Piemonti Lorenzo Professore associatoMedicinaMED/13 – Endocrinologia

Biografia

Pubblicazioni

English version

Biografia

Lorenzo Piemonti, MD, nato a Carate Brianza (MB), si è laureato con Lode presso l’Università di Milano nel 1994, e specializzato con lode in Endocrinologia e Malattie del Ricambio e in Microchirurgia e Chirurgia Sperimentale presso l’Università di Milano nel 2000 e nel 2004, rispettivamente. All’ Istituto Scientifico San Raffaele (Milano, Italia) ricopre il ruolo di Direttore del Diabetes Research Institute, direttore dello Human Islet Transplantation Programme (http://www.sanraffaele.org/ ENGhome / ricerca / divisions_centers_institutes_research_programs / ITP / index.html). Inoltre serve anche come capo della Beta Cell Biology Unit (Diabetes Research Institute), e direttore della Human Islet Processing Facility, nonchè coordinatore del Consorzio Europeo per il Trapianto di Isole (ECIT, http://ecit.drisanraffaele.org/en/islet-transplatntation/index.html). Lorenzo Piemotni è professore di Endocrinologia presso l’Università “Vita Salute San Raffaele” di Milano e Honorary Visiting Professor presso la Vrije Universiteit di Bruxelles. La sua area di competenza è focalizzata principalmente su diabete e la pancreatologia. Egli ha studiato il ruolo della immunità innata nella biologia delle cellule insulari (soprattutto nel modello umano di trapianto di isole pancreatiche) e nella biologia del cancro del pancreas (in particolare il ruolo delle chemochine e del sistema dei recettori delle chemochine nell’indurre l’infiltrazione leucocitaria) . Inoltre, i suoi interessi di ricerca includono la sostituzione delle cellule beta, le strategie di induzione della tolleranza immunitaria, la biologia delle cellule dendritiche, le cellule staminali. Attualmente è curatore di sezione per Cell Transplantation-the Regenerative Medicine Journal e per Current Diabete Reports, e siede nel comitato editoriale di Acta Dibetologia, Inoltre è Consigliere della International Pancreas and Islet Transplantation Association (IPITA) della Transplantation Society (TTS) e membro del comitato esecutivo della European Pancreas and Islet Transplantation Association (EPITA) della European Society for Organ Transplantation (ESOT).

Lorenzo Piemonti è autore di un totale di 158 articoli originali pubblicati su riviste peer-reviewed in PubMed). h-index (06/07/2017): 38 Web of Science; 41 Scopus; 47 Google Scholar.. Considerando il periodo 2001-2017 Lorenzo Piemonti è autore di un totale di 135 articoli originali pubblicati su riviste peer-reviewed per un impact factor di 779.673  (media impact factor: 5.775)

 

Pubblicazioni

153: Sordi V, Bolla A, Pellegrini S, Saita D, Ferrarese R, Barera G, Mariani A, Testoni PA, Doglioni C, Canducci F, Bosi E, Piemonti L. Gut mucosa of patients with type 1 diabetes shows distinctive inflammatory profile and microbiota. JCEM, In press

152: Codella R, Adamo M, Maffi P, Piemonti L, Secchi A, Luzi L. Ultra-marathon 100 km in an islet-transplanted runner. Acta Diabetol. 2016 Nov 23. [Epub aheadof print]

151: Cianciaruso C, Phelps EA, Pasquier M, Hamelin R, Demurtas D, Ahmed MA, Piemonti L, Hirosue S, Swartz MA, De Palma M, Hubbell JA, Baekkeskov S. Primary Human and Rat Beta Cells Release the Intracellular Autoantigens GAD65, IA-2 and Proinsulin in Exosomes Together with Cytokine-Induced Enhancers of Immunity. Diabetes. 2016 Nov 21. pii: db160671. [Epub ahead of print]

150: Sordi V, Ferri A, Ceserani V, Ciusani E, Dugnani E, Pellegrini S, Nano R, Pecciarini L, Pessina A, Pascucci L, Piemonti L§, Alessandri G§. Establishment, characterization and long-term culture of human endocrine pancreas-derived microvascular endothelial cells. Cytotherapy. 2016 Nov 11. pii:S1465-3249(16)30565-5. (§ these authors equally contributed to the study)

149: Balzano G, Dugnani E, Gandolfi A, Scavini M, Pasquale V, Aleotti F, Liberati D, Di Terlizzi G, Petrella G, Reni M, Doglioni C, Bosi E, Falconi M, Piemonti L. Effect of Diabetes on Survival after Resection of Pancreatic Adenocarcinoma. A Prospective, Observational Study. PLoS One. 2016 Nov 4;11(11):e0166008.

148: Pellegrini S, Cantarelli E, Sordi V, Nano R, Piemonti L. The state of the art  of islet transplantation and cell therapy in type 1 diabetes. Acta Diabetol. 2016 Oct;53(5):683-91

147: Vignali D, Gürth CM, Pellegrini S, Sordi V, Sizzano F, Piemonti L§, Monti P§. IL-7 Mediated Homeostatic Expansion of Human CD4+CD25+FOXP3+ Regulatory T Cells After Depletion With Anti-CD25 Monoclonal Antibody. Transplantation. 2016 Sep;100(9):1853-61.

(§ these authors equally contributed to the study)

146: Cantarelli E, Citro A, Pellegrini S, Mercalli A, Melzi R, Dugnani E, Jofra T, Fousteri G, Mondino A, Piemonti L. Transplant Site Influences the Immune Response After Islet Transplantation: Bone Marrow vs Liver. Transplantation. 2016 Aug 29. [Epub ahead of print]

145: Dugnani E, Balzano G, Pasquale V, Scavini M, Aleotti F, Liberati D, Di Terlizzi G, Gandolfi A, Petrella G, Reni M, Doglioni C, Bosi E, Falconi M, Piemonti L. Insulin resistance is associated with the aggressiveness of pancreatic ductal carcinoma. Acta Diabetol. 2016 Dec;53(6):945-956.

144: Dugnani E, Gandolfi A, Balzano G, Scavini M, Pasquale V, Aleotti F, Liberati D, Di Terlizzi G, Petrella G, Reni M, Doglioni C, Bosi E, Falconi M, Piemonti L. Diabetes associated with pancreatic ductal adenocarcinoma is just diabetes: Results of a prospective observational study in surgical patients. Pancreatology. 2016 Aug 11. pii: S1424-3903(16)31173-5.

143: Venturini M, Sallemi C, Colantoni C, Agostini G, Balzano G, Esposito A, Secchi A, De Cobelli F, Falconi M, Piemonti L, Maffi P, Del Maschio A. Single-centre experience of extending indications for percutaneous intraportal islet autotransplantation (PIPIAT) after pancreatic surgery to prevent diabetes: feasibility, radiological aspects, complications and clinical outcome. Br J Radiol. 2016 Aug;89(1064):20160246.

142: Johnston NR, Mitchell RK, Haythorne E, Pessoa MP, Semplici F, Ferrer J, Piemonti L, Marchetti P, Bugliani M, Bosco D, Berishvili E, Duncanson P, Watkinson M, Broichhagen J, Trauner D, Rutter GA, Hodson DJ. Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose. Cell Metab. 2016 Jul 21. pii:

S1550-4131(16)30306-0.

141: Corritore E, Lee YS, Pasquale V, Liberati D, Hsu MJ, Lombard CA, Van Der Smissen P, Vetere A, Bonner-Weir S, Piemonti L, Sokal E, Lysy P. V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog A Synthetic Modified mRNA Drives Reprogramming of Human Pancreatic Duct-Derived Cells Into Insulin-Secreting Cells. Stem Cells Transl Med. 2016 Jul 12. pii: sctm.2015-0318. [Epub ahead of

print]

140 McLaughlin KA, Richardson CC, Ravishankar A, Brigatti C, Liberati D, Lampasona V, Piemonti L, Morgan D, Feltbower RG, Christie MR. Identification of Tetraspanin-7 as a Target of Autoantibodies in Type 1 Diabetes. Diabetes. 2016 Jun;65(6):1690-8

139 Marmugi A, Parnis J, Chen X, Carmichael L, Hardy J, Mannan N, Marchetti P, Piemonti L, Bosco D, Johnson P, Shapiro AM, Cruciani-Guglielmacci C, Magnan C, Ibberson M, Thorens B, Valdivia HH, Rutter GA, Leclerc I. Sorcin links pancreatic β cell lipotoxicity to ER Ca2+ stores. Diabetes. 2016 Apr;65(4):1009-21

138 G Balzano, P Maffi, R Nano, A Mercalli, R Melzi, F Aleotti, A Zerbi, F De Cobelli, F Gavazzi, P Magistretti, M Scavini, J Peccatori, A Secchi, F Ciceri, A Del Maschio, M Falconi, L Piemonti. Autologous Islet Transplantation in Patients Requiring Pancreatectomy:  A Broader Spectrum of Indications Beyond Chronic Pancreatitis. Am J Transplant. 2016 Jun;16(6):1812-26.

137 Peloso A, Urbani L, Cravedi P, Katari R, Maghsoudlou P, Fallas ME, Sordi V, Citro A, Purroy C, Niu G, McQuilling JP, Sittadjody S, Farney AC, Iskandar SS, Zambon JP, Rogers J, Stratta RJ, Opara EC, Piemonti L, Furdui CM, Soker S, De Coppi P, Orlando G. The Human Pancreas as a Source of Protolerogenic Extracellular Matrix Scaffold for a New-generation Bioartificial Endocrine Pancreas. Ann Surg. 2016 Jul;264(1):169-79.

136 Belli C, Piemonti L, D’Incalci M, Zucchetti M, Porcu L, Cappio S, Doglioni C,  Allavena P, Ceraulo D, Maggiora P, Dugnani E, Cangi MG, Garassini G, Reni M. Phase II trial of salvage therapy with trabectedin in metastatic pancreatic adenocarcinoma. Cancer Chemother Pharmacol. 2016 Mar;77(3):477-84.

135 Reni M, Dugnani E, Cereda S, Belli C, Balzano G, Nicoletti R, Liberati D, Pasquale V, Scavini M, Maggiora P, Sordi V, Lampasona V, Ceraulo D, Di Terlizzi G, Doglioni C, Falconi M, Piemonti L. (Ir)relevance of Metformin Treatment in Patients with Metastatic Pancreatic Cancer: An Open-Label, Randomized Phase II Trial. Clin Cancer Res. 2016 Mar 1;22(5):1076-85.

134 Peloso A, Ferrario J, Maiga B, Benzoni I, Bianco C, Citro A, Currao M, Malara  A, Gaspari A, Balduini A, Abelli M, Piemonti L, Dionigi P, Orlando G, Maestri M.  Creation and implantation of acellular rat renal ECM-based scaffolds. Organogenesis. 2015;11(2):58-74.

133 Smura T, Natri O, Ylipaasto P, Hellman M, Al-Hello H, Piemonti L, Roivainen M. Enterovirus strain and type-specific differences in growth kinetics and virus-induced cell destruction in human pancreatic duct epithelial HPDE cells. Virus Res. 2015 Dec 2;210:188-97.

132 Bonomi A, Sordi V, Dugnani E, Ceserani V, Dossena M, Coccè V, Cavicchini L, Ciusani E, Bondiolotti G, Piovani G, Pascucci L, Sisto F, Alessandri G, Piemonti L, Parati E, Pessina A. Gemcitabine-releasing mesenchymal stromal cells inhibit in vitro proliferation of human pancreatic carcinoma cells. Cytotherapy. 2015 Dec;17(12):1687-95.

131 Citro A, Cantarelli E, Piemonti L. The CXCR1/2 Pathway: Involvement in Diabetes Pathophysiology and Potential Target for T1D Interventions. Curr Diab Rep. 2015 Oct;15(10):68.

130 Nano R, Melzi R, Mercalli A, Balzano G, Scavini M, Bonadonna R, Piemonti L. Islet Volume and Indexes of β-Cell Function in Humans. Cell Transplant. 2016;25(3):491-501.

129 Monti P, Vignali D, Piemonti L. Monitoring Inflammation, Humoral and Cell-mediated Immunity in Pancreas and Islet Transplants. Curr Diabetes Rev. 2015;11(3):135-43.

128  Venturini M, Maffi P, Querques G, Agostini G, Piemonti L, Sironi S, De Cobelli F, Fiorina P, Secchi A, Del Maschio A. Hepatic steatosis after islet transplantation: Can ultrasound predict the clinical outcome? A longitudinal study in 108 patients. Pharmacol Res. 2015 Aug;98:52-9.

127 J Marquard, S Otter, A Welters, A Stirban, A Fischer, J Eglinger, D Herebian, O Kletke, MS Klemen, A Stozer, S Wnendt, L Piemonti, M Köhler, J Ferrer, B Thorens, F Schliess5, MS Rupnik, T Heise5, Per-Olof Berggren, Nj Klöcker, T Meissner, E Mayatepek, D Eberhard, M Kragl, E Lammert Characterization of pancreatic N-Methyl-D-Aspartate receptors as possible drug targets for diabetes treatment. Nat Med. 2015 Apr;21(4):363-72

126 Nano R, Bosco D, Kerr-Conte JA, Karlsson M, Charvier S, Melzi R, Ezzouaoui R, Mercalli A, Hwa A, Pattou F, Korsgren O, Berney T, Piemonti L. Human islet distribution programme for basic research: activity over the last 5 years. Diabetologia. 2015 May;58(5):1138-40

125 Scavini M, Dugnani E, Pasquale V, Liberati D, Aleotti F, Di Terlizzi G, Petrella G, Balzano G, Piemonti L. Diabetes after pancreatic surgery: novel issues. Curr Diab Rep. 2015 Apr;15(4):16.

124 Pellegrini S, Ungaro F, Mercalli A, Melzi R, Sebastiani G, Dotta F, Broccoli V, Piemonti L§, Sordi V§. Human induced pluripotent stem cells differentiate into insulin-producing cells able to engraft in vivo. Acta Diabetol. 2015 Dec;52(6):1025-35.

(§ these authors equally contributed to the study)

123 Stasiuk GJ, Minuzzi F, Sae-Heng M, Rivas C, Juretschke HP, Piemonti L, Allegrini PR, Laurent D, Duckworth AR, Beeby A, Rutter GA, Long NJ. Dual-Modal Magnetic Resonance/Fluorescent Zinc Probes for Pancreatic β-Cell Mass Imaging. Chemistry. 2015 Mar 23;21(13):5023-33

122 Malosio ML, Esposito A, Brigatti C, Palmisano A, Piemonti L, Nano R, Maffi P, De Cobelli F, Del Maschio A, Secchi A. MR Imaging Monitoring of Iron-Labeled Pancreatic Islets in a Small Series of Patients: Islet Fate in Successful, Unsuccessful, and Autotransplantation. Cell Transplant. 2015;24(11):2285-96.

121 Citro A, Valle A, Cantarelli E, Mercalli A, Pellegrini S, Liberati D, Daffonchio L, Kastsiuchenka O, Ruffini PA, Battaglia M, Allegretti M, Piemonti L. CXCR1/2 Inhibition Blocks and Reverts Type 1 Diabetes in Mice. Diabetes.  2015 Apr;64(4):1329-40.

120 Corritore E, Dugnani E, Pasquale V, Misawa R, Witkowski P, Lei J, Markmann J, Piemonti L, Sokal EM, Bonner-Weir S, Lysy PA. β-Cell differentiation of human pancreatic duct-derived cells after in vitro expansion. Cell Reprogram. 2014 Dec;16(6):456-66. doi: 10.1089/cell.2014.0025. Erratum in: Cell Reprogram. 2015 Feb;17(1):88.

119 Delmonte, V; Codella, R; Piemonti, L; La Torre, A; Benedini, S; Maffi, P; Ricordi, C; Luzi, L. Effects of exercise in a islet-transplanted half-marathon runner: Outcome on diabetes management, training and metabolic profile Sport Sci. Health: 2014; 10(1): 49-52

118 Maffi P, Berney T, Nano R, Niclauss N, Bosco D, Melzi R, Mercalli A, Magistretti P, De Cobelli F, Battaglia M, Scavini M, Demuylder-Mischler S, Secchi A and Piemonti L.  Calcineurin Inhibitor -Free Immunosuppressive Regimen in T1D Patients Receiving Islet Transplantation: single-group phase 1/2 trial. Transplantation. 2014. 98(12): 1305-1309

117 Figliolini F, Cantaluppi V, De Lena M, Beltramo S, Romagnoli R, Salizzoni M, Melzi R, Nano R, Piemonti L, Tetta C, Biancone L, Camussi G. Isolation, characterization and potential role in Beta cell-endothelium cross-talk of extracellular vesicles released from human pancreatic islets. PLoS One. 2014 Jul  16;9(7):e102521.

116 Balzano G, Dugnani E, Pasquale V, Capretti G, Radaelli MG, Garito T, Stratta G, Nini A, Di Fenza R, Castoldi R, Staudacher C, Reni M, Scavini M, Doglioni C, Piemonti L. Clinical signature and pathogenetic factors of diabetes associated with pancreas disease (T3cDM): a prospective observational study in surgical patients. Acta Diabetol. 2014 Oct;51(5):801-11

115 Balzano G, Piemonti L. Autologous islet transplantation in patients requiring  pancreatectomy for neoplasm. Curr Diab Rep. 2014 Aug;14(8):512.

114 Marzorati S, Melzi R, Citro A, Cantarelli E, Mercalli A, Scavini M, Piemonti L. Engraftment Versus Immunosuppression: Cost-Benefit Analysis of Immunosuppression After Intrahepatic Murine Islet Transplantation. Transplantation. 2014 May 27;97(10):1019-26.

113 Hodson DJ, Mitchell RK, Marselli L, Pullen TJ, Brias SG, Semplici F, Everett KL, Cooper DM, Bugliani M, Marchetti P, Lavallard V, Bosco D, Piemonti L, Johnson PR, Hughes SJ, Li D, Li WH, Shapiro AM, Rutter GA. ADCY5 couples glucose to insulin secretion in human islets. Diabetes. 2014 Sep;63(9):3009-21.

112 Balzano G, Carvello M, Piemonti L, Rita N, Ariotti R, Mercalli A, Melzi R, Maffi P, Braga M, Staudacher C. Combined Laparoscopic Spleen-Preserving Distal Pancreatectomy and Islet Autotransplantation for Benign Pancreatic Neoplasm. World J Gastroenterol. 2014 Apr 14;20(14):4030-6. doi: 10.3748/wjg.v20.i14.4030

111 Cardillo M, Nano R, de Fazio N, Melzi R, Drago F, Mercalli A, Dell’acqua A, Scavini M, Piemonti L. The allocation of pancreas allografts on donor age and duration of intensive care unit stay: the experience of the North Italy Transplant program. Transpl Int. 2014 Apr;27(4):353-61.

110 Granata R, Settanni F, Trovato L, Gallo D, Gesmundo I, Nano R, Gallo MP, Bergandi L, Volante M, Alloatti G, Piemonti L, Leprince J, Papotti M, Vaudry H, Ong H, Ghigo E. RFamide peptides 43RFa and 26RFa both promote survival of pancreatic β-cells and human pancreatic islets but exert opposite effects on insulin secretion. Diabetes. 2014 Jul;63(7):2380-93.

109 Pasquali L, Gaulton KJ, Rodríguez-Seguí SA, Mularoni L, Miguel-Escalada I, Akerman I, Tena JJ, Morán I, Gómez-Marín C, van de Bunt M, Ponsa-Cobas J, Castro  N, Nammo T, Cebola I, García-Hurtado J, Maestro MA, Pattou F, Piemonti L, Berney  T, Gloyn AL, Ravassard P, Gómez-Skarmeta JL, Müller F, McCarthy MI, Ferrer J. Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants. Nat Genet. 2014 Feb;46(2):136-43.

108 Christensen DP, Gysemans C, Lundh M, Dahllöf MS, Noesgaard D, Schmidt SF, Mandrup S, Birkbak N, Workman CT, Piemonti L, Blaabjerg L, Monzani V, Fossati G, Mascagni P, Paraskevas S, Aikin RA, Billestrup N, Grunnet LG, Dinarello CA, Mathieu C, Mandrup-Poulsen T. Lysine deacetylase inhibition prevents diabetes by chromatin-independent immunoregulation and β-cell protection. Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1055-9.

107 D’Addio F, Maffi P, Vezzulli P, Vergani A, Mello A, Bassi R, Nano R, Falautano M, Coppi E, Finzi G, D’Angelo A, Fermo I, Pellegatta F, La Rosa S, Magnani G, Piemonti L, Falini A, Folli F, Secchi A, Fiorina P. Islet transplantation stabilizes hemostatic abnormalities and cerebral metabolism in individuals with type 1 diabetes. Diabetes Care. 2014 Jan;37(1):267-76.

106  Balzano G, Pecorelli N, Piemonti L, Ariotti R, Carvello M, Nano R, Braga M, Staudacher C. Relaparotomy for pancreatic fistula after pancreaticoduodenectomy: a comparison of different surgical strategies. HPB (Oxford). 2014 Jan;16(1):40-5.

105 Esposito A, Palmisano A, Maffi P, Malosio ML, Nano R, Canu T, De Cobelli F, Piemonti L, Ironi G, Secchi A, Del Maschio A. Liver Perfusion Changes Occurring During Pancreatic Islet Engraftment: A Dynamic Contrast-Enhanced Magnetic Resonance Study. Am J Transplant. 2014 Jan;14(1):202-9.

104 Hodson DJ, Mitchell RK, Bellomo EA, Sun G, Vinet L, Meda P, Li D, Li WH, Bugliani M, Marchetti P, Bosco D, Piemonti L, Johnson P, Hughes SJ, Rutter GA. Lipotoxicity disrupts incretin-regulated human β cell connectivity. J Clin Invest. 2013 Oct 1;123(10):4182-94.

103 Monti P, Piemonti L. Homeostatic T cell proliferation after islet transplantation. Clin Dev Immunol. 2013;2013:217934. doi: 10.1155/2013/217934. Epub 2013 Jul 22.

102 Citro A, Cantarelli E, Piemonti L. Anti-Inflammatory Strategies to Enhance Islet Engraftment and Survival. Curr Diab Rep. 2013 Oct;13(5):733-44. doi: 10.1007/s11892-013-0401-0

101 Cantarelli E, Citro A, Marzorati S, Melzi R, Scavini M, Piemonti L. Murine animal models for preclinical islet transplantation: no model fits all (research  purposes). Islets. 2013 Mar-Apr;5(2):79-86.

100 Maffi P, Balzano G, Ponzoni M, Nano R, Sordi V, Melzi R, Mercalli A, Scavini M, Esposito A, Peccatori J, Cantarelli E, Messina C, Bernardi M, Del Maschio A, Staudacher C, Doglioni C, Ciceri F, Secchi A, Piemonti L. Autologous Pancreatic Islet Transplantation in Human Bone Marrow. Diabetes. 2013 Oct;62(10):3523-31.

99 Mercalli A, Calavita I, Dugnani E, Citro A, Cantarelli E, Nano R, Melzi R, Maffi P, Secchi A, Sordi V, Piemonti L. Rapamycin unbalances the polarization of  human macrophages to M1. Immunology. 2013 Oct;140(2):179-90.

98 Balzano G, Maffi P, Nano R, Zerbi A, Venturini M, Melzi R, Mercalli A, Magistretti P, Scavini M, Castoldi R, Carvello M, Braga M, Del Maschio A, Secchi  A, Staudacher C, Piemonti L. Extending indications for islet autotransplantation  in pancreatic surgery. Ann Surg. 2013 Aug;258(2):210-8.

97 Zhou W, Capello M, Fredolini C, Racanicchi L, Dugnani E, Piemonti L, Liotta LA, Novelli F, Petricoin EF. Mass spectrometric analysis reveals O-methylation of pyruvate kinase from pancreatic cancer cells. Anal Bioanal Chem. 2013 May;405(14):4937-43.

96  R Jain, D Jain, Q Liu, B Bartosinska, J Wang, D Schumann, S G Kauschke, P Eickelmann, L Piemonti, N S Gray, E Lammert. Pharmacological inhibition of Eph receptors enhances glucose-stimulated insulin secretion from mouse and human pancreatic islets. Diabetologia. 2013 Jun;56(6):1350-5.

95 Valle A, Giamporcaro GM, Scavini M, Stabilini A, Grogan P, Bianconi E, Sebastiani G, Masini M, Maugeri N, Porretti L, Bonfanti R, Meschi F, De Pellegrin M, Lesma A, Rossini S, Piemonti L, Marchetti P, Dotta F, Bosi E, Battaglia M. Reduced circulating neutrophils precedes and accompanies type 1 diabetes. Diabetes. 2013 Jun;62(6):2072-7.

94 Piemonti L, Everly MJ, Maffi P, Scavini M, Poli F, Nano R, Cardillo M, Melzi R, Mercalli A, Sordi V, Lampasona V, Espadas de Arias A, Scalamogna M, Bosi E, Bonifacio E, Secchi A, Terasaki PI. Alloantibody and Autoantibody Monitoring Predicts Islet Transplantation Outcome in Human Type 1 Diabetes. Diabetes. 2013 May;62(5):1656-64.

93 Giovinazzo F, Malpeli G, Zanini S, Parenti M, Piemonti L, Colombatti M, Valenti MT, Carbonare LD, Scarpa A, Sinnett-Smith J, Rozengurt E, Bassi C, Innamorati G. Ectopic expression of the heterotrimeric G15 protein in pancreatic carcinoma and its potential in cancer signal transduction. Cell Signal. 2013 Mar;25(3):651-9.

92 Marquard J, Welters A, Buschmann T, Barthlen W, Vogelgesang S, Klee D, Krausch M, Raffel A, Otter S, Piemonti L, Mayatepek E, Otonkoski T, Lammert E, Meissner T. Association of exercise-induced hyperinsulinaemic hypoglycaemia with MCT1-expressing insulinoma. Diabetologia. 2013 Jan;56(1):31-5.

91 Capua I, Mercalli A, Pizzuto MS, Romero-Tejeda A, Kasloff S, De Battisti C, Bonfante F, Patrono LV, Vicenzi E, Zappulli V, Lampasona V, Stefani A, Doglioni C, Terregino C, Cattoli G, Piemonti L. Influenza A viruses grow in human pancreatic cells and cause pancreatitis and diabetes in an animal model. J Virol. 2013 Jan;87(1):597-610.

90 Nano R, Racanicchi L, Melzi R, Mercalli A, Maffi P, Sordi V, Ling Z, Scavini M, Korsgren O, Celona B, Secchi A, Piemonti L. Human Pancreatic Islet Preparations Release HMGB1: (Ir)Relevance For Graft Engraftment. Cell Transplant. 2013;22(11):2175-86.

89 Ylipaasto P, Smura T, Gopalacharyulu P, Paananen A, Seppänen-Laakso T, Kaijalainen S, Ahlfors H, Korsgren O, Lakey JR, Lahesmaa R, Piemonti L, Oresic M, Galama J, Roivainen M. Enterovirus-induced gene expression profile is critical for human pancreatic islet destruction. Diabetologia. 2012 Dec; 55(12):3273-83.

88 Morán I, Akerman I, van de Bunt M, Xie R, Benazra M, Nammo T, Arnes L, Nakić N, García-Hurtado J, Rodríguez-Seguí S, Pasquali L, Sauty-Colace C, Beucher A, Scharfmann R, van Arensbergen J, Johnson PR, Berry A, Lee C, Harkins T, Gmyr V, Pattou F, Kerr-Conte J, Piemonti L, Berney T, Hanley N, Gloyn AL, Sussel L, Langman L, Brayman KL, Sander M, McCarthy MI, Ravassard P, Ferrer J. Human β Cell Transcriptome Analysis Uncovers lncRNAs That Are Tissue-Specific, Dynamically Regulated, and Abnormally Expressed in Type 2 Diabetes. Cell Metab. 2012 Oct 3;16(4):435-48.

87 Citro A, Cantarelli E, Maffi P, Nano R, Melzi R, Mercalli A, Dugnani E, Sordi  V, Magistretti P, Daffonchio L, Ruffini PA, Allegretti M, Secchi A, Bonifacio E,  Piemonti L. CXCR1/2 inhibition enhances pancreatic islet survival after transplantation. J Clin Invest. 2012 Oct 1;122(10):3647-51.

86 Mercalli A, Lampasona V, Klingel K, Albarello L, Lombardoni C, Ekström J, Sordi V, Mariani A, Dillner J, Roivainen M, Bosi E,  Piemonti L. No evidence of enteroviruses in the intestine of type 1 diabetic patients. Diabetologia. 2012. 55 (9), pp. 2479-2488.

85 Jain D, Jain R, Ebehard D, Elinger J, Bugliani M, Piemonti L, Marchetti P, Lammert E. Age- and diet-dependent requirement of DJ-1 for glucose homeostasis in mice with implications for human type 2 diabetes. J Mol Cell Biol. 2012 Aug;4(4): 221-30.

84 Corno D, Pala M, Cominelli M, Cipelletti B, Leto K, Croci L, Barili V, Brandalise F, Melzi R, Di Gregorio A, Sergi L, SL Politi, Piemonti L, Bulfone A, Rossi P, Rossi F, Consalez GG, Poliani PL, Galli R. Gene signatures associated with mouse postnatal hindbrain neural stem cells and medulloblastoma cancer stem cells identify novel molecular mediators and predict human MB molecular classification. Cancer Discov. 2012 Jun;2(6):554-68.

83 Zhou W, Capello M, Fredolini C, Racanicchi L, Piemonti L, Liotta LA, Novelli F, Petricoin EF Mass spectrometry analysis reveals O-methylation of L-lactate dehydrogenase from pancreatic ductal adenocarcinoma cells.  Electrophoresis. 2012 Jul;33(12):1850-4.

82 Granata R,  Settanni F, Julien M, Nano R, Togliatto G, Trombetta A, Gallo D, Piemonti L, Brizzi MF, Abribat T, van Der Lely AJ, Ghigo E Des-Acyl Ghrelin Fragments and Analogues Promote Survival of Pancreatic β-Cells and Human Pancreatic Islets and Prevent Diabetes in Streptozotocin-Treated Rats.J Med Chem. 2012 Mar 22;55(6):2585-96.

81  Perseghin G, Calori G, Lattuada G, Dugnani E, Garancini MP, Crosignani P, Villa M, Bosi E, Luzi L, Ruotolo G, Piemonti L. Insulin resistance/hyperinsulinemia and cancer mortality: the Cremona Study at the 15th year of follow-up. Acta Diabetol. 2012 Dec;49(6):421-8.

80 Zhou W, Capello M, Fredolini C, Racanicchi L, Piemonti L, Liotta LA, Novelli F, Petricoin EF Proteomic Analysis Reveals Warburg Effect and Anomalous Metabolism of Glutamine in Pancreatic Cancer Cells. J Proteome Res. 2012 Feb 3;11(2):554-63..

79 Ferraro A, Socci C, Stabilini A, Valle A, Monti P , Piemonti L, Nano R, Olek S, Maffi P, Scavini M, Secchi A, Staudacher C, Bonifacio E, Battaglia M. Expansion of Th17 and functional defects in Tregs are key features of the pancreatic lymph-nodes in patients with type 1 diabetes. Diabetes. 2011 Nov;60(11):2903-13.

78 Cantarelli E, Piemonti L. Alternative transplantation sites for pancreatic islet grafts. Curr Diab Rep. 2011 Oct;11(5):364-74.

77 Caumo A, Maffi P, Nano R, Luzi L, Hilbrands R, Gillard P, Jacobs-Tulleneers-Thevissen D, Secchi A, Keymeulen B, Pipeleers D, Piemonti L. Comparative Evaluation of Simple Indices of Graft Function After Islet Transplantation. Transplantation. 2011 Oct 15;92(7):815-21.

76 Calori G, Lattuada G, Ragogna F, Garancini MP, Crosignani P, Villa M, Bosi E, Ruotolo G,  Piemonti L, Perseghin G Fatty Liver Index (FLI) and mortality: the Cremona Study at the 15th year of follow up.  Hepatology. 2011 Jul;54(1):145-52.

75 Sordi V,  Piemonti L. Therapeutic plasticity of stem cells and allograft tolerance. Cytotherapy. 2011 Jul;13(6):647-60.

74 Zhou W, Capello M, Fredolini C, Piemonti L, Liotta LA, Novelli F, Petricoin EF. Proteomic analysis of pancreatic ductal adenocarcinoma cells reveals metabolic alterations J Proteome Res. 2011 Apr 1;10(4):1944-52.

73 Maffi P, Scavini M, Socci C, Piemonti L, Caldara R, Gremizzi C, Melzi R, Nano R, Orsenigo E, Venturini M, Staudacher C, Del Maschio A, Secchi A. Risks and benefits of transplantation in the cure of type 1 diabetes: whole pancreas versus islet transplantation. A single center study. Rev Diabet Stud. 2011 Spring;8(1):44-50.

72 Piemonti L, Dominguez-Bendala, J. Challenges and prospects for stem cell-based therapy in Type 1 diabetes. Diabetes Management. 2011; 1(1), 23–27.

71 Piemonti L, P Maffi, L Monti, V Lampasona, G Perseghin, P Magistretti, A Secchi, E Bonifacio. Beta cell function during rapamycin monotherapy in long term type 1 diabetes. Diabetologia. 2011 Feb;54(2):433-9.

70 Sordi V,  Piemonti L Mesenchymal stem cells as feeder cells for pancreatic islet transplant. Rev Diabet Stud. 2010 Summer;7(2):132-43.

69 G Calori, G Lattuada,  Piemonti L, M P Garancini, F Ragogna, M Villa, S Mannino, P Crosignani, E Bosi, L Luzi, G Ruotolo, G Perseghin Prevalence, metabolic features and prognosis of metabolically healthy obese Italian individuals: the Cremona Study. Diabetes Care. 2011 Jan;34(1):210-5.

68 T Smura , PYlipaasto, P Klemola , S Kaijalainen, L Kyllönen , V Sordi , L Piemonti and M Roivainen. Cellular tropism of human enterovirus D species serotypes EV-94, EV-70 and EV-68 in vitro implication for  the pathogenesis J Med Virol. 2010 Nov;82(11):1940-9.

67 Ciceri F, Piemonti L. Bone marrow and pancreatic islet: an old story with new perspectives. Cell Transplant. 2010;19(12):1511-22.

66 Zhou W, Capello M, Fredolini C, Piemonti L, Liotta LA, Novelli F, Petricoin EF. Mass Spectrometry Analysis of the Post-Translational Modifications of alpha-Enolase from Pancreatic Ductal Adenocarcinoma Cells.  J Proteome Res. 2010 Jun 4;9(6):2929-36.

65 Melzi R, Antonioli B, Mercalli A, Battaglia M, Valle A, Pluchino S, Galli R, Sordi V, Bosi E, Martino G, Bonifacio E, Doglioni C, Piemonti L. Co-graft of allogeneic immune regulatory neural stem cells (NPC) and pancreatic islets mediates tolerance, while inducing NPC-derived tumors in mice. PLoS One. 2010 Apr 27;5(4):e10357.

64 Piemonti L. Islet Transplantation in Bone Marrow. Journal of Medical Sciences (2010); 3(1): 35-39.

63 Melzi R, Mercalli A, Sordi V, Cantarelli E, Nano R, Maffi P, Sitia G, Guidotti L, Secchi A,  Bonifacio E, Piemonti L Role of CCL2/MCP-1 in islet transplantation. Cell Transplant. 2010;19(8):1031-46.

62 Piemonti L, Guidotti LG, Battaglia M Modulation of early inflammatory reactions to promote engraftment and function of transplanted pancreatic islets in autoimmune diabetes. Adv Exp Med Biol. 2010;654:725-47.

61 Cainarca S, Fenu S, Ferri C, Nucci C, Arioli P, Menegon A, Piemonti L, Lohmer  S, Wrabetz L, Corazza S. A photoprotein in mouse embryonic stem cells measures Ca2+ mobilization in cells and in animals. PLoS One. 2010 Jan 27;5(1):e8882.

60 Missiaglia E, Dalai I, Barbi S, Beghelli S, Falconi M, della Peruta M, Piemonti L, Capurso G, Di Florio A, delle Fave G, Pederzoli P, Croce CM, Scarpa A. Pancreatic endocrine tumors: expression profiling evidences a role for AKT-mTOR pathway. J Clin Oncol. 2010 Jan 10;28(2):245-55.

59 Marchesi F, Piemonti L, Mantovani A, Allavena P. Molecular mechanisms of perineural invasion, a forgotten pathway of dissemination and metastasis. Cytokine Growth Factor Rev. 2010 Feb;21(1):77-82.

58 Sordi V, Melzi R, Mercalli A, Formicola R, Doglioni C, Tiboni F, Ferrari G, Nano R, Chwalek K, Lammert E, Bonifacio E, Borg D, Piemonti L. Mesenchymal cells  appearing in pancreatic tissue culture are bone marrow-derived stem cells with the capacity to improve transplanted islet function. Stem Cells. 2010 Jan;28(1):140-51. Erratum in: Stem Cells. 2010 Feb;28(2):386. Borg, Danielle [added].

57 Cantarelli E, Melzi R, Mercalli A, Sordi V, Ferrari G, Lederer CW, Mrak E, Rubinacci A, Ponzoni M, Sitia G, Guidotti LG, Bonifacio E, Piemonti L. Bone marrow as an alternative site for islet transplantation. Blood. 2009 Nov 12;114(20):4566-74.

56 Melzi R, Maffi P, Nano R, Sordi V, Mercalli A, Scavini M, Secchi A, Bonifacio E, Piemonti L. Rapamycin does not adversely affect intrahepatic islet engraftment in mice and improves early islet engraftment in humans. Islets 1:1, 1-1; July/August 2009.

55 Piemonti L, Calori G, Lattuada G, Mercalli A, Ragogna F, Garancini MP, Ruotolo G, Luzi L, Perseghin G. Association between plasma monocyte chemoattractant protein-1 concentration and cardiovascular disease mortality in middle-aged diabetic and nondiabetic individuals. Diabetes Care. 2009 Nov;32(11):2105-10.

54 Malosio ML, Esposito A, Poletti A, Chiaretti S, Piemonti L, Melzi R, Nano R, Tedoldi F, Tamara C, Santambrogio P, Levi S, De Cobelli F, Maffi P, Secchi A, and Del Maschio A. Improving The Procedure For Detection Of Intrahepatic Transplanted Islets By Magnetic Resonance Imaging.  Am J Transplant. 2009 Oct;9(10):2372-82.

53 Sordi V, Piemonti L. The contribution of hematopoietic stem cells to beta-cell replacement. Curr Diab Rep. 2009 Apr;9(2):119-24.

52 Andralojc KM, Mercalli A, Nowak KW, Albarello L, Calcagno R, Luzi L, Bonifacio E, Doglioni C, Piemonti L. Ghrelin-producing epsilon cells in the developing and  adult human pancreas. Diabetologia. 2009 Mar;52(3):486-93.

51 Marchesi F§, Piemonti L§, Fedele G, Destro A, Roncalli M, Albarello L, Doglioni C, Anselmo A, Doni A, Bianchi P, Laghi L, Malesci A, Cervo L, Malosio M, Reni M,  Zerbi A, Di Carlo V, Mantovani A, Allavena P. The chemokine receptor CX3CR1 is involved in the neural tropism and malignant behavior of pancreatic ductal adenocarcinoma. Cancer Res. 2008 Nov 1;68(21):9060-9. (§ these authors equally contributed to the study).

50 Monti P, Scirpoli M, Maffi P, Piemonti L, Secchi A, Bonifacio E, Roncarolo MG, Battaglia M. Rapamycin monotherapy in patients with type 1 diabetes modifies CD4+CD25+FOXP3+ regulatory T-cells. Diabetes. 2008 Sep;57(9):2341-7..

49 Sordi V, Nano R, Melzi R, Antonioli B, Piemonti L. Beta-cell transplantation for diabetes therapy. Lancet. 2008 Jul 5;372(9632):28; author reply 29-30.

48 Ogliari AC, Caldara R, Socci C, Sordi V, Cagni N, Moretti MP, Dell’acqua A, Mercalli A, Scavini M, Secchi A, Bonifacio E, Bosi E, Piemonti L. High levels of  donor CCL2/MCP-1 predict graft-related complications and poor graft survival after kidney-pancreas transplantation. Am J Transplant. 2008 Jun;8(6):1303-11.

47 Monti P, Scirpoli M, Maffi P, Ghidoli N, De Taddeo F, Bertuzzi F, Piemonti L, Falcone M, Secchi A, Bonifacio E. Islet transplantation in patients with autoimmune diabetes induces homeostatic cytokines that expand autoreactive memory T cells. J Clin Invest. 2008 May;118(5):1806-14.

46 Sordi V, Bertuzzi F, Piemonti L. Diabetes mellitus: an opportunity for therapy with stem cells? Regen Med. 2008 May;3(3):377-97.

45 Caumo A, Maffi P, Nano R, Bertuzzi F, Luzi L, Secchi A, Bonifacio E, Piemonti  L. Transplant estimated function: a simple index to evaluate beta-cell secretion after islet transplantation. Diabetes Care. 2008 Feb;31(2):301-5.

44 Melzi R, Sanvito F, Mercalli A, Andralojc K, Bonifacio E, Piemonti L. Intrahepatic islet transplant in the mouse: functional and morphological characterization. Cell Transplant. 2008;17(12):1361-70.

43 Mercalli A, Sordi V, Formicola R, Dandrea M, Beghelli S, Scarpa A, Di Carlo V, Reni M, Piemonti L.  A preclinical evaluation of pemetrexed and irinotecan combination as second-line chemotherapy in pancreatic cancer.  Br J Cancer. 2007 May 7;96(9):1358-67.

42 Melzi R, Battaglia M, Draghici E, Bonifacio E, Piemonti L.  Relevance of hyperglycemia on the timing of functional loss of allogeneic islet transplants: implication for mouse model. Transplantation. 2007 Jan 27;83(2):167-73.

41 Bosi E, Molteni L, Radaelli MG, Folini L, Fermo I, Bazzigaluppi E, Piemonti L, Pastore MR, Paroni R.  Increased intestinal permeability precedes clinical onset of type 1 diabetes. Diabetologia. 2006;49:2824-7.

40 Marzorati S, Antonioli B, Nano R, Maffi P, Piemonti L, Giliola C, Secchi A, Lakey JR, Bertuzzi F Culture Medium Modulates Proinflammatory Conditions of Human Pancreatic Islets Before Transplantation.  Am J Transplant. 2006; 6:2791-5.

39 Sordi V, Bianchi G, Buracchi C,  Mercalli A, Marchesi F, D’Amico G, Yang C-H, Luini W, Vecchi A, Mantovani A, Allavena P, Piemonti L  Differential effects of immunosuppressive drugs on chemokine receptor CCR7 in human monocyte-derived dendritic cells: selective upregulation by Rapamycin  Transplantation. 2006; 27;82:826-34.

38 Mercalli A, Sordi V, Ponzoni M, Maffi P, De Taddeo F, Gatti G, Servida P, Bernardi M, Bellio L, Bertuzzi F, Secchi A, Bonifacio E , Piemonti L Rapamycin induces an alternative apoptosis-like programmed cell death in human monocytes  Am J Transplant. 2006; 6:1331-41.

37 Zerbini G, Piemonti L, Maestroni A, Dell’Antonio G, Bianchi G.  Stem cells and the kidney: a new therapeutic tool?  J Am Soc Nephrol. 2006;17(4 Suppl 2):S123-6.

36 Reni M, Pasetto L, Aprile G, Cordio S, Bonetto E, Dell’Oro S, Passoni P, Piemonti L, Fugazza C, Luppi G, Milandri C, Nicoletti R, Zerbi A, Balzano G, Di Carlo V, Brandes AA Raltitrexed-eloxatin salvage chemotherapy in gemcitabine-resistant metastatic pancreatic cancer. Br J Cancer. 2006 Mar 27;94:785-91.

35 Sordi V, Malosio ML, Marchesi F, Mercalli A, Giordano T,  Belmonte N, Ferrari G, Leone BE, Bertuzzi F, Zerbini G, Allavena P, Bonifacio E and Piemonti L. Bone marrow mesenchymal stem cells express a restricted set of functionally active chemokine receptors capable of promoting migration to pancreatic islets. Blood. 2005;106:419-27.

34 Bosi E, Pastore MR, Molteni L, Bazzigaluppi E, Bonifacio E, Piemonti L.  Gluten-free diet in subjects at risk for type 1 diabetes: a tool for delaying progression to clinical disease? Adv Exp Med Biol. 2005;569:157-8.

33 Melzi R, Piemonti L, Nano R, Clissi B, Calori G, Antonioli B, Marzorati S, Perseghin G, Di Carlo V, Bertuzzi F Donor and isolations variables associated with human islet monocyte chemoattractant protein-1 release. Transplantation 2004; 78:1564-7.

32 Marchesi F, Monti P, Leone BE, Zerbi A, Vecchi A, Piemonti L, Mantovani A, Allavena A Increased survival, proliferation and migration in metastatic human  pancreatic tumor cells  expressing functional CXCR4. Cancer Res. 2004; 64:8420-7.

31 Bertuzzi F, Marzorati S, Maffi P, Piemonti L, Melzi R, de Taddeo F, Valtolina V, D’Angelo A, di Carlo V, Bonifacio E, Secchi A. Tissue factor and CCL2/monocyte chemoattractant protein-1 released by human islets affect islet engraftment in type 1 diabetic recipients. J Clin Endocrinol Metab. 2004 Nov;89(11):5724-8.

30 Monti P, Marchesi F, Reni M, Mercalli A, Sordi V, Zerbi A, Balzano G, Di Carlo V, Allavena P, Piemonti L. A comprehensive in vitro characterization of pancreatic ductal carcinoma cell line biological behavior and its correlation with the structural and genetic profile. Virchows Arch. 2004 Sep;445(3):236-47.

29 Monti P, Leone BE, Zerbi A, Balzano G, Cainarca S, Sordi V, Pontillo M, Mercalli A, Di Carlo V, Allavena P, Piemonti L.  Tumor-Derived MUC1 Mucins Interact with Differentiating Monocytes and Induce IL-10highIL-12low Regulatory Dendritic Cell. J Immunol. 2004; 172: 7341-9.

28 Marzorati S, Melzi R, Nano R, Antonioli B, Di Carlo V, Piemonti L, Bertuzzi F. In vitro modulation of monocyte chemoattractant protein-1 release in human pancreatic islets. Transplant Proc. 2004; 36:607-8.

27 Allavena P., Chieppa M., Monti P., Piemonti L. From pattern recognition receptor to regulator of homeostasis: the doubble-faced macrophage mannose receptor Crit Rev Immunol. 2004; 24:179-92.

26 Monti P, Leone BE, Marchesi F, Balzano G, Zerbi A, Scaltrini F, Pasquali C, Calori G, Pessi F, Sperti C, Di Carlo V, Allavena P, Piemonti L. The CC chemokine MCP-1/CCL2 in pancreatic cancer progression: regulation of expression and potential mechanisms of antimalignant activity.  Cancer Res. 2003; 63:7451-61.

25 Chieppa M, Bianchi G, Doni A, Del Prete A, Sironi M, Laskarin G, Monti P, Piemonti L, Biondi A, Mantovani A, Introna M, Allavena P.  Cross-linking of the mannose receptor on monocyte-derived dendritic cells activates an anti-inflammatory immunosuppressive program. Journal of Immunology 2003;171:4552-60.

24 Piemonti L, Calori G, Mercalli A, Lattuada G, Monti P, Garancini MP, Costantino F, Ruotolo G, Luzi L, Perseghin G. Fasting plasma leptin, tumor necrosis factor-alpha receptor 2, and monocyte chemoattracting protein 1 concentration in a population of glucose-tolerant and glucose-intolerant women: impact on cardiovascular mortality.  Diabetes Care. 2003;26:2883-9.

23 Piemonti L, Zerbi A, Di Carlo V.  Strategies for tumor immune escape. Drugs Today (Barc) 2003;39:701-24.

22 Monti P, Allavena P, Di Carlo V, Piemonti L.  Effects of anti-lymphocytes and anti-thymocytes globulin on human dendritic cells. Int Immunopharmacol. 2003;3:189-96.

21 Monti P, Mercalli A, Leone BE, Valerio DC, Allavena P, Piemonti L.  Rapamycin impairs antigen uptake of human dendritic cells. Transplantation. 2003 15;75:137-45.

20 Gumbs AA, Bassi C, Moore PS, Falconi M, Frigerio I, Baron A, Piemonti L, Modlin I, Scarpa A. Overexpression of the Sm-like proto-oncogene in primary and metastatic pancreatic endocrine tumors.  JOP 3:109-15; 2002.

19 Piemonti L., Leone B.E., Nano R., Saccani A., Monti P., Maffi P., Bianchi G., Sica A., Peri G., Melzi R., Aldrighetti L., Secchi A., Di Carlo V., Allavena P., Bertuzzi F. Human pancreatic islets produce and secrete MCP-1: relevance in human islet transplantation. Diabetes 51:55-65; 2002.

18 Piemonti L., Monti P., Allavena P., Zerbi A., Balzano P., Valerio Di Carlo Generation and functional characterization of dendritic cells from patients with pancreatic carcinoma with special regard to clinical applicabilità. Cancer Immunology Immunotherapy  49:544-550; 2000.

17 Piemonti L. , Monti P, Allavena P, Sironi M., Di Carlo Valerio Vitamin D3 affects differentiation, maturation and function of human monocytes-derived dendritic cells. Journal of Immunolgy: 164: 4443-4451; 2000.

16 Piemonti L, Bertuzzi F,  Freschi M, Nano R.,  Leone  B. E., Socci C., Pozza G., Di Carlo V. Effects of cryopreservation on in vitro and in vivo long term function of human islets. Transplantation: 68: 655-662,1999. See also Commentary.

15 Piemonti L., Monti P., Allavena P., Leone B.E., Caputo A. Di Carlo V. Glucocorticoids  increase the  endocytiv activity of human dendritic cells. Int. Immunol:  11: 1519-1526; 1999.

14 Piemonti L., Monti P., Allavena P., Sironi M., Soldini L., Leone B.E.,  Socci C., Di Carlo V. Glucocorticoid affects human dendritic cell differentiation and maturation.  Journal of Immunology: 162: 6473-6481, 1999.

13 D’Amico G., Bianchi G., Bernasconi S., Bersani L., Piemonti L, Sozzani S., Mantovani A., Allavena P. Adhesion, transendothelial migration and reverse transmigration of dendritic cells. Blood 92: 207-214, 1998.

12 Allavena P, Piemonti L, Longoni D, Bernasconi S, Stopacciaro A, Ruco L and Mantovani A. Il-10 prevents the  differentiation of monocytes to dendritic cell but promotes their maturation to macrophages. European Journal of Immunology 28:359-369,1998.

11 Longoni D., Piemonti L., Bernasconi S., Mantovani A., Allavena P. IL-10 increases mannose receptor expression and endocytic activity in monocyte-derived dendritic cells. Int J Clin Lab Res  28: 162-169, 1998.

10 Sozzani S, Luini W, Borsatti A, Polentarutti N, Zhou D, Piemonti L, D’Amico G, Power C.A., Wells T.N.C., Gobbi M., , Allavena P., Mantovani A. Receptor expression and responsiveness of human dendritic cells to a defined set of CC and CXC chemokines. Journal of Immunology 159:1993-2000, 1997.

9 Secchi A, Socci C, Maffi P, Taglietti MV, Falqui L, Bertuzzi F, de Nittis P, Piemonti L, Scopsi L, Di Carlo V, and Guido Pozza. Islet transplantation in IDDM patients. Diabetologia  40: 225-231,1997.

8 Allavena P, Piemonti L, Longoni D, Bernasconi S, Stopacciaro A, Ruco L, Mantovani A. Il-10 prevents the generation of dendritic cells from CD14+ blood monocytes, promotes the differentiation to mature macrophages and stimulates endocytosis of FITC-dextran. Advances in Experimental Medicine and Biology  417:323-327, 1997.

7 Secchi A, Socci C, Maffi P, Falqui L, Bertuzzi F, de Nittis P, Piemonti L,  Taglietti MV, Di Carlo V and Guido Pozza. Islet transplantation in Type 1 diabetic patients:  effects  of islets number  on clinical  outcome  Transplant Proc.  28:2861-2865, 1996.

6 Bertuzzi F, Berra C, Socci C, Davalli AM, Calori G, Freschi M, Piemonti L, de Nittis P, Pozza G, Pontiroli AE. Glucagon improves insulin secretion of pig islets in vitro. J Endocrinol. 147:87-93,1995.

5 Sozzani S, Sallusto F, Luini W, Zhou D, Piemonti L, Allavena P, Van Damne Jo, Valitutti S, Lanzavecchia A, Mantovani A. Migration of dendritic cells in response to formyl peptides, C5a and a distinct set of chemokines. Journal of Immunology  7:32-35, 1995.

4 Piemonti L, Bernasconi S, Luini W, Trobonjaca Z, Minty A, Allavena P and Mantovani A. Il -13 supports differentiation of dendritic cells from circulating precursors in concert  with  GM-CSF. Eur. Cytokine Netw. 6: 245-252, 1995.

3 Socci C, Bertuzzi F, de Nittis P, Piemonti L, Taglietti MV, Berra C, Birkeland P, Freschi M, Di Carlo V,  Pozza G. Isolation and function of adult pig islets.  Xenotransplantation  2:218-221, 1995.

2 Socci C, Davalli AM, Maffi P, Falqui L, Secchi A, Bertuzzi F, Vignali A, Magistretti P, Zammarchi O, Scaglia L, Gavazzi F, Piemonti L, de Nittis P, Ferrari P, Di Carlo V, Pozza G. Allotransplantation of fresh and cryopreserved islets in patients with type I diabetes: two year experience.  Transplant Proc 25:989-991,1993.

1 Socci C, Vignali A, Davalli AM, Maffi P, Magistretti P, Bertuzzi F, Zammarchi O, Piemonti L, Di Carlo V, Pozza G. Timing of collagenase injection influences the final islet yield in donors aged under 30 years.  T

English version

Lorenzo Piemonti, MD, born in Carate Brianza, graduated with Summa cum Laude at the University of Milan in 1994, and specialized with Summa Cum Laude in Endocrinology and Metabolic Diseases  and in Micro and Experimental surgery at the University of Milan in 2000 and 2004, respectively. At the San Raffaele Scientific Institute (Milan, Italy) he serves as Director of Diabetes Research Institute, Director of Human Islet Transplantation Program (http://www.sanraffaele.org/ENGhome/ research/ divisions_centers_institutes_research_programs/ ITP/ index.html). He also serves as Chief of the Beta Cell Biology Unit (Diabetes Research Institute), and Director of Human Islet Processing Facility, and coordinator of European Consortium for Islet Transplantation that has been providing Human beta Cell Products for research and clinical applications at OSR, in Italy and across state barriers in Europe since 2000 (See European Consortium for Islet Transplantation, http://ecit.drisanraffaele.org/en/islet-transplatntation/index.html). He also serve as Professor in Endocrinology at University “Vita Salute San Raffaele” of Milan and as Honorary Visiting Professor at Vrije Universiteit of Brussel. His area of expertise is mainly focused on diabetes and pancreatology. In particular he has large experience about diabetes and pancreatic cancer. He has in the past studied the role of innate immunity in islet cell biology (especially in the human model of islet transplantation in type 1 diabetes recipient) and in pancreatic cancer biology (especially the role of chemokines and chemokine receptor system in inducing leukocytes infiltration). In addition, his research interests include beta cell replacement, immune tolerance induction strategies, dendritic cell biology, stem cells. He currently serves as section Editor of Cell Transplantation-the Regenerative Medicine Journal and of Current Diabetes Reports, as editorial board of Acta Dibetologia, as Councilor of the International Pancreas and Islet Transplantation Association (IPITA) of The Transplantation Society  (TTS) and as member of the European Pancreas and Islet Transplantation Association (EPITA) committee of European Society for Organ Transplantation (ESOT).

 

Lorenzo Piemonti authored a total of 158 original articles published in peer-reviewed journals surveyed in PubMed. h-index (06/07/2017): 38 Web of Science; 41 Scopus; 47 Google Scholar. Considering the period 2001-2017 Lorenzo Piemonti authored a total of 135 original articles published in peer-reviewed journals for an impact factor of 779,673 (mean impact factor: 5.775)

Il titolare del presente curriculum vitae, pubblicato online sul portale www.unisr.it, è garante in via esclusiva della correttezza e della veridicità dei dati e delle informazioni in esso riportate e del loro eventuale e puntuale aggiornamento. Egli è dunque il diretto ed unico responsabile dei contenuti indicati nei propri curricula.