Brombin Chiara Professore AssociatoPsychologySECS-S/01

Current position

Assistant Professor in Statistics (SECS-S/01), at the Faculty of Psychology (Vita-Salute San Raffaele University), and involved in the research activities at CUSSB (University Centre for Statistics for the Biomedical Sciences).

Previous experience and education

2013-2016 FIRB Researcher and national coordinator of the FIRB 2012 project (RBFR12VHR7) “Interpreting emotions: a computational tool integrating facial expressions and biosignals based on shape analysis and bayesian networks”.

2010-2013 Research fellowship at C.U.S.S.B. (University Centre for Statistics in the Biomedical Sciences, Vita-Salute San Raffaele University, Milan) and involved in teaching activities at Vita-Salute San Raffaele University, Milan (supervised by Prof. Clelia Di Serio). Research project entitled: “Parametric and non-parametric modeling of multi- variate longitudinal studies”.

2009-2010 Post-doc grant in “Multivariate permutation methods with applications in both biomedical and management field: theoretical development and statistical software applications”. The research project is supported by the University of Padova CPDA088513 (Project Coordinator: Prof. Luigi Salmaso).

2006-2009 PhD in Statistical Sciences, at the Department of Statistical Sciences, University of Padova. Thesis on “A nonparametric permutation approach to statistical shape analysis” (Supervisor: Prof. Luigi Salmaso).

Visiting Ph.D. student, at the Department of Anthropology, EVAN (European Virtual Anthropology Network) Centre, Vienna, (April-June 2007) and at the Department of Ecology and Evolution, State University of New York, Stony Brook, NY (March-June 2008).

2000-2005 Laurea Degree (four years) in Statistics, at the Faculty of Statistical Sciences, University of Padova, Italy. Thesis on “Multivariate analysis with paired observations and missing values”, advisors: Prof. F. Pesarin and Prof. G. A. Fava.

Research interest

Shape analysis

Permutation tests

Multivariate statistics

Linear and nonlinear mixed-effect models

Survival analysis

Joint models for longitudinal and time-to-event data

Application and extension of statistical methods in biomedical research

Teaching activities

Since 2011, Teaching Assistant of the module of Statistics (Master Degree in dentistry and dental implantology,, Vita-Salute San Raffaele University, Milano) and of Advanced statistics→Multidimensional data analysis (Faculty of Psychology, Vita-Salute San Raffaele University, Milano).

Since 2014, Teaching Assistant of Applied Statistics (Faculty of Psychology, Vita-Salute San Raffaele University, Milano).

Since 2017, Professor of the course of Statistical methods in social sciences (Master in Cognitive Psychology in health communication, Vita-Salute San Raffaele University, Milano).

Di Mattei ,V.E., Carnelli, L., Taranto, P., Bernardi, M., Brombin, C., Cugnata, F., Noviello, A., Currin, M., Mangili, G., Rabaiotti, E., Sarno, L., Candiani, M. (2017) “Health in the Mirror”: An Unconventional Approach to Unmet Psychological Needs in Oncology.

Frontiers in Psychology; 1-8:1633. doi: 10.3389/fpsyg.2017.01633. eCollection 2017.

Scaini, S., Rancoita, P.M.V., Martoni, R.M., Omero, M., Ogliari, A., Brombin, C. (2017) Integrating Dimensional and Discrete Theories of Emotions: A New Set of Anger- and Fear-Eliciting Stimuli for Children. Journal of Genetic Psychology 178(5):253-261. doi: 10.1080/00221325.2017.1351416.

Vergara, P., Tung, R., Vaseghi, M., Brombin, C., Frankel, D., Di Biase, L., Nagashima, K., Tedrow, U., Tzou, W.S., Sauer, W.H., Mathuria, N., Nakahara, S., Vakil, K., Tholakanahalli, V., Bunch, T.J., Weiss, J.P., Dickfeld, T., Vunnam, R., Lakireddy, D., Burkhardt, J.D., Correra, A., Santangeli, P., Callans, D., Natale, A., Marchlinski, F., Stevenson, W.G., Shivkumar, K., Della Bella, P. (2017) Successful ventricular tachycardia ablation in patients with electrical storm reduces recurrences and improves survival.

Heart Rhythm pii: S1547-5271(17)31012-3. doi: 10.1016/j.hrthm.2017.08.022.

Martoni, R. M., Rancoita, P. M., Di Serio, C., Brombin, C. (2017). Validating the Italian Version of the Disgust and Propensity Scale-Revised. Frontiers in psychology, 8.

Scaini, S., Ogliari, A., De Carolis, L., Bellodi, L., Di Serio, C., Brombin, C. (2017). Evaluation of mother-child agreement and factorial structures of the SCARED questionnaire in an Italian clinical sample. Frontiers in psychology, 8.

Di Mattei, V. E., Carnelli, L., Bernardi, M., Jongerius, C., Brombin, C., Cugnata, F., Ogliari, A., Rinaldi, S., Candiani, M., Sarno, L. (2016). Identification of Socio-demographic and Psychological Factors Affecting Women’s Propensity to Breastfeed: An Italian Cohort. Frontiers in Psychology, 7.

Scaini, S., Ogliari, A., Brombin, C. (2016) Physiological response to negative emotions in children with anxious symptoms: still many steps to be taken in lite- rature” accepted for publication in Avicenna Journal of Neuro Psycho Physiology

Bolino, A., Piguet, F., Alberizzi, V., Pellegatta, M., Rivellini, C., Guerrero- Valero, M., Noseda, R., Brombin, C., Nonis, A., D’Adamo, P., Taveggia, C., Previtali, S. C. (2016) Niacin-mediated Tace activation ameliorates CMT neuro- pathies with focal hypermyelination, EMBO Molecular Medicine DOI: 10.15252/emmm.201606349

Brombin C, Di Serio C (2016). Evaluating treatment effect within a multivariate stochastic ordering framework: NPC methodology applied to a study on Multiple Sclerosis. STATISTICAL METHODS IN MEDICAL RESEARCH, vol. 25, p. 366-384, ISSN: 0962-2802

Brombin C, Di Serio C, Rancoita PMV (2016). Joint modeling of HIV data in multicentre observational studies: a comparison among different approaches. STATISTICAL METHODS IN MEDICAL RESEARCH, vol. 25, p. 2472-2487, ISSN: 0962-2802

Castronovo, V., Galbiati, A., Marelli, S., Brombin, C., Cugnata, F., Giarolli, L., Anelli, M. M., Rinaldi, F., Ferini-Strambi, L. (2016) Validation study of the Italian version of the Insomnia Severity Index (ISI), Neurological Sciences 37, 1517-24.

Farinelli, G., Jofra Hernandez, R., Rossi, A., Ranucci, S., Sanvito, F., Miglia- vacca, M., Brombin, C., Pramov, A., Di Serio, C., Bovolenta, C., Gentner, B., Bragonzi, A., Aiuti, A. (2016) Lentiviral Vector Gene Therapy Protects XCGD Mice From Acute Staphylococcus aureus Pneumonia and Inflammatory Respon- se. Molecular Therapy doi: 10.1038/mt.2016.150.

Brombin C, Salmaso L, Fontanella L, Ippoliti L (2015). Nonparametric combination- based tests in dynamic Shape Analysis. JOURNAL OF NONPARAMETRIC STATISTICS, vol. 27, p. 460-484, ISSN: 1048-5252

Mazzieri, R., Pietrogrande, G., Gerasi, L., Gandelli, A., Colombo, P., Moi, D., Brombin, C., Ambrosi, A., Mignatti, P., Blasi, F, and D’Alessio, S. (2015) Uro- kinase receptor (uPAR) promotes skin tumor formation by preventing epithelial cell activation of notch1. Cancer Research, 75, 4895-909.

Racioppi, M., Salmaso, L., Brombin, C., Arboretti, R., D’Agostino, D., Colombo, R., Serretta, V., Brausi, M., Casetta, G., Gontero, P., Hurle, R., Tenaglia, R., Altieri, V., Bartoletti, R., Maffezzini, M., Siracusano, S., Morgia, G., Bassi, PF. (2015) The clinical use of statistical permutation test methodology: a tool for identifying predictive variables of outcome. Urol Int. 94, 262-9.

Martoni, R.M., Brombin, C., Nonis, A., Salgari, G.C., Buongiorno, A., Cavallini, M.C., Galimberti, E., Bellodi, L. (2014) Evaluating effect of symptoms hetero- geneity on decision-making ability in obsessive-compulsive disorder. Psychiatry Clin Neurosci. doi: 10.1111/pcn.12264.

Vergara P., Nonis A., Brombin C, Baratto F., Bisceglia C., Sora N., Barbaro M., Mazzone P., Maccabelli G., Della Bella P. (2014). A clinical score to evaluate the survival and recurrence risk in patients undergoing ventricular tachycardia ablation. EUROPEAN HEART JOURNAL, vol. 35, p. 601, ISSN: 0195-668X

Cesana, D., Ranzani, M., Volpin, M., Bartholomae, C. C., Duros, C., Artus, A., Merella, S., Benedicenti, F., Sergi, L., Sanvito, F., Brombin, C., Nonis, A., Di Serio, C., Doglioni, C., von Kalle, C., Schmidt, M., Cohen-Haguenauer, O., Naldini, L., Montini, E. (2014) Uncovering and dissecting the genotoxicity of self-inactivating lentiviral vectors in vivo. Molecular Therapy. Article published online before print.

Brigida, I., Sauer, A. V., Ferrua, F., Giannelli, S., Scaramuzza, S., Pistoia, V., Castiello, M. C., Barendregt, B. H., Cicalese, M. P., Casiraghi, M., Brombin, C., Puck, J., Müller, K., Notarangelo, L. D., Montin, D., van Montfrans, J. M., Roncarolo, M. G., Traggiai, E., van Dongen, J. J.M., van der Burg, M., Aiuti, A. (2014) B-cell development and functions and therapeutic options in adenosine deaminase-deficient patients. Journal of Allergy and Clinical Immunology. Article published online before print.

Brombin, C., Salmaso, L. (2013) Permutation Tests for Shape Analysis. SpringerBriefs in Statistics, Vol. 15, ISBN 978-1-4614-8163-8.

Brombin, C., Salmaso, L. (2013) A review on combination-based tests for shape analysis. In JSM Proceedings, Section on Nonparametric Statistics. Alexandria, VA: American Statistical Association, 715-728.

Brombin, C., Midena, E., Salmaso, L. (2013) Robust non-parametric tests for complex-repeated measures problems in ophthalmology. Statistical Methods in Medical Research 22, 643-660.

Mascheretti, S., Marino, C., Simone, D., Quadrelli, E., Riva, V., Cellino, M.R., Maziade, M., Brombin, C., Battaglia, M. (2013) Putative risk factors in developmental dyslexia: a case-control study of Italian children. Journal of

learning disabilities. DOI:10.1177/0022219413492853. Article published online before print.

Mizuno, H., Vergara, P., Maccabelli, G., Trevisi, N., Colombo, S., Brombin, C. Mazzone, P. and Della Bella, P. (2013) Contact Force Monitoring for cardiac Mapping in Patients with Ventricular Tachycardia. Journal of Cardiovascular Electrophysiology 24, 519-24. DOI: 10.1111/jce.12080.

Brombin, C., Diomede, L., Tudor, D., Drillet, A. S., Pastori, C., Poli, E., Riva, A., Uberti-Foppa, C., Galli, M., Di Serio, C., Bomsel, M. and Lopalco, L. (2013). A nonparametric procedure for defining a new humoral immunological profile in a pilot study on HIV infected patients. PLoS One 8:e58768. DOI: 10.1371/journal.pone.0058768.

Cantore, A., Nair, N., Della Valle, P., Di Matteo, M., Màtrai, J., Sanvito, F., Brombin, C., Di Serio, C., D’Angelo, A., Chuah, M., Naldini, L., VandenDriessche, T. (2012) Hyperfunctional coagulation factor IX improves the efficacy of gene therapy in hemophilic mice. Blood. 120, 4517-20. DOI: 10.1182/blood- 2012-05-432591.

Alfieri, R., Bonnini, S., Brombin, C., Castoro, C., Salmaso, L. (2012) Iterated combination-based paired permutation tests to determine shape effects of chemotherapy in patients with esophageal cancer. Statistical Methods in Medical Research. DOI: 10.1177/0962280212461981. Article published online before print.

Brombin, C., Di Serio, C. and Crippa, M. (2012) Modeling cancer cells growth. Communications in Statistics-Theory and Methods. Special Issue-Statistics for complex problems 41, 3043-3059.

Brombin, C., Salmaso, L., Ferronato, G. and Galzignato, PF. (2011) Multi-aspect procedures for paired data with application to biometric morphing. Communications in Statistics-Simulation and Computation, 40, 1-12.

Floreani, A., Caroli, D., Variola, A., Rizzotto, E. R., Antoniazzi, S., Chiaramonte, M., Cazzagon, N., Brombin, C., Salmaso, L., Baldo, V. (2011) A 35-year follow-up of a large cohort of patients with primary biliary cirrhosis seen at a single centre. Liver international 31, 361-368.

Finos, L., Brombin, C., Salmaso, L. (2010) Adjusting stepwise p-values in generalized linear models. Communications in Statistics – Theory and Methods 39, 1832-1846.

Brombin, C., Pesarin, F. and Salmaso, L. (2010) Dealing with more variables than sample sizes: an application to Shape Analysis. NONPARAMETRIC STATISTICS AND MIXTURE MODELS A Festschrift in Honor of Thomas P. Hettmansperger, The Pennsylvania State University, USA, 23 – 24 May 2008. ISBN: 978-981- 4340-55-7 981-4340-55-3

Brombin, C. and Salmaso, L. (2009) Multi-aspect permutation tests in shape analysis with small sample size. Computational statistics and data analysis 53, 3921-3931.

Brombin, C., Mo, G., Zotti, A., Giurisato, M., Salmaso, L. and Cozzi, B. (2009) A landmark analysis-based approach to age and sex classification of the skull of the Mediterranean monk seal (Monachus monachus) (Hermann, 1779). Anatomia, Histologia, Embryologia 38, 382-386.