2006: American Pancreatic Association Grant award “Connections between genetics and clinical data in the setting of acute, acute recurrent, and chronic pancreatitis”.

 

Professional Service for Scientific Organizations:

– 2014-present: Member of the Scientific committee for the Società Italiana di GastroEnterologia (SIGE)

– 2016-present: Member of the Scientific committee for the Federazione Italiana Malattie Digestive (FISMAD)

Citations: 2700 total citations

h-index: 25

Il titolare del presente curriculum vitae, pubblicato online sul portale www.unisr.it, è garante in via esclusiva della correttezza e della veridicità dei dati e delle informazioni in esso riportate e del loro eventuale e puntuale aggiornamento. Egli è dunque il diretto ed unico responsabile dei contenuti indicati nei propri curricula.