Valtorta Flavia Professore ordinarioMedicineBIO/14




Doctor of Medicine, University of Milan, (110/110 cum laude)

Board Certification in Anesthesiology and Intensive Care

Board Certification in Psychotherapy



1982 -1985: Residency in Intensive Care and Anesthesiology, University of Milan

1985- 1987: Post-doctoral Associate, Laboratory of Paul Greengard (Nobel laureate in Medicine), The Rockefeller University, New York

1988-1990 Post-doctoral fellow, Center for the Study of Peripheral Neuropathies, University of Milan

1991-1998: Assistant Professor of Pharmacology, University of Milan

1996 -1998: Member of the Adjunct Faculty, The Rockefeller University, New York

1998 – 2000: Associate Professor of Pharmacology, University of Bari, Italy

from 1992: Head of the Unit of Neuropsychopharmacology, San Raffaele Scientific Institute, Milan
from 2000: Full Professor of Pharmacology, San Raffaele Vita-Salute University, Milan

2004 – 2007: Rector’s Deputy for International Affairs, San Raffaele Vita-Salute University, Milan
2007- 2010: Coordinator of the Ph.D. Course in Neuroscience, San Raffaele Vita-Salute University, Milan

2008-2011: Dean, Ph.D. School for Molecular Medicine and Rector’s Deputy for Ph.D. Programs, San Raffaele Vita-Salute University, Milan

2008 - 2014: Associate Director, Division of Neuroscience, San Raffaele Scientific Institute, Milan

2014 – 2016: Head, Post-doctoral Programme Committee, San Raffaele Scientific Institute, Milan

2016 – 2019: President, “Nucleo di Valutazione di Ateneo”, San Raffaele Vita-Salute University, Milan (the “Nucleo di Valutazione di Ateneo” is the official body which is responsible for monitoring policies, performance and governance of the University and for providing a yearly report to the Ministry for Education)

2017 – 2019: Director, Division of Neuroscience, San Raffaele Scientific Institute, Milan

From 2019: Dean of the School of Medicine, San Raffaele University, Milan, Italy

From 2018: President, National Committee on Doping and Health Protection in Sports, Italian Ministry of Health

From 2018: Member of the Board of Directors, Zardi-Gori Foundation for the Study of Addiction


Listed among the “Top Italian Scientists” and member of  TIWS, the Society of “Top Italian Women scientists”.

Member of ad hoc committees for grant agencies: INSERM (France); CNRS (France); ANR (France); Medical Research Council UK, US-Israeli Bilateral Foundation; Association Française contre les Myopathies; Dutch Organization for Scientific Research, Finnish Academy of Sciences, Royal Academy of Sweden, Israel Science Foundation, Italian Ministry of Health, Italian Ministry for Research.


PUBLICATIONS: Author of ≅ 140 research papers in peer-reviewed international journals, including: Science (2), Nature (1), Neuron (3), Nature Genetics (1), J. Cell Biology (6), J. Clin. Invest. (1), EMBO J. (2), Proc. Natl. Acad. Sci. USA (3).


Bibliometric parameters:

Citations: more than 10,000

h-Index: 57




F. Valtorta, L. Madeddu, J. Meldolesi and B. Ceccarelli.

Specific localization of the -latrotoxin receptor in the nerve terminal plasma membrane. 

Journal of Cell Biology, 99: 124-132, 1984


D. Pang, J. Wang, F. Valtorta, F. Benfenati and P. Greengard.

Protein tyrosine phosphorylation in synaptic vesicles.

Proceedings of the  National Academy of Sciences U.S.A., 85: 762-766, 1988.


F. Valtorta, R. Jahn, R. Fesce, P. Greengard and B. Ceccarelli.

Synaptophysin (p38) at the frog neuromuscular junction: its incorporation into the plasma membrane and recycling after intense quantal secretion.

Journal of Cell Biology, 107: 2719-2730, 1988.


M. Bähler, F. Benfenati, F. Valtorta, A. Czernik and P. Greengard.

Characterization of Synapsin I fragments produced by cysteine-specific cleavage:a study of their interactions with F-actin.

Journal of Cell Biology, 108: 1841-1849, 1989.


F. Torri Tarelli, A. Villa, F. Valtorta, P. De Camilli, P. Greengard and B. Ceccarelli.

Redistribution of synaptophysin and synapsin I during  -latrotoxin-induced release of neurotransmitter at the neuromuscular junction.

Journal of Cell Biology, 110: 449-459, 1990.


F. Valtorta, R. Fesce, F. Grohovaz, C. Haimann, W.P. Hurlbut, N. Iezzi, F. Torri-Tarelli, A. Villa and B. Ceccarelli.

Neurotransmitter release and synaptic vesicle recycling.

Neuroscience, 35 :477-489, 1990.


P. De Camilli, F. Benfenati, F. Valtorta and P. Greengard.

The Synapsins.

 Annual Review of Cell Biology, 6: 433-460, 1990.


F. Benfenati, F. Valtorta and P. Greengard.

Computer modeling of synapsin I binding to synaptic vesicles and F-actin: implications for the regulation of neurotransmitter release.

Proceedings of the National Academy of Sciences USA, 88: 575-579, 1991.


F. Benfenati, F. Valtorta, E. Chieregatti and P. Greengard.

Interaction of free and synaptic vesicle-bound synapsin I with F-actin.

Neuron, 8:377-386, 1992.


F. Valtorta, F. Benfenati and P. Greengard.

Structure and function of the synapsins.

Journal of Biological Chemistry, 267:7195-7198, 1992.


F. Valtorta, P. Greengard, R. Fesce and F. Benfenati.

Effects of the neuronal phosphoprotein synapsin I on actin polymerization. I.Evidence for a phosphorylation-dependent nucleating effect.

Journal of Biological Chemistry, 267:11281-11288, 1992.


R. Fesce, F. Benfenati, P. Greengard and F. Valtorta.

Effects of the neuronal phosphoprotein synapsin I on actin polymerization. II. Analytical interpretation of kinetic curves.

Journal of Biological Chemistry, 267:11289-11299, 1992.


J. Alder, B. Lu, F. Valtorta, P. Greengard and M.-m. Poo.

Calcium-dependent transmitter secretion reconstituted in Xenopus oocytes: requirement for synaptophysin.

Science, 257:657-661, 1992.


F. Benfenati, F. Valtorta, J. R. Rubenstein, F. S. Gorelick, P. Greengard and A. J. Czernik.

Synaptic vesicle-associated Ca2+/calmodulin-dependent protein kinase II is a binding protein for synapsin I.

Nature, 359:417-420, 1992.


J. Alder, Z.-P. Xie, F. Valtorta, P. Greengard and M.-m. Poo.

Antibodies to synaptophysin interfere with transmitter secretion at neuromuscular synapses.

Neuron, 9:759-768, 1992.


F. Torri Tarelli, M. Bossi, R. Fesce, P. Greengard and F. Valtorta.

Synapsin I partially dissociates from synaptic vesicles during exocytosis induced by electrical stimulation.

Neuron, 9:1143-1153, 1992.


P. Greengard, F. Valtorta, A.J. Czernik and F. Benfenati.

Synaptic vesicle phosphoproteins and regulation of synaptic function.

Science, 259:780-785, 1993.


F. Facchiano, F. Valtorta, F. Benfenati and A. Luini.

The transglutaminase hypothesis of tetanus toxin action.

Trends in Biochemical Sciences, 18:327-329, 1993.


F. Benfenati, F. Valtorta, M.C. Rossi, F. Onofri, T. Sihra and P. Greengard.

Interactions of synapsin I with phospholipids: possible role in synaptic vesicle clustering and in the maintenance of the bilayer structures.

Journal of Cell Biology, 123:1845-1855, 1993.


R. Fesce, F. Grohovaz, F. Valtorta and J. Meldolesi. Neurotransmitter release: fusion or kiss-and-run?

Trends in Cell Biology, 4: 1-4, 1994.


J. Alder, H. Kanki, F. Valtorta, P. Greengard and M.M. Poo.

Overexpression of synaptophysin enhances neurotransmitter secretion at Xenopus neuromuscular synapses.

Journal of Neuroscience, 15: 511-519, 1995.


P.E. Ceccaldi, F. Grohovaz, F. Benfenati, E. Chieregatti, P. Greengard and F. Valtorta.

Dephosphorylated synapsin I anchors synaptic vesicles to actin cytoskeleton: an analysis by videomicroscopy.

Journal of Cell Biology, 128: 905-912, 1995.


A. Barrie, E. Chieregatti, M.R. Miloso, F. Benfenati and F. Valtorta.

Epidermal growth factor-mediated inhibition of neurotransmitter glutamate release from rat forebrain synaptosomes.

Molecular Pharmacology, 49: 399-403, 1996.


F. Onofri, S. Giovedi, P. Vaccaro, F. Valtorta, A. Czernik, P. De Camilli, P. Greengard and F. Benfenati.

Synapsin I interacts with c-src and stimulates its tyrosine kinase activity.

Proceedings of the National Academy of Sciences U.S.A., 94:12168-12173, 1997.


P. D’Adamo, A. Menegon, C. Lo Nigro, M. Grasso, M. Gulisano, F. Tamanini, T. Bienvenu, A.K. Gedeon,  B. Oostra, S.-k. Wu, A. Tandon,  F. Valtorta, W. Balch, J. Chelly and D. Toniolo

Mutations in GDI1 are responsible for X-linked non-specific mental retardation.

Nature Genetics, 19: 134-139, 1998.


C. Leoni, A. Menegon, F. Benfenati, D. Toniolo and F. Valtorta

Neurite extension occurs in the absence of regulated exocytosis in PC12 subclones.

Molecular Biology of the Cell, 10: 2919-2931, 1999.


A. Menegon, D.D. Dunlap, A.J. Czernik, P. Greengard, F. Benfenati, and F. Valtorta

Use of phosphosynapsin I –specific antibodies for image analysis of signal transduction in single nerve terminals.

Journal of Cell Science, 113: 3573-3582, 2000.


F. Valtorta, J. Meldolesi and R. Fesce

Synaptic vesicles: is kissing a matter of competence?

Trends in Cell Biology, 11: 324-328, 2001.


M. Pennuto, A. Contestabile, D. D. Dunlap, F. Benfenati and F. Valtorta

Fluorescence resonance energy transfer detection of synaptophysin I and Vesicle-associated membrane protein 2  interactions during exocytosis from single live synapses.

Molecular Biology of the Cell, 13: 2706-2717, 2002.


A. Menegon, C. Verderio, C. Leoni, F. Benfenati, A.J. Czernik, P. Greengard, M. Matteoli and F. Valtorta

Spatial and temporal regulation of Ca2+/calmodulin-dependent protein kinase II activity in developing neurons.

Journal of Neuroscience, 22: 7016-7026, 2002.


P. D’Adamo, H. Welzl, S. Papadimitriou, M. Raffaele di Barletta, C. Tiveron, L. Tatangelo, P. F. Chapman, S. G. Knevett, M. F. Ramsay, F. Valtorta, C. Leoni, A. Menegon, D. P. Wolfer, H. P. Lipp and D. Toniolo

Deletion of the mental retardation gene Gdi1 impairs associative memory and alters social behavior in mice.

Human Molecular Genetics, 11: 2567-2580, 2002.


M. Pennuto, D. Bonanomi, F. Benfenati and F. Valtorta

Synaptophysin I controls the targeting of VAMP2/synaptobrevin II to synaptic vesicles.

Molecular Biology of the Cell, 14: 4909-4919, 2003.


F. Valtorta, M. Pennuto, D. Bonanomi and F. Benfenati

Synaptophysin: leading actor or walk-on role in synaptic vesicle exo-endocytosis?

BioEssays, 26: 445-453, 2004.


M. Rigoni, G. Schiavo, A.E. Weston, P. Caccin, F. Allegrini, M. Pennuto, F. Valtorta, C. Montecucco and O. Rossetto

Snake presynaptic neurotoxins with phospholipase A2 activity induce punctate swellings of neurites and exocytosis of synaptic vesicles.

Journal of Cell Science, 117: 3561-3570, 2004.


D. Bonanomi, M. Pennuto, M. Rigoni, O. Rossetto, C. Montecucco and F. Valtorta

Taipoxin induces synaptic vesicle exocytosis and disrupts the interaction of synaptophysin I with VAMP2.

Molecular Pharmacology, 67: 1901-08, 2005.


D. Bonanomi, A. Menegon, A. Miccio, G. Ferrari, A. Corradi, H.T.  Kao, F. Benfenati and F. Valtorta

Phosphorylation of Synapsin I by cAMP-dependent protein kinase controls synaptic vesicle dynamics in  developing neurons.

Journal of Neuroscience, 25: 7299-7308, 2005.


A. Menegon, D. Bonanomi, C. Albertinazzi, F. Lotti, G. Ferrari, H.T.  Kao, F. Benfenati, P. Baldelli and F. Valtorta.

Protein kinase a-mediated synapsin I phosphorylation is a central modulator of Ca2+-dependent synaptic activity

Journal of Neuroscience, 26:11670-11681, 2006.


D. Bonanomi, F. Benfenati and F. Valtorta.

Protein sorting in the synaptic vesicle life cycle.

Progress in Neurobiology, 80: 177-217, 2006.


D. Bonanomi, L. Rusconi, C. Colombo, F. Benfenati and F. Valtorta

Synaptophysin I selectively specifies the exocytic pathway of Synaptobrevin2/VAMP2.

Biochemical Journal, 404: 525-534, 2007.


P. Baldelli, A. Fassio, F. Valtorta, and F. Benfenati

Lack of synapsin I reduces the readily releasable pool of synaptic vesicles at central inhibitory synapses.

Journal of Neuroscience, 27: 13520-13531, 2007.


M. Tschernatsch, M. Klotz, C. Probst, M. Strittmatter, F. Valtorta, T. Gerriets, M. Kaps, K.H. Schäfer, and F. Blaes

Synaptophysin is an autoantigen in paraneoplastic neuropathy.

Journal of Neuroimmunology, 197: 81-86, 2008.


A. Corradi, A. Zanardi, C. Giacomini, F. Onofri, F. Valtorta, M. Zoli and F. Benfenati

Synapsin null mice display an increased age-dependent cognitive impairment.

Journal of Cell Science, 121: 3042-3051, 2008.


D. Bonanomi, E. Fornasiero, G. Valdez, S. Halegoua, F. Benfenati, A. Menegon, F. Valtorta

Identification of a developmentally-regulated pathway of membrane retrieval in neuronal growth cones.

Journal of Cell Science, 121: 3757-3769, 2008.


G. Colasante, P. Collombat, V. Raimondi, D. Bonanomi, C. Ferrai, M. Maira, K. Yoshikawa, A. Mansouri, F. Valtorta, J.L. Rubenstein and V. Broccoli

Arx is a direct Dlx target gene in the developing forebrain and modulates its GABAergic migration activity.

Journal of Neuroscience, 28: 10674-10686, 2008.


M. Chiappalone, S. Casagrande, M. Tedesco, F. Valtorta, P. Baldelli, S. Martinoia, F. Benfenati

Opposite changes in glutamatergic and GABAergic transmission underlie the diffuse hyperexcitability of synapsin I-deficient cortical networks.

Cerebral Cortex, 19:1422-1439, 2009.


E. Fornasiero, D. Bonanomi, F. Benfenati, F. Valtorta

The role of synapsins in neuronal development.

Cellular and Molecular Life Sciences, 67:1383-96, 2010.


R. Henriques, M. Lelek, E. Fornasiero, F. Valtorta, C. Zimmer, M. Mhlanga

QuickPALM: 3D real-time photoactivation nanoscopy image processing in ImageJ.

Nature Methods, 7: 339-40, 2010.


F. Cesca, P. Baldelli, F. Valtorta and F. Benfenati

The synapsins: key actors of synapse function and plasticity

Progress in Neurobiology, 91: 313-48, 2010.


A. Fassio, L. Patry, S. Congia, F. Onofri, A. Piton, J. Gauthier, D. Pozzi, M. Messa, E. De Franchi, A. Corradi, P. Baldelli, L. Lapointe, J. St-Onge, L. Mottron, F. Valtorta, D. Khoa Nguyen, G. A. Rouleau, F. Benfenati, P. Cossette

SYN1 loss-of-function mutations in ASD and partial epilepsy cause impaired synaptic function

Human  Molecular Genetics, 20: 2297-2307, 2011.


L. Perlini, F. Botti, E.F. Fornasiero, M. Giannandrea, D. Bonanomi, M. Amendola, L. Naldini, F. Benfenati and  F. Valtorta

Effects of phosphorylation and neuronal activity on the control of synapse formation by synapsin I.            

Journal of Cell Science, 124: 3643-3653, 2011.


A. Gärtner *, E. F. Fornasiero *, S. Munck , K. Vennekens, E. Seuntjens, W.B. Huttner, F.         Valtorta  and C.G. Dotti

N-Cadherin specifies first asymmetry in developing pyramidal neurons.

EMBO Journal, 31: 1893-903, 2012.


F. Fornasiero, A. Raimondi, F. Guarnieri, R. Fesce, F. Benfenati and F. Valtorta

Synapsins contribute to the dynamic spatial organization of synaptic vesicles in an activity-dependent manner.

Journal of Neuroscience, 32:12214-27, 2012.


P. Valente, S. Casagrande, T. Nieus, A. M.J. Verstagen, F. Valtorta, F. Benfenati, P. Baldelli

Synapsin  I phosphorylation differentially participates in the expression of post-tetanic potentiation and in its enhancement by BDNF.

Journal of Neuroscience, 32: 5868-79, 2012.


E G. Gelsomino, E. Menna, F. Antonucci, S. Rodighiero, Riganti L., C. Mulle, F. Benfenati, F. Valtorta, C. Verderio and M. Matteoli,  

Kainate induces mobilization of synaptic vesicles at the growth cone through the activation of protein kinase A.

Cerebral Cortex, 23: 531-541, 2013.


P. Farisello, D. Boido, T. Nieus, Medrihan L, Cesca F, F. Valtorta, P. Baldelli and F. Benfenati

Synaptic and extrasynaptic origin of the excitation/inhibition imbalance in the hippocampus of synapsin I/II/III knockout mice.

Cerebral Cortex, 23 : 581-593, 2013.


B. Greco, F. Managò, V. Tucci, H.-T. Kao, F. Valtorta and F. Benfenati

Autism-related behavioral abnormalities in synapsin knockout mice

Behavioral Brain Research, 251:65-74, 2013.


G. Lignani, A. Raimondi, E. Ferrea, A. Rocchi, Paonessa F, F. Cesca, Orlando M, T. Tkatch, F. Valtorta, P. Cossette, P. Baldelli  and F. Benfenati

Epileptogenic Q555X SYN1 mutant triggers imbalances in release dynamics and short-term plasticity.

Human Molecular Genetics 22: 2186-2199, 2013.


M. Giannandrea, N.H. Gehring, E. Monzani, F. Benfenati, A.E. Kulozik and F. Valtorta

Nonsense-mediated mRNA decay and loss of-function of the protein underlie the X-linked epilepsy associated with the W356X nonsense mutation in SYN1.

PLOS One, 8:e67724, 2013; doi: 10.1371/journal.pone.0067724. Print 2013.


Pozzi D, Lignani G, Ferrea E, Contestabile A, Paonessa F, D’Alessandro R, Lippiello P, Boido D, Fassio A, Meldolesi J, Valtorta F, Benfenati F and Baldelli P.

REST/NRSF-mediated intrinsic homeostasis protects neuronal networks from hyperexcitability.

EMBO Journal, 32:2994-3007, 2013


A. Corradi, M. Fadda, A. Piton, L. Patry, A. Marte, P. Rossi, M. Cadieux-Dion, J. Gauthier, L. Lapointe, L. Mottron, F. Valtorta, G. A. Rouleau, A. Fassio, F. Benfenati, P. Cossette

SYN2 is an Autism Predisposing Gene: Loss-of-function Mutations Alter Synaptic Vesicle Cycling and Axon Outgrowth.

Human Molecular Genetics, 23:90-103, 2014


A.M.G. Verstegen, E. Tagliatti, G. Lignani, A. Marte, T. Stolero, A. Orenbuch, A. Corradi , F. Valtorta, D. Gitler, F. Onofri, A. Fassio, F. Benfenati

Phosphorylation of synapsin I by cdk5 sets the ratio between the resting and recycling pools of synaptic vesicles at hippocampal synapses.

Journal of Neuroscience, 34: 7266-7280, 2014.


A. Gärtner, E. F. Fornasiero, F. Valtorta  and C. G. Dotti

Distinct temporal hierarchies in membrane and cytoskeleton dynamics precede the morphological polarization of developing neurons.

Journal of Cell Science, 127: 4409-4419, 2014.


S. Bellani, A. Mescola, G. Ronzitti, H. Tsushima, S. Tilve, C. Canale,  F. Valtorta* and E. Chieregatti* (shared last authorship)

GRP78 clustering at the cell surface of neurons transduces the action of exogenous alpha-synuclein.

Cell Death and Differentiation, 21: 1971-1983, 2014.


Pia Rossi, Bruno Sterlini, Enrico Castroflorio, Antonella Marte, Franco Onofri, Flavia Valtorta, Luca Maragliano, Anna Corradi and Fabio Benfenati

A novel membrane topology model for proline-rich transmembrane protein 2 (PRRT2) suggests intracellular functions at the synapse.

Journal of Biological Chemistry, 291: 6111-6123, 2016.


Pierluigi Valente, Enrico Castroflorio, Pia Rossi, Manuela Fadda, Bruno Sterlini, Romina Ines Cervigni, Cosimo Prestigio, Silvia Giovedì, Franco Onofri, Elisa Mura, Fabrizia Guarnieri, Marta Orlando, Federico Zara, Anna Fassio, Flavia Valtorta, Pietro Baldelli, Anna Corradi, Fabio Benfenati

PRRT2 is a key component of the Ca2+-dependent release machinery.

Cell Reports, 15: 117-131, 2016.


Loredana Riganti, Flavia Antonucci, Martina Gabrielli, Ilaria Prada, Paola Giussani, Paola Viani, Flavia Valtorta, Elisabetta Menna, Michela Matteoli, Claudia Verderio

Sphingosine-1-phosphate (S1P) impacts presynaptic functions by regulating synapsin I localization in the presynaptic compartment.

Journal of Neuroscience, 36: 4624-4634, 2016.


Flavia Valtorta, Fabio Benfenati, Federico Zara, Jacopo Meldolesi

PRRT2: from paroxysmal disorders to regulation of synaptic function.

Trends in Neurosciences, 39: 668-679, 2016.


Heise C, Taha E, Murru L, Ponzoni L, Cattaneo A, Guarnieri FC, Montani C, Mossa A, Vezzoli E, Ippolito G, Zapata J, Barrera I, Ryazanov AG, Cook J, Poe M, Stephen MR, Kopanitsa M, Benfante R, Rusconi F, Braida D, Francolini M, Proud CG, Valtorta F, Passafaro M, Sala M, Bachi A, Verpelli C, Rosenblum K, Sala C.

eEF2K/eEF2 pathway controls the excitation/inhibition balance and susceptibility to epileptic seizures.

Cerebral Cortex  27: 2226-2248, 2017.


Caterina Michetti, Enrico Castroflorio, Ivan Marchionni, Nicola Forte, Bruno Sterlini, Francesca Binda, Floriana Fruscione, Flavia Valtorta, Federico Zara, Anna Corradi and Fabio Benfenati

The PRRT2 knockout mouse recapitulates the neurological diseases associated with PRRT2 mutations.

Neurobiology of Disease, 99: 66-83, 2017.


Jenny Sassone, Giulia Maia Serratto, Maria Passafaro, Flavia Valtorta, and Andrea Ciammola

The synaptic function of parkin.

Brain, 140: 2265-2272, 2017.


Fabrizia C. Guarnieri, Davide Pozzi, Andrea Raimondi, Riccardo Fesce, Maria M. Valente, Vincenza S. Delvecchio, Hilde Van Esch, Michela Matteoli, Fabio Benfenati, Patrizia D’Adamo and Flavia Valtorta

A novel SYN1 missense mutation in nonsyndromic X-linked intellectual disability affects synaptic vesicle life cycle, clustering and mobility.

Human Molecular Genetics, 26: 4699-4714, 2017.


Alessandra Piccini, Enrico Castroflorio, Pierluigi Valente, Fabrizia C. Guarnieri, Davide Aprile, Mattia Bramini, Giorgia Giansante, Fabrizia Cesca, Angela Bachi, Angela Cattaneo, Jonathan D. Wren, Anna Fassio, Flavia Valtorta, Fabio Benfenati, Silvia Giovedì

APache: a novel AP-2 interacting protein involved in synaptic vesicle trafficking and in vitro neuronal development.

Cell Reports, 21: 3596–3611, 2017



Fabrizia C. Guarnieri, Serena Bellani, Latefa Yekhlef, Andrea Bergamaschi, Annamaria Finardi, Riccardo Fesce, Davide Pozzi, Elena Monzani, Eugenio F. Fornasiero, Michela Matteoli, Gianvito Martino, Roberto Furlan, Stefano Taverna, Luca Muzio and Flavia Valtorta

Synapsin I deletion reduces neuronal damage and ameliorates clinical progression of experimental autoimmune encephalomyelitis.

Brain Behaviour and Immunity, 68: 197-210, 2018.


Pierluigi Valente, Alessandra Romei, Manuela Fadda, Bruno Sterlini, Davide Lonardoni, Floriana Fruscione, Enrico Castroflorio, Caterina Michetti, Giorgia Giansante, Flavia Valtorta, Jin-Wu Tsai, Federico Zara, Thierry Nieus, Anna Corradi, Anna Fassio, Pietro Baldelli and Fabio Benfenati

Constitutive inactivation of the PRRT2 gene alters short-term synaptic plasticity and promotes network hyperexcitability in hippocampal neurons.

Cerebral Cortex, 29: 2010-2033, 2019.


Danilo De Gregorio, Mirko Manchia, Bernardo Carpiniello, Flavia Valtorta, Maria

Nobile, Gabriella Gobbi, Stefano Comai

Role of palmitoylethanolamide (PEA) in depression: Translational evidence.

Journal of Affective Disorders, 255. pii: S0165-0327(18)31599-4. PMID: 30391203, 2019. doi: 10.1016/j.jad.2018.10.117.


Jenny Sassone, Flavia Valtorta, Andrea Ciammola

Early dyskinesias in Parkinson’s disease patients with parkin mutation: a primary corticostriatal synaptopathy?

Frontiers in Neuroscience, doi: 10.3389/fnins.2019.00273, 2019


Sara Poletti, Stefano Comai, Elisa Melloni, Cristina Colombo, Flavia Valtorta, Francesco Benedetti

Grey and white matter structure associates with the activation of the tryptophan to kynurenine pathway in bipolar disorder.

Journal of Affective Disorders: 259:404-412, 2019


Marco Cambiaghi, Mario Buffelli, Laura Masin, Flavia Valtorta  and Stefano Comai.

Transcranial direct current stimulation of the mouse prefrontal cortex modulates serotonergic neural activity of the dorsal raphe nucleus.

Brain Stimulation, 13: 548-550, 2020.


Elisa Savino, Romina Inès Cervigni, Miriana Povolo, Alessandra Stefanetti, Daniele Ferrante, Pierluigi Valente, Anna Corradi, Fabio Benfenati, Fabrizia Claudia Guarnieri and Flavia Valtorta

Proline rich transmembrane protein 2 (PRRT2) regulates the actin cytoskeleton during synaptogenesis.

Cell Death and Disease, 11(10):856. doi: 10.1038/s41419-020-03073-w,2020.


Maria Regoni, Stefano Cattaneo, Daniela Mercatelli, Salvatore Novello, Alice Passoni, Renzo Bagnati, Enrico Davoli, Laura Croci, Gian Giacomo Consalez, Federica Albanese, Letizia Zanetti, Maria Passafaro, Giulia Maia Serratto, Alessio Di Fonzo, Flavia Valtorta, Andrea Ciammola, Stefano Taverna, Michele Morari and Jenny Sassone

Pharmacological antagonism of kainate receptor rescues dysfunction and loss of dopamine neurons in a mouse model of human parkin-induced toxicity.

Cell Death and Disease, 11(11):963. doi: 10.1038/s41419-020-03172-8, 2020







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