Filippi Massimo Professore ordinarioMedicineMED/26





  • Facoltà di Medicina e Chirurgia – University of Milan 1986 MD
  • Specialità in Neurologia – University of Milan 1990 Registrar in Neurology
  • Specialità in Neurofisiopatologia – University of Pavia 1994 Registrar in Neurophysiology


Post-doctoral Fellowship/Relevant Training/Professional Experience

  • Assistant in Clinical Neurophysiology, Scientific Institute H S. Raffaele 04/01/1987-12/31/1987
  • Research Fellow – Multiple Sclerosis Center, Scientific Institute H S. Raffaele 02/01/1988-12/31/1993
  • Assistant in Clinical Neurology, Scientific Institute H S. Raffaele 09/01/1990-11/08/1991
  • Research Fellow for the National Health Service of the Italian Government – Scientific Institutes S. Raffaele and C Besta – Milan 12/15/1991-08/31/1992
  • Research Fellow and Honorary Clinical Assistant – NMR Research Group – Institute of Neurology London 04/01/1992-12/31/1992
  • Scientific Director, MS MR Centre, Dept. of Neurology, HSR 01/01/94 -10/31/97
  • Director, NMR Unit, Centro “S. Maria Nascente” IRCCS Fondazione Don Gnocchi, Milano 2005-2008
  • Scientific Director, MS Biosignal Analysis Center, Dept of Neurophysiology, HSR 07/01/96-present
  • Director, Neuroimaging Research Unit, Department of Neurology, HSR 01/08/99-present
  • Director, “BrainMap” (Human BRAin IN-vivo MAPping with Neuroimaging) Scientific Interdepartmental Program, Division of Neuroscience, HSR 2009-present
  • Associate Professor of Neurology, Vita-Salute San Raffaele University March 2011-December 2015
  • Full Professor of Neurology, Vita-Salute San Raffaele University Since January 2016
  • 01.11.2018 Chair, Neurology Unit, IRCCS Ospedale San Raffaele, Milan

  • 01.11.2018 Director, MS Center, IRCCS Ospedale San Raffaele, Milan


Teaching Activity

1996-1999. Non-Tenured Professor (Neuroradiology and Neuroimages II Course) at the Post-degree Neurological School (III year) of Chieti University.

Since the academic year 1997/98 Non-Tenured Professor (Physiopathology of the Central Nervous system) at the University of Milan – University Degree for Neurophysiopathology Technicians.

Since the academic year 2000-2001, Non-Tenured Professor of Clinical Neurology, Università Vita-Salute San Raffaele, Milan.

Since 2006 – Visiting Professor, School of Medicine University of Belgrade

Since 2006 – Adjunct Professor, Temple University School of Medicine, Department of Neurosurgery.

Since 2007 – John Whitaker Professor of the American Neurological Association

Since 2008 – Visiting Professor at Heinrich-Heine University Duesseldorf, Germany

March 2011-December 2015 – Associate Professor of Neurology, Università Vita-Salute San Raffaele, Milan

January 2016 – Full Professor of Neurology, Università Vita-Salute San Raffaele, Milan

01/11/2016 – Director, Neurology Residency Course, Faculty of Medicine, Vita-Salute San Raffaele University, Milan

01/11/2016 – President, Board of the Bachelor Degree in Physiotherapy, Vita-Salute San Raffaele University, Milan

01/11/2016 – Member, Academic Senate, Vita-Salute San Raffaele University, Milan

Academies and Scientific Societies

Italian Society of Clinical Neurophysiology; Italian Society of Neurology; American Academy of Neurology; European Neurological Society

1989– Italian Multicenter Study Group on MS;

1993– Steering Committee, MAGNIMS; Steering Committee,  PRESTIMUS

1995– Steering Committee, ETOMS

1997– International Cladribine MS Scientific/Clinical Advisory Group

1997-2004 Scientific Committee, AISM

1998– Member of ISMRM and Chairman the “White Matter Study Group”

1999– New York Academy of Sciences; EFNS Task Force on the future of MR-based Techniques in Neurology; MRI Working Group of the International Multiple Sclerosis Data Centre – International Federation of Multiple Sclerosis Societies

2000-2003 – Advisory Committee on Clinical Trials of New Drugs in MS of the US MS Society

2000– American Association for the Advancement of Science; International Scientific Advisory Board, Joint Infrastrucuture Fund UK Government + Wellcome Trust

2001– ISMRM Study Group Review Committee for 2001-2002; Member, MRI Working Group of the Sylvia Lawry Centre for Multiple Sclerosis Research (Munich, Germany.

2002–ISMRM Publication Committee for 2002-2003; ISMRM Study Group Review Committee for 2002-2003; Clinical Advisory Board on Fatigue in MS under Copaxone Treatment; Steering Committee, Tolerance Trial (European Charcot Foundation and BioPartners GmbH)

2003–ISMRM Publication Committee for 2003-2004; EFNS Scientific Panel of Neuroimaging of MS; Scientific Committee, ARIN; Member, Comitato Operativo del Centro di Eccellenza Laboratorio di Risonanza Magnetica Funzionale ad Alto Campo, HSR

2004– Member, Gruppo di Studio Neuroimmagini Funzionali of the Italian Neurological Society; ISMRM Workshop Committee for 2004-2005; ECTRIMS+ACTRIMS 2005 Congress Scientific Advisory Committee; Member, Pepgen’s Clinical Advisory Board

2005–Advisor, European Brain Council; ISMRM Workshop Committee for 2005-2006; Member, Scientific Board, Institute of Sperimental Neurology (INSPE), HSR, Milan, Italy; Editorial Expert, European Charcot Foundation; Member, Scientific Committee of Associazione Italiana Sclerosi Multipla (AISM); Advisory Board, BrainImaGen application, 2005

2006–Member, MS Differential Diagnosis Task Force of the US National MS Society and Chair of the Subgroup on Multifocal Presentations; Member, HSR Foundational Research Committee; Member, Steering Committee of the Beyond Study; Member, Executive Committee of the European Neurological Society

2007– Member, Study Group on MS, Assessorato alla Sanità Regione Lombardia; Member, Scientific Advisory Board for HBM 2007;

2008–Coordinator, ENS Neuroimaging Subcommittee; Coordinator, Neuroimaging Study Group of the Italian Neurological Society; Advisory Board, neuGRID (develpment of e-infrastructure fom medical sciences); Project Reviewer, National Research Grants Council, Singapore; Chairman, EFNS Panel of Neuroimaging and Sonology;

2009– Fellow of the ISMRM; Member, Board of Trustees of the ISMRM; Chair, EFNS Task Force Neuroimaging of motor neuron disease; Member, 2009-2010 Student Stipend Committee of the ISMRM; ENS Teaching Course Director for 2009-2011; Bayer Advisory Board, Understanding changing MS treatment paradigms; Advisory Board of the German Competence Network for Multiple Sclerosis

2010– Editorial Board, Lancet Neurology; ISMRM, Education Committee (2010-2011); ISMRM, Affiliated Sections (2010-2011); ISMRM, Trainee Stipend Subcommittee (2010-2011); ISMRM, Awards Committee (2010-2011); EFNS: Chairman Scientist Panel on Neuroimaging and –sonology; Cognitive Engineering, LLC, Scientific Advisory Board; Project reviewer, Swiss National Science Foundation; classed 33° among Top Italian Scientists ( issued by the Virtual Italian Academy (University of Manchester)

2011-  Editorial Board, Journal of Alzheimer’s Disease; Editorial Board, Journal of the Neurological Sciences; ISMRM, Education Committee (2011-2012); ISMRM, Awards Committee (2011-2012); Member, Scientific Committee of Corso Residenziale per le Scuole di Specializzazione in Neurologia – Neuroimaging della SIN

2012 Co-Chief Editor, Journal of Neurology; Member, International Pediatric MS Study Group (IPMSSG) – Research Committee; Member, ISMRM Awards Committee; Member, ISMRM Education Committee; Faculty Member, F1000 Prime – Neurological disorders; FISM Scientific Secretariat for research project triage; Member, Advisory Board Serono Symposia International Foundation.

2013 – Member, Editorial Board, Journal of the Neurological Sciences;Member, Assembly of Delegates of the European Academy of Neurology; Member, Local Scientific Committee, 44th Congress of the Italian Neurological Society (SIN); “Dr Laza K Lazarevic” Award for Exceptional Contribution to Neurological Sciences. Society of Serbian Neurologists. Belgrade, Serbia; Member, Steering Committee, NISALS

2014   Qualification as Full Professor of Neurology; Member, General Assembly of the European Academy of Neurology (EAN); Chair, EAN Panel of Neuroimaging; Member, Managing Committee, Centro studi PML – Università Vita-Salute San Raffaele, Milano; Editorial Board Member, Radiology; ADDF Scientific Review Board for 2015

2015   Editorial Board, eNeurologicalSci; Editorial Board, Multiple Sclerosis and Demyelinating Disorders; Fellow, European Academy of Neurology; Member, Health Engineering SL Scientific Advisory Board, University of Jaén (Spain); Distinguished Dr Luis Barraquer Ferré Lecture at the LXVII Congress of the Spanish Society of Neurology (SEN)


Important positions in congresses

Invited lectures: over 680

Chairman in important international congresses: AAN, ECTRIMS, EFNS, ENS, ISMRM, SIN

Scientific Director of Teaching Courses at national and international congresses


Editorial Activity

Co-Editor in Chief, Journal of Neurology (2012-)

Editorial Board Member: AJNR, BMC Musculoskeletal Disorders, Clinical Neurology and Neurosurgery, eNeurologicalSci (eNS), Erciyes Medical Journal, European Neurology, Journal of Alzheimer’s Disease, Journal of Neuroimaging, JNNP (2002-2006), Journal of the Neurological Sciences (2011-present), Journal of Neurovirology (2006-2014), Lancet Neurology, Magnetic Resonance Imaging, Multiple Sclerosis, Multiple Sclerosis and Demyelinating Disorders, Neurological Sciences, Neuroradiology, World Journal of Radiology.
Reviewer on a regular basis for several journals in the neurology and neuroimaging fields, for many Governmental Organizations and private Foundations, and for several national and international congresses.

Author/co-author of over 1037 full papers on indexed journals and 196 book chapters. H-index (Scopus): 116


  • Caso F, Agosta F, Filippi M. Insights on white matter damage in Alzheimer’s disease: from postmortem to in vivo diffusion tensor MRI studies. Neurodegenerative Dis 2016; 16: 26-33 [Epub ahead of print 1 December 2015; doi: 10.1159/000441422]


  • Repellino P, Khonsari R, Stecco A, Filippi M, Perchinunno M, Cantello R. Clues on Balò’s concentric sclerosis evolution from serial analysis of ADC values. Int J Neurosci 2016; 126: 88-95 [Epub ahead of print 18 November 2014; doi: 10.3109/00207454.2014.989524]


  • Preziosa P, Martinelli V, Moiola L, Radaelli M, Gerevini S, Guidetti D, Immovilli P, Michieletti E, Scagnelli P, Comola M, Rocca MA, Filippi M, Comi G. Dynamic pattern of clinical and MRI findings in a tumefactive demyelinating lesion: a case report. J Neurol Sci 2016; 361: 184-186 [doi: 10.1016/j.jns.2015.12.039]


  • Filippi M, Agosta F, Ferraro PM. Charting frontotemporal dementia: from genes to networks. J Neuroimaging 2016; 26: 16-27 [Epub ahead of print 29 November 2015; doi: 10.1111/jon.12316]


  • Rocca MA, Valsasina P, Meani A, Falini A, Comi G, Filippi M. Impaired functional integration in multiple sclerosis: a graph theory study. Brain Struct Funct 2016; 221: 115-131 [Epub ahead of print 26 September 2014; doi: 10.1007/s00429-014-0896-4]


  • Sumowski JF, Rocca MA, Leavitt VM, Riccitelli G, Sandry J, DeLuca J, Comi G, Filippi M. Searching for the neural basis of reserve against memory decline: intellectual enrichment linked to larger hippocampal volume in multiple sclerosis. Eur J Neurol 2016; 23: 39-44 [Epub ahead of print 4 February 2015; doi: 10.1111/ene.12662]


  • Filippi M, Rocca MA, Ciccarelli O, De Stefano N, Evangelou N, Kappos L, Rovira A, Sastre-Garriga J, Tintorè M, Frederiksen JL, Gasperini C, Palace J, Reich DS, Banwell B, Montalban X, Barkhof F, on behalf of the MAGNIMS Study Group. MRI criteria for the diagnosis of multiple sclerosis: MAGNIMS consensus guidelines. Lancet Neurol 2016; 15: 292-303 [doi: 10.1016/S1474-4422(15)00393-2]


  • Filippi M, Barker RA, Strupp M. The neurology community mourns the passing of Dr. John F. Kurtzke. J Neurol 2016; 263: 421 [Epub ahead of print 28 February 2016; doi: 10.1007/s00415-016-8043-1]


  • Rocca MA, Preziosa P, Mesaros S, Pagani E, Dackovic J, Stosic-Opincal T, Drulovic J, Filippi M. Clinically isolated syndromes suggestive of multiple sclerosis: dynamic patterns of gray and white matter changes – a 2 year MR imaging study. Radiology 2016; 278: 841-853 [Epub ahead of print 4 September 2015; doi: 10.1148/radiol.2015150532]


  • Enzinger C, Pinter D, Rocca MA, De Luca J, Sastre-Garriga J, Audoin B, Filippi M. Longitudinal fMRI studies: exploring brain plasticity and repair in MS. Mult Scler 2016; 22: 269-278 [Epub ahead of print 18 December 2015; doi: 10.1177/1352458515619781]


  • Cirillo S, Rocca MA, Ghezzi A, Valsasina P, Moiola L, Veggiotti P, Amato MP, Comi G, Falini A, Filippi M. Abnormal cerebellar functional MRI connectivity in patients with paediatric multiple sclerosis. Mult Scler 2016; 22: 292-301 [Epub ahead of print 11 July 2015; doi: 10.1177/1352458515592191]


  • Agosta F, Ferraro PM, Riva N, Spinelli EG, Chiò A, Canu E, Valsasina P, Lunetta C, Iannaccone S, Copetti M, Prudente E, Comi G, Falini A, Filippi M. Structural brain correlates of cognitive and behavioral impairment in MND. Hum Brain Mapp 2016; 37: 1614-1626 [Epub ahead of print 2 February 2016; doi: 10.1002/hbm.23124]


  • Preziosa P, Rocca MA, Pagani E, Stromillo ML, Enzinger C, Gallo A, Hulst HE, Atzori M, Pareto D, Riccitelli GC, Copetti M, De Stefano N, Fazekas F, Bisecco A, Barkhof F, Yousry TA, Arévalo MJ, Filippi M, and the MAGNIMS Study Group. Structural MRI correlates of cognitive impairment in patients with multiple sclerosis: a multicenter study. Hum Brain Mapp 2016; 37: 1627-1644 [Epub ahead of print 2 February 2016; doi: 10.1002/hbm.23125]


  • Rocca MA, Sonkin M, Copetti M, Pagani E, Arnold DL, Narayanan S, Sled JG, Banwell B, Filippi M. Diffusion tensor magnetic resonance imaging in very early onset pediatric multiple sclerosis. Mult Slcer J 2016; 22: 620-627 [Epub ahead of print 22 July 2015; doi: 10.1177/1352458515596600]


  • Rocca MA, Morelli ME, Amato MP, Moiola L, ghezzi A, Veggiotti P, Capra R, Pagani E, Portaccio E, Fiorino A, Pippolo L, Pera MC, Comi G, Falini A, Filippi M. Regional hippocampal involvement and cognitive impairment in pediatric multiple sclerosis. Mult Scler 2016; 22: 628-640 [Epub ahead of print 18 August 2015; doi: 10.1177/1352458515598569]


  • Kostic VS, Agosta F, Sarro L, Tomic A, Kresojevic N, Galantucci S, Svetel M, Valsasina P, Filippi M. Brain structural changes in spasmodic dysphonia: a multimodal magnetic resonance imaging study. Parkinsonism Relat Disord 2016; 25: 78-84 [Epub ahead of print 12 February 2016; doi: 10.1016/j.parkreldis.2016.02.003]


  • Gerevini S, Agosta F, Riva N, Spinelli EG, Pagani E, Chaabane L, Copetti M, Quattrini A, Comi G, Falini A, Filippi M. MR imaging of brachial plexus and limb-girdle muscles in patients with amyotrophic lateral sclerosis. Radiology 2016; 279: 553-561 [Epub ahead of print 18 November 2015; doi: 1148/radiol.2015150559]


  • Keshavan A, Paul F, Beyer MK, Zhu AH, Papinutto N, Shinohara RT, Stern W, Amann M, Bakshi R, Bischof A, Carriero A, Comabella M, Crane JC, D’Alfonso S, Demaerel P, Dubois B, Filippi M, Fleischer V, Fontaine B, Gaetano L, Goris A, Graetz C, Gröger A, Groppa S, Hafler DA, Harbo HF, Hemmer B, Jordan K, Kappos L, Kirkish G, Llufriu S, Magon S, Martinelli-Boneschi F, McCauley J, Montalban X, Muhlau M, Pelletier D, Pattany PM, Pericak-Vance M, Rebeix I, Rocca M, Rovira A, Schlaeger R, Saiz A, Sprenger T, Stecco A, Uitdehaag BM, Villoslada P, Wattjes MP, Weiner H, Wuerfel J, Zimmer C, Zipp F; International Multiple Sclerosis Genetics Consortium, Hauser S, Oksenberg JR, Henry RG. Power estimation for non-standardized multisite studies. Neuroimage 2016; 134: 281-294 [Epub ahead of print 31 March 2016; doi: 10.1016/j.neuroimage.2016.03.051]


  • Müller HP, Turner MR, Grosskreutz J, Abrahams S, Bede P, Govind V, Prudlo J, Ludolph AC, Filippi M, Kassubek J; Neuroimaging Society in ALS (NiSALS) DTI Study Group; Neuroimaging Society in ALS NiSALS DTI Study Group. A large-scale multicentre cerebral diffusion tensor imaging study in amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry 2016; 87: 570-579 [Epub ahead of print 8 January 2016; doi: 10.1136/jnnp-2015-311952]


  • Kostic M, Canu E, Agosta F, Munjiza A, Novakovic I, Dobricic V, Ferraro PM, Miler Jerkovic V, Pekmezovic T, Lecic Tosevski D, Filippi M. The cumulative effect of genetic polymorphisms on depression and brain structural integrity. Hum Brain Mapp 2016; 37: 2173–2184 [Epub ahead of print 9 March 2016; doi: 10.1002/hbm.23165]


  • Dobryakova E, Rocca MA, Valsasina P, Ghezzi A, Colombo B, Martinelli V, Comi G, DeLuca J, Filippi M. Abnormalities of the executive control network in multiple sclerosis phenotypes: an fMRI effective connectivity study. Hum Brain Mapp 2016; 37: 2293-2304 [Epub ahead of print 9 March 20162016; doi: 10.1002/hbm.23174]


  • Sumowski J, Rocca MA, Leavitt VM, Meani A, Mesaros S, Drulovic JS, Preziosa P, Habeck C, Filippi M. Brain reserve against physical disability progression over 5 years in multiple sclerosis. Neurology 2016; 86: 2006-2009 [Epub ahead of print 27 April 2016; doi: 10.1212/WNL.0000000000002702]


  • Riva N, Agosta F, Lunetta C, Filippi M, Quattrini A. Recent advances in amyotrophic lateral sclerosis. J Neurol 201; 263: 1241-1254 [Epub ahead of print 30 March 2016; doi: 10.1007/s00415-016-8091-6]


  • Tillema JM, Hulst HE, Rocca MA, Vrenken H, Steenwijk MD, Damjanovic D, Enzinger C, Ropele S, Tedeschi G, Gallo A, Ciccarelli O, Rovira A, Montalban X, de Stefano N, Stromillo ML, Filippi M, Barkhof F; MAGNIMS Study Group. Regional cortical thinning in multiple sclerosis and its relation with cognitive impairment: A multicenter study. Mult Scler 2016; 22: 901-909 [Epub ahead of print 2 October 2015; doi: 10.1177/1352458515607650]


  • Fraidakis MJ, Brunetti M, Blackstone C, Filippi M, Chiò A. Novel compound heterozygous spatacsin mutations in a Greek kindred with hereditary spastic paraplegia SPG11 and dementia. Neurodegener Dis 2016; 16: 373-381 [doi: 10.1159/000444715]


  • Absinta M, Sati P, Schindler M, Leibovitch EC, Ohayon J, Wu T, Meani A, Filippi M, Jacobson S, Cortese ICM, Reich DS. Persistent 7-tesla phase rim predicts poor outcome in new multiple sclerosis patient lesions. J Clin Invest 2016; 126: 2597-2609 [Epub ahead of print 6 June 2016; doi: 10.1172/JCI86198]


  • Schippling S, O’Connor P, Knappertz V, Pohl C, Bogumil T, Suarez G, Cook S, Filippi M, Hartung HP, Comi G, Jeffery DR, Kappos L, Goodin DS, Arnason B. Incidence and course of depression in multiple sclerosis in the multinational BEYOND trial. J Neurol 2016; 263: 1418-1426 [Epub ahead of print 13 May 2016; doi: 10.1007/s00415-016-8146-8]


  • Horsfield MA, Rocca MA, Pagani E, Storelli L, Preziosa P, Messina R, Camesasca F, Copetti M, Filippi M. Estimating brain lesion volume change in multiple sclerosis by subtraction of magnetic resonance images. J Neuroimaging 2016; 26: 395-402 [Epub ahead of print 28 March 2016; doi: 10.1111/jon.12344]


  • Sormani MP, Gasperini C, Romeo M, Rio J, Calabrese M, Cocco E, Enzingher C, Fazekas F, Filippi M, Gallo A, Kappos L, Marrosu MG, Martinelli V, Prosperini L, Rocca MA, Rovira A, Sprenger T, Stromillo ML, Tedeschi G, Tintorè M, Tortorella C, Trojano M, Montalban X, Pozzilli C, Comi G, De Stefano N; MAGNIMS study group. Assessing response to interferon-β in a multicenter dataset of patients with MS. Neurology 2016; 87: 134-140 [Epub ahead of print 15 June 2016; doi: 10.1212/WNL.0000000000002830]


  • Preziosa P, Comi G, Filippi M. Optic neuritis in multiple sclerosis: looking from patient’s eyes. Neurology 2016; 87: 338-339 [doi: 10.1212/WNL.0000000000002869]


  • Rocca MA, Meani A, Riccitelli GC, Colombo B, Rodegher M, Falini A, Comi G, Filippi M. Abnormal adaptation over time of motor network recruitment in multiple sclerosis patients with fatigue. Mult Scler 2016; 22: 1144-1153 [Epub ahead of print 22 October 2015; doi: 10.1177/1352458515614407]


  • Spinelli EG, Agosta F, Ferraro PM, Riva N, Lunetta C, Falzone Y, Comi G, Falini A, Filippi M. Brain MR imaging in patients with lower motor neuron-predominant disease. Radiology 2016; 280: 545-556 [Epub ahead of print 9 March 2016; doi: 10.1148/radiol.2016151846]


  • Banwell BL, Arnold DL, Tillema JM, Rocca MA, Filippi M, Weinstock-Guttman B, Zivadinov R, Sormani MP. MRI in the evaluation of pediatric multiple sclerosis. Neurology 2016; 87 (9 Suppl 2): S88-S96 [doi: 10.1212/WNL.0000000000002787]


  • Moroni F, Ammirati E, Magnoni M, D’Ascenzo F, Anselmino M, Anzalone N, Rocca MA, Falini A, Filippi M, Camici PG. Carotid atherosclerosis, silent ischemic brain damage and brain atrophy: A systematic review and meta-analysis. Int J Cardiol 2016; 223: 681-687 [doi: 10.1016/j.ijcard.2016.08.234]


  • Koini M, Filippi M, Rocca MA, Yousry T, Ciccarelli O, Tedeschi G, Gallo A, Ropele S, Valsasina P, Riccitelli G, Damjanovic D, Muhlert N, Mancini L, Fazekas F, Enzinger C for the MAGNIMS fMRI Study Group. Correlates of executive functions in multiple sclerosis based on structural and functional MR imaging – insights from a multicenter study. Radiology 2016; 280: 869-879 [Epub ahead of print 22 March 20162016; doi: 10.1148/radiol.2016151809]


  • Teggi R, Colombo B, Rocca MA, Bondi S, Messina R, Comi G, Filippi M. A review of recent literature on functional MRI and personal experience in two cases of definite vestibular migraine. Neurol Sci 2016; 37: 1399-1402 [Epub ahead of print 13 May 2016; doi: 10.1007/s10072-016-2618-6]


  • Absinta M, Reich DS, Filippi M. Spring cleaning: time to rethink imaging research lines in MS? J Neurol 2016; 263: 1893-1902 [Epub ahead of print 17 February 2016; doi: 10.1007/s00415-016-8060-0]


  • Caso F, Agosta F, Volonté MA, Ferraro PM, Tiraboschi P, Copetti M, Valsasina P, Falautano M, Comi G, Falini A, Filippi M. Cognitive impairment in progressive supranuclear palsy-Richardson’s syndrome is related to white matter damage. Parkinsonism Relat Disord 2016; 31: 65-71 [Epub ahead of print 18 July 2016; doi: 10.1016/j.parkreldis.2016.07.007]


  • Sumowski JF, Rocca MA, Leavitt VM, Riccitelli G, Meani A, Comi G, Filippi M. Reading, writing, and reserve: Literacy activities are linked to hippocampal volume and memory in multiple sclerosis. Mult Scler 2016; 22: 1621-1625 [Epub ahead of print 28 February 2016; doi: 10.1177/1352458516630822]


  • Pravatà E, Zecca C, Sestieri C, Caulo M, Riccitelli GC, Rocca MA, Filippi M, Cianfoni A, Gobbi C. Hyperconnectivity of the dorsolateral prefrontal cortex following mental effort in multiple sclerosis patients with cognitive fatigue. Mult Scler 2016; 22: 1665-1675 [Epub ahead of print 4 February 2016; doi: 10.1177/1352458515625806]


  • Rocca MA, De Meo E, Filippi M. Functional MRI in investigating cognitive impairment in multiple sclerosis. Acta Neurol Scand 2016; 134 Suppl 200: 39-46 [Epub ahead of print 1 September 2016; doi: 10.1111/ane.12654]


  • Sarro L, Senjem ML, Lundt ES, Przybelski SA, Lesnick TG, Graff-Radford J, Boeve BF, Lowe VJ, Ferman TJ, Knopman DS, Comi G, Filippi M, Petersen RC, Jack CR Jr, Kantarci K. Amyloid-β deposition and regional grey matter atrophy rates in dementia with Lewy bodies. Brain 2016; 139: 2740-2750 [Epub ahead of print 24 July 2016; doi: 10.1093/brain/aww193]


  • Martinelli V, Colombo B, Dalla Costa G, Dalla Libera D, Moiola L, Falini A, Comi G, Filippi M. Recurrent disease-activity rebound in a patient with multiple sclerosis after natalizumab discontinuations for pregnancy planning. Mult Scler 2016; 22: 1506-1508 [Epub ahead of print 17 June 2013; doi: 10.1177/1352458513492246]


  • Bisecco A, Caiazzo G, d’Ambrosio A, Sacco R, Bonavita S, Docimo R, Cirillo M, Pagani E, Filippi M, Esposito F, Tedeschi G, Gallo A. Fatigue in multiple sclerosis: The contribution of occult white matter damage. Mult Scler 2016; 22: 1676-1684 [Epub ahead of print 4 February 2016; doi: 10.1177/1352458516628331]


  • Filippi M, Agosta F. Does neuroinflammation sustain neurodegeneration in ALS? Neurology 2016; 87: 2508-2509 [editorial] [Epub ahead of print 11 November 2016; doi: 10.1212/WNL.0000000000003441]


  • Storelli L, Pagani E, Rocca MA, Horsfield MA, Gallo A, Bisecco A, Battaglini M, De Stefano N, Vrenken H, Thomas DL, Mancini L, Ropele S, Enzinger C, Preziosa P, Filippi M. A semiautomatic method for multiple sclerosis lesion segmentation on dual-echo MR imaging: application in a multicenter context. AJNR Am J Neuroradiol 2016; 37: 2043-2049 [Epub ahead of print 21 July 2016; doi: 10.3174/ajnr.A4874]


  • Bonanni L, Cagnin A, Agosta F, Babiloni C, Borroni B, Bozzali M, Bruni AC, Filippi M, Galimberti D, Monastero R, Muscio C, Parnetti L, Perani D, Serra L, Silani V, Tiraboschi P, Padovani A; DLB-SINdem study group. The Italian dementia with Lewy bodies study group (DLB-SINdem): toward a standardization of clinical procedures and multicenter cohort studies design. Neurol Sci 2017; 38: 83-91 [Epub ahead of print 13 September 2016; doi: 10.1007/s10072-016-2713-8]


  • Brueggen K, Grothe MJ, Dyrba M, Fellgiebel A, Fischer F, Filippi M, Agosta F, Nestor P, Meisenzahl E, Blautzik J, Frölich L, Hausner L, Bokde AL, Frisoni G, Pievani M, Klöppel S, Prvulovic D, Barkhof F, Pouwels PJ, Schröder J, Hampel H, Hauenstein K, Teipel S. The European DTI Study on Dementia – a multicenter DTI and MRI study on Alzheimer’s disease and Mild Cognitive Impairment. Neuroimage 2017; 144: 305-308 [Epub ahead of print 1 April 2016; doi: 10.1016/j.neuroimage.2016.03.067]


  • Damjanovic D, Valsasina P, Rocca MA, Stromillo ML, Gallo A, Enzinger C, Hulst HE, Rovira A, Muhlert N, De Stefano N, Bisecco A, Fazekas F, Arevalo MJ, Yousry TA, Filippi M. Hippocampal and deep gray matter nuclei atrophy is relevant for explaining cognitive impairment in MS: a multicenter study. AJNR Am J Neuroradiol 2017; 38: 18-24 [Epub ahead of print 29 September 2016; doi: 10.3174/ajnr.A4952]


  • Menke RA, Agosta F, Grosskreutz J, Filippi M, Turner MR. Neuroimaging endpoints in amyotrophic lateral sclerosis. Neurotherapeutics 2017; 14: 11-23 [Epub ahead of print 17 October 2016; doi: 10.1007/s13311-016-0484-9]


  • Agosta F, Gatti R, Sarasso E, Volonté MA, Canu E, Meani A, Sarro L, Copetti M, Cattrysse E, Kerckhofs E, Comi G, Falini A, Filippi M. Brain plasticity in Parkinson’s disease with freezing of gait induced by action observation training. J Neurol 2017; 264: 88-101 [Epub ahead of print 24 October 2016; doi: 10.1007/s00415-016-8309-7]


  • Rocca MA, Battaglini M, Benedict RHB, De Stefano N, Geurts JJG, Henry RG, Horsfield MA, Jenkinson M, Pagani E, Filippi M. Brain MRI atrophy quantification in MS: from methods to clinical application. Neurology 2017; 88: 403-413 [Epub ahead of print 16 December 2016; doi: 10.1212/WNL.0000000000003542]
  • Agosta F, Galantucci S, Filippi M. Advanced magnetic resonance imaging of neurodegenerative diseases. Neurol Sci 2017; 38: 41-51 [Epub ahead of print 18 November 2016; doi: 10.1007/s10072-016-2764-x]


  • Molteni E, Rocca MA, Strazzer S, Pagani E, Colombo K, Arrigoni F, Boffa G, Copetti M, Pastore V, Filippi M. A diffusion tensor magnetic resonance imaging study of paediatric patients with severe non-traumatic brain injury. Develop Med Child Neurol 2017; 59: 199-206 [Epub ahead of print 2 December 2016; doi: 10.1111/dmcn.13332]


  • Messina R, Rocca MA, Colombo B, Teggi R, Falini A, Comi G, Filippi M. Structural brain abnormalities in patients with vestibular migraine. J Neurol 2017; 264: 295-303 [Epub ahead of print 28 November 2016; doi: 10.1007/s00415-016-8349-z]


  • Preziosa P, Sangalli F, Esposito F, Moiola L, Martinelli V, Falini A, Comi G, Filippi M. Clinical deterioration due to co-occurrence of multiple sclerosis and glioblastoma: report of two cases. Neurol Sci 2017; 38: 361-364 [Epub ahead of print 11 November 2016; doi: 10.1007/s10072-016-2763-y]


  • Rocca MA, Filippi M. Functional reorganization is a maladaptive response to injury –Yes. Mult Scler 2017; 23: 191-193 [Epub ahead of print 8 December 2016; doi: 10.1177/1352458516667242]


  • Rizzo G, Li X, Galantucci S, Filippi M, Cho YW. Brain imaging and networks in restless legs syndrome. Sleep Med 2017; 31: 39-48 [Epub ahead of print 9 November 2016; doi: 10.1016/j.sleep.2016.07.018]


  • Sarro L, Tosakulwong N, Schwarz CG, Graff-Radford J, Przybelski SA, Lesnick TG, Zuk SM, Reid RI, Raman MR, Boeve BF, Ferman TJ, Knopman DS, Comi G, Filippi M, Murray ME, Parisi JE, Dickson DW, Petersen RC, Jack CR, Kantarci K. An investigation of cerebrovascular lesions in dementia with Lewy bodies compared to Alzheimer’s disease. Alzheimers Dement 2017; 13: 257-266 [Epub ahead of print 10 August 2016; doi: 10.1016/j.jalz.2016.07.003]


  • Vacchi L, Rocca MA, Meani A, Rodegher M, Martinelli V, Comi G, Falini A, Filippi M. Working memory network dysfunction in relapse-onset multiple sclerosis phenotypes: a clinical-imaging evaluation. Mult Scler 2017; 23: 577-587 [Epub ahead of print 28 June 2016; doi: 10.1177/1352458516656809]


  • Spinelli EG, Mandelli ML, Santos-Santos MA, Wilson SM, Agosta F, Grinberg LT, Huang EJ, Trojanowski JQ, Meyer M, Henry ML, Comi G, Rabinovici G, Rosen HJ, Filippi M, Miller BL, Seeley WW, Gorno-Tempini ML. Typical and atypical pathology in primary progressive aphasia variants. Ann Neurol 2017; 81: 430-443 [Epub ahead of print 30 January 2017; doi: 10.1002/ana.24885]


  • Dobryakova E, Rocca MA, Valsasina P, DeLuca J, Filippi M. Altered neural mechanisms of cognitive control in patients with primary progressive multiple sclerosis: an effective connectivity study. Hum Brain Mapp 2017; 38: 2580-2588 [Epub ahead of print 16 February 2017; doi: 10.1002/hbm.23542]


  • Absinta M, Cortese ICM, Vuolo L, Nair G, Manori de Alwis P, Ohayon J, Meani A, Martinelli V, Scotti R, Falini A, Smith BR, Nath A, Jacobson S, Filippi M, Reich DS. Leptomeningeal gadolinium enhancement across the spectrum of chronic neuroinflammatory diseases. Neurology 2017; 88: 1439-1444 [Epub ahead of print 10 March 2017; doi: 10.1212/WNL.0000000000003820]


  • Filippi M, Preziosa P, Rocca MA. Microstructural MR imaging techniques in multiple sclerosis. Neuroimag Clin N Am 2017; 27: 313-333 [doi: 10.1016/j.nic.2016.12.004]


  • Kilimann I, Hausner L, Fellgiebel A, Filippi M, Würdemann TJ, Heinsen H, Teipel SJ. Parallel atrophy of cortex and basal forebrain cholinergic system in mild cognitive impairment. Cer Cor 2017; 27: 1841-1848 [Epub ahead of print 14 February 2016; doi: 10.1093/cercor/bhw019]


  • Gatti R, Rocca MA, Fumagalli S, Cattrysse E, Kerckhofs E, Falini A, Filippi M. The effect of action observation/execution on mirror neuron system recruitment: an fMRI study in healthy individuals. Brain Imag Behav 2017; 11: 565-576 [Epub ahead of print 24 March 2016; doi: 10.1007/s11682-016-9536-3]


  • Galantucci S, Agosta F, Stefanova E, Basaia S, van den Heuvel MP, Stojkovic T, Canu E, Stankovic I, Spica V, Copetti M, Gagliardi D, Kostic VS, Filippi M. Structural brain connectome and cognitive impairment in Parkinson’s disease. Radiology 2017; 283: 515-525 [Epub ahead of print 7 December 2016; doi: 10.1148/radiol.2016160274]


  • Longoni G, Brown RA, MomayyezSiahkal P, Brown RA, Elliott C, Narayanan S, Bar-Or A, Marrie RA, Yeh EA, Filippi M, Banwell B, Arnold DL, on behalf of The Canadian Pediatric Demyelinating Disease Network. White matter changes in paediatric multiple sclerosis and monophasic demyelinating disorders. Brain 2017; 140: 1300-1315 [Epub ahead of print 14 March 2017; doi: 10.1093/brain/awx041]


  • Rocca MA, Filippi M. Modulation of cortical excitability to normalise brain function and improve cognition in multiple sclerosis. J Neurol Neurosurg Psychiatry 2017; 88; 373 [Epub ahead of print 30 December 2016; doi: 10.1136/jnnp-2016-315195]


  • Preziosa P, Martinelli V, Ferré L, Guaschino C, Simionato F, Moiola L, Comi G, Filippi M. Moyamoya disease mimicking the first attack of multiple sclerosis. J Neurol 2017; 264: 1005-1007 [Epub ahead of print 17 March 2017; doi: 10.1007/s00415-017-8458-3]


  • Markovic V, Agosta F, Canu E, Inuggi A, Petrovic I, Stankovic I, Imperiale F, Stojkovic T, Kostic VS, Filippi M. Role of habenula and amygdala dysfunction in Parkinson disease patients with punding. Neurology 2017; 88: 2207-2215 [Epub ahead of print 10 May 2017; doi: 10.1212/WNL.0000000000004012]


  • Filippi M, Tedeschi G, Pantano P, De Stefano N, Zaratin P, Rocca MA for the INNI Network. The Italian Neuroimaging Network Initiative (INNI): enabling the use of advanced MRI techniques in patients with MS. Neurol Sci 2017; 38: 1029-1038 [Epub ahead of print 14 March 2017; doi: 10.1007/s10072-017-2903-z]


  • Canu E, Agosta F, Mandic-Stojmenovic G, Stojković T, Stefanova E, Inuggi A, Imperiale F, Copetti M, Kostic VS, Filippi M. Multiparametric MRI to distinguish early onset Alzheimer’s disease and behavioural variant of frontotemporal dementia. NeuroImage Clinical 2017; 15; 428-438 [Epub ahead of print 25 May 2017; doi: 10.1016/j.nicl.2017.05.018]


  • Agosta F, Ferraro PM, Riva N, Spinelli EG, Domi T, Carrera P, Copetti M, Falzone Y, Ferrari M, Lunetta C, Comi G, Falini A, Quattrini A, Filippi M. Structural and functional brain signatures of C9orf72 in motor neuron disease. Neurobiol Aging 2017; 57: 206-219 [Epub ahead of print 27 June 2017; doi: 10.1016/j.neurobiolaging.2017.05.024]


  • d’ Ambrosio A, Pagani E, Riccitelli GC, Colombo B, Rodegher M, Falini A, Comi G, Filippi M, Rocca MA. Cerebellar contribution to motor and cognitive performance in multiple sclerosis: an MRI sub-regional volumetric analysis. Mult Scler 2017; 23: 1194-1203 [Epub ahead of print 20 October 2016; doi: 10.1177/1352458516674567]


  • Filippi M, Rocca MA. Simvastatin and cognition in multiple sclerosis. Lancet Neurol 2017; 16: 572-573 [Epub ahead of print 6 June 2017; doi: 10.1016/ S1474-4422(17)30162-X]


  • Ferraro PM, Agosta F, Riva N, Copetti M, Spinelli EG, Falzone Y, Sorarù G, Comi G, Chiò A, Filippi M. Multimodal structural MRI in the diagnosis of motor neuron diseases. NeuroImage Clin 2017; 16: 240-247 [Epub ahead of print 5 August 2017; doi: 10.1016/j.nicl.2017.08.002]


  • Ammirati E, Moroni F, Magnoni M, Rocca MA, Messina R, Anzalone N, De Filippis C, Scotti I, Besana F, Spagnolo P, Rimoldi OE, Chiesa R, Falini A, Filippi M, Camici PG. Relation between characteristics of carotid atherosclerotic plaques and brain white matter hyperintensities in asymptomatic patients. Sci Rep 2017; 7: 10559 [Epub ahead of print 5 September 2017; doi: 10.1038/s41598-017-11216-x]


  • De Meo E, Moiola L, Ghezzi A, Veggiotti P, Capra R, Amato MP, Pagani E, Fiorino A, Pippolo L, Pera MC, Comi G, Falini A, Filippi M, Rocca MA. MRI substrates of sustained attention system and cognitive impairment in pediatric MS patients. Neurology 2017; 89: 1265-1273 [Epub ahead of print 18 August 2017; doi: 10.1212/WNL.0000000000004388]


  • Rocca MA, Comi G, Filippi M. The role of T1-weighted derived measures of neurodegeneration for assessing disability progression in multiple sclerosis. Front Neurol 2017; 8: 433 [Epub ahead of print 1 September 2017; doi: 10.3389/fneur.2017.00433]


  • de Sitter A, Steenwijk MD, Ruet A, Versteeg A, van Schijndel RA, Pouwels PJW, Kilsdonk ID, Cover KS, van Dijk BW, Ropele S, Rocca MA, Yiannakas M, Amann M, Wattjes MP, Damangir S, Frisoni GB, Sastre-Garriga J, Rovira A, Enzinger C, Filippi M, Frederiksen J, Ciccarelli O, Kappos L, Barkhof L, Vrenken H for the MAGNIMS study group and neuGRID. Performance of five research-domain automated WM lesion segmentation methods in a multi-center MS study. NeuroImage 2017; 163: 106-114 [doi: 10.1016/j.neuroimage.2017.09.011]


  • Rocca MA, Vacchi L, Rodegher M, Meani A, Martinelli V, Possa F, Comi G, Falini A, Filippi M. Mapping face encoding using functional MRI in multiple sclerosis across disease phenotypes. Brain Imag Behav 2017; 11: 1238-1247 [Epub ahead of print 6 October 2016; doi: 10.1007/s11682-016-9591-9]


  • Rocca MA, Fumagalli S, Pagani E, Gatti R, Riccitelli GC, Preziosa P, Comi G, Falini A, Filippi M. Action observation training modifies brain gray matter structure in healthy adult individuals. Brain Imag Behav 2017; 11: 1343–1352 [Epub ahead of print 11 October 2016; doi: 10.1007/s11682-016-9625-3]


  • Filippi M, Basaia S, Canu E, Imperiale F, Meani A, Caso F, Magnani G, Falautano M, Comi G, Falini A, Agosta F. Brain network connectivity differs in early-onset neurodegenerative dementia. Neurology 2017; 89: 1764-1772 [epub ahead of print 27 September 2017; doi: 10.1212/WNL.0000000000004577]


  • Preziosa P, Pagani E, Mesaros S, Riccitelli GC, Dackovic J, Drulovic J, Filippi M. Rocca MA. Progression of regional atrophy in the left hemisphere contributes to clinical and cognitive deterioration in multiple sclerosis: a 5-year study. Hum Brain Mapp 2017; 38: 5648-5665 [Epub ahead of print 9 August 2017; doi: 10.1002/hbm.23755]


  • Rocca MA, Sormani MP, Rovaris M, Caputo D, Ghezzi A, Montanari E, Bertolotto A, Laroni A, Bergamaschi R, Martinelli V, Comi G, Filippi M. Long-term disability progression in primary progressive multiple sclerosis: a 15 year study. Brain 2017; 140: 2814-2819 [epub ahead of print 27 September 2017; doi: 10.1093/brain/awx250]


  • d’Ambrosio A, Hidalgo de la Cruz M, Valsasina P, Pagani E, Colombo B, Rodegher M, Comi G, Filippi M, Rocca MA. Structural connectivity-defined thalamic subregions have different functional connectivity abnormalities in multiple sclerosis patients: implications for clinical correlations. Hum Brain Mapp 2017; 38: 6005-6018 [Epub ahead of print 7 September 2017; doi: 10.1002/hbm.23805]


  • Canu E, Agosta F, Markovic V, Petrovic I, Stankovic I, Imperiale F, Stojkovic T, Copetti M, Kostic VS, Filippi M. White matter tract alterations in Parkinson’s disease patients with punding. Parkinsonism Relat Disord 2017; 43: 85-91 [Epub ahead of print 2 August 2017; doi: 10.1016/j.parkreldis.2017.07.025]


  • Preziosa P, Pagani E, Morelli ME, Copetti M, Martinelli V, Pirro F, Falini A, Comi G, Filippi M, Rocca MA. DT MRI microstructural cortical lesion damage does not explain cognitive impairment in MS. Mult Scler 2017: 23: 1918-1928 [Epub ahead of print 18 January 2017; doi: 10.1177/1352458516689147]


  • Pravatà E, Rocca MA, Valsasina P, Riccitelli GC, Gobbi C, Comi G, Falini A, Filippi M. Gray matter trophism, cognitive impairment and depression in patients with multiple sclerosis. Mult Scler 2017; 23: 1864-1874 [Epub ahead of print 1 February 2017; doi: 10.1177/1352458517692886]


  • Comi G, Patti F, Rocca MA,·Mattioli FC,·Amato MP,·Gallo P, Centonze D,·Pozzilli C, Saccà F, Then Bergh F, Bartezaghi M, Turrini R, Filippi M for the Golden Study Group. Efficacy of fingolimod and interferon beta‑1b on cognitive, MRI, and clinical outcomes in relapsing–remitting multiple sclerosis: an 18‑month, open‑label, rater‑blinded, randomised, multicentre study (the GOLDEN study). J Neurol 2017; 264: 2436-2449 [epub ahead of print 23 October 2017; doi: 10.1007/s00415-017-8642-5]


  • Müller HP, Agosta F, Riva N, Spinelli EG, Comi G, Ludolph AC, Filippi M, Kassubek J. Fast progressive lower motor neuron disease is an ALS variant: a two-centre tract of interest-based MRI data analysis. Neuroimage Clinical 2018; 17: 145-152 [doi: 10.1016/j.nicl.2017.10.008]


  • Preziosa P, Moiola L, Baldoli C, Longo D, Sangalli F, Radaelli M, Comi G, Martinelli V, Filippi M. Necrotic-hemorragic myelitis: a rare malignant variant of parainfectious acute disseminated encephalomyelitis in childhood. J Neurol Sci 2018; 384: 58-60 [epub ahead of print 27 November 2017; doi: 10.1016/j.jns.2017.11.032]


  • Imperiale F, Agosta F, Canu E, Markovic V, Inuggi A, Jecmenica-Lukic M, Tomic A, Copetti M, Basaia S, Kostic VS, Filippi M. Brain structural and functional signatures of impulsive-compulsive behaviours in Parkinson’s disease. Mol Psychiatr 2018; 23: 459-466 [Epub ahead of print 7 March 2017; doi: 10.1038/mp.2017.18]


  • Filippi M, Preziosa P, Meani A, Ciccarelli O, Mesaros S, Rovira A, Frederiksen J, Enzinger C, Barkhof F, Gasperini C, Brownlee W, Drulovic J, Montalban X, Cramer SP, Pichler A, Hagens M, Ruggieri S, Martinelli V, Miszkiel K, Tintorè M, Comi G, Dekker I, Uitdehaag B, Dujmovic-Basuroski I, Rocca MA. Prediction of a multiple sclerosis diagnosis in patients with clinically isolated syndrome using the 2016 MAGNIMS and 2010 McDonald criteria: a retrospective study. Lancet Neurol 2018; 17: 133-142 [epub ahead of print 21 December 2017; doi: 10.1016/S1474-4422(17)30469-6]


  • Thompson AJ, Banwell BL, Barkhof F, Carroll WM, Coetzee T, Comi G, Correale G, Fazekas F, Filippi F, Freedman MS, Fujihara K, Galetta SL, Hartung HP, Kappos L, Lublin FD, Marrie RA, Miller AE, Miller DH, Montalban X, Mowry EM, Soelberg-Sorensen P, Tintoré M, Traboulsee AL, Trojano M, Uitdehaag BMJ, Vukusic S, Waubant E, Weinshenker BG, Reingold SC, Cohen JA. Diagnosis of multiple sclerosis: 2017 revisions of the McDonald Criteria. Lancet Neurol 2018; 17: 162-173 [epub ahead of print 21 December 2017; doi: 10.1016/S1474-4422(17)30470-2]


  • De Stefano N, Giorgio A, Tintoré M, Amato MP, Kappos L, Palace J, Yousry TA, Rocca MA, Ciccarelli O, Enzinger C, Frederiksen J, Filippi M, Vrenken H, Rovira A, on behalf of the MAGNIMS study group. Radiologically isolated syndrome or subclinical multiple sclerosis: MAGNIMS consensus recommendations. Mult Scler 2018; 24: 214-221 [doi: 10.1177/1352458517717808]


  • Sumowski JF, Benedict RHB, Enzinger C, Filippi M, Geurts JJG, Hamalainen P, Hulst HE, Inglese M, Leavitt VM, Rocca MA, Rosti-Otajarvi E, Rao SM. Cognition in multiple sclerosis: state of the field and priorities for the future. Neurology 2018; 90: 278-288 [epub ahead of print 17 January 2018; doi: 10.1212/WNL.0000000000004977]


  • Preziosa P, Rocca MA, Mesaros S, Meani A, Montalban X, Drulovic J, Droby A, Zipp F, Calabrese M, Sastre-Garriga J, Dujmovic-Basuroski I, Rovira A, Filippi M. Diagnosis of multiple sclerosis: a multicenter study to compare revised McDonald-2010 and Filippi-2010 criteria. J Neurol Neurosurg Psychiatry 2018; 89: 316-318 [Epub ahead of print 24 July 2017; doi: 10.1136/jnnp-2017-315863]


  • Canu E, Sarasso E, Filippi M, Agosta F. Effects of pharmacological and nonpharmacological treatments on brain functional magnetic resonance imaging in Alzheimer’s disease and mild cognitive impairment: A critical review. Alzheimers Res Ther 2018; 10: 21 [published online 20 February 2018; doi: 10.1186/s13195-018-0347-1]


  • Eshaghi A, Prados F, Brownlee W, Altmann D, Tur C, Cardoso M, De Angelis F, Van De Pavert S, Cawley N, De Stefano N, Stromillo ML, Battaglini M, Ruggieri S, Gasperini C, Filippi M, Rocca MA, Rovira A, Sastre-Garriga J, Vrenken H, Leurs C, Killestein J, Pirpamer L, Enzinger C, Ourselin S, Wheeler-Kingshott C, Chard D, Thompson AJ, Alexander D, Barkhof F, Ciccarelli O. Deep grey matter volume loss drives disability worsening in multiple sclerosis. Ann Neurol 2018; 83: 210-222 [epub ahead of print 13 January 2018; doi: 10.1002/ana.25145]


  • Maggi P, Absinta M, Grammatico M, Vuolo L, Emmi G, Carlucci G, Spagni G, Barilaro A, Repice AM, Emmi L, Prisco D, Martinelli V, Scotti R, Sadeghi N, Perrotta G, Sati P, Dachy B, Reich DS, Filippi M, Massacesi L. The central vein sign differentiates multiple sclerosis from central nervous system inflammatory vasculopathies. Ann Neurol 2018; 83: 283-294 [epub ahead of print 12 January 2018; doi: 10.1002/ana.25146]


  • Agosta F, Spinelli EG, Marjanovic IV, Stevic Z, Pagani E, Valsasina P, Salak-Djokic B, Jankovic M, Lavrnic D, Kostic VS, Filippi M. Unraveling ALS due to SOD1 mutation through the combination of brain and cervical cord MRI. Neurology 2018; 90: e707-e716 [epub ahead of print 24 January 2018; doi: 10.1212/WNL.0000000000005002]


  • Caso F, Agosta F, Ječmenica-Lukić M, Petrović I, Meani A, Kostic VS, Filippi M. Progression of white matter damage in progressive supranuclear palsy with predominant parkinsonism. Parkinsonism Relat Disord 2018; 49: 95-99 [epub ahead of print 12 January 2018; doi: 10.1016/j.parkreldis.2018.01.001]


  • Rocca MA, Valsasina P, Leavitt VM, Rodegher M, Radaelli M, Riccitelli GC, Martinelli V, Martinelli-Boneschi F, Falini A, Comi G, Filippi M. Functional network connectivity abnormalities in multiple sclerosis: correlations with disability and cognitive impairment. Mult Scler 2018; 24: 459-471 [Epub ahead of print 15 March 2017; doi: 10.1177/1352458517699875]


  • Esposito F, Ferrè L, Clarelli F, Rocca MA, Sferruzza G, Storelli L, Radaelli M, Sangalli F, Moiola L, Colombo B, Martinelli Boneschi F, Comi G, Filippi M, Martinelli V. Effectiveness and baseline factors associated to fingolimod response in a real-world study on multiple sclerosis patients. J Neurol 2018; 265: 896-905 [epub ahead of print 12 February 2018; doi: 10.1007/s00415-018-8791-1]


  • Parmar K, Stadelmann C, Rocca MA, Langdon D, D’Angelo E, D’Souza M, Burggraaff J, Wegner C, Sastre-Garriga J, Barrantes-Freer A, Dorn J, Uitdehaag BMJ, Montalban X, Wuerfel J, Enzinger C, Rovira A, Tintoré M, Filippi M, Kappos L, Sprenger T, for the MAGNIMS study group. The role of the cerebellum in multiple sclerosis – 150 years after Charcot. Neurosci Biobehav Rev 2018; 89: 85-98 [epub ahead of print 23 February 2018; doi: 10.1016/j.neubiorev.2018.02.012]


  • Geraldes R, Ciccarelli O, Barkhof F, De Stefano N, Enzinger C, Filippi M, Hofer M, Paul F, Preziosa P, Rovira A, DeLuca G, Kappos L, Yousry T, Fazekas F, Frederiksen J, Gasperini C, Sastre-Garriga J, Evangelou N, Palace J on behalf of MAGNIMS study group. The current role of MRI in differentiating multiple sclerosis from its imaging mimics. Nature Rev Neurol 2018; 14: 199-213 [epub ahead of print 9 March 2018; doi: 10.1038/nrneurol.2018.14]


  • Sumowski JF, Leavitt V, Rocca MA, Inglese M, Riccitelli GC, Buyukturkoglu K, Meani A, Filippi M. Mesial temporal lobe and subcortical grey matter volumes differentially predict memory across stages of multiple sclerosis. Mult Scler 2018; 24: 675-678 [Epub ahead of print 18 May 2017; doi: 10.1177/1352458517708873]


  • Agosta F, Spinelli EG, Filippi M. Neuroimaging in amyotrophic lateral sclerosis: current and emerging uses. Expert Rev Neurother 2018; 18: 395-406 [epub ahead of print 15 April 2018; doi: 10.1080/14737175.2018.1463160]


  • Stojkovic T, Stefanova E, Soldatovic I, Markovic V, Stankovic I, Petrovic I, Agosta F, Galantucci S, Filippi M, Kostic VS. Exploring the relationship between motor impairment, vascular burden and cognition in Parkinson’s disease. J Neurol 2018; 265: 1320-1327 [epub ahead of print 23 March 2018; doi: 10.1007/s00415-018-8838-3]


  • Eshaghi A, Marinescu RV, Young AL, Firth NC, Prados F, Cardoso MJ, Tur C, De Angelis F, Cawley N, Brownlee W, De Stefano N, Stromillo ML, Battaglini M, Ruggieri S, Gasperini C, Filippi M, Rocca MA, Rovira A, Sastre-Garriga J, Geurts J, Vrenken H, Wottschel V, Leurs CE, Uitdehaag B, Pirpamer L, Enzinger C, Ourselin S, Wheeler-Kingshott CAG, Chard D, Thompson AJ, Barkhof F, Alexander DC, Ciccarelli O, on behalf of the MAGNIMS study group. Progression of regional grey matter atrophy in multiple sclerosis. Brain 2018; 141: 1665-1677 [epub ahead of print 8 May 2018; doi: 10.1093/brain/awy088]


  • Moroni F, Ammirati E, Rocca MA, Filippi M, Magnoni M, Camici PG. Cardiovascular disease and brain health: Focus on white matter hyperintensities. Int J Cardiol Heart Vasc 2018; 19: 63-69 [doi: 10.1016/j.ijcha.2018.04.006]


  • Agosta F, Caso F, Ječmenica-Lukić M, Petrović I, Valsasina P, Meani A, Copetti M, Kostic VS, Filippi M. Tracking brain damage in progressive supranuclear palsy: a longitudinal MRI study. J Neurol Neurosurg Psychiatry 2018; 89; 696-701 [epub ahead of print 21 January 2018; doi: 10.1136/jnnp-2017-317443]


  • Amiri H, de Sitter A, Bendfeldt K, Battaglini M, Gandini Wheeler-Kingshott CAM, Calabrese M, Geurts JJG, Rocca MA, Sastre-Garriga J, Enzinger C, de Stefano N, Filippi M, Rovira A, Barkhof F, Vrenken H, MAGNIMS Study Group. Urgent challenges in quantification and interpretation of brain grey matter atrophy in individual MS patients using MRI. NeuroImage Clin 2018; 19: 466-475 [doi: 10.1016/j.nicl.2018.04.023]


  • Valsasina P, Aboulwafa M, Preziosa P, Messina R, Falini A, Comi G, Filippi M, Rocca MA. Cervical cord T1-hypointense MR imaging lesions in multiple sclerosis: relationship to cord atrophy and disability. Radiology 2018; 288: 234-244 [epub ahead of print 17 April 2018; doi: 10.1148/radiol.2018172311]


  • Messina R, Filippi M, Goadsby PJ. Recent advances in headache neuroimaging. Curr Opin Neurol 2018; 31: 379-385 [doi: 10.1097/WCO.0000000000000573]


  • Filippi M, Preziosa P, Rocca MA. MRI in multiple sclerosis: what is changing? Curr Opin Neurol 2018; 31: 386-395 [doi: 10.1097/WCO.0000000000000572]


  • Filippi M, Agosta F. MRI of non-Alzheimer’s dementia: current and emerging knowledge. Curr Opin Neurol 2018; 31: 405-414 [epub ahead of print 8 May 2018; doi: 10.1097/WCO.0000000000000571]


  • Ferraro PM, Jester C, Olm CA, Placek K, Agosta F, Elman L, McCluskey L, Irwin DJ, Detre JA, Filippi M, Grossman M, McMillan CT. Perfusion alterations converge with patterns of pathological spread in TDP-43 proteinopathies. Neurobiol Aging 2018; 68: 85-92 [doi: 10.1016/j.neurobiolaging.2018.04.008]


  • Agosta F, Mandic-Stojmenovic G, Canu E, Stojkovic T, Imperiale F, Caso F, Stefanova E, Copetti M, Kostic VS, Filippi M. Functional and structural brain networks in posterior cortical atrophy: a two-centre multiparametric MRI study. NeuroImage Clin 2018; 19: 901-910 [doi: 10.1016/j.nicl.2018.06.013]


  • Messina R, Rocca MA, Colombo B, Pagani E, Falini A, Goadsby PJ, Filippi M. Gray matter volume modifications in migraine: a cross-sectional and longitudinal study. Neurology 2018; 91: e280-e292 [epub ahead of print 20 June 2018; doi: 10.1212/WNL.0000000000005819]


  • Hidalgo de la Cruz M, d’Ambrosio A, Valsasina P, Pagani E, Colombo B, Rodegher M, Falini A, Comi G, Filippi M, Rocca MA. Abnormal functional connectivity of thalamic sub-regions contributes to fatigue in multiple sclerosis. Mult Scler 2018; 24: 1183-1195 [Epub ahead of print 28 June 2017; doi: 10.1177/1352458517717807]


  • Storelli L, Rocca MA, Pagani E, van Hecke W, Horsfield MA, De Stefano N, Rovira A, Sastre-Garriga J, Palace J, Sima D, Smeets D, Filippi M, for the MAGNIMS Stidy Group. Measurement of whole brain and gray matter atrophy in multiple sclerosis: assessment by MR imaging. Radiology 2018; 288: 554-564 [epub ahead of print 1 May 2018; doi: 10.1148/radiol.2018172468]


  • Sarasso E, Agosta F, Temporiti F, Adamo P, Piccolo F, Copetti M, Gatti R, Filippi M. Brain motor functional changes after somatosensory discrimination training. Brain Imag Behav 2018 (in press) [Epub ahead of print 31 August 2017; doi: 10.1007/s11682-017-9763-2]


  • Filippi M, Preziosa P, Rocca MA. Brain mapping in multiple sclerosis: lessons learned about the human brain. NeuroImage 2018 (in press) [epub ahead of print 19 September 2017; doi: 10.1016/j.neuroimage.2017.09.021]


  • Riccitelli GC, Pagani E, Rodegher M, Colombo B, Preziosa P, Falini A, Comi G, Filippi M, Rocca MA. Imaging patterns of gray and white matter abnormalities associated with PASAT and SDMT performance in relapsing-remitting multiple sclerosis. Mult Scler 2018 (in press) [epub ahead of print 27 November 2017; doi: 10.1177/1352458517743091]


  • Rocca MA, Riccitelli GC, Meani A, Pagani E, Del Sette P, Martinelli V, Comi G, Falini A, Filippi M. Cognitive reserve, cognition, and regional brain damage in MS: a two-year longitudinal study. Mult Scler 2018 (in press) [epub ahead of print 5 January 2018; doi: 10.1177/1352458517750767]


  • Buck D, Andlauer TF, Igl W, Wicklein EM, Mühlau M, Weber F, Köchert K, Pohl C, Arnason B, Comi G, Cook S, Filippi M, Hartung HP, Jeffery D, Kappos L, Barkhof F, Edan G, Freedman MS, Montalbán X, Müller-Myhsok B, Hemmer B; BEYOND and BENEFIT Study Groups. Effect of HLA-DRB1 alleles and genetic variants on the development of neutralizing antibodies to interferon beta in the BEYOND and BENEFIT trials. Mult Scler 2018 (in press) [epub ahead of print 9 March 2018; doi: 10.1177/1352458518763089]



  • Lavie C, Rollot F, Durand-Dubief F, Marignier R, Ionescu I, Casey R, Moreau T, Tourniaire P, Hutchinson M, D’Hooghe MB, Laplaud D-A, Clavelou P, De Sèze J, Debouverie M, Brassat D, Pelletier J, Lebrun-Frenay C, Le Page E, Castelnovo G, Berger E, Hautecoeur P, Heinzlef O, Durelli L, Clerico M, Trojano M, Patti F, Vukusic S, for the PRIMS and POPARTMUS investigators. Neuraxial analgesia is not associated with an increased risk of post-partum relapses in MS. Mult Scler 2018 (in press) [epub ahead of print 20 March 2018; doi: 10.1177/1352458518763080]


  • Llufriu S, Rocca MA, Pagani E, Riccitelli GC, Solana E, Colombo C, Rodegher M, Falini A, Comi C, Filippi M. Hippocampal-related memory network in multiple sclerosis: a structural connectivity analysis. Mult Scler 2018 (in press) [epub ahead of print 23 April 2018; doi: 10.1177/1352458518771838]


  • Filippi M, Basaia S, Canu E, Imperiale F, Magnani G, Falautano M, Comi G, Falini A, Agosta F. Changes in functional and structural brain connectome along the Alzheimer’s disease continuum. Mol Psychiatr 2018 (in press) [epub ahead of print 9 May 2018; doi: 10.1038/s41380-018-0067-8]


  • Ferré L, Clarelli F, Sferruzza G, Rocca MA, Mascia E, Radaelli M, Sangalli F, Dalla Costa G, Moiola L, Aboulwafa M, Martinelli Boneschi F, Comi G, Filippi M, Martinelli V, Esposito F. Basal vitamin D levels and disease activity in multiple sclerosis patients treated with fingolimod. Neurol Sci 2018 (in press) [epub ahead of print 13 May 2018; doi: 10.1007/s10072-018-3440-0]


  • Rocca MA, Savoldi F, Valsasina P, Radaelli M, Preziosa P, Comi G, Falini A, Filippi M. Cross-modal plasticity among sensory networks in neuromyelitis optica spectrum disorders. Mult Scler 2018 (in press) [epub ahead of print 17 May 2018; doi: 10.1177/135245851877800]

Il titolare del presente curriculum vitae, pubblicato online sul portale, è garante in via esclusiva della correttezza e della veridicità dei dati e delle informazioni in esso riportate e del loro eventuale e puntuale aggiornamento. Egli è dunque il diretto ed unico responsabile dei contenuti indicati nei propri curricula.