Brombin Chiara Professore AssociatoPsychologySECS-S/01

CURRENT POSITION

Associate Professor in Statistics SECS-S/01, at the Faculty of Psychology (Vita-Salute San Raffaele University), and involved in CUSSB (University Centre for Statistics in the Biomedical Sciences) research activities.

PREVIOUS EXPERIENCES AND EDUCATION

2018-2021: Assistant Professor in Statistics SECS-S/01 (RTD-B) at the Faculty of Psychology (Vita-Salute San Raffaele University).

2016-2018: Assistant Professor in Statistics SECS-S/01 (RTD-A) at the Faculty of Psychology (Vita-Salute San Raffaele University).

2013-2016: FIRB Researcher and national coordinator of the FIRB 2012 project (RBFR12VHR7) “Interpreting emotions: a computational tool integrating facial expressions and biosignals based on shape analysis and bayesian networks”. Assistant Professor in Statistics SECS-S/01 (RTD-A) at the Faculty of Psychology (Vita-Salute San Raffaele University).

2010-2013: Research fellowship at CUSSB, University Centre for Statistics in the Biomedical Sciences, Vita-Salute San Raffaele University, Milan (supervised by Prof. Clelia Di Serio). Research project entitled: “Parametric and non-parametric modeling of multivariate longitudinal studies”.

2009-2010: Post-doc grant in “Multivariate permutation methods with applications in both biomedical and management field: theoretical development and statistical software applications”. The research project is supported by the University of Padova CPDA088513 (Project Coordinator: Prof. Luigi Salmaso).

2006-2009: PhD in Statistical Sciences, at the Department of Statistical Sciences, University of Padova. Thesis on “A nonparametric permutation approach to statistical shape analysis” (Supervisor: Prof. Luigi Salmaso).

2000-2005: Laurea Degree (four years) in Statistics, at the Faculty of Statistical Sciences, University of Padova, Italy. Thesis on “Multivariate analysis with paired observations and missing values”, advisors: Prof. Fortunato Pesarin and Prof. Giovanni A. Fava.

 

RESEARCH INTEREST

Shape analysis

Permutation tests

Multivariate statistics

Linear and nonlinear mixed-effect models

Survival analysis

Joint models for longitudinal and time-to-event data

Application and extension of statistical methods in biomedical research

TEACHING ACTIVITIES

From 2021 to 2022: Teaching Assistant of Statistics (Faculty of Psychology, Vita-Salute San Raffaele University, Milano).

Since 2011: Teaching Assistant of Advanced statistics → Multidimensional data analysis (Faculty of Psychology, Vita-Salute San Raffaele University, Milano).

Since 2014: Teaching Assistant of Applied Statistics (Faculty of Psychology, Vita-Salute San Raffaele University, Milano).

Since 2017: Professor of the course of Statistical methods in social sciences → Advanced models for social and psychological sciences → Advanced modelling in psychology (Master in Cognitive Psychology in health communication, Vita-Salute San Raffaele University, Milano).

Perego, G., Cugnata, F., Brombin, C., Milano, F., Mazzetti, M., Taranto, P., Preti, E., Di Pierro, R., De Panfilis, C., Madeddu, F. and Di Mattei, V.E., 2023. Analysis of healthcare workers’ mental health during the COVID-19 pandemic: Evidence from a Three-Wave Longitudinal Study. Journal of Health Psychology, p.13591053231168040.

Ferrari, S., Jacob, A., Cesana, D., Laugel, M., Beretta, S., Varesi, A., Unali, G., Conti, A., Canarutto, D., Albano, L., Calabria, A., Vavassori, V., Cipriani, C., Castiello, M.C., Esposito, S., Brombin, C., Cugnata, F., Adjali, O., Ayuso, E., Merelli, I., Villa, A., Di Micco, R., Kajaste-Rudnitski, A., Montini, E., Penaud-Budloo, M., Naldini, L. (2022) Choice of template delivery mitigates the genotoxic risk and adverse impact of editing in human hematopoietic stem cells. Cell Stem Cell 29, 1428-44.

Brombin, C., Bagaglio, S., Cugnata, F., Castagna, A., Uberti-Foppa, C., Salpietro, S., Di Serio, C., Morsica, G. (2022). Modelling the impact of protein-kinase R allelic variant on HIV biomarkers trajectories by means of latent class mixed models. Scientific Reports 12, 18575, https://doi.org/10.1038/s41598022-23289-4

Milani, M., Canepari, C., Liu, T., Biffi, M., Russo, F., Plati, T., Curto, R., Patarroyo-White, S., Drager, D., Visigalli, I., Brombin, C., Albertini, P., Follenzi, A., Ayuso, E., Mueller, C., Annoni, A., Naldini L., Cantore, A. (2022). Liver-directed lentiviral gene therapy corrects hemophilia A mice and achieves normal-range factor VIII activity in non-human primates. Nature communications 13, 1-14.

Perego, G., Cugnata, F., Brombin, C., Milano, F., Preti, E., Di Pierro, R., De Panfilis, C., Madeddu, F., Di Mattei, V. E. (2022). The “Healthcare Workers’ Wellbeing [Benessere Operatori]” Project: A Longitudinal Evaluation of Psychological Responses of Italian Healthcare Workers during the COVID19 Pandemic. Journal of clinical medicine 11, 2317.

Fodor, A., Brombin, C., Mangili, P., Tummineri, R., Pasetti, M., Zerbetto, F., Longobardi, B., Galvan, A.S., Deantoni, C.L., Dell’Oca, I. and Castriconi, R. (2022). Toxicity of Hypofractionated Whole Breast Radiotherapy Without Boost and Timescale of Late Skin Responses in a Large Cohort of Early-Stage Breast Cancer Patients. Clinical Breast Cancer 22, e480-e487.

Di Muzio, N.G., Deantoni, C.L., Brombin, C., Fiorino, C., Cozzarini, C., Zerbetto, F., Mangili, P., Tummineri, R., Dell’Oca, I., Broggi, S. and Pasetti, M. (2021). Ten Year Results of Extensive Nodal Radiotherapy and Moderately Hypofractionated Simultaneous Integrated Boost in Unfavorable Intermediate-, High-, and Very High-Risk Prostate Cancer. Cancers 13, 4970.

Siracusano, G., Brombin, C., Pastori, C., Cugnata, F., Noviello, M., Tassi, E., Princi, D., Cantoni, D., Malnati, M.S., Maugeri, N. and Bozzi, C. (2021). Profiling Antibody Response Patterns in COVID-19: Spike S1-Reactive IgA Signature in the Evolution of SARS-CoV-2 Infection. Frontiers in immunology 12:772239.

Cippà, P. E., Cugnata, F., Ferrari, P., Brombin, C., Ruinelli, L., Bianchi, G., Beria, N., Schulz, L., Bernasconi, E., Merlani, P., Ceschi, A. Di Serio, C. (2021). A data-driven approach to identify risk profiles and protective drugs in COVID-19. Proceedings of the National Academy of Sciences 118 (1) e2016877118.

Caputi, M., Cugnata, F., Brombin, C. (2021). Theory of mind and loneliness: Effects of a conversation-based training at school. International Journal of Psychology 56, 257-265.

Fodor, A., Brombin, C., Mangili, P., Borroni, F., Pasetti, M., Tummineri, R., . . . , & Di Muzio, N. G. (2021). Impact of molecular subtype on 1325 early-stage breast cancer patients homogeneously treated with hypofractionated radiotherapy without boost: Should the indications for radiotherapy be more personalized? The Breast 55, 45-54.

Di Mattei, V., Mazzetti, M., Perego, G., Cugnata, F., Brombin, C., Bergamini, A., Cioffi, R., Vasta, F., Pella, F., Rabaiotti, E., Mangili, G., Candiani, M. (2021). Psychological factors influencing emotional reactions to gestational trophoblastic disease: The role of coping mechanisms and illness perception. European Journal of Cancer Care 30, e13404.

Scaini, S., Centorame, G., Lissandrello, F., Sardella, S., Stazi, M.A., Fagnani, C., Brombin, C. and Battaglia, M. (2021) The role of genetic and environmental factors in covariation between anxiety and anger in childhood. European Child & Adolescent Psychiatry, 30, 607-617.

Caputi, M., Cugnata, F. and Brombin, C. (2021) Theory of mind and loneliness: Effects of a conversation‐based training at school. International Journal of Psychology, 56, 257-265.

Gaviraghi, M., Rabellino, A., Andolfo, A., Brand, M., Brombin, C., Bagnato, P., De Feudis, G., Raimondi, A., Locatelli, A., Tosoni, D., MazzaD., Gianni, L., Tonon, G., Yarden, Y., Tacchetti, D., Daniele, T. (2020). Direct stimulation of ERBB2 highlights a novel cytostatic signaling pathway driven by the receptor Thr701 phosphorylation. Scientific reports 10, 1-17.

Ferrari, S., Jacob, A., Beretta, S., Unali, G., Albano, L., Vavassori, V., Cittaro, D., Lazarevic, D., Brombin, C., Cugnata, F., Kajaste-Rudnitski, A., Merelli, I., Genovese, P. & Naldini, L. (2020). Efficient gene editing of human long-term hematopoietic stem cells validated by clonal tracking. Nature Biotechnology 38, 1298-1308.

Bertani, L., Rossari, F., Barberio, B., Demarzo, M. G., Tapete, G., Albano, E., Baiano Svizzero, G., Ceccarelli, L., Mumolo, M. G., Brombin, C., de Bortoli, N., Bellini, M., Marchi, S., Bodini, G., Savarino, E., Costa, F. (2020). Novel Prognostic Biomarkers of Mucosal Healing in Ulcerative Colitis Patients Treated With Anti-TNF: Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio. Inflammatory Bowel Diseases, 26, 1579-1587.

Deantoni, C. L., Fodor, A., Cozzarini, C., Fiorino, C., Brombin, C., Di Serio, C., Calandrino, R. and Di Muzio, N. (2020). Prostate cancer with low burden skeletal disease at diagnosis: outcome of concomitant radiotherapy on primary tumor and metastases. The British Journal of Radiology, 93(1108), 20190353.

Schiroli, G., Conti, A., Ferrari, S., della Volpe, L., Jacob, A., Albano, L., Beretta, s., Calabria, A., Vavassori V, Gasparini P, Salataj, E., Ndiaye-Lobry, D., Brombin, C., Chaumeil, J., Montini, E., Merelli, I., Genovese, P., Naldini, L., Di Micco, R. (2019). Precise gene editing preserves hematopoietic stem cell function following transient p53-mediated DNA damage response. Cell stem cell 24, 551-565.e8.

Sereni L, Castiello MC, Di Silvestre D, Della Valle P, Brombin, C., Ferrua F, Cicalese MP, Pozzi L, Migliavacca M, Bernardo ME, Pignata C, Farah R, Notarangelo LD, Marcus N, Cattaneo L, Spinelli M, Giannelli S, Bosticardo M, van Rossem K, D’Angelo A, Aiuti A, Mauri P, Villa A. (2019). Lentiviral gene therapy corrects platelet phenotype and function in Wiskott-Aldrich patients. Journal of Allergy and Clinical Immunology, 144, 825-838.

Cugnata, F., Martoni, R. M., Ferrario, M., Di Serio, C., Brombin, C. (2018). Modeling physiological responses induced by an emotion recognition task using latent class mixed models. PloS one 13, e0207123.

Martoni, R. M., Rancoita, P. M., De Filippis, R., Di Serio, C., Brombin, C. (2018). Exploring and integrating discrete and dimensional approaches while inducing negative emotional states. The Journal of general psychology 145, 238-265.

Vergara, P., Tzou, W. S., Tung, R., Brombin, C., Nonis, A., Vaseghi, M., ... & Nakahara, S. (2018). Predictive Score for Identifying Survival and Recurrence Risk Profiles in Patients Undergoing Ventricular Tachycardia Ablation: The I-VT Score. Circulation: Arrhythmia and Electrophysiology 11, e006730.

Di Mattei, V.E., Carnelli, L., Bernardi, M., Bienati, R., Brombin, C., Cugnata, F., Rabaiotti, E., Zambetti, M., Sarno, L., Candiani, M. and Gentilini, O. (2018) Coping mechanisms, psychological distress, and quality of life prior to cancer genetic counseling. Frontiers in Psychology, 9, 1218.

Escobar, G., Barbarossa, L., Barbiera, G., Norelli, M., Genua, M., Ranghetti, A., Plati, T., Camisa, B., Brombin, C.,Cittaro, D., Annoni, A., Bondanza, A., Ostuni, R., Gentner, B., Naldini, L. (2018). Interferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens. Nature communications 9, 2896 DOI: 10.1038/s41467-018-05315-0.

Di Mattei ,V.E., Carnelli, L., Taranto, P., Bernardi, M., Brombin, C., Cugnata, F., Noviello, A., Currin, M., Mangili, G., Rabaiotti, E., Sarno, L., Candiani, M. (2017) ”Health in the Mirror”: An Unconventional Approach to Unmet Psychological Needs in Oncology. Frontiers in Psychology 21, 1-8:1633. doi: 10.3389/fpsyg.2017.01633.

Scaini, S., Rancoita, P.M.V., Martoni, R.M., Omero, M., Ogliari, A., Brombin, C. (2017) Integrating Dimensional and Discrete Theories of Emotions: A New Set of Angerand Fear-Eliciting Stimuli for Children. Journal of Genetic Psychology 178, 253-261. doi: 10.1080/00221325.2017.1351416.

Vergara, P., Tung, R., Vaseghi, M., Brombin, C., Frankel, D., Di Biase, L., Nagashima, K., Tedrow, U., Tzou, W.S., Sauer, W.H., Mathuria, N., Nakahara, S., Vakil, K., Tholakanahalli, V., Bunch, T.J., Weiss, J.P., Dickfeld, T., Vunnam, R., Lakireddy, D., Burkhardt, J.D., Correra, A., Santangeli, P., Callans, D., Natale, A., Marchlinski, F., Stevenson, W.G., Shivkumar, K., Della Bella, P. (2017) Successful ventricular tachycardia ablation in patients with electrical storm reduces recurrences and improves survival. Heart Rhythm pii: S1547-5271(17)31012-3. doi: 10.1016/j.hrthm.2017.08.022.

Martoni, R. M., Rancoita, P. M., Di Serio, C., Brombin, C. (2017). Validating the Italian Version of the Disgust and Propensity Scale-Revised. Frontiers in psychology 8, 765.

Scaini, S., Ogliari, A., De Carolis, L., Bellodi, L., Di Serio, C., Brombin, C. (2017). Evaluation of mother-child agreement and factorial structures of the SCARED questionnaire in an Italian clinical sample. Frontiers in psychology 8, 242.

Di Mattei, V. E., Carnelli, L., Bernardi, M., Jongerius, C., Brombin, C., Cugnata, F., Ogliari, A., Rinaldi, S., Candiani, M., Sarno, L. (2016). Identification of Socio-demographic and Psychological Factors Affecting Womens Propensity to Breastfeed: An Italian Cohort. Frontiers in Psychology 7, 1872.

Scaini, S., Ogliari, A., Brombin, C. (2016) Physiological Response to Negative Emotions in Children with Anxiety Symptoms: Many Steps Still to be Taken. Avicenna Journal of Neuro Psycho Physiology 3, 92-93.

Bolino, A., Piguet, F., Alberizzi, V., Pellegatta, M., Rivellini, C., Guerrero-Valero, M., Noseda, R., Brombin, C., Nonis, A., D’Adamo, P., Taveggia, C., Previtali, S. C. (2016) Niacin-mediated Tace activation ameliorates CMT neuropathies with focal hypermyelination, EMBO Molecular Medicine DOI: 10.15252/emmm.201606349

Brombin, C., Di Serio, C. (2016). Evaluating treatment effect within a multivariate stochastic ordering framework: NPC methodology applied to a study on Multiple Sclerosis. Statistical Methods in Medical Research, 25, 366-384, ISSN: 0962-2802

Brombin, C., Di Serio, C., Rancoita, P.M.V. (2016). Joint modeling of HIV data in multicentre observational studies: a comparison among different approaches. Statistical Methods in Medical Research, 25, 2472-2487, ISSN: 0962-2802

Castronovo, V., Galbiati, A., Marelli, S., Brombin, C., Cugnata, F., Giarolli, L., Anelli, M. M., Rinaldi, F., Ferini-Strambi, L. (2016) Validation study of the Italian version of the Insomnia Severity Index (ISI), Neurological Sciences 37, 1517-24.

Farinelli, G., Jofra Hernandez, R., Rossi, A., Ranucci, S., Sanvito, F., Migliavacca, M., Brombin, C., Pramov, A., Di Serio, C., Bovolenta, C., Gentner, B., Bragonzi, A., Aiuti, A. (2016) Lentiviral Vector Gene Therapy Protects XCGD Mice From Acute Staphylococcus aureus Pneumonia and Inflammatory Response. Molecular Therapy doi: 10.1038/mt.2016.150.

Brombin, C., Salmaso, L., Fontanella, L., Ippoliti, L., Fusilli, C. (2015) Parametric and Nonparametric Inference for Statistical Dynamic Shape Analysis with Applications, SpringerBriefs in Statistics, ISBN 978-3-319-26310-6.

Brombin, C., Salmaso, L., Fontanella, L., Ippoliti, L. (2015). Nonparametric combination-based tests in dynamic Shape Analysis. JOURNAL OF NONPARAMETRIC STATISTICS, 27, 460-484.

Mazzieri, R., Pietrogrande, G., Gerasi, L., Gandelli, A., Colombo, P., Moi, D., Brombin, C., Ambrosi, A., Mignatti, P., Blasi, F, and D’Alessio, S. (2015) Urokinase receptor (uPAR) promotes skin tumor formation by preventing epithelial cell activation of notch1. Cancer Research 75, 4895-909.

Racioppi, M., Salmaso, L., Brombin, C., Arboretti, R., D’Agostino, D., Colombo, R., Serretta, V., Brausi, M., Casetta, G., Gontero, P., Hurle, R., Tenaglia, R., Altieri, V., Bartoletti, R., Maffezzini, M., Siracusano, S., Morgia, G., Bassi, PF. (2015) The clinical use of statistical permutation test methodology: a tool for identifying predictive variables of outcome. Urologia internationalis 94, 262-9.

Martoni, R.M., Brombin, C., Nonis, A., Salgari, G.C., Buongiorno, A., Cavallini, M.C., Galimberti, E., Bellodi, L. (2015) Evaluating effect of symptoms heterogeneity on decision-making ability in obsessive-compulsive disorder. Psychiatry and clinical neurosciences 69, 402-410.

Mascheretti, S., Marino, C., Simone, D., Quadrelli, E., Riva, V., Cellino, M.R., Maziade, M., Brombin, C., Battaglia, M. (2015) Putative risk factors in developmental dyslexia: a case-control study of Italian children. Journal of learning disabilities 48, 120-129.

Vergara, P., Nonis, A., Brombin, C., Baratto F., Bisceglia, C., Sora, N., Barbaro, M., Mazzone, P., Maccabelli, G., Della Bella, P. (2014). A clinical score to evaluate the survival and recurrence risk in patients undergoing ventricular tachycardia ablation. EUROPEAN HEART JOURNAL, 35, p. 601, ISSN: 0195-668X

Arboretti Giancristofaro, R., Brombin, C. (2014) Overview of NonParametric Combination-based permutation tests for Multivariate multi-sample problems. Statistica, 74, 233-246

Cesana, D., Ranzani, M., Volpin, M., Bartholomae, C. C., Duros, C., Artus, A., Merella, S., Benedicenti, F., Sergi, L., Sanvito, F., Brombin, C., Nonis, A., Di Serio, C., Doglioni, C., von Kalle, C., Schmidt, M., Cohen-Haguenauer, O., Naldini, L., Montini, E. (2014) Uncovering and dissecting the genotoxicity of self-inactivating lentiviral vectors in vivo. Molecular Therapy 22, 774-785.

Brigida, I., Sauer, A. V., Ferrua, F., Giannelli, S., Scaramuzza, S., Pistoia, V., Castiello, M. C., Barendregt, B. H., Cicalese, M. P., Casiraghi, M., Brombin, C.,Puck, J., Mller, K., Notarangelo, L. D., Montin, D., van Montfrans, J. M., Roncarolo, M. G., Traggiai, E., van Dongen, J. J.M., van der Burg, M., Aiuti, A. (2014) B-cell development and functions and therapeutic options in adenosine deaminase-deficient patients. Journal of Allergy and Clinical Immunology 133, 799-806.

Brombin, C., Midena, E., Salmaso, L. (2013) Robust non-parametric tests for complex-repeated measures problems in ophthalmology. Statistical Methods in Medical Research 22, 643-660.

Mizuno, H., Vergara, P., Maccabelli, G., Trevisi, N., Colombo, S., Brombin, C. Mazzone, P. and Della Bella, P. (2013) Contact Force Monitoring for cardiac Mapping in Patients with Ventricular Tachycardia. Journal of Cardiovascular Electrophysiology 24, 519-24. DOI: 10.1111/jce.12080.

Brombin, C., Diomede, L., Tudor, D., Drillet, A. S., Pastori, C., Poli, E., Riva, A., Uberti-Foppa, C., Galli, M., Di Serio, C., Bomsel, M. and Lopalco, L. (2013). A nonparametric procedure for defining a new humoral immunological profile in a pilot study on HIV infected patients. PLoS One vol. 8, ISSN: 1932-6203, doi: 10.1371/journal.pone.0058768

Brombin, C., Salmaso, L. (2013) Permutation Tests for Shape Analysis. SpringerBriefs in Statistics, Vol. 15, ISBN 978-1-4614-8163-8.