Guidotti Luca Professore ordinarioMedicineMED/04 Patologia generale




Short Narrative

Luca G. Guidotti (LGG) is an experimental pathologist of international renown. LGG spent many years as part of the TSRI faculty in La Jolla, California and he currently serves as Deputy Scientific Director of the largest private Research Institute in Italy, the IRCCS Ospedale San Raffaele (OSR) in Milan, Italy. Over the years, LGG has published his work in prestigious scientific journals such as Cell, Nature, Science, Nature Medicine, Journal of Clinical Investigation, Journal of Experimental Medicine and others and his research activities have been financed by the National Institute of Health (NIH) and the European Research Council (ERC). LGG has been a member of numerous Study Sections at the NIH and the ERC for the allocation of funds to biomedical research.

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Current Positions

2017-present  Full Professor of General Pathology, Vita-Salute University, Milan, Italy

2013-present  Deputy Scientific Director, Ospedale San Raffaele (OSR), Milan, Italy.

2005-present  Head, Immunopathology Unit, OSR, Milan, Italy.

2005-present   Adjunct Professor, Department of Immunology & Microbial Sciences, The Scripps Research Institute (TSRI), La Jolla, California, USA.

Previous Positions

2012-2013       Chair, Division of Immunology, Transplantation and Infectious Diseases, OSR, Milan, Italy.

1999-2005       Associate Professor, Department of Immunology & Microbial Sciences, TSRI, La Jolla, California, USA.

1995-1999       Assistant Professor, Department of Molecular and Experimental Medicine, TSRI, La Jolla, California, USA.

1992-1995       Assistant Professor (Ricercatore), Department of General Pathology, University of Parma, Medical School, Parma, Italy.

1991-1994       Post-doctoral fellow, Department of Molecular and Experimental Medicine, TSRI, La Jolla, California, USA.

Major awarded grants, honors and memberships

2010-2016       Recipient, ERC Advanced Grant: “Imaging liver immunopathology by intravital microscopy (IVM).

2008-present  Member, Eureka Institute for Translational Medicine.

2004                            Honorary Member, Academic Society of Philosophy and Medicine, University of Parma.

2003                            Member, NIH/NIAID Advisory Panel for the Study of Liver Diseases.

2001                            Gold Medal for excellence in Antiviral Research, Schering Plough Japan, Tokyo, Japan.

1998-present Member, Organizing Committee, Annual International Meeting on Hepatitis B Viruses.

1996-2014      Recipient, NIH RO1 Grant AI40696: “Regulation of HBV replication by the immune system”.

Commissions of trust

2013-present   Reviewer and Member of the Panel, LS6 Immunity and Infection Panel, ERC Starting Grants (StG).

2012              Reviewer, NIH Special Emphasis Panel ZRG1 IDM-B (03).

2011-2012       Reviewer, The Research Foundation Flanders (FWO), Brussels, Belgium, Postdoctoral Fellowships and Senior Investigator Grants.

2010                            Reviewer, Recovery act limited competition: NIH Directors’ opportunity for research in 5 thematic areas (RC4).

2009    Chairman, European Congress of Immunology (ECI), Berlin, Germany.

2008-2010         Reviewer, BMRC & NMRC Singapore Grants.

2008    Reviewer, NIH RFA-ZDK1-GRB-G “Hepatitis B Clinical Research Network” Review.

2007-2014         External Reviewer, ERC StG and Consolidator Grants, 2007, 2010, 2014 and 2017.

2002-2003         Reviewer, The Wellcome Trust, UK, Project Grants.

2002               Reviewer, RFP-NIH-NIAID “Drug Development for Opportunistic Infections: Hepatitis C” Study Section ZAI1-GPJ-A-C1.

2001                             Reviewer, NIH Special Study Section (ZRG MBC-2).

2000-2001         Reviewer, NIH Virology (VR) B, Study Section.

1998-2000         Reviewer, NIH General Medicine (GM) 2, Study Section.

Editorial Boards

2015-present     Current Opinion of Virology

Manuscript reviewing

1995-present   Reviewer for Cell, Nature, Nature Medicine, Science, Science Immunology, Proc. Nat’l Acad. Sci., USA, The Lancet, Journal of Experimental Medicine, Journal of Clinical Investigation, PloS Pathogens, American Journal of Pathology, Journal of Immunology, Journal of Virology, Virology, Journal of Infectious Diseases, Human Gene Therapy, Hepatology, Journal of Hepatology. 

Organization of scientific meetings

2017                            Co-Organizer of the international Nature Conference on “Regeneration” (, OSR, Milan, Italy.

1998                            Organizer of the international meeting: “The Molecular Biology of Hepatitis B Viruses”, University of California San Diego (UCSD), San Diego, CA.

Teaching activities

2008-2017           Adjunct Professor of General Pathology, Vita-Salute University, Medical School, Milan, Italy

 Institutional activities

2010-present     Member, Institutional Animal Care and Use Committees (OSR-IACUC)

2013-present     Member, Financial Conflict of Interest Committee (OSR-FCOI)

2013-present     Member, OSR Ethics Committee (OSR-EC).

2013-present     Member, OSR Committee on Cooperative Research, Patents, and Licensing.

 Professional Societies

Henry Kunkel Society, American Association of Immunology, American Society for Microbiology, Italian Society of Clinical Immunology and Allergology (SIICA)

Advisory Boards

2020-present   Member, Scientific Advisory Board, IP-cure B, EU H2020  Program, Lyon, France

2019-present   Member, Board of Directors, Epsilen Bio, Milan, Italy

2018-present   Member, Board of Directors, Genenta Science, Milan, Italy

2017-present   Member, International Coalition to Eliminate Hepatitis B virus (ICE-HBV), Melbourne, Australia

2015-present, Member and Deputy Spokesman, Research4life, Milan, Italy

2013-present   Member, Gilead Sciences "HBV CURE Advisory Board", Foster City, CA, USA.

2004-present   Co-founder and Member of the Board of Capitalife Inc., Reno, Nevada, USA.





  • 1.         Jiménez de Oya N, M. De Giovann, J. Fioravanti, R. Übelhart, P. Di Lucia, A. Fiocchi, S. Iacovelli, D.G. Efremov, F. Caligaris-Cappio, H. Jumaa, P. Ghia, L.G. Guidotti and M. Iannacone. Pathogen-specific B-cell receptors drive chronic lymphocytic leukemia by light-chain-dependent cross-reaction with autoantigens. EMBO Mol Med. 2017. doi: 10.15252/emmm.201707732.
  • 2.         Sammicheli S., M. Kuka, P. Di Lucia, N. Jimenez de Oya, M. De Giovanni, J. Fioravanti, C. Cristofani, C.G. Maganuco, B. Fallet, L. Ganzer, L. Sironi, M. Mainetti, R. Ostuni, K. Larimore, P.D. Greenberg, J.C. de la Torre, L.G. Guidotti and M. Iannacone. Inflammatory monocytes hinder antiviral B cell responses. Science Immunology, 2016, doi: 10.1126/sciimmunol.aah6789.
  • 3.         M. Catarinella, A. Monestiroli A, G. Escobar, A. Fiocchi, N.L. Tran, R. Aiolfi, P. Marra, A. Esposito, F. Cipriani, L. Aldrighetti, M. Iannacone, L. Naldini, L.G. Guidotti and G. Sitia. IFNα gene/cell therapy curbs colorectal cancer colonization of the liver by acting on the hepatic microenvironment. EMBO Mol Med. 14:155-170, 2016.
  • 4.         Guidotti L.G., D. Inverso, L. Sironi, P. Di Lucia, J. Fioravanti, L. Ganzer, A. Fiocchi, M. Vacca, R. Aiolfi, S. Sammicheli, M. Mainetti, T. Cataudella, A. Raimondi, G. Gonzalez-Aseguinolaza, U. Protzer, F.V. Chisari, Z.M. Ruggeri, M. Isogawa, G. Sitia, and M. Iannacone. Immunosurveillance of the Liver by Intravascular Effector CD8+ T cells. Cell 3:486-500, 2015.
  • 5.         Sitia G., R. Aiolfi , P. Di Lucia, M. Mainetti, A. Fiocchi, F. Mingozzi, A. Esposito, Z.M. Ruggeri, F.V. Chisari, M. Iannacone and L.G. Guidotti. Anti-platelet therapy prevents hepatocellular carcinoma and improves survival in a mouse model of chronic hepatitis B. Proc. Nat’l Acad. Sci, USA Plus 109(32):E2165-E2172, 2012.
  • 6.         Sitia G., M. Iannacone, R. Aiolfi, M. Isogawa, N. van Rooijen, C. Scozzesi, M.E. Bianchi, U.H. von Andrian, F.V. Chisari and L.G. Guidotti. Kupffer cells hasten resolution of liver immunopathology in mouse models of viral hepatitis. Plos Pathogens 2011 Jun;7(6):e1002061. Epub 2011 Jun 2.
  • 7.         Iannacone, M., E.A. Moseman, E. Tonti, L. Bosurgi, T. Junt, S.E. Henrickson, S.P. Whelan, L.G. Guidotti and U.H. von Andrian. Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus. Nature 465:1079-83, 2010.
  • 8.         Iannacone, M., G. Sitia, M. Isogawa, J.K. Whitmire, P. Marchese, F.V. Chisari, Z.M. Ruggeri and L.G. Guidotti. Platelets prevent IFNα-/ß-induced lethal hemorrhage promoting CTL-dependent clearance of lymphocytic choriomeningitis virus. Proc. Nat’l Acad. Sci, USA105:629-634, 2008.
  • 9.         Sitia G, M. Iannacone, Su. Müller, M.E Bianchi and L.G Guidotti. Treatment with HMGB1 inhibitors diminishes CTL-induced liver disease. J. Leukoc. Biol. 81:100-107, 2007.
  • 10.       Iannacone, M., G. Sitia G., M. Isogawa, P. Marchese, M.G. Castro, P.R. Lowenstein, F.V. Chisari, Z.M. Ruggeri and L.G. Guidotti. Platelets mediate cytotoxic T lymphocyte-induced liver damage. Nat. Med. 11:1167-1169, 2005.
  • 11.       Sitia G., M. Isogawa, M. Iannacone, I.L. Campbell, F.V. Chisari and L.G. Guidotti. MMPs are required for recruitment of antigen non-specific mononuclear cells into the liver by CTLs. J. Clinical Investigation. 113:1158-1167, 2004.
  • 12.       Sitia G., M. Isogawa, K. Kakimi, S.F. Wieland, F.V. Chisari and L.G. Guidotti. Depletion of neutrophils blocks the recruitment of antigen non-specific cells into the liver without affecting the antiviral activity of hepatitis B virus-specific cytotoxic T lymphocytes. Proc. Nat’l Acad. Sci, USA  99:13717-13722, 2002.
  • 13.       Kakimi, K., T. E. Lane, S. F. Wieland, V.C. Asensio, I. L. Campbell, F.V. Chisari and L.G. Guidotti. Blocking chemokine responsive to {gamma}–2/interferon (IFN)-{gamma} inducible protein and monokine induced by IFN-{gamma} activity in vivo reduces the pathogenetic but not the antiviral potential of hepatitis B virus–specific cytotoxic T lymphocytes J. Exp. Med. 194:1755-1766, 2001.
  • 14.       McClary, H., R. Koch, F.V. Chisari and L.G. Guidotti. Inhibition of hepatitis B virus replication during Schistosoma mansoni infection in transgenic mice. J. Exp. Med. 192: 289-294, 2000.
  • 15.       Guidotti, L.G., H. McClary, J. Moorhead and F.V. Chisari. Nitric oxide inhibits HBV replication in the liver of transgenic mice. J. Exp. Med. 191:1247-1252, 2000.
  • 16.       McClary, H., R. Koch, F.V. Chisari and L.G. Guidotti. Relative sensitivity of hepatitis B virus and other hepatotropic viruses to the antiviral effects of cytokines. J. Virol. 74:2255-2264, 2000.
  • 17.       von Herrath, M., B. Coon, D. Homann T. Wolf and L.G. Guidotti. Thymic tolerance to only one viral protein reduces lymphocytic choriomeningitis virus-induced immunopathology and increases survival in perforin-deficient mice. J. Virol. 73:5918-5925, 1999.
  • 18.       Guidotti, L.G., P. Borrow, A. Brown, H. McClary, R. Koch and F.V. Chisari. Noncytopathic clearance of lymphocytic choriomeningitis virus from the hepatocyte. J. Exp. Med. 189:1555-1564, 1999.
  • 19.       Guidotti, L.G., R. Rochford, J. Chung, M. Shapiro, R. Purcell and F.V. Chisari. Viral clearance without destruction of infected cells in acute HBV infection. Science 284:825-829, 1999.
  • 20.       Nakamoto, Y., L.G. Guidotti, C. Kuhlen, P. Fowler and F.V. Chisari. Immune pathogenesis of hepatocellular carcinoma. J. Exp. Med. 188:341-350, 1998.
  • 21.       Guidotti, L.G., B. Matzke and F.V. Chisari. HBV replication is cell cycle independent during liver regeneration in transgenic mice. J. Virol. 71:4804-4808, 1997.
  • 22.       Guidotti, L.G., P. Borrow, M.V. Hobbs, B. Matzke, I. Gresser, M.B.A. Oldstone and F.V. Chisari. Viral cross talk: Intracellular inactivation of the hepatitis B virus during an unrelated viral infection of the liver. Proc. Nat’l Acad. Sci, USA, 93:4589-4594, 1996.
  • 23.       Guidotti, L.G., T. Ishikawa, M.V. Hobbs, B. Matzke, R. Schreiber and F.V. Chisari. Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes. Immunity 4:25-36, 1996.
  • 24.       Guidotti, L.G., B. Matzke, H. Schaller and F.V. Chisari. High-level hepatitis B virus replication in transgenic mice. J. Virol. 69:6158-6169, 1995.
  • 25.       Guidotti, L.G., V. Martinez, Y.T. Loh, C.E. Rogler and F.V. Chisari. Hepatitis B virus nucleocapsid particles do not cross the hepatocyte nuclear membrane in transgenic mice. J. Virol. 68:5469-5475, 1994.
  • 26.       Guidotti, L.G., K. Ando, M.V. Hobbs, T. Ishikawa, L. Runkel, R.D. Schreiber and F.V. Chisari. Cytotoxic T lymphocytes inhibit hepatitis B virus gene expression by a noncytolytic mechanism in transgenic mice. Proc. Nat’l Acad. Sci, USA 91:3764-3768, 1994.
  • 27.       Guidotti, L.G., S. Guilhot and F.V. Chisari. Interleukin-2 and interferon alpha/beta down-regulate hepatitis B virus gene expression in vivo by tumor necrosis factor dependent and independent pathways. J. Virol. 68:1265-1270, 1994.


Peer-reviewed reviews

  • 1.         Guidotti L.G., M. Isogawa and F.V. Chisari. Host-virus interactions in hepatitis B virus infection. Current Opinion Immunology, 36:61-66, 2015.
  • 2.         Sitia G., M. Iannacone and L.G. Guidotti. Anti-platelet therapy in the prevention of hepatitis B virus-associated hepatocellular carcinoma. J Hepatol. 59:1135-1138, 2013.
  • 3.         Guidotti, L.G. and F.V. Chisari. Immunobiology and pathogenesis of viral hepatitis. Review. Annu. Rev. Pathology. 1:23-61, 2006.
  • 4.         Guidotti, L.G. and F.V. Chisari. Noncytolytic control of viral infections by the innate and adaptive immune response. Review. Annu. Rev. Immunol. 19:65-91, 2001.


Capitoli di libri

  • 1.         Iannacone M., F.V. Chisari and L.G. Guidotti. Protective and Pathogenic T Cell Responses to Virus Infections. Encyclopedia of Immunobiology. Edited by Michael J.H. Ratcliffe. Elsevier, Volume 4, pages 318-323, 2016.
  • 2.         Iannacone M., and L.G. Guidotti. HBV Immunopathogenesis. In: Hepatitis B Virus in human diseases. Edited by Fabien Zoulim and Yun-Fan Liaw, Springer Book, pages 79-93, 2016.


  • 3.         Iannacone M., and L.G. Guidotti. Mouse Models of Hepatitis B Virus Pathogenesis. Hepatitis B and Delta Viruses, Edited by Christoph Seeger and Stephen A. Locarnini, Cold Spring Harbor Perspectives in Medicine, doi: 10.1101/cshperspect.a021477, 2015.
  • 4.         Guidotti L.G. Animal models of hepatitis B and C. Encyclopedia of Medical Immunology. Editors I.R. Mackay and N.R. Rose, Springer. 2014, Vol. 1, pages 44-49, ISBN 978-0-387-84827-3.

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