Briganti Alberto Professore ordinarioMedicineMED/24

Alberto Briganti is Full Professor of Urology at Vita-Salute San Raffaele University, one of most experienced clinical centers worldwide in the surgical treatment of genitourinary cancers. He is also deputy-director of the Urological Research Institute (URI) and director of the Robotic Surgical Program of the Department of Urology at San Raffaele Hospital. He was awarded his medical degree from Vita-Salute San Raffaele University, where he also completed his residency training in Urology.

He gained his Ph.D. in Clinical and Experimental Biotechnology in Urology in 2016. At present, Prof. Briganti’s main research interests are in the field preclinical and clinical prostate cancer. He is the author of more than 1100 scientific works published in international peer-reviewed journals (H-Index is 83 – November 2021) and he is a reviewer of numerous scientific journals in the field of urology and oncology. 

Prof. Briganti is member of several international scientific societies including the European Association of Urology (EAU) and the American Association of Genitourinary Surgeons (AAGUS). He is also a member of the EAU Scientific Committee.

Since 2018, Prof. Briganti is the Editor-in-Chief of European Urology Oncology, one of the official Journals of the European Association of Urology, fully devoted to the research of genitourinary cancers. He has contributed to the development of several multi-institutional data-bases for prostate cancer staging and outcomes which have been used for improving currently available prediction models.

Through his career, Prof. Briganti has been the recipient of highly prestigious grants to fund multiple research projects. Of note, he won the Giovani Ricercatori (Young Researcher’s) award from the Italian Ministry of Health in 2009 for a project aimed at identifying the genetic profile of men at risk of developing prostate cancer. In 2010, he was awarded a grant from the European Society of Sexual Medicine (ESSM) to develop a project to study the recovery of sexual function following radical prostatectomy. In 2018, Prof. Briganti was awarded a grant from the Italian Ministry of Health with a project titled “Development of a Novel Signature Integrating Clinical, Imaging And Epigenetic Information to Tailor Pelvic Nodal Treatment in Prostate Cancer”.

In recognition of his academic career, in 2016 Prof. Briganti received the Matula Award, assigned yearly by the European Association of Urology (EAU) to the most promising academic urologist younger than 40 years of age.

(Nov. 2021)

Selected publications

Commensal bacteria promote endocrine resistance in prostate cancer through androgen biosynthesis. Pernigoni, N., Zagato, E., Calcinotto, A., Troiani, M., Mestre, R.P., Calì, B., Attanasio, G., Troisi, J., Minini, M., Mosole, S., Revandkar, A., Pasquini, E., Elia, A.R., Bossi, D., Rinaldi, A., Rescigno, P., Flohr, P., Hunt, J., Neeb, A., Buroni, L., Guo, C., Welti, J., Ferrari, M., Grioni, M., Gauthier, J., Gharaibeh, R.Z., Palmisano, A., Lucchini, G.M., D’Antonio, E., Merler, S., Bolis, M., Grassi, F., Esposito, A., Bellone, M., Briganti, A., Rescigno, M., Theurillat, J.-P., Jobin, C., Gillessen, S., de Bono, J., Alimonti, A. Science. 2021 Oct 8;374(6564):216-224.

Long-term Outcomes of Salvage Lymph Node Dissection for Nodal Recurrence of Prostate Cancer After Radical Prostatectomy: Not as Good as Previously Thought. Bravi CA, Fossati N, Gandaglia G, Suardi N, Mazzone E, Robesti D, Osmonov D, Juenemann KP, Boeri L, Jeffrey Karnes R, Kretschmer A, Buchner A, Stief C, Hiester A, Nini A, Albers P, Devos G, Joniau S, Van Poppel H, Shariat SF, Heidenreich A, Pfister D, Tilki D, Graefen M, Gill IS, Mottrie A, Karakiewicz PI, Montorsi F, Briganti A.Eur Urol. 2020 Nov;78(5):661-669.

Metastasis-Directed Therapy for Oligorecurrent Prostate Cancer-Not All That Glitters Is Gold.  Briganti, A., Gandaglia, G., Montorsi, F. JAMA Oncol. 2020 Oct 1;6(10):1638-1639

Assessing the Best Surgical Template at Salvage Pelvic Lymph Node Dissection for Nodal Recurrence of Prostate Cancer After Radical Prostatectomy: When Can Bilateral Dissection be Omitted? Results from a Multi-institutional Series. Bravi CA, Fossati N, Gandaglia G, Suardi N, Mazzone E, Robesti D, Osmonov D, Juenemann KP, Boeri L, Jeffrey Karnes R, Kretschmer A, Buchner A, Stief C, Hiester A, Nini A, Albers P, Devos G, Joniau S, Van Poppel H, Shariat SF, Heidenreich A, Pfister D, Tilki D, Graefen M, Gill IS, Mottrie A, Karakiewicz PI, Montorsi F, Briganti A. Eur Urol. 2020 Dec;78(6):779-782.

Risk Stratification of Patients Candidate to Radical Prostatectomy Based on Clinical and Multiparametric Magnetic Resonance Imaging Parameters: Development and External Validation of Novel Risk Groups. Mazzone E, Gandaglia G, Ploussard G, Marra G, Valerio M, Campi R, Mari A, Minervini A, Serni S, Moschini M, Marquis A, Beauval JB, van den Bergh R, Rahota RG, Soeterik T, Roumiguiè M, Afferi L, Zhuang J, Tuo H, Mattei A, Gontero P, Cucchiara V, Stabile A, Fossati N, Montorsi F, Briganti A. Eur Urol. 2021 Aug 13:S0302-2838(21)01930-8. 

Surgical Safety of Radical Cystectomy and Pelvic Lymph Node Dissection Following Neoadjuvant Pembrolizumab in Patients with Bladder Cancer: Prospective Assessment of Perioperative Outcomes from the PURE-01 Trial. Briganti A, Gandaglia G, Scuderi S, Gallina A, Colombo R, Fossati N, Barletta F, Pellegrino A, Nocera L, Montorsi F, Necchi A.Eur Urol. 2020 May;77(5):576-580.

MRI-targeted or standard biopsy for prostate-cancer diagnosis. Kasivisvanathan, V., Rannikko, A.S., Borghi, M., Panebianco, V., Mynderse, L.A., Vaarala, M.H., Briganti, A., et al. N Engl J Med. 2018 May 10;378(19):1767-1777

IL-23 secreted by myeloid cells drives castration-resistant prostate cancer. Calcinotto, A., Spataro, C., Zagato, E., Di Mitri, D., Gil, V., Crespo, M., De Bernardis, G., Losa, M., Mirenda, M., Pasquini, E., Rinaldi, A., Sumanasuriya, S., Lambros, M.B., Neeb, A., Lucianò, R., Bravi, C.A., Nava-Rodrigues, D., Dolling, D., Prayer-Galetti, T., Ferreira, A., Briganti, A., Esposito, A., Barry, S., Yuan, W., Sharp, A., De Bono, J., Alimonti, A. Nature. 2018 Jul;559(7714):363-369.

Active Surveillance for Low-risk Prostate Cancer: The European Association of Urology Position in 2018. Briganti, A., Fossati, N., Catto, J.W.F., Cornford, P., Montorsi, F., Mottet, N., Wirth, M., Van Poppel, H. Eur Urol. 2018 Sep;74(3):357-368

Updated nomogram predicting lymph node invasion in patients with prostate cancer undergoing extended pelvic lymph node dissection: The essential importance of percentage of positive cores. Briganti, A., Larcher, A., Abdollah, F., Capitanio, U., Gallina, A., Suardi, N., Bianchi, M., Sun, M., Freschi, M., Salonia, A., Karakiewicz, P.I., Rigatti, P., Montorsi, F. Eur Urol 2012 Mar;61(3):480-7.

Implementation of Germline Testing for Prostate Cancer: Philadelphia Prostate Cancer Consensus Conference 2019. Giri, V.N., Knudsen, K.E., Kelly, W.K., Cheng, H.H., Cooney, K.A., Cookson, M.S., Dahut, W., Weissman, S., Soule, H.R., Petrylak, D.P., Dicker, A.P., AlDubayan, S.H., Toland, A.E., Pritchard, C.C., Pettaway, C.A., Daly, M.B., Mohler, J.L., Parsons, J.K., Carroll, P.R., Pilarski, R., Blanco, A., Woodson, A., Rahm, A., Taplin, M.-E., Polascik, T.J., Helfand, B.T., Hyatt, C., Morgans, A.K., Feng, F., Mullane, M., Powers, J., Concepcion, R., Lin, D.W., Wender, R., Mark, J.R., Costello, A., Burnett, A.L., Sartor, O., Isaacs, W.B., Xu, J., Weitzel, J., Andriole, G.L., Beltran, H., Briganti, A., et al. J Clin Oncol. 2020 Aug 20;38(24):2798-2811

Assessing the optimal timing for early salvage radiation therapy in patients with prostate-specific antigen rise after radical prostatectomy. Fossati, N., Karnes, R.J., Cozzarini, C., Fiorino, C., Gandaglia, G., Joniau, S., Boorjian, S.A., Goldner, G., Hinkelbein, W., Haustermans, K., Tombal, B., Shariat, S., Karakiewicz, P.I., Montorsi, F., Van Poppel, H., Wiegel, T., Briganti, A. Eur Urol. 2016 Apr;69(4):728-733.

Metastasis-directed therapy of regional and distant recurrences after curative treatment of prostate cancer: A systematic review of the literature. Ost, P., Bossi, A., Decaestecker, K., De Meerleer, G., Giannarini, G., Karnes, R.J., Roach, M., Briganti, A. Eur Urol. 2015 May;67(5):852-63.

Two Positive Nodes Represent a Significant Cut-off Value for Cancer Specific Survival in Patients with Node Positive Prostate Cancer. A New Proposal Based on a Two-Institution Experience on 703 Consecutive N+ Patients Treated with Radical Prostatectomy, Extended Pelvic Lymph Node Dissection and Adjuvant Therapy. Briganti, A., Karnes, J.R., Da Pozzo, L.F., Cozzarini, C., Gallina, A., Suardi, N., Bianchi, M., Freschi, M., Doglioni, C., Fazio, F., Rigatti, P., Montorsi, F., Blute, M.L. Eur Urol. 2009 Feb;55(2):261-70.

Validation of a Nomogram Predicting the Probability of Lymph Node Invasion among Patients Undergoing Radical Prostatectomy and an Extended Pelvic Lymphadenectomy. Briganti, A., Chun, F.K.-H., Salonia, A., Zanni, G., Scattoni, V., Valiquette, L., Rigatti, P., Montorsi, F., Karakiewicz, P.I. Eur Urol. 2006 Jun;49(6):1019-26; discussion 1026-7

Impact of adjuvant radiotherapy on survival of patients with node-positive prostate cancer. Abdollah, F., Karnes, R.J., Suardi, N., Cozzarini, C., Gandaglia, G., Fossati, N., Vizziello, D., Sun, M., Karakiewicz, P.I., Menon, M., Montorsi, F., Briganti, A. J Clin Oncol. 2014 Dec 10;32(35):3939-47.

Long-term outcomes of salvage lymph node dissection for clinically recurrent prostate cancer: Results of a single-institution series with a minimum follow-up of 5 years. Suardi, N., Gandaglia, G., Gallina, A., Di Trapani, E., Scattoni, V., Vizziello, D., Cucchiara, V., Bertini, R., Colombo, R., Picchio, M., Giovacchini, G., Montorsi, F., Briganti, A. Eur Urol. 2015 Feb;67(2):299-309.

Combination of adjuvant hormonal and radiation therapy significantly prolongs survival of patients with pT2-4 pN+ prostate cancer: Results of a matched analysis. Briganti, A., Karnes, R.J., Pozzo, L.F.D., Cozzarini, C., Capitanio, U., Gallina, A., Suardi, N., Bianchi, M., Tutolo, M., Salonia, A., Di Muzio, N., Rigatti, P., Montorsi, F., Blute, M. Eur Urol. 2011 May;59(5):832-40.

More extensive pelvic lymph node dissection improves survival in patients with node-positive prostate cancer. Abdollah, F., Gandaglia, G., Suardi, N., Capitanio, U., Salonia, A., Nini, A., Moschini, M., Sun, M., Karakiewicz, P.I., Shariat, S.F., Montorsi, F., Briganti, A. Eur Urol. 2015 Feb;67(2):212-9

 

Early salvage radiation therapy does not compromise cancer control in patients with pT3N0 prostate cancer after radical prostatectomy: Results of a match-controlled multi-institutional analysis. Briganti, A., Wiegel, T., Joniau, S., Cozzarini, C., Bianchi, M., Sun, M., Tombal, B., Haustermans, K., Budiharto, T., Hinkelbein, W., Di Muzio, N., Karakiewicz, P.I., Montorsi, F., Van Poppel, H.
Eur Urol. 2012 Sep;62(3):472-87.

 

When to Perform Bone Scan in Patients with Newly Diagnosed Prostate Cancer: External Validation of the Currently Available Guidelines and Proposal of a Novel Risk Stratification Tool. Briganti, A., Passoni, N., Ferrari, M., Capitanio, U., Suardi, N., Gallina, A., Pozzo, L.F.D., Picchio, M., Di Girolamo, V., Salonia, A., Gianolli, L., Messa, C., Rigatti, P., Montorsi, F. Eur Urol. 2010 Apr;57(4):551-8.

Identifying the best candidate for radical prostatectomy among patients with high-risk prostate cancer. Briganti, A., Joniau, S., Gontero, P., Abdollah, F., Passoni, N.M., Tombal, B., Marchioro, G., Kneitz, B., Walz, J., Frohneberg, D., Bangma, C.H., Graefen, M., Tizzani, A., Frea, B., Karnes, R.J., Montorsi, F., Van Poppel, H., Spahn, M. Eur Urol. 2012 Mar;61(3):584-92

Prediction of outcome following early salvage radiotherapy among patients with biochemical recurrence after radical prostatectomy. Briganti, A., Karnes, R.J., Joniau, S., Boorjian, S.A., Cozzarini, C., Gandaglia, G., Hinkelbein, W., Haustermans, K., Tombal, B., Shariat, S., Sun, M., Karakiewicz, P.I., Montorsi, F., Van Poppel, H., Wiegel, T. Eur Urol. 2014 Sep;66(3):479-86.

Performance characteristics of computed tomography in detecting lymph node metastases in contemporary patients with prostate cancer treated with extended pelvic lymph node dissection. Briganti, A., Abdollah, F., Nini, A., Suardi, N., Gallina, A., Capitanio, U., Bianchi, M., Tutolo, M., Passoni, N.M., Salonia, A., Colombo, R., Freschi, M., Rigatti, P., Montorsi, F. Eur Urol. 2012 Jun;61(6):1132-8

 

Predicting Erectile Function Recovery after Bilateral Nerve Sparing Radical Prostatectomy: A Proposal of a Novel Preoperative Risk Stratification. Briganti, A., Gallina, A., Suardi, N., Capitanio, U., Tutolo, M., Bianchi, M., Passoni, N., Salonia, A., Colombo, R., Di Girolamo, V., Guazzoni, G., Rigatti, P., Montorsi, F. J Sex Med. 2010 Jul;7(7):2521-31.

Impact of age and comorbidities on long-term survival of patients with high-risk prostate cancer treated with radical prostatectomy: A multi-institutional competing-risks analysis

Briganti, A., Spahn, M., Joniau, S., Gontero, P., Bianchi, M., Kneitz, B., Chun, F.K.H., Sun, M., Graefen, M., Abdollah, F., Marchioro, G., Frohenberg, D., Giona, S., Frea, B., Karakiewicz, P.I., Montorsi, F., Van Poppel, H., Jeffrey Karnes, R.
Eur Urol. 2013 Apr;63(4):693-701

Natural history of surgically treated high-risk prostate cancer. Briganti, A., Karnes, R.J., Gandaglia, G., Spahn, M., Gontero, P., Tosco, L., Kneitz, B., Chun, F.K.H., Zaffuto, E., Sun, M., Graefen, M., Marchioro, G., Frohneberg, D., Giona, S., Karakiewicz, P.I., Van Poppel, H., Montorsi, F., Joniau, S. Urol Oncol. 2015 Apr;33(4):163.e7-13.

Development and Internal Validation of a Novel Model to Identify the Candidates for Extended Pelvic Lymph Node Dissection in Prostate Cancer. Gandaglia, G., Fossati, N., Zaffuto, E., Bandini, M., Dell'Oglio, P., Bravi, C.A., Fallara, G., Pellegrino, F., Nocera, L., Karakiewicz, P.I., Tian, Z., Freschi, M., Montironi, R., Montorsi, F., Briganti, A. Eur Urol. 2017 Oct;72(4):632-640.

Impact of adjuvant radiation therapy on urinary continence recovery after radical prostatectomy. Suardi, N., Gallina, A., Lista, G., Gandaglia, G., Abdollah, F., Capitanio, U., Dell'Oglio, P., Nini, A., Salonia, A., Montorsi, F., Briganti, A. Eur Urol. 2014 Mar;65(3):546-51.

Pelvic Lymph Node Dissection in Prostate Cancer. Briganti, A., Blute, M.L., Eastham, J.H., Graefen, M., Heidenreich, A., Karnes, J.R., Montorsi, F., Studer, U.E. Eur Urol. 2009 Jun;55(6):1251-65