Mazza Davide Professore AssociatoMedicineFIS/07
Following a degree in Physics and a PhD in Biophysics awarded at the University of Genoa under the supervision of Prof. Alberto Diaspro, Prof. Davide Mazza was appointed a post-doctoral position at the National Institutes of Health/National Cancer Institutes (Bethesda, MD, USA). In 2012, Prof. Mazza returned to Italy with European Marie Curie Fellowship, and he currently leads the Imaging of Gene Regulation Unit at the Experimental Imaging Center of the San Raffaele Scientific Institute. He authored 50+ pubblications in international peer-reviewed journals and he has been awarded multiple national and international research grants. The research of Prof. Mazza focuses on developing novel microscopy techniques and to apply them to identify the action mechanism of onco-suppressors and oncogenes in living cells.
Scopus Author ID: 7006691131
Researcher ID: R-5340-2016
Google Scholar: https://scholar.google.com/citations?hl=en&user=u2mWhpwAAAAJ
2008 PhD in Physics (University of Genoa, IT).
2004 Master Degree in Physics (University of Genoa, IT).
2022-To date Associate Professor in Physics (SSD FIS/07). Università Vita-Salute San Raffaele.
2020- To date Head of Research Unit - Imaging of Gene Regulation Unit. Experimental Imaging Center, Ospedale San Raffaele. Milan, Italy.
2014-2019 Project Leader - Advanced Fluorescence Microscopy and Nanoscopy R&D, Cancer Imaging Unit, Experimental Imaging Center, Ospedale San Raffaele. Milan, Italy
2015-2018 Junior Group Leader - CEN European Center for Nanomedicine, Milan, Italy.
2012-2014 Postdoctoral Fellow - Università Vita-Salute San Raffaele. Milan, Italy (Adviser: Prof Carlo Tacchetti.
2008-2012 Postdoctoral Fellow - National Institutes of Health. National Cancer Institutes. Laboratory for Gene Expression and Receptor Biology. Bethesda, MD, USA (Adviser Dr. James G. McNally).
2022-2025 Worldwide cancer research. Project Title: Chromatin organization and transcription factor targeting in the establishment of oncogene-induced senescence and cancer progression. Role in the project. Project Coordinator.
2019-2023 AIRC Investigator Grant. Project Title: Role of DNA-damage induced chromatin reorganization in controlling p53-mediated cellular fate. Role in the project. Project Coordinator.
2019-2022 Marie Curie Innovative Training Networks. Project Title: Predictive Epigenetics Fusing Theory and Experiments.Role in the project: Beneficiary. Coordinator: Prof. Leonie Ringrose.
2018 Marie Curie Individual fellowship. Project Title: Imaging Pancreatic Alpha-Cell Calcium Tied with Heterogeneous analysis of labeled transcription factors with in-situ Hybridization. Role in the project: Supervisor. Awarded Researcher: Dr. Zeno Lavagnino.
2017 OSR Seed Grant. Project title. Towards single-molecule quantification of p53 action at individual responsive elements in living cells. Role in the project: Project Coordinator.
2016 Hosting scientist for an EMBO Short-term fellowship. Visiting Researcher: Andrea Callegari (EPFL).
2015-2018 Fondazione Cariplo. Bando Ricerca biomedical condotta da giovani ricercatori. Project Title: Role of p53 single moleculedynamics in controlling tumor cell fate . Role in the project: Project Coordinator.
2010 Marie Curie International Incoming Fellowship (IIF). Role in the project: Awarded Researcher. Supervisor: Prof. Carlo Tacchetti. MC grant agreement: PIIF-GA-2010-274323 (from April 2012 to April 2014). Success rate 11.8%. Amount 168.000 euro.
2005 Italian prize for best M.SC. thesis in Cytometry. Italian cytometry society (GIC).
Peer-reviewer Activity. Reviewer for: Nature chemical biology, Nature Communications, Nucleic Acids Research, eLife, Journal of Molecular Biology, Open Biology, Biophysical Journal, Biochemical Society Transactions, Journal of Cell Science, PLOS computational biology.
Reviewer for Grant Agencies. Research Foundation – Flanders (FWO), United States Israel Binational Science Foundation (BSF).
Organization of meetings/congresses/PhD schools. Member of the Scientific committee of the San Raffaele Scientific Institute Retreat (2018-2022), Organizer of the Ph.D. course on Liquid-Liquid Phase Separation in Biology, San Raffaele University, Milan (2021), Organizer of the Ph.D. school in Microscopy, San Raffaele University, Milan (2020), Organizer of the PEP-NET Spring School on microscopy and mathematical models. Online course (2020), Organizer of the Experimental Imaging Seminar Series. Ospedale San Raffaele, Milan, Italy (2015-2018), Co-organizer of the Ph.D. school in fluorescence Microscopy, Università Milano-Bicocca, Milan, Italy (2015).
2018-to date. Member of the residing board of the Cellular and Molecular biology curriculum of the San Raffaele Vita-Salute University Ph.D. program.
2019- to date. Scientific support for image handling ethics of the Research Integrity Office of the San Raffaele Scientific Institute.
2019- to date. Member of the oversight committee for the PEP-NET EU funded International Training Network.
2016-to date. Member of the scientific committee of the San Raffaele Scientific Institute Retreat.
2016-2017. Member of the selection committee of San Raffaele Vita-Salute University Ph.D. program.
2016- 2022. Adjunct Professor in Physics at Università Vita-Salute San Raffaele Milan. Topics: Physics, Microscopy, Imaging and Quantitative Biology.
2012- 2022. Teacher in national and international PhD schools, in various institutions, including: Università Vita-Salute San Raffaele, SEMM PhD school (at IFOM-IEO, Milan, Italy), ICGEB PhD workshops (ICGEB, Trieste, Italy).
Pubblicazioni Recenti (Ultimi due anni):
UV-A and UV-B Can Neutralize SARS-CoV-2 Infectivity. M. Biasin, S. Strizzi, A. Bianco, A. Macchi O Utyro, G. Pareschi, A. Loffreda, A. Cavalleri, M. Luandi, D. Trabattoni, C. Tacchetti, D. Mazza, M.S. Clerici. (2022) J. Photochem. Photobiol. B, in press.
Mazzocca, M., Colombo, E., Callegari, A., and Mazza D. (2021). Transcription factor kinetics and transcriptional bursting: what do we really know? Curr Op Struct Biol, 7: 239-248.
Mazzocca, M., Fillot, T., Loffreda, A., Gnani, D., and Mazza, D. (2021). The needle and the haystack: single molecule tracking to probe the transcription factor search in eukaryotes. Biochem Soc Trans: 49(3):1121-1132. PMID: 34003257.
Biavasco, R., Molteni, R., Stefanoni, D., Nemkov, T., Netea, M.G., Domínguez-Andrés J, Arts RJ, Merelli I, Mazza D, Zambrano S, Panigada M, Cantoni E, Tengesdal I, Maksud P, Piras F, De Luca G, Cassina L, Distefano G, Loffreda A, Gnani D, Doglioni C, Tomelleri A, Campochiaro C, Joosten L, Dinarello CA, Kajaste-Rudnitski A, Haroche J, Cardaci S, Cenci S, Dagna L, Ferrarini M, Ferrero E, Boletta A, D'Alessandro A, Montini E, Cavalli G. (2021). Oncogene-induced maladaptive activation of trained immunity in the pathogenesis and treatment of Erdheim-Chester disease. Blood:2020009594. PMID: 34077954.
Pellanda, P., Dalsass, M., Filipuzzi, M., Loffreda, A., Verrecchia, A., Castillo Cano V,., Thabussot, H., Doni, M., Morelli, M.J., Soucek, L., Kress, T., Mazza, D., Mapelli, M., Beaulieu, M.E., Amati, B., Sabò, A. (2021). Integrated requirement of non-specific and sequence-specific DNA binding in Myc-driven transcription. EMBO J. 40(19):e105464. PMID: 33792944.
Rainone, P., De Palma, A., Sudati, F., Roffia, V., Rigamonti, V., Salvioni, L., Colombo, M., Ripamonti, M., Spinelli, A.E., Mazza, D., Mauri, P., Moresco, R.M., Prosperi, D., and Belloli, S. (2021). 99mTc-Radiolabeled Silica Nanocarriers for Targeted Detection and Treatment of HER2-Positive Breast Cancer. Int J Nanomedicine., 8;16:1943-1960.
Gaviraghi, M., Rabellino, A., Andolfo, A., Brand, M., Brombin, C., Bagnato, P., De Feudis G., Raimondi, A., Locatelli, A., Tosoni, D., Mazza, D., Gianni, L., Tonon G., and Tacchetti, C. (2020). Direct stimulation of ERBB2 highlights a novel cytostatic signaling pathway driven by the receptor Thr701 phosphorylation. Sci. Rep., 10(1),1-17. PMID: 33037285.
Zambrano, S., Loffreda, A., Carelli, E., Stefanelli, G., Colombo, F., Bertrand, E., Tacchetti, C., Bianchi, M.E., Agresti, A., Molina, N. and Mazza, D. (2020). First responders shape a prompt and sharp NF-κB –mediated transcriptional response to TNF-α. iScience, 23(9), 101529. PMID: 33083759.
Louphrasitthiphol, P., Siddaway R., Loffreda, A., Steingrímsson, E., Mazza, D.* and Goding C.R.* (2020). Tuning transcription factor activity through acetylation mediated genomic redistribution. Molecular Cell, 79(3): 472-487. PMID. 32531202. * = co-corresponding authors.
Patrone, M., Cammarota, E., Berno, V. Tornaghi, P., Mazza, D., and Degano, M. (2020). Combinatorial allosteric modulation of agonist response in a self-interacting G-protein coupled receptor. Nat. Comms. Biol., 3:27. PMID: 31941999.
Update mar. 2022)
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