Palmieri Michela Ricercatore tempo determinato tipo aMedicina

La Dr.ssa Michela Palmieri e’ Ricercatrice (RTDA) presso l’Universita’ Vita-Salute San Raffaele, e Project Leader nella Divisione di Neuroscienze dell’Ospedale San Raffaele. La sua attivita’ di ricerca e’ basata sulla comprensione del pathway autofagico-lisosomiale durante lo sviluppo del cervello sia in condizione di salute che di malattia. I suoi studi sono infatti incentrati sulla caratterizzazione dei pathway molecolari alterati nella sindrome di Rett e sulla identificazione di nuovi bersagli terapeutici per la cura della malattia.

 

Formazione:

2010    Dottorato di Ricerca (PhD) in Genetica Medica, Seconda Universita’ degli Studi di         Napoli, presso il Telethon Institute of Genetics and Medicine (TIGEM), Napoli (IT).

2006    Laurea Specialistica in Biologia, (110/110 e lode), Seconda Universita’ degli Studi di    Napoli, Caserta (IT).

2004    Laurea Triennale in Science Biologiche, (110/110 e lode), Seconda Universita’ degli      Studi di Napoli, Caserta (IT).

 

Cariche attuali e precedenti:

2022-presente Ricercatore (RTDA), Facolta’ di Medicina e Chirurgia, Universita’ Vita-Salute               San Raffaele, Milano (IT).

2019-presente Project Leader, Divisione di Neuroscienze, Ospedale San Raffaele, Milano (IT)

2016-2019      Postdoctoral Fellow, Divisione di Neuroscienze, Ospedale San Raffaele,                          Milano (IT).

2010-2016      Postdoctoral Fellow, Dipartimento di Genetica Molecolare ed Umana, Baylor                  College of Medicine, Houston (TX).

2007-2010      Studente di Dottorato, Telethon Institute of Genetics and Medicine, (TIGEM)                 Napoli (IT).

 

Premi e Riconoscimenti

2022    PNRR Giovane Ricercatore - MSCA (Ministero dell’Universita’ e della Ricerca, IT)

2019    Giovani Ricercatori - Ricerca Finalizzata (Ministero della Salute, IT)

2018    Marie Skłodowska-Curie Individual Fellowship – Horizon 2020 (Commissione   Europea)          

2016    Miglior Poster della Gordon Research Conference on Autophagy in Stress,          Development and Disease, Ventura (CA).

 

Attivita’ editoriali:

2021- present  Reviewer Editor in Cellular Neuropathology.

 

 

Identificatore univoco del ricercatore:

ORCID ID: 0000-0001-9373-1133

Researcher ID: H-7546-2018

Google scholar:

Linkedin

 

 

Frasca A, Spiombi E, Palmieri Michela, Albizzati E, Valente M, Bergo A, Leva B, Kilstrup-Nielsen C, Bianchi F, Di Cunto F, Landsberger N. MECP2 mutations affect ciliogenesis: a novel perspective for Rett syndrome and related disorders. EMBO Mol Med. 2020 Jun8; 12(6): e10270. 

 

Gandaglia A, Brivio E, Carli S, Palmieri M, Bedogni F, Stefanelli G, Bergo A, Leva B, Cattaneo C, Pizzamiglio L, Cicerone M, Bianchi V, Kilstrup-Nielsen C, D’Annessa I, Di Marino D, D’Adamo P, Antonucci F, Frasca A and Landsberger N. A novel Mecp2 Y120D knock-in model displays similar behavioral traits but distinct molecular features compared to the Mecp2-null mouse implying precision medicine for the treatment of Rett syndrome. Mol Neurobiol. 2018 Nov 6 doi: 10.1007/s12035-018-1412-2.

 

di Ronza A, Bajaj L, Sharma J, Sanagasetti D, Lotfi P, Adamski CJ, Collette J, Palmieri M, Amawi A, Popp L, Chang KT, Meschini MC, Leung HE, Segatori L, Simonati A, Sifers RN, Santorelli FM and Sardiello M. CLN8 is an endoplasmic reticulum cargo receptor that regulates lysosome biogenesis. Nat Cell Biol. 2018 Dec;20(12):1370-1377.

 

Pal R, Palmieri M, Chaudhury A, Klisch TJ, di Ronza A, Neilson J, Rodney GG and Sardiello M. Src regulates amino acid-mediated mTORC1 activation by disrupting GATOR1-Rag GTPase interaction. Nat Commun. 2018 Oct 19;9(1):4351.

 

Palmieri M, Pal R and Sardiello M. AKT modulates the autophagy-lysosome pathway via TFEB. Cell Cycle. 2017 Jul 3;16:1237-1238.

 

Palmieri M, Pal R, Nelvagal HR, Lotfi P, Stinnett GR, Seymour ML, Chaudhury A, Bajaj L, Bremner L, Saleem U, Tse DY, Sanagasetti D, Wu SM, Neilson JR, Pereira FA, Pautler RG, Rodney GG, Cooper JD and Sardiello M. mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases. Nat Commun. 2017 Feb 6;8:14338.

 

Pal R, Bajaj L, Sharma J, Palmieri M, di  Ronza A, Lotfi P, Sardiello  M and  Rodney GG. NADPH oxidase promotes Parkinsonian phenotypes by impairing autophagic flux in an mTORC1-independent fashion in cellular model of Parkinson’s disease. Sci Rep. 2016 Mar 10;6:22866.

 

Wong CO, Palmieri M, Li J, Akhmedov D, Chao Y, Broadhead GT, Zhu MX, Berdeaux R, Collins CA, Sardiello M and Venkatachalam K. Diminished MTORC1-Dependent JNK-Activation Underlies the Neurodevelopmental Defects Associated with Lysosomal Dysfunction. Cell Rep. 2015 Sep 29;12(12):2009-20.

 

Polito VA, Li H, Martini-Stoica H, Wang B, Yang L, Xu Y, Swartzlander D, Palmieri M, di Ronza A, Lee V, Sardiello M, Ballabio A and Zheng H. Selective clearance of aberrant Tau proteins and rescue of neurotoxicity by transcription factor EB. EMBO Mol Med. 2014 Sep 6(9):1142–1160.

 

Pal R, Palmieri M, Loehr JA, Li S, Abo-Zahrah R, Monroe TO, Thakur PB, Sardiello M and Rodney GG. Src-dependent impairment of autophagy by oxidative stress in a mouse model of Duchenne muscular dystrophy. Nat Commun. 2014 Jul 16;5:4425.

 

Pal R., Monroe T.O., Palmieri M., Sardiello M. and Rodney G.G. Rotenone induces neurotoxicity through Rac1-dependent activation of NADPH oxidase in SHSY-5Y cells. FEBS Lett. 2014 Jan 31;588(3):472-481.

 

Medina DL, Fraldi A, Bouche V, Annunziata F, Mansueto G, Spampanato C, Pignata A, Martina JA, Sardiello M, Palmieri M, Polischuk R, Puertollano R and Ballabio A. Transcriptional activation of lysosomal exocytosis promotes cellular clearance. Dev Cell.  2011 Sep 13;21(3):421-30.

 

Palmieri M, Impey D, Kang H, di Ronza A, Pelz C, Sardiello M and Ballabio A. Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways. Hum Mol Genet. 2011 Oct 1;20(19):3852-66.

 

Sardiello M, Palmieri M, di Ronza A, Medina DL, Valenza M, Gennarino VA, Di Malta C, Donaudy F, Embrione V, Polishchuk RS, Banfi S, Parenti G, Cattaneo E and Ballabio A. A gene network regulating lysosomal biogenesis and function. Science 2009 Jul 24;325(5939):473-7.