Iannacone Matteo Professore AssociatoMedicineMed 04




Short narrative

Matteo Iannacone obtained a M.D. degree from the University of Milan, Italy, followed by a residency in Internal Medicine and a Ph.D. in Immunology from Vita-Salute San Raffaele University in Milan, Italy. He trained as a postdoctoral fellow at The Scripps Research Institute, La Jolla, CA and at Harvard Medical School, Boston, MA. Since 2010, he directs the Dynamics of Immune Responses Laboratory at the San Raffaele Scientific Institute in Milan, Italy. By combining cutting-edge in vivo imaging techniques and advanced animal models, Matteo has made fundamental contributions to our understanding of the immune response and viral-induced immunopathology. His work has been published in the most important scientific journals (including Nature, Cell, Science, Immunity, Nature Medicine) and he holds 11 international patents. He has received numerous awards for his work, including the Armenise-Harvard Foundation Career Development Award, an ERC Starting Grant, the Young Investigator Award from the European Association for the Study of the Liver, the EMBO Young Investigator Award, an ERC Consolidator Grant, an ERC Proof of Concept and the Chiara D’Onofrio Award. As of November 2020, his work has received more than 6000 citations with an H-index of 37.

Iannacone Lab Website: www.iannaconelab.com

Unique identifiers

ORCID ID: 0000-0002-9370-2671

Scopus Author ID: 6507012016

Researcher ID: I-8507-2018

Google Scholar: http://tiny.cc/4pibcz


2011    Ph.D. in Immunology, Vita-Salute San Raffaele University, Milan (IT)

2007    European Board Certification in Internal Medicine

2001    M.D. degree, University of Milan (IT)

Positions and Training

2015 – present             Head of Research Unit, San Raffaele Scientific Institute, Milan (IT)

2010 – 2015                Group Leader, San Raffaele Scientific Institute, Milan (IT)

2007 – 2010                Postdoctoral Fellow, Harvard Medical School, Boston, MA (Advisor: Uli von Andrian)

2002 – 2006                Postdoctoral Fellow, The Scripps Research Institute, La Jolla, CA (Advisors: Luca Guidotti and Frank Chisari)

Honors and Awards

2020    ERC panel member for Starting Grants LS6 “Immunity, Infection and Immunotherapy”

2020    ERC Proof of Concept Grant

2019    Member of the Top Italian Scientists (www.topitalianscientists.org)

2017    Chiara D’Onofrio Award

2016    ERC Consolidator Grant

2016    EMBO Young Investigator Award

2015    European Association for the Study of the Liver (EASL) Young Investigator Award

2011    ERC Starting Grant

2010    Armenise-Harvard Foundation Career Development Award

2008    Armenise-Harvard Foundation Postdoctoral Fellowship

Professional Activities

Journal Reviewer: Nature, Science, Cell, Immunity, Nature Immunology, Nature Medicine, Science Immunology, Journal of Experimental Medicine, Journal of Clinical Investigation, Science Translational Medicine, Proceedings of the National Academy of Sciences, Cell Host & Microbe, Trends in Immunology, Cell Reports, Nature Communications, eLife, PLoS Pathogens, Hepatology, Journal of Hepatology, Gut, Gastroenterology, Journal of Immunology, Journal of Virology, European Journal of Immunology

Grant Reviewer: European Research Council (ERC), UK Medical Research Council (MRC), European Molecular Biology Organization (EMBO), Marie Curie Individual Fellowships, Institut National de la Sante et de la Recherche Medicale (INSERM), Centre National de la Recherche Scientifique (CNRS), French National Research Agency (ANR), Israel Science Foundation, Swiss National Science Foundation, Swiss Cancer League, Austrian Science Fund (FWF), Einstein Foundation Berlin, Helmholtz Association, Singapore Agency for Science, Technology & Research (A*STAR), Singapore National Medical Research Council, Canadian Institutes of Health Research, Hellenic Foundation for Research and Innovation.

Editorial Board: Science Immunology, Current Opinion in Virology (Section Editor of Viral Immunology), Review Commons

Conference Organization: 1st International Workshop “Imaging the Immune System”, Milan, Italy (2014); International Workshop “Viral Immunity”, Milan (2016); 2nd International Workshop “Imaging the Immune System”, Rehovot, Israel (2016); 1st EMBO Sectoral Meeting on Immunology, Bergamo, Italy (2017); MACS day “T cells”, Milan, Italy (2017); 3rd International Workshop “Imaging the Immune System”, Paris, France (2018); 2nd EMBO Sectoral Meeting on Immunology, Lisbon, Portugal (2018); 1st EMBO Workshop “Pathogen Immunity and Signaling”, Oxford, UK (2019); 3rd EMBO Sectoral Meeting on Immunology, Cambridge, UK (2019); 1st T cell memory meeting, Stresa, Italy (2020); 20th EMBO Workshop “Germinal Centers and Immune Niches”, Rehovot, Israel (2021); 2nd EMBO Workshop “Pathogen Immunity and Signaling”, Saint-Malo, France (2021); Global Immunotalks (2021 Virtual Conference Series).

Scientific Advisory Board: Department of Immunology, Institut Pasteur (2019)

Commissions of trust: European Research Council (ERC) Panel Member for the LS6 Starting Grants (2021 – present), INSERM Panel Member for the ATIP-AVENIR Program (2018 – present), Singapore National Medical Research Council (Panel Member 2018-2020), Italian Association of Immunologists (SIICA) Executive Committee (2020 – present)

Major administrative and institutional responsibilities

2014 – present            Director, Intravital Imaging Facility, San Raffaele Scientific Institute, Milan, Italy

2014 – 2020    Immunology Seminar Series Organizing Committee, San Raffaele Scientific Institute, Milan, Italy

2015 – 2020    External Seminar Committee, San Raffaele Scientific Institute, Milan, Italy

2020 – present Committee for Appointment and Promotion, San Raffaele Scientific Institute, Milan, Italy

2017 – 2019    Scientific Board, PhD program in Molecular Medicine, Vita-Salute San Raffaele University, Milan, Italy

Teaching experience

2012 – 2020    Adjunct Professor of Pathology and Immunology, Vita-Salute San Raffaele University, Milan, Italy

Consultantship and Advisory Boards

Gilead Sciences, Foster City, CA

Roche, Basel, Switzerland

Third Rock Ventures, Boston, MA

Amgen, Thousand Oaks, CA


Ficht X and Iannacone M✉ (2020) Immune surveillance of the liver by T cells. Science Immunology, 5:eaba2351

Fumagalli V, Di Lucia P, Venzin V, Bono E, Jordan R, Frey C, Delaney W, Chisari FV, Guidotti LG#✉, Iannacone M#✉ (2020) Antibody-mediated clearance of serum HBsAg has minimal impact on CD8+ T cell responses in mouse models of HBV pathogenesis. Journal of Experimental Medicine, 217:e20200298 (#co-last authors)

Stolp B, Thelen F, Ficht X, Altenburger LM, Ruef N, Inavalli VVGK, Germann P, Page N, Moalli F, Raimondi A, Keyser K, Seyed Jafari SM, Barone F, Dettmer MS, Merkler D, Iannacone M, Sharpe J, Schlapbach C, Fackler OT, Nägerl UV, Stein JV (2020) Salivary gland macrophages and tissue-resident CD8+ T cells cooperate for homeostatic organ surveillance. Science Immunology, 5:eaaz4371

De Giovanni M, Cutillo V, Giladi A, Maganuco CG, Medaglia C, Bono E, Di Lucia P, Giustini L, Cristofani C, Pinschewer DD, Kastenmuller W, Amit I, Kuka M#✉, Iannacone M#✉ (2020) Spatiotemporal regulation of type I interferon expression determines antiviral CD4+ T cell polarization. Nature Immunology, 21:321 (#co-last authors)

De Simone G, Mazza EMC, Cassotta A, Davydov A, Kuka M, Zanon V, De Paoli F, Scamardella E, Metsger M, Roberto A, Pilipow K, Colombo FS, Tenedini E, Tagliafico E, Gattinoni L, Mavilio D, Peano C, Price DA, Singh SP, Farber JM, Ferrari F, Orrù V, Fiorillo E, Iannacone M*, Chudakov DM*, Sallusto F*, Lugli E (2019) CXCR3 identifies human naive CD8+ T cells with enhanced effector differentiation potential. Journal of Immunology, 203:3179 (*equal contribution)

Benechet AP*, De Simone G*, Di Lucia P, Cilenti F, Barbiera G, Le Bert N, Moalli F, Lusito E, Fumagalli V, Bianchessi V, Zordan P, Bono E, Giustini L, Bonilla WD, Bleriot C, Kunasegaran K, Gonzalez-Aseguinolaza G, Pinschewer DD, Kennedy PTF, Naldini L, Kuka M, Ginhoux F, Cantore A, Bertoletti A, Ostuni R#, Guidotti LG#, Iannacone M#✉ (2019) Dynamics and genomic landscape of CD8+ T cells undergoing hepatic priming. Nature, 574:200 (*co-first authors; #co-last authors). Awarded with the 2019 Best Publication in Hepatology by the Italian Association for the Study of the Liver.

Milani M, Annoni A, Moalli F, Liu T, Cesana D, Calabria A, Bartolaccini S, Biffi M, Russo F, Visigalli I, Raimondi A, Patarroyo-White S, Drager D, Cristofori P, Ayuso E, Montini E, Nichols TC, Peters R, Iannacone M, Cantore A#, Naldini L# (2019) Phagocytosis-shielded lentiviral vectors allow safe and robust liver gene transfer in non-human primates. Science Translational Medicine, 11:eaav7325 (#co-last authors)

Kuka M, De Giovanni M, Iannacone M✉ (2019) The role of type I interferons in CD4+ T cell differentiation. Immunology Letters, 215:19

Thierry G, Kuka M, De Giovanni M, Mondor I, Brouilly I, Iannacone M#, Bajenoff M# (2018) The conduit system exports locally secreted IgM from lymph nodes. Journal of Experimental Medicine, 215:2972 (#co-last authors)

Pilipow K, Scamardella E, Puccio S, Gautam S, De Paoli F, Mazza EMC, De Simone G, Polletti S, Buccilli M, Zanon V, Di Lucia P, Iannacone M, Gattinoni L, Lugli E (2018) Antioxidant metabolism in activated CD8+ T cells regulates stem-like human memory T cell formation and anti-tumor immunity. JCI Insight, 3:e122299

Moalli F, Ficht X, Germann P, Vladymyrov M, Stolp B, de Vries I, Lyck RV, Balmer J, Fiocchi A, Kreutzfeld M, Merkler D, Iannacone M, Ariga A, Stoffel MH, Sharpe J, Bähler M, Sixt M, Diz-Muñoz A, Stein JV (2018) The Rho regulator Myosin IXb enables non-lymphoid tissue seeding of protective CD8+ T cells. Journal of Experimental Medicine, 215:1869

Volpi VG, Pagani I, Ghezzi S, Iannacone M, D’Antonio M, Vicenzi E (2018) Zika virus replication in dorsal root ganglia explants causes myelin degeneration. Scientific Reports, 8:10166

Jofra T, Di Fonte R, Galvani G, Kuka M, Iannacone M, Battaglia M, Fousteri G (2018) Tr1 cell immunotherapy promotes transplant tolerance via de novo Tr1 cell induction and is safe and effective during acute viral infection in mouse. European Journal of Immunology, 48:1389

Vo HTM, Baudner BC, Sammicheli S, Iannacone M, D’Oro U, Piccioli D (2018) Alum/TLR7 adjuvant enhances the expansion of memory B cell compartment within the draining lymph node. Frontiers in Immunology, 9:641

Kuka M and Iannacone M✉ (2018) Viral subversion of B cell responses within secondary lymphoid organs. Nature Reviews Immunology, 18:255

Sammicheli S, Kuka M, Iannacone M✉ (2018) Intravital imaging of B cell responses in lymph nodes. Methods in Molecular Biology, 1763:63

De Giovanni M and Iannacone M✉ (2018) In vivo imaging of adaptive immune responses to viruses. Current Opinion in Virology, 28:102

Medaglia C*, Giladi A*, Stoler Barak L*, De Giovanni M*, Meir Salame T, Biram A, David E, Iannacone M#✉, Shulman Z#✉, Amit I#✉ (2017) Spatial reconstruction of immune niches by combining photoactivatable fluorescent reporters and single-cell RNA-seq. Science, 358:1622 (*co-first authors; #co-last and co-corresponding authors)

Gaertner F, Ahmad Z, Rosenberg G, Fan S, Nicolai L, Busch B, Yavuz G, Luckner M, Luckner M, Ishikawa-Ankerhold H, Hennel R, Benechet AP, Lorenz M, Chandraratne S, Schubert I, Helmer S, Striednig B, Stark K, Janko M, Bottcher RT, Verschoor A, Leon C, Gachet C, Gudermann T, Mederos y Schnitzler M, Pincus Z, Iannacone M, Hass R, Wanner G, Lauber K, Sixt M, Massberg S (2017) Migrating platelets are mechano-scavengers that collect and bundle bacteria. Cell, 171:1368

Kuka M and Iannacone M✉ (2017) Intestinal flossing keeps pathogens at bay. Developmental Cell, 43:383

Pirzgalska RM*, Seixas E*, Seidman JS, Link VM, Martinez Sanchez N, Mahú I, Mendes R, Gres V, Kubasova N, Morris I, Arús BA, Larabee CM, Vasques M, Tortosa F, Sousa AL, Anandan S, Tranfield E, Hahn MK, Iannacone M, Spann NJ, Glass KC, Domingos AI (2017) Sympathetic associated macrophages clear norepinephrine and sustain obesity. Nature Medicine, 23:1309 (*co-first authors)

Jimenez de Oya N*, De Giovanni M*, Fioravanti J, Ubelhart R, Di Lucia P, Fiocchi A, Iacovelli S, Efremov DG, Caligaris-Cappio F, Jumaa H, Ghia P, Guidotti LG, Iannacone M✉ (2017) Pathogen-specific B cell receptors drive chronic lymphocytic leukemia by light chain-dependent cross-reaction with autoantigens. EMBO Molecular Medicine, 9:1482 (*co-first authors)

Piergiovanni M, Bianchi E, Capitani G, Li Piani I, Ganzer L, Guidotti LG, Iannacone M, Dubini G (2017) Microcirculation in mouse liver lobule: a Computational Fluid Dynamic model based on 3D reconstruction from in vivo microscopy. Journal of Biomechanics, 63:125

Jofra T, Di Fonte R, Kuka M, Mfarrej B, Iannacone M, Battaglia M, Fousteri G. (2017) Protein tyrosine phosphatase PTPN22 dampens T cell immune responses and drives 
viral persistence. Frontiers in Immunology, 8:811

Silvin A, Yu CI, Lahaye X, Imperatore F, Brault JB, Cardinaud S, Becker C, Kwan WH, Conrad C, Maurin M, Goudot C, Marques-Ladeira S, Wang Y, Pascual V, Anguiano E, Albrecht RA, Iannacone M, Garcia-Sastre A, Goud B, Dalod M, Moris A, Merad M, Palucka CA, Manel N (2017) Constitutive resistance to viral infection in human CD141+ dendritic cells. Science Immunology, 2:eaai8071

Fioravanti J, Magini D, Di Lucia P, Boni C, Benechet AP, Inverso D, Fiocchi A, Wieland S, Purcell R, Ferrari C, Chisari FV, Guidotti LG, Iannacone M✉ (2017) Effector CD8+ T cell-derived interleukin-10 enhances liver immunopathology. Journal of Hepatology, 67:543

Castiello MC, Pala F, Sereni L, Draghici E, Inverso D, Sauer AV, Schena F, Fontana E, Radaelli E, Uva P, Cervantes-Luevano KE, Benvenuti F, Poliani PL, Iannacone M, Traggiai E, Villa A, Bosticardo M (2017) In vivo chronic stimulation unveils intrinsic autoreactive potential of Wiskott-Aldrich syndrome protein-deficient B cells. Frontiers in Immunology, 8:490

Brewitz A, Eickhoff S, Dähling S, Quast T, Bedoui S, Kroczek RA, Kurts C, Garbi N, Barchet W, Iannacone M, Klauschen F, Kolanus W, Kaisho T, Colonna M, Germain RN, Kastenmüller W (2017) CD8+ T cells orchestrate pDC–XCR1+ dendritic cell spatial and functional cooperativity to optimize priming. Immunity, 46:205

Benechet AP, Ganzer L, Iannacone M✉ (2017) Intravital microscopy analysis of hepatic T cell dynamics. Methods in Molecular Biology, 1514:49

Benechet AP, Iannacone M✉ (2017) Determinants of hepatic effector CD8+ T cell dynamics. Journal of Hepatology, 66:228

Iannacone M✉ (2016) Platelet-mediated modulation of adaptive immunity. Seminars in Immunology, 28:555

Sammicheli S*, Kuka M*, Di Lucia P, Jimenez de Oya N, De Giovanni M, Fioravanti J, Cristofani C, Maganuco CG, Fallet B, Ganzer L, Sironi L, Mainetti M, Ostuni R, Larimore K, Greenberg PD, de la Torre JC, Guidotti LG, Iannacone M✉ (2016) Inflammatory monocytes hinder antiviral B cell responses. Science Immunology, 1:eaah6789 (*co-first authors)

Iannacone M✉, Chisari FV, Guidotti LG (2016) Protective and Pathogenic T Cell Responses to Virus Infections. Encyclopedia of Immunobiology, 4:318

Catarinella M, Monestiroli A, Escobar G, Fiocchi A, Tran NL, Aiolfi R, Marra P, Esposito A, Cipriani F, Aldrighetti L, Iannacone M, Naldini L, Guidotti LG, Sitia G (2016) IFN gene/cell therapy curbs colorectal cancer colonization of the liver by acting on the hepatic microenvironment. EMBO Molecular Medicine, 8:155

Inverso D, Iannacone M✉ (2016) Spatiotemporal dynamics of effector CD8+ T cell responses within the liver. Journal of Leukocyte Biology, 99:51

Iannacone M✉, Guidotti LG (2016) HBV Immunopathogenesis. In Hepatitis B Virus in Human Diseases, Molecular and Translational Medicine – Book series, Springer, 4:79

Guidotti LG*, Inverso D*, Sironi L, Di Lucia P, Fioravanti J, Fiocchi A, Vacca M, Aiolfi R, Sammicheli S, Mainetti M, Ganzer L, Cataudella T, Raimondi A, Gonzalez-Aseguinolaza G, Protzer U, Ruggeri ZM, Chisari FV, Isogawa M, Sitia G, Iannacone M✉ (2015) Immunosurveillance of the liver by intravascular effector CD8+ T cells. Cell, 161:486 (*co-first authors)

Iannacone M✉, Guidotti LG (2015) Mouse models of HBV pathogenesis. Cold Spring Harbor Perspectives in Medicine, 5:a021477

Iannacone M✉, Guidotti LG (2015). Viral Pathogenesis. Current Opinion in Virology, 11:1 (invited section editor)

Maggioni D, Galli M, D'Alfonso L, Inverso D, Dozzi MV, Iannacone M, Collini M, Ferruti P, Ranucci E, D'Alfonso G (2015) A luminescent Poly(amidoamine)-Iridium complex as a new singlet-oxygen sensitizer for photodynamic therapy. Inorganic Chemistry, 54:544

Iannacone M✉ (2015) Hepatic effector CD8+ T cell dynamics. Cellular and Molecular Immunology, 12:269

Fousteri G, Jofra T, Di Fonte R, Kuka M, Iannacone M, Battaglia M (2014) PTPN22 controls virally-induced autoimmune diabetes by modulating cytotoxic T lymphocyte responses in an epitope-specific manner. Clinical Immunology, 156:98

Sironi L, Bouzin M, Inverso D, D’Alfonso L, Pozzi P, Cotelli F, Guidotti LG, Iannacone M, Collini M, Chirico G (2014) In Vivo Flow Mapping in Complex Vessel Networks by Single Image Correlation. Scientific Reports, 4:7341

Ilyinskii PO, Roy CJ, O’Neil CP, Browning EA, Pittet LA, Altreuter DH, Alexis F, Tonti E, Shi J, Basto PA, Iannacone M, Radovic-Moreno AF, Langer RS, Farokhzad OC, von Andrian UH, Johnston LP, Kishimoto TK (2014) Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release. Vaccine, 32:2882

Kuka M, Iannacone M✉ (2014) The role of lymph node sinus macrophages in host defense. Ann N Y Acad Sci, 1319:38

Tonti E, Jimenez de Oya N, Galliverti G, Moseman EA, Di Lucia P, Amabile A, Sammicheli S, De Giovanni M, Sironi L, Chevrier N, Sitia G, Gennari L, Guidotti LG, von Andrian UH, Iannacone M✉ (2013) Bisphosphonates target B cells to enhance humoral immune responses. Cell Reports, 5:323

Henrickson SE, Perro M, Loughhead SM, Senman B, Stutte S, Quigley M, Alexe G, Iannacone M, Flynn MP, Omid S, Jesneck JL, Imam S, Mempel TR, Mazo IB, Haining WN, von Andrian UH (2013) Antigen availability determines CD8+ T cell-dendritic cell interaction kinetics and effector/memory fate decisions. Immunity, 39:496

Sitia G, Iannacone M, Guidotti LG (2013) Antiplatelet therapy in the prevention of hepatitis B virus-associated hepatocellular carcinoma. Journal of Hepatology, 59:1135

Guidotti LG, Iannacone M✉ (2013) Effector CD8 T cell trafficking within the liver. Molecular Immunology, 55:94

Sung JH, Zhang H, Moseman EA, Alvarez D, Iannacone M, Henrickson SE, de la Torre JC, Luster AD, von Andrian UH (2012) Chemokine guidance of central memory T cells is critical for anti-viral recall responses in lymph nodes. Cell, 150:1249

Sitia G, Aiolfi R, Di Lucia P, Mainetti M, Fiocchi A, Mingozzi F, Esposito A, Ruggeri ZM, Chisari FV, Iannacone M, Guidotti LG (2012) Antiplatelet therapy prevents hepatocellular carcinoma and improves survival in a mouse model of chronic hepatitis B. PNAS, 109:E2165

Moseman EA*, Iannacone M*✉, Bosurgi L, Tonti E, Chevrier N, Tumanov A, Fu Y-X, Hacohen N, von Andrian UH✉ (2012) B cell maintenance of subcapsular sinus macrophages protects against a fatal viral infection independent of adaptive immunity. Immunity, 36:415 (*co-first authors)

Tonti E, Fedeli M, Napolitano A, Iannacone M, von Andrian UH, Guidotti LG, Abrignani S, Casorati G, Dellabona P (2012) Follicular helper Natural Killer T cells provide CD1d-restricted help to B cells eliciting specific antibody responses in the absence of CD4+ T cells. Journal of Immunology, 188:3217

Chevrier N, Mertins P, Artyomov MN, Shalek AK, Garber M, Iannacone M, Ciaccio MF, Gat-Viks I, Eisenhaure TM, Clauser KR, Yosef N, Tonti E, Root DE, Beutler B, von Andrian UH, Jones RB, Park H, Carr SA, Regev A, Amit A, Hacohen N (2011) Systematic discovery of signaling components identifies new branches in viral-sensing pathways. Cell, 147:853

Sitia G*✉, Iannacone M*✉, Aiolfi R, Isogawa M, van Rooijen N, Scozzesi C, Bianchi ME, von Andrian UH, Chisari FV, Guidotti LG✉ (2011) Kupffer cells hasten resolution of liver immunopathology in mouse models of viral hepatitis. PLoS Pathogens, 7:e1002061 (*co-first authors)

Iannacone M*✉, Moseman EA*, Tonti E, Bosurgi L, Henrickson SE, Whelan S, Guidotti LG, von Andrian UH✉ (2010) Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus. Nature, 465:1079 (*co-first authors)

Iannacone M✉, Sitia G✉, Guidotti LG✉ (2009) On the role of platelets in the pathogenesis of viral hepatitis. Journal of Hepatology, 51:593

Iannacone M, Sitia G, Isogawa M, Whitmire JK, Marchese P, Chisari FV, Ruggeri ZM, Guidotti LG (2008) Platelets prevent IFN-ab-induced lethal hemorrhage promoting CTL-dependent clearance of lymphocytic choriomeningitis virus. PNAS, 105:631

Junt T, Moseman EA, Iannacone M, Massberg S, Lang PA, Boes M, Fink K, Henrickson S, Shayakhmetov DM, van Rooijen N, Mempel T, Whelan S., von Andrian UH (2007) Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells. Nature, 450:110

Iannacone M, Sitia G, Narvaiza I, Ruggeri ZM, Guidotti LG (2007) Antiplatelet Drug Therapy Moderates Immune-Mediated Liver Disease and Inhibits Viral Clearance in Mice Infected with a Replication-Deficient Adenovirus. Clinical and Vaccine Immunology, 14:1532

Nascimbene A, Iannacone M, Brando B, De Gasperi A (2007) Acute thrombocytopenia after liver transplant: Role of platelet activation, thrombopoietin deficiency and response to high dose intravenous IgG treatment. Journal of Hepatology, 47:651

Iannacone M, Sitia G, Ruggeri ZM, Guidotti LG (2007) HBV pathogenesis in animal models: recent advances on the role of platelets. Journal of Hepatology, 46:719

Sitia G*, Iannacone M*, Muller S, Bianchi ME, Guidotti LG (2007) Treatment with HMGB1 inhibitors diminishes CTL-induced liver disease in HBV transgenic mice. Journal of Leukocyte Biology, 81:100 (*Co-first authors)

Iannacone M, Sitia G, Guidotti LG (2006) Pathogenetic and antiviral immune responses against Hepatitis B virus. Future Virology, 1:189

Iannacone M, Sitia G, Isogawa M, Marchese P, Castro MG, Lowenstein PR, Chisari FV, Ruggeri ZM, Guidotti LG (2005) Platelets mediate cytotoxic T lymphocytes-induced liver damage. Nature Medicine, 11:1167

Sitia G, Iannacone M, Chisari FV, Guidotti LG (2005) Pathogenesis of Hepatitis B Virus in Transgenic Mice. Models of viral hepatitis, Vol. 25. F. F. von Weizsacker, and M. E. Roggendorf, eds. Karger, Basel, Switzerland, p. 25

Sitia G, Isogawa M, Iannacone M, Campbell IL, Chisari FV, Guidotti LG (2004) MMPs are required for recruitment of antigen-nonspecific mononuclear cells into the liver by CTLs. Journal of Clinical Investigation, 113:1158

Rovere-Querini P, Capobianco A, Scaffidi P, Valentinis B, Catalanotti F, Giazzon M, Dumitriu IE, Muller S, Iannacone M, Traversari C, Bianchi ME, Manfredi AA (2004) HMGB1 is an endogenous immune adjuvant released by necrotic cells. EMBO Reports, 5:825

Mauvais-Jarvis, F, Ueki K, Fruman DA, Hirshman MF, Sakamoto K, Goodyear LJ, Iannacone M, Accili D, Cantley LC, Kahn CR (2002) Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes. Journal of Clinical Investigation, 109:141

Manfredi AA, Iannacone M, D'Auria F, Rovere-Querini P (2002) The disposal of dying cells in living tissues. Apoptosis, 7:153

Bondanza A, Manfredi AA, Zimmermann VS, Iannacone M, Tincani A, Balestrieri G, Sabbadini MG, Querini PR (2001) Anti-beta2 glycoprotein I antibodies cause inflammation and recruit dendritic cells in platelet clearance. Thrombosis and Haemostasis, 86:1257

Il titolare del presente curriculum vitae, pubblicato online sul portale www.unisr.it, è garante in via esclusiva della correttezza e della veridicità dei dati e delle informazioni in esso riportate e del loro eventuale e puntuale aggiornamento. Egli è dunque il diretto ed unico responsabile dei contenuti indicati nei propri curricula.