Malesci Alberto MedicineMED/12 Straordinario (ai sensi dell’art.1, comma 12, L. 230/2005)




Alberto Malesci is Professor of Gastroenterology at San Raffaele University and Senior Consultant of the Division of Gastroenterology at San Raffaele Hospital in Milan.

After graduating in Medicine in 1975, he obtained board certifications in Gastroenterology and Internal Medicine.
The academic career of professor Malesci started with a fellowship in the lab of dr. Rosalyn Yalow, 1977 Nobel Laureate for Medicine, at the Bronx VA Medical Centre-Mount Sinai School of Medicine of New York, where he conducted pioneeristic studies on gastrointestinal hormones.
From 1980 to 2018, he was Professor of Internal Medicine and Gastroenterology at Milan University.
From 2018 to 2022, he was affiliated to Humanitas University as Professor of Internal Medicine and Director of the Internal Medicine Residency Program. Previous clinical positions of Professor Malesci include the role of Staff Physician at the Ospedale Maggiore Policlinico of Milan (from 1980 to 1996) and the lead of the Department of Gastroenterology of Humanitas Research Hospital from 1996 to 2022. Under his guidance, that Department gained worldwide recognition as a clinical and academic excellence in Gastroenterology, particularly in the fields of colorectal and pancreatic neoplasia, inflammatory bowel disease and interventional endoscopy.
In the ’80s and in the ‘90s, the research activity of Professor Malesci focused on gastrointestinal pathophysiology and on biochemical diagnosis of pancreatic diseases. A major scientific achievement of that period was the development and the clinical validation of serum CA19-9 as a biomarker for diagnosis and follow-up of pancreatic cancer.
More recently, the field of research interest extended to the characterization of molecular subtypes and to the development of prognostic and predictive biomarkers for colorectal cancer. In this context, he has contributed highly-cited papers on the role of tumor-associated lymphocytes and macrophages in predicting colorectal cancer progression and response to chemotherapy. Professor Malesci published over 200 Medline-indexed papers, scoring a h-index of 60 in Google Scholar and of 50 in Scopus

(Update apr. 2022)



1. Tumour-associated macrophages as treatment targets in oncology.
Mantovani A, Marchesi F, Malesci A, et al.

Nat Rev Clin Oncol. 2017 Jul;14(7):399-416

2. Prediction of the first variceal hemorrhage in patients with cirrhosis of the liver and esophageal varices. A prospective multicenter study.
North Italian Endoscopic Club for the Study and Treatment of Esophageal Varices.
N Engl J Med. 1988 Oct 13; 319(15):983-9.

3. Genomewide Association Study of Severe Covid-19 with Respiratory Failure.
Severe Covid-19 GWAS Group
N Engl J Med. 2020 Oct 15;383(16):1522-1534

4. Pneumatic dilation versus laparoscopic Heller's myotomy for idiopathic achalasia.
Boeckxstaens GE, Annese V, des Varannes SB, et al.
N Engl J Med. 2011 May 12;364(19):1807-16

5. Diabetes and the risk of pancreatic cancer.
Gullo L, Pezzilli R, Morselli-Labate AM; Italian Pancreatic Cancer Study Group.
N Engl J Med. 1994 Jul 14;331(2):81-4.

6. Inflammation and coagulation in inflammatory bowel disease: The clot thickens.
Danese S, Papa A, Saibeni S, et al.
Am J Gastroenterol. 2007 Jan;102(1):174-8

7. VEGF-A links angiogenesis and inflammation in inflammatory bowel disease pathogenesis.
Scaldaferri F, Vetrano S, Sans M, et al.
Gastroenterology. 2009 Feb;136(2):585-95

8. Reduced likelihood of metastases in patients with microsatellite-unstable colorectal cancer.
Malesci A, Laghi L, Bianchi P, et. al.
Clin Cancer Res. 2007 Jul 1;13(13):3831-9

9. Unique role of junctional adhesion molecule-a in maintaining mucosal homeostasis in inflammatory bowel disease.
Vetrano S, Rescigno M, Cera MR, et al.
Gastroenterology. 2008 Jul;135(1):173-84

10. CD3+ cells at the invasive margin of deeply invading (pT3-T4) colorectal cancer and risk of post-surgical metastasis: a longitudinal study.
Laghi L, Bianchi P, Miranda E, et al.
Lancet Oncol. 2009 Sep;10(9):877-84

11. Prospective comparison of computed tomography enterography and magnetic resonance enterography for assessment of disease activity and complications in ileocolonic Crohn's disease.
Fiorino G, Bonifacio C, Peyrin-Biroulet L, et al.
Inflamm Bowel Dis. 2011 May;17(5):1073-80

12. Safety of cold polypectomy for <10mm polyps at colonoscopy: a prospective multicenter study.
Repici A, Hassan C, Vitetta E, et al.
Endoscopy. 2012 Jan;44(1):27-31

13. Occurrence of tertiary lymphoid tissue is associated with T-cell infiltration and predicts better prognosis in early-stage colorectal cancers.
Di Caro G, Bergomas F, Grizzi F, et al.
Clin Cancer Res. 2014 Apr 15;20(8):2147-58

14. Efficacy and safety of biodegradable stents for refractory benign esophageal strictures: the BEST (Biodegradable Esophageal Stent) study.
Repici A, Vleggaar FP, Hassan C, et al.
Gastrointest Endosc. 2010 Nov;72(5):927-34

15. Endoscopic submucosal dissection in patients with early esophageal squamous cell carcinoma: results from a prospective Western series.
Repici A, Hassan C, Carlino A, et al.
Gastrointest Endosc. 2010 Apr;71(4):715-21

(Update apr. 2022)

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