Colecchia Maurizio Professore AssociatoMedicinaMED/08

Istruzione

1983 Laurea in Medicina e Chirurgia, Università di Napoli Federico IIo

1987 Specializzazione in Anatomia Patologica, Università di Napoli Federico IIo

1992 Specializzazione in Neuropatologia, Università di Milano

 

Attività clinica, di insegnamento  e di ricerca

1989 Aiuto, Servizio di Anatomia Patologica, Ospedale Maggiore di Lodi

1994 Responsabile Unità Citologia Diagnostica, Ospedale Maggiore di Lodi

2005 Direttore S.C. Anatomia Patologica, Ospedale Maggiore di Lodi

1990-2002  Professore, Diploma Universitario in Scienze Infermieristiche, Università di Pavia

2004-2010 Professore a Contratto, Scuola di Specialità in Anatomia Patologica, Università dell’ Insubria

2006 -2020 Patologo , Responsabile SS Diagnostica uropatologica e Diagnostica istopatologica dei Tumori dell’adulto (2013-2020) , IRCCS Istituto Nazionale dei Tumori di Milano

2021- Professore Associato di Patologia, Università Vita – Salute San Raffaele , IRCCS San Raffaele

La sua ricerca è focalizzata a temi di patologia applicata in stretta collaborazione con i clinici fondandosi su un appropriato supporto epidemiologico, non trascurando la diagnostica tradizionale e la moderna caratterizzazione delle patologie con lo sviluppo di progetti di ricerca traslazionale su argomenti quali la sorveglianza attiva nei carcinomi della prostata basso rischio di progressione, la validazione funzionale microRna nel carcinoma prostatico, la valutazione di markers predittivi di risposta alla chemioterapia ed alla immunoterapia nelle neoplasie dell’ apparato urogenitale. Ha analizzato e refertato più di 20000 casi bioptici e campioni chirurgici di neoplasie dell’ apparato urogenitale, la maggior parte relativi a patologia prostatica e testicolare, con particolare interesse alle neoplasie rare del testicolo.  Ha svolto periodi di frequenza e studio presso centri ospedalieri ed universitari (Royal Hallamshire Hospital in Sheffield, United Kingdom, the Johns Hopkins Hospital, Baltimore, USA, Champalimaud Clinical Center, Lisbon, Portugal).

Coautore della Classificazione dei Tumori del Tratto Genitourinario della Organizzazione Mondiale della Sanità (WHO,  quinta edizione, 2021). Coautore delle linee guida AIOM relative alle neoplasie del rene, della prostata e del testicolo.

 

Società Scientifiche di appartenenza

European Society of Pathology (ESP)

Chair European Association of Urology (EAU)- (European Society of Uropathology) ESUP(2021-)

Chair Uropathology Working Group -Società Europea di Patologia (2021-)

Genitourinary Society of Pathology (GUPS) Companion Society of the U.S. and Canadian Academy of Pathology –Membro Educational Board Genitourinary Society of Pathology (GUPS)

International Society of Uropathology (ISUP)

Coordinatore Gruppo Italiano di Uropatologia Società Italiana di Patologia (SIAPEC) (2007-2021)

Siapec -Membro Comitato Scientifico (2018-)

Italian Germ cell Group (IGG)(2011- )

Reviewer per : Human Pathology, Virchows Archiv, Histopathology,  Analytical Quantitative Cytology and Histology, Cancer Letters,  Journal of Oncology, Journal of Urology, European Urology Focus, Intern J Biomarkers, Pathologica, Tumori, International Journal Urology and Nephrology, International Journal of Molecular Sciences.

Membro dell’ Editorial Board di Pathologica.

Invited membership in expert panel

2014 Expert Member Consensus Conference on grade grouping of prostate carcinoma

2018 Expert Member ERQCC working group on prostate carcinoma

2018 Expert Member Consensus on Active Surveillance in low risk prostate carcinoma (EAU-ESTRO)

2018 Member of Collaboration on Cancer Reporting (ICCR) Penile carcinoma

2019 Member of expert panel for Grade recommendation in Prostate Cancer (on behalf of GUPS)

Attività Scientifica

Relatore su invito a più di 200 Congressi internazionali e nazionali. L’attività scientifica è documentata da più di 150 pubblicazioni su riviste di rilievo internazionale dotate di comitato di revisione alla pari presenti nelle banche dati Pub Med, Scopus, Web of Science e 20 capitoli su libri di Uropatologia ed oncologia. Editore di “Pathology of Testicular and Penile neoplasms” (Springer, Basel, 2016).

ORCID ID: 0000-0003-1914-0743

SCOPUS Author ID:7003513744

Researcher ID: c-2745-0743. 

Google scholar: scholar.google.it/citations?userCNqR84MAAAAJ&hl=it

 

22 giugno 2021

PUBBLICAZIONI ULTIMI DUE ANNI (2019-21)

1: Necchi A, Martini A, Raggi D, Cucchiara V, Colecchia M, Lucianò R, Villa L,

Mazzone E, Basile G, Scuderi S, Pederzoli F, Bandini M, Barletta F, Larcher A,

Capitanio U, Salonia A, Briganti A, Ross JS, Messina A, Montorsi F. A

feasibility study of preoperative pembrolizumab before radical

nephroureterectomy in patients with high-risk, upper tract urothelial carcinoma:

PURE-02. Urol Oncol. 2021 Jun 16:S1078-1439(21)00220-9 PMID: 34147313.

 

2: Gandellini P, Ciniselli CM, Rancati T, Marenghi C, Doldi V, El Bezawy R,

Lecchi M, Claps M, Catanzaro M, Avuzzi B, Campi E, Colecchia M, Badenchini F,

Verderio P, Valdagni R, Zaffaroni N. Prediction of Grade Reclassification of

Prostate Cancer Patients on Active Surveillance through the Combination of a

Three-miRNA Signature and Selected Clinical Variables. Cancers (Basel). 2021 May

18;13(10):2433. PMID: 34069838.

 

3: Nazzani S, Catanzaro M, Biasoni D, Maccauro M, Zaborra C, Stagni S, Torelli

T, Macchi A, Tesone A, Lorenzoni A, Piva L, Lanocita R, Colecchia M, Montanari

E, Salvioni R, Pizzocaro G, Nicolai N. Reply by Authors. J Urol. 2021 May

6:101097JU000000000000177503.Epub ahead of print. PMID: 33955773.

 

4: Nazzani S, Catanzaro M, Biasoni D, Maccauro M, Zaborra C, Stagni S, Torelli

T, Macchi A, Tesone A, Lorenzoni A, Piva L, Lanocita R, Colecchia M, Montanari

E, Salvioni R, Pizzocaro G, Nicolai N. Clinical Outcomes in Clinical N0 Squamous

Cell Carcinoma of the Penis According to Nodal Management: Early, Delayed or

Selective (following Dynamic Sentinel Node Biopsy) Inguinal Lymph-Node

Dissection. J Urol. 2021 Apr 12:101097JU0000000000001775.

Epub ahead of print. PMID: 33843260.

 

5: Marandino L, Capozza A, Bandini M, Raggi D, Farè E, Pederzoli F, Gallina A,

Capitanio U, Bianchi M, Gandaglia G, Fossati N, Colecchia M, Giannatempo P,

Serafini G, Padovano B, Salonia A, Briganti A, Montorsi F, Alessi A, Necchi A.

Incidence and Clinical Impact of Inflammatory Fluorodeoxyglucose Positron

Emission Tomography Uptake After Neoadjuvant Pembrolizumab in Patients with

Organ-confined Bladder Cancer Undergoing Radical Cystectomy. Eur Urol Focus.

2020 Nov 7:S2405-4569(20)30287-X PMID: 33172772.

 

6: Pini GM, Uccella S, Corinti M, Colecchia M, Pelosi G, Patriarca C. Primary

MiNEN of the urinary bladder: an hitherto undescribed entity composed of large

cell neuroendocrine carcinoma and adenocarcinoma with a distinct clinical

behavior : Description of a case and review of the pertinent literature.

Virchows Arch. 2021 Jan 17. doi: 10.1007/s00428-021-03023-7. PMID: 33454836.

 

7: Renne SL, Valeri M, Tosoni A, Bertolotti A, Rossi R, Renne G, Colecchia M.

Myoid gonadal tumor. Case series, systematic review, and Bayesian analysis.

Virchows Arch. 2021 Apr;478(4):727-734. doi: 10.1007/s00428-020-02957-8

Nov 2. PMID: 33140129.

 

8: Marandino L, Raggi D, Calareso G, Alessi A, Colecchia M, Martini A, Briganti

A, Montorsi F, Madison R, Ross JS, Necchi A. Cabozantinib Plus Durvalumab in

Patients With Advanced Urothelial Carcinoma After Platinum Chemotherapy: Safety

and Preliminary Activity of the Open-Label, Single-Arm, Phase 2 ARCADIA Trial.

Clin Genitourin Cancer. 2021 Apr 21:S1558-7673(21)00086-0 PMID: 34006499.

 

9: Marandino L, Capozza A, Bandini M, Raggi D, Farè E, Pederzoli F, Gallina A,

Capitanio U, Bianchi M, Gandaglia G, Fossati N, Colecchia M, Giannatempo P,

Serafini G, Padovano B, Salonia A, Briganti A, Montorsi F, Alessi A, Necchi A.

[18F]Fluoro-Deoxy-Glucose positron emission tomography to evaluate lymph node

involvement in patients with muscle-invasive bladder cancer receiving

neoadjuvant pembrolizumab. Urol Oncol. 2021 Apr;39(4):235.e15-235.e21 PMID: 33071107.

 

10: Raggi D, Bandini M, Giannatempo P, Farè E, Marandino L, Colecchia M,

Calareso G, Padovano B, Serafini G, Alessi A, Necchi A. Prognostic Role of Early

Interim Fluorodeoxyglucose Positron Emission Tomography in Patients With

Advanced Seminoma Undergoing Standard Treatment. Clin Genitourin Cancer. 2020

Aug 13:S1558-7673(20)30197-X PMID: 32980271.

 

11: Giannatempo P, Raggi D, Marandino L, Bandini M, Farè E, Calareso G,

Colecchia M, Gallina A, Ross JS, Alessi A, Briganti A, Montorsi F, Madison R,

Necchi A. Pembrolizumab and nab-paclitaxel as salvage therapy for platinum-

treated, locally advanced or metastatic urothelial carcinoma: interim results of

the open-label, single-arm, phase II PEANUT study. Ann Oncol. 2020

Dec;31(12):1764-1772 PMID: 32979512.

 

12: Bandini M, Gibb EA, Gallina A, Raggi D, Marandino L, Bianchi M, Ross JS,

Colecchia M, Gandaglia G, Fossati N, Pederzoli F, Lucianò R, Colombo R, Salonia

A, Briganti A, Montorsi F, Necchi A. Does the administration of preoperative

pembrolizumab lead to sustained remission post-cystectomy? First survival

outcomes from the PURE-01 study^☆. Ann Oncol. 2020

Dec;31(12):1755-1763. PMID: 32979511.

 

13: Fine SW, Trpkov K, Amin MB, Algaba F, Aron M, Baydar DE, Beltran AL, Brimo

F, Cheville JC, Colecchia M, Comperat E, Costello T, da Cunha IW, Delprado W,

DeMarzo AM, Giannico GA, Gordetsky JB, Guo CC, Hansel DE, Hirsch MS, Huang J,

Humphrey PA, Jimenez RE, Khani F, Kong MX, Kryvenko ON, Kunju LP, Lal P, Latour

M, Lotan T, Maclean F, Magi-Galluzzi C, Mehra R, Menon S, Miyamoto H, Montironi

R, Netto GJ, Nguyen JK, Osunkoya AO, Parwani A, Pavlovich CP, Robinson BD, Rubin

MA, Shah RB, So JS, Takahashi H, Tavora F, Tretiakova MS, True L, Wobker SE,

Yang XJ, Zhou M, Zynger DL, Epstein JI. Practice patterns related to prostate

cancer grading: results of a 2019 Genitourinary Pathology Society clinician

survey. Urol Oncol. 2021 May;39(5):295.e1-295.e8.

PMID: 32948433.

 

14: Colecchia M, Bertolotti A, Paolini B, Giunchi F, Necchi A, Paganoni AM,

Ricci C, Fiorentino M, Dagrada GP. The Leydig cell tumour Scaled Score (LeSS): a

method to distinguish benign from malignant cases, with additional correlation

with MDM2 and CDK4 amplification. Histopathology. 2021 Jan;78(2):290-299.

PMID: 32757426.

 

15: Bandini M, Calareso G, Raggi D, Marandino L, Colecchia M, Gallina A,

Giannatempo P, Pederzoli F, Gandaglia G, Fossati N, Capitanio U, Colombo R,

Salonia A, Briganti A, Montorsi F, De Cobelli F, Messina A, Necchi A. The Value

of Multiparametric Magnetic Resonance Imaging Sequences to Assist in the

Decision Making of Muscle-invasive Bladder Cancer. Eur Urol Oncol. 2020 Jun

27:S2588-9311(20)30082-1. PMID: 32605888.

 

16: Epstein JI, Amin MB, Fine SW, Algaba F, Aron M, Baydar DE, Beltran AL, Brimo

F, Cheville JC, Colecchia M, Comperat E, da Cunha IW, Delprado W, DeMarzo AM,

Giannico GA, Gordetsky JB, Guo CC, Hansel DE, Hirsch MS, Huang J, Humphrey PA,

Jimenez RE, Khani F, Kong Q, Kryvenko ON, Kunju LP, Lal P, Latour M, Lotan T,

Maclean F, Magi-Galluzzi C, Mehra R, Menon S, Miyamoto H, Montironi R, Netto GJ,

Nguyen JK, Osunkoya AO, Parwani A, Robinson BD, Rubin MA, Shah RB, So JS,

Takahashi H, Tavora F, Tretiakova MS, True L, Wobker SE, Yang XJ, Zhou M, Zynger

DL, Trpkov K. The 2019 Genitourinary Pathology Society (GUPS) White Paper on

Contemporary Grading of Prostate Cancer. Arch Pathol Lab Med. 2021 Apr

1;145(4):461-493. PMID: 32589068.

 

17:Bandini M, Ross JS, Raggi D, Gallina A, Colecchia M, Lucianò R, Giannatempo

P, Farè E, Pederzoli F, Bianchi M, Colombo R, Gandaglia G, Fossati N, Marandino

L, Capitanio U, Deho' F, Ali SM, Madison R, Chung JH, Salonia A, Briganti A,

Montorsi F, Necchi A. Predicting the Pathologic Complete Response After

Neoadjuvant Pembrolizumab in Muscle-Invasive Bladder Cancer. J Natl Cancer Inst.

2021 Jan 4;113(1):48-53. PMID: 32516377

 

18: Necchi A, Raggi D, Giannatempo P, Marandino L, Farè E, Gallina A, Colecchia

M, Lucianò R, Salonia A, Gandaglia G, Fossati N, Bandini M, Pederzoli F,

Dittamore R, Liu Y, Davicioni E, Ross JS, de Jong JJ, Briganti A, Montorsi F,

Gibb EA. Can Patients with Muscle-invasive Bladder Cancer and Fibroblast Growth

Factor Receptor-3 Alterations Still Be Considered for Neoadjuvant Pembrolizumab?

A Comprehensive Assessment from the Updated Results of the PURE-01 Study. Eur

Urol Oncol. 2020 May 14:S2588-9311(20)30053-5. PMID: 32417369.

 

19: Necchi A, Raggi D, Gallina A, Ross JS, Farè E, Giannatempo P, Marandino L,

Colecchia M, Lucianò R, Bianchi M, Colombo R, Salonia A, Gandaglia G, Fossati N,

Bandini M, Pederzoli F, Capitanio U, Montorsi F, de Jong JJ, Dittamore R, Liu Y,

Davicioni E, Boormans JL, Briganti A, Black PC, Gibb EA. Impact of Molecular

Subtyping and Immune Infiltration on Pathological Response and Outcome Following

Neoadjuvant Pembrolizumab in Muscle-invasive Bladder Cancer. Eur Urol. 2020

Jun;77(6):701-710. PMID: 32165065.

 

20: Brausi M, Hoskin P, Andritsch E, Banks I, Beishon M, Boyle H, Colecchia M,

Delgado-Bolton R, Höckel M, Leonard K, Lövey J, Maroto P, Mastris K, Medeiros R,

Naredi P, Oyen R, de Reijke T, Selby P, Saarto T, Valdagni R, Costa A, Poortmans

P. ECCO Essential Requirements for Quality Cancer Care: Prostate cancer. Crit

Rev Oncol Hematol. 2020 Apr;148:102861. PMID: 32151466.

 

21: Patriarca C, Colecchia M, Clerici CA. Enrico Sertoli and the supporting

cells of the testis "<i>Morphology is function</i>". Pathologica. 2019

Dec;111(4):375-381 PMID: 31965116.

 

22: Necchi A, Bandini M, Calareso G, Raggi D, Pederzoli F, Farè E, Colecchia M,

Marandino L, Bianchi M, Gallina A, Colombo R, Fossati N, Gandaglia G, Capitanio

U, Dehò F, Giannatempo P, Lucianò R, Salonia A, Madison R, Ali SM, Chung JH,

Ross JS, Briganti A, Montorsi F, De Cobelli F, Messina A. Multiparametric

Magnetic Resonance Imaging as a Noninvasive Assessment of Tumor Response to

Neoadjuvant Pembrolizumab in Muscle-invasive Bladder Cancer: Preliminary

Findings from the PURE-01 Study. Eur Urol. 2020 May;77(5):636-643. PMID: 31882281.

 

23: Gandhi JS, Smith SC, Paner GP, McKenney JK, Sekhri R, Osunkoya AO, Baras AS,

DeMarzo AM, Cheville JC, Jimenez RE, Trpkov K, Colecchia M, Ro JY, Montironi R,

Menon S, Hes O, Williamson SR, Hirsch MS, Netto GJ, Fine SW, Sirohi D, Kaushal

S, Sangoi A, Robinson BD, Kweldam CF, Humphrey PA, Hansel DE, Schultz L, Magi-

Galluzzi C, Przybycin CG, Shah RB, Mehra R, Kunju LP, Aron M, Kryvenko ON, Kench

JG, Kuroda N, Tavora F, van der Kwast T, Grignon DJ, Epstein JI, Reuter VE, Amin

MB. Reporting Practices and Resource Utilization in the Era of Intraductal

Carcinoma of the Prostate: A Survey of Genitourinary Subspecialists. Am J Surg

Pathol. 2020 May;44(5):673-680. PMID: 31876580.

 

24: Necchi A, Raggi D, Gallina A, Madison R, Colecchia M, Lucianò R, Montironi

R, Giannatempo P, Farè E, Pederzoli F, Bandini M, Bianchi M, Colombo R,

Gandaglia G, Fossati N, Marandino L, Capitanio U, Dehò F, Ali SM, Chung JH, Ross

JS, Salonia A, Briganti A, Montorsi F. Updated Results of PURE-01 with

Preliminary Activity of Neoadjuvant Pembrolizumab in Patients with Muscle-

invasive Bladder Carcinoma with Variant Histologies. Eur Urol. 2020

Apr;77(4):439-446. PMID: 31708296.

 

25: Lam TBL, MacLennan S, Willemse PM, Mason MD, Plass K, Shepherd R, Baanders

R, Bangma CH, Bjartell A, Bossi A, Briers E, Briganti A, Buddingh KT, Catto JWF,

Colecchia M, Cox BW, Cumberbatch MG, Davies J, Davis NF, De Santis M, Dell'Oglio

P, Deschamps A, Donaldson JF, Egawa S, Fankhauser CD, Fanti S, Fossati N,

Gandaglia G, Gillessen S, Grivas N, Gross T, Grummet JP, Henry AM, Ingels A,

Irani J, Lardas M, Liew M, Lin DW, Moris L, Omar MI, Pang KH, Paterson CC,

Renard-Penna R, Ribal MJ, Roobol MJ, Rouprêt M, Rouvière O, Sancho Pardo G,

Richenberg J, Schoots IG, Sedelaar JPM, Stricker P, Tilki D, Vahr Lauridsen S,

van den Bergh RCN, Van den Broeck T, van der Kwast TH, van der Poel HG, van

Leenders GJLH, Varma M, Violette PD, Wallis CJD, Wiegel T, Wilkinson K, Zattoni

F, N'Dow JMO, Van Poppel H, Cornford P, Mottet N. EAU-EANM-ESTRO-ESUR-SIOG

Prostate Cancer Guideline Panel Consensus Statements for Deferred Treatment with

Curative Intent for Localised Prostate Cancer from an International

Collaborative Study (DETECTIVE Study). Eur Urol. 2019 Dec;76(6):790-813.

PMID: 31587989.

 

26: Voskuilen CS, Oo HZ, Genitsch V, Smit LA, Vidal A, Meneses M, Necchi A,

Colecchia M, Xylinas E, Fontugne J, Sibony M, Rouprêt M, Lenfant L, Côté JF,

Buser L, Saba K, Furrer MA, van der Heijden MS, Daugaard M, Black PC, van Rhijn

BWG, Hendricksen K, Poyet C, Seiler R. Multicenter Validation of Histopathologic

Tumor Regression Grade After Neoadjuvant Chemotherapy in Muscle-invasive Bladder

Carcinoma. Am J Surg Pathol. 2019 Dec;43(12):1600-1610. PMID: 31524642.

 

27: Pagani F, Colecchia M, Sepe P, Apollonio G, Claps M, Verzoni E, de Braud F,

Procopio G. Collecting ducts carcinoma: An orphan disease. Literature overview

and future perspectives. Cancer Treat Rev. 2019 Sep;79:101891. PMID: 31491662.

 

28: Gandellini P, Casiraghi N, Rancati T, Benelli M, Doldi V, Romanel A,

Colecchia M, Marenghi C, Valdagni R, Demichelis F, Zaffaroni N. Core Biopsies

from Prostate Cancer Patients in Active Surveillance Protocols Harbor PTEN and

MYC Alterations. Eur Urol Oncol. 2019 May;2(3):277-285. PMID: 31200842.

 

29: Elgendy M, Fusco JP, Segura V, Lozano MD, Minucci S, Echeveste JI, Gurpide

A, Andueza M, Melero I, Sanmamed MF, Ruiz MR, Calvo A, Pascual JI, Velis JM,

Miñana B, Valle RD, Pio R, Agorreta J, Abengozar M, Colecchia M, Brich S, Renne

SL, Guruceaga E, Patiño-García A, Perez-Gracia JL. Identification of mutations

associated with acquired resistance to sunitinib in renal cell cancer. Int J

Cancer. 2019 Oct 1;145(7):1991-2001 PMID: 30848481.

 

30: Necchi A, Giannatempo P, Raggi D, Mariani L, Colecchia M, Farè E, Monopoli

F, Calareso G, Ali SM, Ross JS, Chung JH, Salvioni R. An Open-label Randomized

Phase 2 study of Durvalumab Alone or in Combination with Tremelimumab in

Patients with Advanced Germ Cell Tumors (APACHE): Results from the First Planned

Interim Analysis. Eur Urol. 2019 Jan;75(1):201-203. PMID: 30243800.

 

31: Nicolai N, Biasoni D, Catanzaro MA, Colecchia M, Trama A; RARECAREnet

Working Group. Testicular germ-cell tumours and penile squamous cell carcinoma:

Appropriate management makes the difference. Eur J Surg Oncol. 2019

Jan;45(1):60-66. PMID: 29526370.

 

32: Necchi A, Lo Vullo S, Raggi D, Gloghini A, Giannatempo P, Colecchia M,

Mariani L. Prognostic Effect of FGFR Mutations or Gene Fusions in Patients with

Metastatic Urothelial Carcinoma Receiving First-line Platinum-based

Chemotherapy: Results from a Large, Single-institution Cohort. Eur Urol Focus.

2019 Sep;5(5):853-856 PMID:29525380.

 

33: Necchi A, Raggi D, Volpi CC, Giannatempo P, Colecchia M, Gloghini A.

Comparison of Fibroblast Growth-factor Receptor Gene Alterations at the DNA

versus Messenger RNA Level in Advanced Urothelial Cancer: Insights for Clinical

Research. Eur Urol Focus. 2019 Jul;5(4):689-692 PMID: 28855072.