Arbore Giuseppina Ricercatore tempo determinato tipo aMedicine




Dr. Giuseppina Arbore is Researcher in Biochemistry at Vita-Salute San Raffaele University, and Researcher in Immunology in the Division of Immunology, Transplantation and Infectious Diseases (DITID) at the San Raffaele Scientific Institute. Her scientific research activity is focussed in studying the molecular and biochemical mechanisms involved in autoimmunity, infectious diseases and cancer.

On 2011 Dr. Arbore started her research activity in Immunology in the United Kingdom, at the beginning in Cambridge University (Babraham Institute) and from 2012 at King’s College London. Here she studied novel molecular mechanisms involved in the regulation of immune response in autoimmune and autoinflammatory diseases, obtaining in 2016 the title of PhD in Immunology.  On 2017 Giuseppina Arbore moved back to Italy and started to work at the Experimental Immunology Unit at the San Raffaele Scientific Institute.She is currently studying the role of the immune system in cancer progression, and in particular immune responses directed against esophageal cancer, in collaboration with the Gastroenterology Surgery Unit at IRCCS San Raffaele Hospital.


2016: Ph.D. in Immunology, King’s College London (London, United Kingdom)

2010: Master Degree, Medical Biotechnologies and Molecular Medicine (110/110 e lode), University of Bari Aldo Moro (Italy)

2008: Bachelor Degree, Sanitary and Pharmaceutical Biotechnologies (110/110 e lode), University of Bari Aldo Moro (Italy)


2022-Present: Researcher in Biochemistry (BIO/10) - Faculty of Medicine and Surgery of the Vita-Salute San Raffaele University

2017-Present: Researcher in Immunology –Experimental Immunology Unit, Division of Immunology, Transplantation and Infectious diseases (DITID), San Raffaele Scientific Institute, Milan (Italy)

2013-2017: PhD student and Junior Post-Doc – King’s College London (United Kingdom)

2011-2012: Junior Researcher, Babraham Institute, Cambridge University (United Kingdom)

2008-2010: Thesis internship (Bachelor and Master degree) – Institute of Biomembranes, Bioenergetics and Molecular Biotechnology, National Research Council (CNR) Bari (Italy) 


Tumor Immunology, Immune responses to viral infection, Immune responses in autoimmune diseases, biochemical and molecular mechanisms involved in the regulation of innate and adaptive immunity, T and B lymphocytes, biology and dynamics of the cells of the immune system


2022-Present: PNRR Young Researcher MSCA (Italian Ministry of University and Research)

2021-2022: My first AIRC grant (AIRC Foundation)

2020: L’Oréal UNESCO for Women in Science Italy (L’Oréal Italy)

2018-2020: Marie Curie Individual Fellowship (European Commission)

2017-2018: EMBO Long-term fellowship (European Molecular Biology Organization)    


 2018-Present: Member of the Organizing Committee of the Congress “Milan Meets Immunology”, Milan (Italy)

2021-Present: Reviewer in scientific journals in Immunology and Oncology


ORCID ID: 0000-0002-8318-7557

Scopus ID: 56730838300


(Update january 2023)


Arbore G, Ong VH, Costantini B, Denton CP, Abraham D, Placais L, Blighe K, Mitchell L, Ellis R, Heck S, Nocerino P, Woodruff TM, Kordasti S, Kemper C, Hourcade DE. (2020) Deep phenotyping detects a pathological CD4+ T-cell complosome signature in systemic sclerosis, Cell Mol Immunol 17(9):1010-1013. doi: 10.1038/s41423-019-0360-8. PMID: 31974397

Arbore G, Henley T, Biggins L, Andrews S, Vigorito E, Turner M, Leyland R. (2019) MicroRNA-155 is essential for the optimal proliferation and survival of plasmablast B cells. Life Sci Alliance. 2(3). pii: e201800244. doi: 10.26508/lsa.201800244. PMID: 31097471

Arbore G, West EE, Rahman J, Le Friec G, Niyonzima N, Pirooznia M, Tunc I, Pavlidis P, Powell N, Li Y, Liu P, Servais A, Couzi L, Fremeaux-Bacchi V, Placais L, Ferraro A, Walsh PR, Kavanagh D, Afzali B, Lavender P, Lachmann HJ, Kemper C. (2018) Complement receptor CD46 co-stimulates optimal human CD8+ T cell effector function via fatty acid metabolism. Nat Commun 9(1):4186. doi: 10.1038/s41467-018-06706-z. PMID: 30305631

Jiménez-Reinoso A, Marin AV, Subias M, López-Lera A, Román-Ortiz E, Payne K, Ma CS, Arbore G, Kolev M, Freeley SJ, Kemper C, Tangye SG, Fernández-Malavé E, Rodríguez de Córdoba S, López-Trascasa M, Regueiro JR. (2018) Human plasma C3 is essential for the development of memory B, but not T, lymphocytes. J Allergy Clin Immunol 141(3):1151-1154.e14. doi: 10.1016/j.jaci.2017.09.037. PMID: 29113906

Arbore G, Kemper C, Kolev M. (2017) Intracellular complement - the complosome - in immune cell regulation. Mol Immunol 89:2-9. – Review doi: 10.1016/j.molimm.2017.05.012. PMID: 28601357

Papin J, Brennand A, Arbore G, Hohenstein B, Kamvissi V, Kemper C, Bornstein SR. (2017) Dysregulation of the CD4+ T cells lineage differentiation in dyslipidemic patients and impact of lipoprotein-apheresis treatment: A case study. Atheroscler Suppl 30:238-245. doi: 10.1016/j.atherosclerosissup.2017.05.046. PMID: 29096844

Arbore G, West EE, Spolski R, Robertson AAB, Klos A, Rheinheimer C, Dutow P, Woodruff TM, Yu ZX, O'Neill LA, Coll RC, Sher A, Leonard WJ, Köhl J, Monk P, Cooper MA, Arno M, Afzali B, Lachmann HJ, Cope AP, Mayer-Barber KD, Kemper C. (2016) T helper 1 immunity requires complement-driven, NLRP3 inflammasome activity in CD4+ T cells. Science. 352(6292):aad1210. doi: 10.1126/science.aad1210. PMID: 27313051

Arbore G, Kemper C. (2016) A novel ‘Complement – Metabolism – Inflammasome Triangle’ as key regulator of immune cell effector function. Eur J Immunol 46(7):1563-1573. – Review doi: 10.1002/eji.201546131. PMID: 27184294

Nakagawa R, Leyland R, Meyer-Hermann M, Lu D, Turner M, Arbore G, Phan TG, Brink R, Vigorito E. (2016) MicroRNA-155 controls affinity-based selection by protecting c-MYC+ B cells from apoptosis. Journal of Clinical Investigation 126(1):377-88. doi: 10.1172/JCI82914. PMID: 26657861

Kolev M, Dimeloe S, Le Friec G, Navarini A, Arbore G, Povoleri GA, Fischer M, Belle R, Loeliger J, Develioglu L, Bantug GR, Watson J, Couzi L, Afzali B, Lavender P, Hess C, Kemper C. (2015) Complement regulates nutrient influx and metabolic reprogramming during Th1responses. Immunity 42:1033-47. doi: 10.1016/j.immuni.2015.05.024. PMID: 26084023

(Update january 2023)

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