Fumagalli Valeria Ricercatore a tempo determinatoMedicine

Valeria Fumagalli is Researcher in General Pathology at UniSR and Research Immunologist in the laboratory of Matteo Iannacone at San Raffaele Scientific Institute. She obtained her PhD in Molecular Medicine at Vita-Salute San Raffaele University in 2020. She is interested in studying the complex dynamics of host-virus interactions with a particular focus on the function of immune response and seeks to dissect the role of innate lymphoid cells and B cells in mouse models of HBV pathogenesis. During the last three years, she has played a leading role in establishing novel mouse models of SARS-CoV-2 infection to study pathogenesis and to test vaccines and and antivirals.

 

 

EDUCATION

2020  Ph.D. in Molecular Medicine with Honor,

Vita-Salute San Raffaele University, Milan (IT)

2016   Enabled to the profession of Senior Biologist

2016   Medical Biotechnology second level master’s degree,

University of Milano-Bicocca (IT) (score 110/110 cum laude)

2013    Biotechnology first level master’s degree,

University of Milano-Bicocca (IT) (score 110/110 cum laude)

 

PROFESSIONAL EXPERIENCE

2023 – present       Researcher (RTD-A), General Pathology (MED/04)                                  Vita-Salute San Raffaele University, Milan (Italy)

2022 – 2023 Teaching assistant, Pathology and Immunology (MED/04),

Vita-Salute San Raffaele University, Milan (IT)

2022 – 2023 AIRC Fellow for Italy, (ID 26813-2021),

Vita-Salute San Raffaele University, Milan (IT)

(Advisor: Iannacone Matteo)

“Spatiotemporal dynamics and genomic landscape of intrahepatic CD8+ T cells during chronic hepatitis and liver cancer”

2020 – 2022 Research Fellow, MIUR-PRIN 2017 (n. 2017ZXT5WR_002),

Vita-Salute San Raffaele University, Milan (IT)

(Advisors: Iannacone Matteo and Kuka Mirela)

“Exploring the spatiotemporal dynamics of B lymphoma cells in the bone marrow and in lymph nodes”

2017 – 2020  International PhD Course in Molecular Medicine,                                 

Vita-Salute San Raffaele University, Milan (IT)

(Advisor: Iannacone Matteo)

“Characterization of Hepatitis B Virus (HBV)-specific B cells and Group 1

Innate Lymphoid Cells (ILCs) in mouse model of HBV pathogenesis”

2016 – 2017   Pre-Doctoral Fellow “Immune cell dynamics”,                                             

San Raffaele Scientific Institute, Milan (IT) (Advisor: Iannacone Matteo)

2016   Post-graduation Fellow “Immunology and Cellular Therapy”,               

“Matilde Tettamanti Research Centre”, Monza (IT)

(Advisors: Biondi Andrea and D’Amico Giovanna)

2015 – 2016  Internship for experimental thesis,

“Matilde Tettamanti Research Centre”, Monza (IT)

(Advisor: Biondi Andrea and D’Amico Giovanna)

“Study the role of Chemerin/ChemR23 axis in a mouse model of Graft-

versus Host Disease (GvHD) pathogenesis”

2012    Stage at Laboratory of Cellular and Molecular Immunology,             

University of Milano-Bicocca, Milan (IT)

(Adivsors: Granucci Francesca and Zanoni Ivan)

“Study the role of dendritic cells in the activation of Natural Killer cells”

 

PROFESSIONAL ACTIVITIES

Journal Reviewer: Communications biology; Antiviral Research

 

MAJOR FIELDS OF INTEREST

Viral Immunology, Adaptive and Innate Immune Responses, B and T Lymphocytes, Innate Lymphoid Cells (ILCs), Immune Cell Dynamics, Mouse Models, Hepatitis B Virus (HBV), Immunity in the Liver, Immunity in the Lung

 

PROFESSIONAL HONORS

2022   Travel Grant Award at “XIII National Congress SIICA 2022”, Naples (IT)

2022   Best Oral Presentation at “DITID Scientific Retreat”, Milan (IT)

2021    “AIRC Fellowship for Italy”, three-years fellowship, ID 26813-2021

2021    Member of the DITID Retreat Committee (Division of Immunology, Transplantation, and Infectious Disease Scientific Retreat), Vita-Salute San Raffaele University, Milan (IT)

2020  MIUR-PRIN 2017 Fellowship (n. 2017ZXT5WR_002)

2019   Best Oral Presentation at “International HBV Meeting”, Melbourne (AU),

 

PROFESSIONAL SOCIETIES

2017– present         Member of Italian Society of Immunology Clinical Immunology and Allergology (SIICA)

 

ADDITIONAL INFORMATION

ORCID ID: 0000-0003-2583-2498

Scopus Author ID: 57194541756

Google Scholar: https://scholar.google.com/citations?user=f7lTPIwAAAAJ&hl=it

 

 

1.          Fumagalli V, Di Lucia P, Ravà M, Marotta D, Bono E, Grassi S, Donnici L, Cannalire R, Stefanelli I, Ferraro A, Esposito F, Pariani E, Inverso D, Montesano C, Delbue S, Tramontano E, De Francesco R, Summa V, Guidotti LG, Iannacone M. Nirmatrelvir treatment of SARS-CoV-2 infected mice blunts the development of antiviral adaptive immune responses. EMBO Molecular Medicine, doi:10.15252/emmm.202317580. (2023)

2.         Fumagalli V, Venzin V, Di Lucia P, Moalli F, Ficht X, Ambrosi G, Giustini L, Andreata F, Grillo M, Magini D, Ravà M, Friedrich C, Fontenot JD, Bousso P, Gasteiger G, Vivier E, Kuka M, Guidotti LG, Iannacone M. Group 1 ILCs regulate T cell-mediated liver immunopathology by controlling local IL-2 availability. Science Immunology, 7(68):eabI6112 (2022).

3.         Fumagalli V*, Ravà M*, Marotta D*, Di Lucia P, Laura C, Sala E, Grillo M, Bono E, Giustini L, Perucchini C, Mainetti M, Sessa A, Garcia-Manteiga JM, Donnici L, Manganaro L, Delbue S, Broccoli V, De Francesco R, D’Adamo P, Kuka M, Guidotti LG, Iannacone M. Administration of aerosolized SARS-CoV-2 to K18-hACE2 mice uncouples respiratory infection from fatal neuroinvasion. Science Immunology, 7(67):eabl9929. (2022). (*co-first authors)

4.         Fumagalli V, Di Lucia P, Venzin V, Bono E, Jordan R, Frey C, Delaney W, Chisari FV, Guidotti LG, Iannacone M. Serum HBsAg clearance has minimal impact on CD8+ T cell responses in mouse models of HBV infection. Journal of Experimental Medicine 217 (11), (2020).

5.         De Simone G*, Andreata F*, Bleriot C*, Fumagalli V*, Laura C, Garcia-Manteiga JM, Di Lucia P, Gilotto S, Ficht X, Bono EB, Giustini L, De Ponti F, Ambrosi G, Mainetti M, Zordan P, Benechet AP, Ravà M, Chakarov S, Moalli F, Bajenoff M, Guidotti LG, Ginhoux F. Iannacone M. Identification of a Kupffer cell subset capable of reverting the T cell dysfunction induced by hepatocellular priming. Immunity, 54 (9), 2089-2100 (2021). (*co-first authors)

6.         Conforti A*, Marra E*, Palombo F*, Roscilli G*, Ravà M*, Fumagalli V*, Muzi A, Maffei M, Luberto L, Lione L, Salvatori E, Compagnone M, Pinto E, Pavoni E, Bucci F, Vitagliano G, Stoppoloni D, Pacello ML, Cappelletti M, Ferrara FF, D'Acunto E, Chiarini V, Arriga R, Nyska A, Di Lucia P, Marotta D, Bono E, Giustini L, Sala E, Perucchini C, Paterson J, Ryan KA, Challis AR, Matusali G, Colavita F, Caselli G, Criscuolo E, Clementi N, Mancini N, Groß R, Seidel A, Wettstein L, Münch J, Donnici L, Conti M, De Francesco R, Kuka M, Ciliberto G, Castilletti C, Capobianchi MR, Ippolito G, Guidotti LG, Rovati L, Iannacone M, Aurisicchio L. COVID-eVax, an electroporated DNA vaccine candidate encoding the SARS-CoV-2 RBD, elicits protective responses in animal models. Molecular Therapy, 30(1):311-326 (2022)  (*co-first authors)

7.         Scherer S ,Oberle S , Kanev K, Gerullis A-K, Wu M, De Almeida G, Puleston D, Baixauli F, Aly L, Greco A, Nizharadze T, Becker N, Von Hoesslin M, Donhauser L, Berner J, Chu T, McNamara H, Esencan Z, Roelli P, Wurmser C, Kleiter I, Vehrenschild M, Mayer C, Knolle P, Klingenspor M, Fumagalli V, Iannacone M, Prlic M, Korn T, Pearce E, Höfer T, Schulz A and Zehn D. Pyrimidine de novo synthesis inhibition selectively blocks effector but not memory T-cell development. Nature Immunology, doi: 10.1038/s41590-023-01436-x; (2023)

8.         Gioia U, Tavella S, Martínez-Orellana P, Cicio G, Colliva A, Ceccon M, Cabrini M, Henriques A.C, Fumagalli V, Paldino A, Presot E, Rajasekharan S, Iacomino N, Pisati F, Matti V, Sepe S, Conte M, Barozzi S, Lavagnino Z, Carletti T, Volpe M. C, Cavalcante P, Iannacone M, Rampazzo C, Bussani R, Tripodo C, Zacchigna S, Marcello A and Fabrizio d’Adda di Fagagna. SARS-CoV-2 infection causes DNA damage and an altered DNA damage response. Nature Cell Biology, doi: 10.1038/s41556-023-01096-x, (2023).

9.         Benechet AP, De Simone G, Di Lucia P, Cilenti F, Barbiera G, Le Bert N, Moalli F, Lusito E, Fumagalli V, Bianchessi V, Zordan P, Bono E, Giustini L, Bonilla WD, Bleriot C, Kunasegaran K, Gonzalez-Aseguinolaza G, Pinschewer DD, Kennedy PTF, Naldini L, Kuka M, Ginhoux F, Cantore A, Bertoletti A, Ostuni R, Guidotti LG, Iannacone M. Dynamics and genomic landscape of CD8+ T cells undergoing hepatic priming. Nature, 574:200, (2019). Awarded with the 2019 Best Publication in Hepatology by the Italian Association for the Study of the Liver.

10.       Blériot C, Barreby E, Dunsmore G, Ballaire R, Chakarov S, Ficht X, De Simone G, Andreata F, Fumagalli V, Guo W, Wan G, Gessain G, Khalilnezhad A, Zhang XM, Ang N, Chen P, Morgantini C, Azzimato V, Kong WT, Liu Z, Pai R, Lum J, Shihui F, Low I, Xu C, Malleret B, Kairi MFM, Balachander A, Cexus O, Larbi A, Lee B, Newell EW, Ng LG, Phoo WW, Sobota RM, Sharma A, Howland SW, Chen J, Bajenoff M, Yvan-Charvet L, Venteclef N, Iannacone M, Aouadi M, Ginhoux F. A subset of Kupffer cells regulates metabolism through the expression of CD36. Immunity, 54 (9), 2101-2116 (2021).

11.         Pekayvaz K, Leunig A, Kaiser R, Joppich M, Brambs S, Janjic A, Popp O, Nixdorf D, Fumagalli V, Schmidt N, Polewka V, Anjum A, Knottenberg V, Eivers L, Wange LE, Gold C, Kirchner M, Muenchhoff M, Hellmuth JC, Scherer C, Rubio-Acero R, Eser T, Deák F, Puchinger K, Kuhl N, Linder A, Saar K, Tomas L, Schulz C, Wieser A, Enard W, Kroidl I, Geldmacher C, von Bergwelt-Baildon M, Keppler OT, Munschauer M, Iannacone M, Zimmer R, Mertins P, Hubner N, Hoelscher M, Massberg S, Stark K, Nicolai L. Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection. Nature Communications 13(1),1-21 (2022).

12.        Andreata F, Bleriot C, Di Lucia P, De Simone G, Fumagalli V, Ficht X, Beccaria CG, Kuka M, Ginhoux F, Iannacone M. Isolation of mouse Kupffer cells for phenotypic and functional studies. STAR Protocols, 2 (4), 100831, (2021).

13.        Fioravanti J, Magini D, Di Lucia P, Boni C, Benechet AP, Fumagalli V, Inverso D, Fiocchi A, Wieland S, Purcell R, Ferrari C, Chisari FV, Guidotti LG, Iannacone M. Effector CD8+ T cell-derived interleukin-10 enhances liver immunopathology. Journal of Hepatology, 67, 543–548 (2017).