Piemonti Lorenzo Professore associatoMedicineMED/13 – Endocrinologia




Lorenzo Piemonti, MD, born in Carate Brianza, graduated with Summa cum Laude at the University of Milan in 1994, and specialized with Summa Cum Laude in Endocrinology and Metabolic Diseases and in Micro and Experimental surgery at the University of Milan in 2000 and 2004, respectively.

At the San Raffaele Scientific Institute (Milan, Italy) he serves as Director of Diabetes Research Institute and Chief of the Department of Regenerative Medicine and Transplantation. He also serves as Head of the Beta Cell Biology Unit (Diabetes Research Institute), and Director of Human Islet Processing Facility, and coordinator of European Consortium for Islet Transplantation that has been providing Human beta Cell Products for research and clinical applications at HSR, in Italy and across state barriers in Europe since 2000 (See European Consortium for Islet Transplantation).

He also serves as Professor in Endocrinology at University “Vita Salute San Raffaele” of Milan and as Honorary Visiting Professor at Vrije Universiteit of Brussel. His area of expertise is mainly focused on diabetes and pancreatology. In particular, he has large experience about diabetes therapy and pathophysiology, regenerative medicine and pancreatic cancer.

In addition, his research interests include beta cell replacement, immune tolerance induction strategies, dendritic cell biology, and stem cells. He currently serves as section Editor of Cell Transplantation-the Regenerative Medicine Journal, as associated editor of Transplant International and Journal of Endocrinological Investigation, as member of editorial board of Acta Dibetologia, as treasurer of the International Pancreas and Islet Transplantation Association (2019-2023, IPITA) of The Transplantation Society (TTS), as member of the steering committee The European Pancreas and Islet Transplant Registry (EPITR 2020-2025) and as member of the National Board and scientific coordinator of the Italian Society of Diabetes (SID, 2020-2024). He previously served (2011-2017) as member of the European Pancreas and Islet Transplantation Association (EPITA) committee of European Society for Organ Transplantation (ESOT), as member of the National Committee for Food Safety (2018-2021, Italian Ministry of Health),and as Councilor of IPITA (2015-2019).


Lorenzo Piemonti authored a total of 285 original articles published in peer-reviewed journals surveyed in PubMed. H-index (31/12/2022): 61 Web of Science; 64 Scopus; 73 Google Scholar. Considering the period 2017-present Lorenzo Piemonti authored a total of 122 original articles published in peer-reviewed journals for an impact factor of 902.505 (mean impact factor: 7.398)


Selected publications (2020-2023)


Piemonti L. Islet Transplantation. 2022 Sep 16. In: Feingold KR, Anawalt B, Blackman MR, Boyce A, Chrousos G, Corpas E, de Herder WW, Dhatariya K, Hofland J, Dungan K, Hofland J, Kalra S, Kaltsas G, Kapoor N, Koch C, Kopp P, Korbonits M, Kovacs CS, Kuohung W, Laferrère B, Levy M, McGee EA, McLachlan R, New M, Purnell J, Sahay R, Singer F, Sperling MA, Stratakis CA, Trence DL, Wilson DP, editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000–.

PMID: 25905200.


Sordi V, Monaco L, Piemonti L. Cell therapy for type 1 diabetes: from islet transplantation to stem cells. Horm Res Paediatr. 2022 Aug 30. doi:10.1159/000526618. Epub ahead of print. PMID: 36041412.


Laurenzi A, Caretto A, Molinari C, Mercalli A, Melzi R, Nano R, Tresoldi C, Rovere Querini P, Ciceri F, Lampasona V, Bosi E, Scavini M, Piemonti L. No Evidence of Long-Term Disruption of Glycometabolic Control After SARS-CoV-2 Infection. J Clin Endocrinol Metab. 2022 Feb 17;107(3):e1009-e1019. doi:10.1210/clinem/dgab792. PMID: 34718627; PMCID: PMC8691144.


Chimienti R, Baccega T, Torchio S, Manenti F, Pellegrini S, Cospito A, Amabile A, Lombardo MT, Monti P, Sordi V, Lombardo A, Malnati M, Piemonti L. Engineering of immune checkpoints B7-H3 and CD155 enhances immune compatibility of MHC-I<sup>-/-</sup> iPSCs for β cell replacement. Cell Rep. 2022 Sep 27;40(13):111423. doi: 10.1016/j.celrep.2022.111423. PMID: 36170817; PMCID: PMC9532846.


Ferrara B, Dugnani E, Sordi V, Pasquale V, Pellegrini S, Reni M, Balzano G, Piemonti L. A Comprehensive Characterization of Stemness in Cell Lines and Primary Cells of Pancreatic Ductal Adenocarcinoma. Int J Mol Sci. 2022 Sep 14;23(18):10663. doi: 10.3390/ijms231810663. PMID: 36142575; PMCID: PMC9503169.


Balzano G, Zerbi A, Aleotti F, Capretti G, Melzi R, Pecorelli N, Mercalli A, Nano R, Magistretti P, Gavazzi F, De Cobelli F, Poretti D, Scavini M, Molinari C, Partelli S, Crippa S, Maffi P, Falconi M, Piemonti L. Total Pancreatectomy with islet Autotransplantation as an Alternative to high-risk

Pancreatojejunostomy after Pancreaticoduodenectomy: A Prospective Randomized Trial. Ann Surg. 2022 Sep 30. doi: 10.1097/SLA.0000000000005713. Epub ahead of print. PMID: 36177837.


Landoni G, Zangrillo A, Piersanti G, Scquizzato T, Piemonti L. The effect of reparixin on survival in patients at high risk for in-hospital mortality: a meta-analysis of randomized trials. Front Immunol. 2022 Jul 25;13:932251. doi:10.3389/fimmu.2022.932251. PMID: 35958623; PMCID: PMC9358031.


Piemonti L, Keymeulen B, Gillard P, Linn T, Bosi E, Rose L, Pozzilli P, Giorgino F, Cossu E, Daffonchio L, Goisis G, Ruffini PA, Maurizi AR, Mantelli F, Allegretti M. Ladarixin, an inhibitor of the interleukin-8 receptors CXCR1 and CXCR2, in new-onset type 1 diabetes: A multicentre, randomized, double-blind, placebo-controlled trial. Diabetes Obes Metab. 2022 Sep;24(9):1840-1849. doi: 10.1111/dom.14770. Epub 2022 Jul 4. PMID: 35589610; PMCID: PMC9540558.


Piemonti L, Sordi V, Pellegrini S, Scotti GM, Scavini M, Sioli V, Gianelli Castiglione A, Cardillo M. Circulating CXCL10 and IL-6 in solid organ donors after brain death predict graft outcomes. Sci Rep. 2021 Mar 23;11(1):6624. doi: 10.1038/s41598-021-86085-6. PMID: 33758270.


Dispinseri S, Lampasona V, Secchi M, Cara A, Bazzigaluppi E, Negri D, Brigatti C, Pirillo MF, Marzinotto I, Borghi M, Rovere-Querini P, Tresoldi C, Ciceri F, Scavini M, Scarlatti G, Piemonti L. Robust neutralizing antibodies to SARS-CoV-2 develop and persist in subjects with diabetes and COVID-19 pneumonia. J Clin Endocrinol Metab. 2021 Jan 29:dgab055. doi: 10.1210/clinem/dgab055. Epub ahead of print. PMID: 33513242


Pellegrini S, Pipitone GB, Cospito A, Manenti F, Poggi G, Lombardo MT, Nano R, Martino G, Ferrari M, Carrera P, Sordi V, Piemonti L. Generation of β cells from iPSC of a MODY8 patient with a novel mutation in the carboxyl ester lipase (CEL) gene. J Clin Endocrinol Metab. 2021 Jan 8:dgaa986. doi: 10.1210/clinem/dgaa986. Epub ahead of print. PMID: 33417713.


Bolla AM, Gandolfi A, Borgonovo E, Laurenzi A, Caretto A, Molinari C, Catalano RS, Bianconi E, Monti P, Sordi V, Pellegrini S, Lampasona V, Costa S, Scavini M, Bosi E, Piemonti L. Rapamycin Plus Vildagliptin to Recover β-Cell Function in Long-Standing Type 1 Diabetes: A Double-Blind, Randomized Trial. J Clin Endocrinol Metab. 2021 Jan 23;106(2):e507-e519. doi: 10.1210/clinem/dgaa791. PMID: 33124663.


Lampasona V, Secchi M, Scavini M, Bazzigaluppi E, Brigatti C, Marzinotto I, Davalli A, Caretto A, Laurenzi A, Martinenghi S, Molinari C, Vitali G, Di Filippo L, Mercalli A, Melzi R, Tresoldi C, Rovere-Querini P, Landoni G, Ciceri F, Bosi E, Piemonti L. Antibody response to multiple antigens of SARS-CoV-2 in patients with diabetes: an observational cohort study. Diabetologia. 2020 Dec;63(12):2548-2558. doi: 10.1007/s00125-020-05284-4. Epub 2020 Oct 8. PMID: 33029657; PMCID: PMC7541098.


Secchi M, Bazzigaluppi E, Brigatti C, Marzinotto I, Tresoldi C, Rovere-Querini P, Poli A, Castagna A, Scarlatti G, Zangrillo A, Ciceri F, Piemonti L§, Lampasona V§. COVID-19 survival associates with the immunoglobulin response to the SARS-CoV-2 spike receptor binding domain. J Clin Invest. 2020 Dec 1;130(12):6366-6378. doi: 10.1172/JCI142804. PMID: 32991329; PMCID: PMC7685720. (§ these authors equally contributed to the study)


Maffi P, Lundgren T, Tufveson G, Rafael E, Shaw JAM, Liew A, Saudek F, Witkowski P, Golab K, Bertuzzi F, Gustafsson B, Daffonchio L, Ruffini PA, Piemonti L; and the REP0211 Study Group; REP0211 Study Group. Targeting CXCR1/2 Does Not Improve Insulin Secretion After Pancreatic Islet Transplantation: A Phase 3, Double-Blind, Randomized, Placebo-Controlled Trial in Type 1 Diabetes. Diabetes Care. 2020 Apr;43(4):710-718. doi: 10.2337/dc19-1480. Epub 2020 Feb 4. PMID: 32019854


Nano R, Kerr-Conte JA, Scholz H, Engelse M, Karlsson M, Saudek F, Bosco D, Antonioli B, Bertuzzi F, Johnson PRV, Ludwing B, Ling Z, De Paep DL, Keymeulen B, Pattou F, Berney T, Korsgren O, de Koning E, Piemonti L. Heterogeneity of human pancreatic islet isolation around Europe: results of a survey study. Transplantation. 2020 Jan;104(1):190-196. doi: 10.1097/TP.0000000000002777. PMID: 31365472.

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