Guidotti Luca Professore ordinarioMedicineMED/04 Patologia generale
Biography
Publications
Biography
Short Narrative
Luca G. Guidotti (LGG) is an experimental pathologist of international renown. LGG spent many years as part of the TSRI faculty in La Jolla, California and he currently serves as Deputy Scientific Director of the largest private Research Institute in Italy, the IRCCS Ospedale San Raffaele (OSR) in Milan, Italy. Over the years, LGG has published his work in prestigious scientific journals such as Cell, Nature, Science, Nature Medicine, Journal of Clinical Investigation, Journal of Experimental Medicine and others and his research activities have been financed by the National Institute of Health (NIH) and the European Research Council (ERC). LGG has been a member of numerous Study Sections at the NIH and the ERC for the allocation of funds to biomedical research.
Researcher unique identifier: http://orcid.org/0000-0002-0205-2678
http://scholar.google.it/citations?user=qkFz9wYAAAAJ&hl=it;
Current Positions
2017-present Full Professor of General Pathology, Vita-Salute University, Milan, Italy
2013-present Deputy Scientific Director, Ospedale San Raffaele (OSR), Milan, Italy.
2005-present Head, Immunopathology Unit, OSR, Milan, Italy.
2005-present Adjunct Professor, Department of Immunology & Microbial Sciences, The Scripps Research Institute (TSRI), La Jolla, California, USA.
Previous Positions
2012-2013 Chair, Division of Immunology, Transplantation and Infectious Diseases, OSR, Milan, Italy.
1999-2005 Associate Professor, Department of Immunology & Microbial Sciences, TSRI, La Jolla, California, USA.
1995-1999 Assistant Professor, Department of Molecular and Experimental Medicine, TSRI, La Jolla, California, USA.
1992-1995 Assistant Professor (Ricercatore), Department of General Pathology, University of Parma, Medical School, Parma, Italy.
1991-1994 Post-doctoral fellow, Department of Molecular and Experimental Medicine, TSRI, La Jolla, California, USA.
Major awarded grants, honors and memberships
2010-2016 Recipient, ERC Advanced Grant: “Imaging liver immunopathology by intravital microscopy (IVM).
2008-present Member, Eureka Institute for Translational Medicine.
2004 Honorary Member, Academic Society of Philosophy and Medicine, University of Parma.
2003 Member, NIH/NIAID Advisory Panel for the Study of Liver Diseases.
2001 Gold Medal for excellence in Antiviral Research, Schering Plough Japan, Tokyo, Japan.
1998-present Member, Organizing Committee, Annual International Meeting on Hepatitis B Viruses.
1996-2014 Recipient, NIH RO1 Grant AI40696: “Regulation of HBV replication by the immune system”.
Commissions of trust
2013-present Reviewer and Member of the Panel, LS6 Immunity and Infection Panel, ERC Starting Grants (StG).
2012 Reviewer, NIH Special Emphasis Panel ZRG1 IDM-B (03).
2011-2012 Reviewer, The Research Foundation Flanders (FWO), Brussels, Belgium, Postdoctoral Fellowships and Senior Investigator Grants.
2010 Reviewer, Recovery act limited competition: NIH Directors’ opportunity for research in 5 thematic areas (RC4).
2009 Chairman, European Congress of Immunology (ECI), Berlin, Germany.
2008-2010 Reviewer, BMRC & NMRC Singapore Grants.
2008 Reviewer, NIH RFA-ZDK1-GRB-G “Hepatitis B Clinical Research Network” Review.
2007-2014 External Reviewer, ERC StG and Consolidator Grants, 2007, 2010, 2014 and 2017.
2002-2003 Reviewer, The Wellcome Trust, UK, Project Grants.
2002 Reviewer, RFP-NIH-NIAID “Drug Development for Opportunistic Infections: Hepatitis C” Study Section ZAI1-GPJ-A-C1.
2001 Reviewer, NIH Special Study Section (ZRG MBC-2).
2000-2001 Reviewer, NIH Virology (VR) B, Study Section.
1998-2000 Reviewer, NIH General Medicine (GM) 2, Study Section.
Editorial Boards
2015-present Current Opinion of Virology
Manuscript reviewing
1995-present Reviewer for Cell, Nature, Nature Medicine, Science, Science Immunology, Proc. Nat’l Acad. Sci., USA, The Lancet, Journal of Experimental Medicine, Journal of Clinical Investigation, PloS Pathogens, American Journal of Pathology, Journal of Immunology, Journal of Virology, Virology, Journal of Infectious Diseases, Human Gene Therapy, Hepatology, Journal of Hepatology.
Organization of scientific meetings
2017 Co-Organizer of the international Nature Conference on “Regeneration” (http://www.nature.com/natureconferences/regen17/index.html), OSR, Milan, Italy.
1998 Organizer of the international meeting: “The Molecular Biology of Hepatitis B Viruses”, University of California San Diego (UCSD), San Diego, CA.
Teaching activities
2008-2017 Adjunct Professor of General Pathology, Vita-Salute University, Medical School, Milan, Italy
Institutional activities
2010-present Member, Institutional Animal Care and Use Committees (OSR-IACUC)
2013-present Member, Financial Conflict of Interest Committee (OSR-FCOI)
2013-present Member, OSR Ethics Committee (OSR-EC).
2013-present Member, OSR Committee on Cooperative Research, Patents, and Licensing.
Professional Societies
Henry Kunkel Society, American Association of Immunology, American Society for Microbiology, Italian Society of Clinical Immunology and Allergology (SIICA)
Advisory Boards
2020-present Member, Scientific Advisory Board, IP-cure B, EU H2020 Program, Lyon, France
2019-present Member, Board of Directors, Epsilen Bio, Milan, Italy
2018-present Member, Board of Directors, Genenta Science, Milan, Italy
2017-present Member, International Coalition to Eliminate Hepatitis B virus (ICE-HBV), Melbourne, Australia
2015-present, Member and Deputy Spokesman, Research4life, Milan, Italy
2013-present Member, Gilead Sciences "HBV CURE Advisory Board", Foster City, CA, USA.
2004-present Co-founder and Member of the Board of Capitalife Inc., Reno, Nevada, USA.
Publications
- PUBBLICAZIONI SELEZIONATE(vedi anche: http://scholar.google.it/citations?user=qkFz9wYAAAAJ&hl=it)H-Index (Scopus) = 56; H-Index (Google Scholar) = 63Articoli peer-reviewed
- 1. Jiménez de Oya N, M. De Giovann, J. Fioravanti, R. Übelhart, P. Di Lucia, A. Fiocchi, S. Iacovelli, D.G. Efremov, F. Caligaris-Cappio, H. Jumaa, P. Ghia, L.G. Guidotti and M. Iannacone. Pathogen-specific B-cell receptors drive chronic lymphocytic leukemia by light-chain-dependent cross-reaction with autoantigens. EMBO Mol Med. 2017. doi: 10.15252/emmm.201707732.
- 2. Sammicheli S., M. Kuka, P. Di Lucia, N. Jimenez de Oya, M. De Giovanni, J. Fioravanti, C. Cristofani, C.G. Maganuco, B. Fallet, L. Ganzer, L. Sironi, M. Mainetti, R. Ostuni, K. Larimore, P.D. Greenberg, J.C. de la Torre, L.G. Guidotti and M. Iannacone. Inflammatory monocytes hinder antiviral B cell responses. Science Immunology, 2016, doi: 10.1126/sciimmunol.aah6789.
- 3. M. Catarinella, A. Monestiroli A, G. Escobar, A. Fiocchi, N.L. Tran, R. Aiolfi, P. Marra, A. Esposito, F. Cipriani, L. Aldrighetti, M. Iannacone, L. Naldini, L.G. Guidotti and G. Sitia. IFNα gene/cell therapy curbs colorectal cancer colonization of the liver by acting on the hepatic microenvironment. EMBO Mol Med. 14:155-170, 2016.
- 4. Guidotti L.G., D. Inverso, L. Sironi, P. Di Lucia, J. Fioravanti, L. Ganzer, A. Fiocchi, M. Vacca, R. Aiolfi, S. Sammicheli, M. Mainetti, T. Cataudella, A. Raimondi, G. Gonzalez-Aseguinolaza, U. Protzer, F.V. Chisari, Z.M. Ruggeri, M. Isogawa, G. Sitia, and M. Iannacone. Immunosurveillance of the Liver by Intravascular Effector CD8+ T cells. Cell 3:486-500, 2015.
- 5. Sitia G., R. Aiolfi , P. Di Lucia, M. Mainetti, A. Fiocchi, F. Mingozzi, A. Esposito, Z.M. Ruggeri, F.V. Chisari, M. Iannacone and L.G. Guidotti. Anti-platelet therapy prevents hepatocellular carcinoma and improves survival in a mouse model of chronic hepatitis B. Proc. Nat’l Acad. Sci, USA Plus 109(32):E2165-E2172, 2012.
- 6. Sitia G., M. Iannacone, R. Aiolfi, M. Isogawa, N. van Rooijen, C. Scozzesi, M.E. Bianchi, U.H. von Andrian, F.V. Chisari and L.G. Guidotti. Kupffer cells hasten resolution of liver immunopathology in mouse models of viral hepatitis. Plos Pathogens 2011 Jun;7(6):e1002061. Epub 2011 Jun 2.
- 7. Iannacone, M., E.A. Moseman, E. Tonti, L. Bosurgi, T. Junt, S.E. Henrickson, S.P. Whelan, L.G. Guidotti and U.H. von Andrian. Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus. Nature 465:1079-83, 2010.
- 8. Iannacone, M., G. Sitia, M. Isogawa, J.K. Whitmire, P. Marchese, F.V. Chisari, Z.M. Ruggeri and L.G. Guidotti. Platelets prevent IFNα-/ß-induced lethal hemorrhage promoting CTL-dependent clearance of lymphocytic choriomeningitis virus. Proc. Nat’l Acad. Sci, USA105:629-634, 2008.
- 9. Sitia G, M. Iannacone, Su. Müller, M.E Bianchi and L.G Guidotti. Treatment with HMGB1 inhibitors diminishes CTL-induced liver disease. J. Leukoc. Biol. 81:100-107, 2007.
- 10. Iannacone, M., G. Sitia G., M. Isogawa, P. Marchese, M.G. Castro, P.R. Lowenstein, F.V. Chisari, Z.M. Ruggeri and L.G. Guidotti. Platelets mediate cytotoxic T lymphocyte-induced liver damage. Nat. Med. 11:1167-1169, 2005.
- 11. Sitia G., M. Isogawa, M. Iannacone, I.L. Campbell, F.V. Chisari and L.G. Guidotti. MMPs are required for recruitment of antigen non-specific mononuclear cells into the liver by CTLs. J. Clinical Investigation. 113:1158-1167, 2004.
- 12. Sitia G., M. Isogawa, K. Kakimi, S.F. Wieland, F.V. Chisari and L.G. Guidotti. Depletion of neutrophils blocks the recruitment of antigen non-specific cells into the liver without affecting the antiviral activity of hepatitis B virus-specific cytotoxic T lymphocytes. Proc. Nat’l Acad. Sci, USA 99:13717-13722, 2002.
- 13. Kakimi, K., T. E. Lane, S. F. Wieland, V.C. Asensio, I. L. Campbell, F.V. Chisari and L.G. Guidotti. Blocking chemokine responsive to {gamma}–2/interferon (IFN)-{gamma} inducible protein and monokine induced by IFN-{gamma} activity in vivo reduces the pathogenetic but not the antiviral potential of hepatitis B virus–specific cytotoxic T lymphocytes J. Exp. Med. 194:1755-1766, 2001.
- 14. McClary, H., R. Koch, F.V. Chisari and L.G. Guidotti. Inhibition of hepatitis B virus replication during Schistosoma mansoni infection in transgenic mice. J. Exp. Med. 192: 289-294, 2000.
- 15. Guidotti, L.G., H. McClary, J. Moorhead and F.V. Chisari. Nitric oxide inhibits HBV replication in the liver of transgenic mice. J. Exp. Med. 191:1247-1252, 2000.
- 16. McClary, H., R. Koch, F.V. Chisari and L.G. Guidotti. Relative sensitivity of hepatitis B virus and other hepatotropic viruses to the antiviral effects of cytokines. J. Virol. 74:2255-2264, 2000.
- 17. von Herrath, M., B. Coon, D. Homann T. Wolf and L.G. Guidotti. Thymic tolerance to only one viral protein reduces lymphocytic choriomeningitis virus-induced immunopathology and increases survival in perforin-deficient mice. J. Virol. 73:5918-5925, 1999.
- 18. Guidotti, L.G., P. Borrow, A. Brown, H. McClary, R. Koch and F.V. Chisari. Noncytopathic clearance of lymphocytic choriomeningitis virus from the hepatocyte. J. Exp. Med. 189:1555-1564, 1999.
- 19. Guidotti, L.G., R. Rochford, J. Chung, M. Shapiro, R. Purcell and F.V. Chisari. Viral clearance without destruction of infected cells in acute HBV infection. Science 284:825-829, 1999.
- 20. Nakamoto, Y., L.G. Guidotti, C. Kuhlen, P. Fowler and F.V. Chisari. Immune pathogenesis of hepatocellular carcinoma. J. Exp. Med. 188:341-350, 1998.
- 21. Guidotti, L.G., B. Matzke and F.V. Chisari. HBV replication is cell cycle independent during liver regeneration in transgenic mice. J. Virol. 71:4804-4808, 1997.
- 22. Guidotti, L.G., P. Borrow, M.V. Hobbs, B. Matzke, I. Gresser, M.B.A. Oldstone and F.V. Chisari. Viral cross talk: Intracellular inactivation of the hepatitis B virus during an unrelated viral infection of the liver. Proc. Nat’l Acad. Sci, USA, 93:4589-4594, 1996.
- 23. Guidotti, L.G., T. Ishikawa, M.V. Hobbs, B. Matzke, R. Schreiber and F.V. Chisari. Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes. Immunity 4:25-36, 1996.
- 24. Guidotti, L.G., B. Matzke, H. Schaller and F.V. Chisari. High-level hepatitis B virus replication in transgenic mice. J. Virol. 69:6158-6169, 1995.
- 25. Guidotti, L.G., V. Martinez, Y.T. Loh, C.E. Rogler and F.V. Chisari. Hepatitis B virus nucleocapsid particles do not cross the hepatocyte nuclear membrane in transgenic mice. J. Virol. 68:5469-5475, 1994.
- 26. Guidotti, L.G., K. Ando, M.V. Hobbs, T. Ishikawa, L. Runkel, R.D. Schreiber and F.V. Chisari. Cytotoxic T lymphocytes inhibit hepatitis B virus gene expression by a noncytolytic mechanism in transgenic mice. Proc. Nat’l Acad. Sci, USA 91:3764-3768, 1994.
- 27. Guidotti, L.G., S. Guilhot and F.V. Chisari. Interleukin-2 and interferon alpha/beta down-regulate hepatitis B virus gene expression in vivo by tumor necrosis factor dependent and independent pathways. J. Virol. 68:1265-1270, 1994.
Peer-reviewed reviews
- 1. Guidotti L.G., M. Isogawa and F.V. Chisari. Host-virus interactions in hepatitis B virus infection. Current Opinion Immunology, 36:61-66, 2015.
- 2. Sitia G., M. Iannacone and L.G. Guidotti. Anti-platelet therapy in the prevention of hepatitis B virus-associated hepatocellular carcinoma. J Hepatol. 59:1135-1138, 2013.
- 3. Guidotti, L.G. and F.V. Chisari. Immunobiology and pathogenesis of viral hepatitis. Review. Annu. Rev. Pathology. 1:23-61, 2006.
- 4. Guidotti, L.G. and F.V. Chisari. Noncytolytic control of viral infections by the innate and adaptive immune response. Review. Annu. Rev. Immunol. 19:65-91, 2001.
Capitoli di libri
- 1. Iannacone M., F.V. Chisari and L.G. Guidotti. Protective and Pathogenic T Cell Responses to Virus Infections. Encyclopedia of Immunobiology. Edited by Michael J.H. Ratcliffe. Elsevier, Volume 4, pages 318-323, 2016.
- 2. Iannacone M., and L.G. Guidotti. HBV Immunopathogenesis. In: Hepatitis B Virus in human diseases. Edited by Fabien Zoulim and Yun-Fan Liaw, Springer Book, pages 79-93, 2016.
- 3. Iannacone M., and L.G. Guidotti. Mouse Models of Hepatitis B Virus Pathogenesis. Hepatitis B and Delta Viruses, Edited by Christoph Seeger and Stephen A. Locarnini, Cold Spring Harbor Perspectives in Medicine, doi: 10.1101/cshperspect.a021477, 2015.
- 4. Guidotti L.G. Animal models of hepatitis B and C. Encyclopedia of Medical Immunology. Editors I.R. Mackay and N.R. Rose, Springer. 2014, Vol. 1, pages 44-49, ISBN 978-0-387-84827-3.
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