Iannacone Matteo Professore AssociatoMedicinaMed 04
Biografia
Biografia
Breve narrativa
Dopo la laurea in Medicina e Chirurgia presso l'Università degli Studi di Milano, la specializzazione in Medicina Interna e un dottorato di ricerca in Immunologia presso l'Università Vita-Salute San Raffaele di Milano, il Prof. Iannacone ha svolto il suo post-dottorato negli Stati Uniti presso lo Scripps Research Institute di La Jolla e la Harvard Medical School di Boston. Attualmente è Direttore della Divisione di Immunologia, Trapianti e Malattie Infettive, Professore di Patologia e Responsabile del laboratorio di Dinamiche delle Risposte Immunitarie presso l'Istituto Scientifico San Raffaele e l'Università Vita-Salute a Milano. Combinando tecniche di imaging in vivo all’avanguardia e modelli animali avanzati, Matteo ha dato contributi fondamentali alla comprensione della risposta immunitaria e della immunopatologia indotta da virus. Il suo lavoro è stato pubblicato sulle riviste scientifiche più importanti (tra cui Nature, Cell, Science, Immunity, Nature Medicine, Nature Immunology) e detiene 14 brevetti internazionali. È vincitore di numerosi premi internazionali, tra cui l’Armenise-Harvard Foundation Career Development Award, un ERC Starting Grant, il Young Investigator Award dalla European Association for the Study of the Liver, l'EMBO Young Investigator Award, un ERC Consolidator Grant, il Premio Chiara D’Onofrio, due ERC Proof of Concept Grants e un ERC Advanced Grant. È un membro eletto della Henry Kunkel Society e di EMBO, fa parte del comitato editoriale di Science Immunology, Journal of Experimental Medicine, EMBO Journal, European Journal of Immunology, hLife, Virology, Review Commons e Faculty Opinion. Ha pubblicato più di 120 articoli che hanno ricevuto più di 13.000 citazioni con un H-index di 54.
Identificatori univoci del ricercatore
Researcher ID: I-8507-2018
ORCID ID: 0000-0002-9370-2671
Scopus Author ID: 6507012016
Matteo Iannacone - Google Scholar
Educazione
2011 Dottorato di ricerca in Immunologia, Università Vita-Salute San Raffaele, Milano (IT)
2007 European Board Certification in Medicina Interna
2001 Laurea in Medicina e Chirurgia, Università degli Studi di Milano (IT)
Cariche attuali e precedenti
2023 – presente Direttore, Divisione di Immunologia, Trapianti, e Malattie Infettive, San Raffaele Scientific Institute, Milano (IT)
2020 – presente Professore di Patologia, Università Vita-Salute San Raffaele, Milano (IT)
2010 – presente Group Leader, San Raffaele Scientific Institute, Milano (IT)
2007 – 2010 Postdoctoral Fellow, Harvard Medical School, Boston, MA (Advisor: Uli von Andrian)
2002 – 2006 Postdoctoral Fellow, The Scripps Research Institute, La Jolla, CA (Referenti: Luca Guidotti e Frank Chisari)
Attività professionali
Attività di revisione per articoli scientifici: Nature, Science, Cell, Immunity, Nature Immunology, Nature Medicine, Nature Biotechnology, Science Immunology, Journal of Experimental Medicine, Journal of Clinical Investigation, Science Translational Medicine, Proceedings of the National Academy of Sciences, Cell Host & Microbe, Trends in Immunology, Cell Reports, Nature Communications, eLife, PLoS Pathogens, Hepatology, Journal of Hepatology, Gut, Gastroenterology, Journal of Immunology, Journal of Virology, European Journal of Immunology, Heliyon, Mucosal Immunology
Attività di revisione per grants: European Research Council (ERC), UK Medical Research Council (MRC), Wellcome Trust, European Molecular Biology Organization (EMBO), Marie Curie Individual Fellowships, Institut National de la Sante et de la Recherche Medicale (INSERM), Centre National de la Recherche Scientifique (CNRS), French National Research Agency (ANR), La Caixa Foundation, Israel Science Foundation, Austrian Academy of Sciences (ÖAW),Swiss National Science Foundation, Swiss Cancer League, Austrian Science Fund (FWF), Einstein Foundation Berlin, Helmholtz Association, Singapore Agency for Science, Technology & Research (A*STAR), Singapore National Medical Research Council, Canadian Institutes of Health Research, Hellenic Foundation for Research and Innovation.
Board editoriali: Science Immunology (2019 – present), Journal of Experimental Medicine (2023 – present), EMBO Journal (2022 – present; founding member of the Catalysts program), European Journal of Immunology (Executive Committee 2022 – present; Editor-in-chief, 2025 – present), hLife (2023 – present), Genes & Immunity (2023 – present), Virology (2023 – present), Review Commons (2021 – present), Faculty Opinion (2021 – present), Current Opinion in Virology (section editor of Viral Immunity in 2015 and 2022).
Organizzazione di congressi: 1st International Workshop “Imaging the Immune System”, Milan, Italy (2014); International Workshop “Viral Immunity”, Milan (2016); 2nd International Workshop “Imaging the Immune System”, Rehovot, Israel (2016); 1st EMBO Sectoral Meeting on Immunology, Bergamo, Italy (2017); MACS day “T cells”, Milan, Italy (2017); 3rd International Workshop “Imaging the Immune System”, Paris, France (2018); 2nd EMBO Sectoral Meeting on Immunology, Lisbon, Portugal (2018); 1st EMBO Workshop “Pathogen Immunity and Signaling”, Oxford, UK (2019); 3rd EMBO Sectoral Meeting on Immunology, Cambridge, UK (2019); Global Immunotalks (Virtual Conference Series; 2021 – present); 4th International Workshop “Imaging the Immune System” (2021, virtual); 2nd EMBO Workshop “Pathogen Immunity and Signaling”, Saint-Malo, France (2022); 20th EMBO Workshop “Germinal Centers and Immune Niches”, Rehovot, Israel (2022); EMBO Annual Young Investigator Meeting, Milan, Italy (2023); 5th EMBO Workshop “Imaging the Immune System”, Lugano, Switzerland (2023); 20th International Microscopy Congress (Live Imaging of Cells, Tissues and Organisms sessions), Busan, Korea (2023); Gordon Research Conference, Immunochemistry and Immunobiology (2024, Co-Vice Chair); 3rd EMBO Workshop “Pathogen Immunity and Signaling”, San Servolo, Venice, Italy (2024); International HBV Meeting, Chicago, USA (2024); European Congress of Virology, Cavtat/Dubrovnik, Croatia (2025, Scientific Committee Member); Cell Bio 2025 (Annual Meeting of the American Society of Cell Biology), Philadelphia, PA (2025, Program Committee Member); Gordon Research Conference, Immunochemistry and Immunobiology (2026, Co-Chair); Cell Bio 2026 (Annual Meeting of the American Society of Cell Biology), TBD (2026, Program Committee Member).
Scientific Advisory Boards: Department of Immunology, Institut Pasteur (2019); GentiBio (2023 – present)
Commissions of trust: European Research Council (ERC) Panel Member for the LS6 Starting Grants (2021 – present), ATIP-AVENIR Program (LS6 Panel Member 2018 – present; LS6 Panel Chair 2022- present), Swiss National Science Foundation Panel Member (Division Biology and Medicine, 2023 - present), Chair of the Expert Committee at HCERES for the evaluation of INSERM and CNRS units (2022 – present), MED3 Panel Member for the Research Foundation – Flanders (FWO), COVID-19 Animal Models WHO Working Group (2021 – present), Singapore National Medical Research Council (Panel Member 2018 – 2020), Italian Association of Immunologists (SIICA) Executive Committee (2020 – 2021 and 2024 – 2027); Reviewer for the Liver Immunology abstracts at EASL Congress (2023 – 2025), EMBO Installation Grants Committee (2023 – 2027).
Incarichi istituzionali
2023 – presente Director, Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute
2023 – presente Steering Committee, Liver Center, San Raffaele Scientific Institute
2020 – 2022 Committee for Appointment and Promotion, San Raffaele Scientific Institute
2014 – 2020 Immunology Seminar Series Organizing Committee, San Raffaele Scientific Institute
2017 – 2019 Scientific Board, PhD program in Molecular Medicine, Vita-Salute San Raffaele University
2015 – 2020 External Seminar Committee, San Raffaele Scientific Institute
Premi e riconoscimenti
2024 ERC Advanced Grant
2024 “Alessandro Moretta - Ambasciatori della Ricerca” Prize from Il Cenacolo delle Scienze e della Cultura
2023 ERC Proof of Concept Grant
2021 Elected EMBO Member
2020 Elected Member of the Henry Kunkel Society
2020 ERC panel member for Starting Grants LS6 “Immunity, Infection and Immunotherapy”
2020 ERC Proof of Concept Grant
2016 EMBO Young Investigator Award
2015 European Association for the Study of the Liver (EASL) Emerging Leader Award
2011 ERC Starting Grant
2010 Armenise-Harvard Foundation Career Development Award
2008 Armenise-Harvard Foundation Postdoctoral Fellowship
Selected invited lectures (ultimi 5 anni)
2025, Netherlands Cancer Institute (NKI), Amsterdam
2025, Falk Symposium: Experimental Hepatology Days, Lyon, France (keynote)
2025, University College London, UK (hosts: Mala Maini and Claudia Mauri)
2025, Institut Curie, Paris, France (hosts: Ana-Maria Lennon-Dumenil, Sebastian Amigorena and Nicolas Manel)
2024, Program in Immunology, UC San Diego, CA (host: Elina Zuniga)
2024, NOMIS Center for Immunobiology and Microbial Pathogenesis, The Salk Institute, La Jolla, CA (host: Susan Kaech)
2024, Babraham Institute’s Distinguished Lecture Series, Cambridge, UK
2024, Champalimaud Research Symposium, Lisbon, Portugal
2024, Centre d’Immunologie de Marseille-Luminy, Marseille, France (host: Marc Bajenoff)
2024, GSK Global (host: Ennio De Gregorio)
2024, ImmuneOctoberFest, Bridging innovation and translation in T cell immunotherapy, Munich, Germany
2024, Division of Medicine and of Gastroenterology, Perelman School of Medicine, University of Pennsylvania (host: Rebecca G. Wells)
2024, 19th Armenise-Harvard Symposium, “Visualizing biology: from the nano to the macro scale”, Boston, MA
2024, The Ragon Institute of Harvard and MIT, USA (host: Facundo Batista)
2024, Summer School, Helmholtz Centre for Infection Research, Braunschweig, Germany
2024, European Association for the Study of the Liver, ILC2024, Milan, Italy
2024, Stiftung Experimentelle Biomedizin (SEB), Zurich, Switzerland
2024, Bellinzona Institutes of Science (BIOS+), Switzerland
2024, Retreat of the University of Geneva (Pathology and Immunology Department), Annecy, France (keynote)
2024, 6th International Conference of Translational Immunology, Monopoli, Italy
2024, PhD Retreat of the Italian Association of Immunologists (SIICA), Otranto, Italy
2024, ENII Summer School of Advanced Immunology, Alghero, Italy
2024, Center for Applied Medical Research, Pamplona, Spain
2024, Keystone Symposium on Myeloid Targeting Strategies, Killarney, Ireland
2024, Annual Retreat of the San Raffaele Scientific Institute, Baveno, Italy
2024, University of Rijeka, Croatia (host: Stipan Joniic)
2024, EMBO PhD Course, Heidelberg, Germany
2024, Beyond Science Initiative, 9th Annual International Conference (keynote)
2024, Istituto Nazionale di Genetica Molecolare (INGM), Milan (host: Sergio Abrignani)
2024, SIICA Advanced School of Immunology
2024, 4th Midwinter Conference, Seefeld, Austria
2023, 18th International Congress of Immunology, Cape Town, South Africa
2023, Karolinska Institutet, Stockholm, Sweden (host: Carmen Gerlach)
2023, 10th European Seminars in Virology (EUSEV), Bertinoro, Italy (keynote)
2023, 8th PhD Conference in Immunology, Czechia (keynote speaker)
2023, International HBV Meeting, Kobe, Japan
2023, The Catholic University of Korea, Seoul, Korea (host: In-Beom Kim)
2023, IMMOX23 – Immunology across time and space, Oxford, UK
2023, EMBO Workshop “Imaging the Immune System”, Lugano, Switzerland
2023, European Association for the study of the Liver (EASL) Congress 2023, Vienna, Austria
2023, Keystone Symposium on B cell biology in the context of infectious diseases, autoimmunity and B cell cancers, Keystone, CO (declined for conflicting schedule)
2023, Division of Medicine and of Gastroenterology, Perelman School of Medicine, University of Pennsylvania (host: Rebecca G. Wells)
2023, 8th European Congress of Virology, Gdańsk, Poland
2023, AASLD HBV Special Interest Group Webinar on “Immune Tolerance in Chronic Hepatitis B: Mechanisms, Management and Controversies”
2023, Department of Immunology, Institut Pasteur, Paris, France (host: Pierre Bruhns)
2023, Symposium in Immunothrombosis, Munich, Germany
2023, Multimodal imaging in life sciences and cancer research, Lausanne, Switzerland
2022, Dutch Society for Immunology Annual Meeting, Leeuwenhorst (keynote)
2022, Cluster Science Days 2022 Bonn, Germany (keynote)
2022, FEBS-IUBMBM-ENABLE conference (The perfect tandem: how technology expands the frontiers of biomedicine), Sevilla, Spain (keynote)
2022, 9th European Seminars in Virology (EUSEV), Bertinoro, Italy (keynote)
2022, 6th IAAASS Innovative Approaches for Identification of Antiviral Agents, Pula (CA, Sardinia, Italy
2022, CRC 841 Symposium “Tissue inflammation”, Hamburg, Germany
2022, Immune OctoberFest, Bridging innovation and translation in T cell immunotherapy, Munich, Germany
2022, EMBO Workshop on Germinal Centers and Immune Niches (GCC 2022), Weizmann Institute of Science, Rehovot, Israel
2022, 1st Summer Symposium Systems Immunology “Network across scales”, Wurzburg, Germany
2022, 9th ANRS HBV Cure Workshop, Lyon, France
2022, Gordon Research Conference on Immunochemistry and Immunobiology, Spain
2022, EMBL in Italy 2022: Emerging approaches in human health and infectious diseases, GSK Vaccines, Siena, Italy
2022, XIII meeting of the Italian Society of Immunology (SIICA), Naples, Italy
2022, Vir Biotechnology, Bellinzona, Switzerland (host: Davide Corti)
2022, Ludwig Cancer Distinguished Seminar Series, Lausanne (host: Ping-Chih Ho)
2022, Distinguished Seminar Series, The Jackson Laboratory for Genomic Medicine, Farmington, CT
2022, Princeton University, USA (host: Alex Ploss)
2022, Portuguese Society of Immunology (SPI) annual meeting, Lisbon, Portugal
2022, King’s College, London, UK (host: Alberto Sanchez-Fueyo)
2022, Scottish Immunology Groups Network, Perth, Scotland (keynote lecture)
2022, European School of Molecular Medicine, Milan, Italy
2021, University of Salzburg, Austria (host: Iris Gratz)
2021, Argentinean Society of Immunology, Cordoba, Argentina (keynote lecture)
2021, University of Milan, Italy (PhD invited lecture)
2021, University of Massachusetts Medical School (host: Andrea Reboldi)
2021, International HBV Meeting, Toronto, Canada (keynote lecture)
2021, Austrian Association of the Molecular Life Sciences and Biotechnology annual meeting, Innsbruck, Tyrol, Austria
2021, 5th Innovative Approaches for Identification of Antiviral Agents Summer School (IAAASS), Cagliari, Italy
2021, Swiss Society for Allergology and Immunology, Zurich, Switzerland
2021, French Germinal Center Symposium, Paris (keynote lecture)
2021, Oxford Imaging Symposium, UK (host: Michael Dustin)
2021, Immunology Seminar Series, Harvard Medical School, Boston, MA
2021, Global Immunotalk (hosts: Carla Rothlin and Elina Zuniga)
2021, University of Fribourg, Switzerland (host: Jens Stein)
2021, T cell connect Europe, Immunology lecture series
2020, Ludwig-Maximilians University, Munich, Germany (PhD invited lecture)
2020, Kantonsspital, St. Gallen, Switzerland (host: Burkhard Ludewig)
2020, Louis Jeantet Symposium, Geneva, Switzerland
2020, Cambridge Immunology Network, UK (host: Menna Clatworthy)
2020, Advanced School of Immunology, Italian Association of Immunologists (SIICA)
2020, ANRS “Basic and Translation Research on Hepatitis Viruses”, Paris (keynote)
2020, Keystone Symposium on Tissue Immunity, Boulder, CO
2019, Institut Curie, Paris, France (host: Nicolas Manel)
2019, The Convergence of Hematology and Immunology (CHI), Tianjin, China
2019, Armenise-Harvard Lecture, Harvard Medical School, Boston
2019, Icahn School of Medicine at Mount Sinai, NYC (hosts: Brian Brown, Miriam Merad)
2019, Tri-Institutional Seminar, New York City (hosts: Andrea Schietinger, Gabriel Victora)
2019, International Congress of Immunology, Beijing
2019, Peter Doherty Institute, Melbourne (host: Scott Mueller)
2019, Joint German-Italian Immunological Society meeting, Munich
2019, Swiss Society of Allergology and Immunology meeting, Lugano, Switzerland
2019, EMBO Young Scientist Forum, Prague, Czech Republic
2019, Immune Cell Responses Unfolded by Single Cell Technologies, Karolinska Institute
2019, TRON, Mainz, Germany (host: Ugur Sahin)
2019, Tissue Immunity Symposium with a Focus on T cells, Lisbon, Portugal
2019, CeMM, Vienna, Austria (host: Sylvia Knapp)
2019, EASL International Liver Congress, Vienna, Austria
2019, EMBO Gold Medalists Meeting, Singapore
2019, Department of Pathology, UCSF (host: Max Krummel)
2019, Gilead Sciences, Foster City, CA (host: Sarah Gilmore)
2019, Stanford University, CA (host: Maria Grazia Roncarolo)
2019, IRBM Science Park, Roma (host: Carlo Toniatti)
2019, Harald von Boehmer Midwinter Conference, Seefeld, Austria
2018, Cumming School of Medicine, University of Calgary, Canada (host: Paul Kubes)
2018, Translational Approaches to Inflammatory Liver Injury and Repair, Banff, Canada
2018, World Congress on Microcirculation, Vancouver, Canada
2018, 5th European Congress of Immunology, Amsterdam
2018, SIICA Advanced School in Immunology, Messina, Italy
2018, European Institute of Oncology, Milan, Italy (host: Luigi Nezi)
2018, Oxford University, UK (host: Jan Rehwinkel)
2018, Cambridge University, UK (host: Milka Sarris)
2018, 44th Portuguese Society for Immunology Meeting, Lisbon, Portugal
2018, Gordon Research Conference on Immunochemistry and Immunobiology, VT
2018, Gordon Research Conference on Chemotactic Cytokines, Newry, ME
2018, TRR179 Symposium on Viral hepatitis and strategies of persistence, Heidelberg
2018, DKFZ, Heidelberg (host: Hellmut Augustin)
2018, 33rd Congress of the International Society for Advancement of Cytometry, Prague
2018, The Crick Institute, London, UK (host: Caetano Reis e Sousa)
2018, William Harvey Research Institute, London UK (host: Sussan Nourshargh)
2018, University of Bern, Switzerland (host: Jens Stein)
2018, University of Perugia, Italy (host: Francesca Fallarino)
2018, Falk Foundation Workshop ‘Liver-Gut-Microbiome Interactions’, Hamburg, Germany
2018, 27th Cytomeet (Keynote Lecture), Bern, Switzerland
2018, Institute for Immunology, Munich, Germany (host: Thomas Brocker)
Brevetti
- Iannacone M, Alexis F, Basto P, Moseman EA, Shi J, Langer RS, Farokhzad OC, von Andrian UH, Tonti E. Immunonanotherapeutics that Provide IgG Humoral Response without T-Cell Antigen, United States Patent 8,906,381 – licensed to Selecta Biosciences
- Shi J, Alexis F, Iannacone M, Moseman EA, Basto P, Langer RS, Farokhzad OC, von Andrian UH, Tonti E. Targeting of Antigen Presenting Cells with Immunonanotherapeutics, United States Patent 9,308,280 – licensed to Selecta Biosciences
- Alexis F, Iannacone M, Shi J, Basto P, Moseman EA, von Andrian UH, Langer RS, Farokhzad OC, Tonti E. Adjuvant Incorporation in Immunonanotherapeutics, United States Patent 9,439,859 – licensed to Selecta Biosciences
- Iannacone M, von Andrian UH, Farokhzad OC, Frank A, Basto P, Shi J, Moseman EA, Langer RS, Tonti E. Nicotine Immunonanotherapeutics, United States Patent 8,932,595 – licensed to Selecta Biosciences
- Von Andrian UH, Farokhzad OC, Langer RS, Tobias J, Moseman EA, Zhang L, Basto P, Iannacone M, Alexis F. Vaccine Nanotechnology, United States Patent 9,539,210 – licensed to Selecta Biosciences
- Von Andrian UH, Iannacone M, Tonti E, Moseman EA. Vaccines Comprising Bisphosphonates and Methods of Use Thereof, United States Patent 10,188,733
- Summa V, Di Fabio R, Bencheva L, De Matteo M, Ferrante L, Prandi A, Randazzo P, Donnici L, De Francesco R, Iannacone M, Guidotti LG. Inhibitors of Hepatitis B Virus, WO2020/016427
- Summa V, Di Fabio R, Bencheva L, De Matteo M, Ferrante L, Prandi A, Randazzo P, Donnici L, De Francesco R, Iannacone M, Guidotti LG. Cyclic Inhibitors of Hepatitis B Virus, WO2020/016434 – sold to Antios Therapeutics
- Summa V, Di Fabio R, Bencheva L, De Matteo M, Ferrante L, Prandi A, Randazzo P, Gornati D, Grillo A, Ferrara M, Donnici L, De Francesco R, Iannacone M, Guidotti LG. Tricyclic Inhibitors of Hepatitis B Virus (I), WO2020/030781 – sold to Antios Therapeutics
- De Francesco R, Donnici L, Guidotti LG, Iannacone M, Bencheva LI, De Matteo M, Ferrante L, Prandi A, Randazzo P, Gornati D, Grillo A, Di Fabio R, Summa V. Oxalamido-substituted Tricyclic Inhibitors of Hepatitis B Virus (I), WO2020/234483
- Iannacone M, Guidotti LG, Naldini L, Cantore A, Ostuni R. Agents and methods for treating viral infections, PCT/EP2020/064933
- Summa V, Di Fabio R, Bencheva L, De Matteo M, Ferrante L, Prandi A, Randazzo P, Gornati D, Grillo A, Ferrara M, Donnici L, De Francesco R, Iannacone M, Guidotti LG. Tricyclic Inhibitors of Hepatitis B Virus. WO2020/030781
- Summa V, Di Fabio R, Bencheva L, De Matteo M, Ferrante L, Prandi A, Randazzo P, Gornati D, Grillo A, Ferrara M, Donnici L, De Francesco R, Iannacone M, Guidotti LG. Spirocyclic inhibitors of hepatitis B virus. WO2021/160617
- Iannacone M, Guidotti LG. Agents and methods for increasing liver immune response. UK Patent Application 2018657.3
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