Palmieri Michela Ricercatore tempo determinato tipo aMedicine
Biography
Publications
Biography
Dr. Michela Palmieri is a Researcher (RTDA) at Vita-Salute San Raffaele University, and Project Leader at Division of Neuroscience at San Raffaele Hospital. Her research activity is focused on understanding the autophagy function during brain development in health and disease, with particular focus at defining potential therapeutic strategy that could revert the symptoms associated with Rett syndrome (RTT), a devastating neurodevelopmental disorder that mainly affects females.
Education:
2010 PhD in Medical Genetics, Seconda Universita’ degli Studi di Napoli, at Telethon Institute of Genetics and Medicine (TIGEM), Naples (IT).
2006 Master Degree in Biology, (110/110 cum laude), Seconda Universita’ degli Studi di Napoli, Caserta (IT).
2004 Bachelor Degree in Biological Sciences, (110/110 cum laude), Seconda Universita’ degli Studi di Napoli, Caserta (IT).
Professional Experiences:
2022-present Researcher (RTDA), Faculty of Medicine and Surgery, Vita-Salute San Raffaele University, Milan (IT).
2019-present Project Leader, Division of Neuroscience, San Raffaele Hospital, Milan
2016-2019 Postdoctoral Fellow, Division of Neuroscience, San Raffaele Hospital, Milan
2010-2016 Postdoctoral Fellow, Human and Molecular Genetics Department, Baylor College of Medicine, Houston (TX).
2007-2010 PhD student, Telethon Institute of Genetics and Medicine (TIGEM), Naples
Prizes and Honors
2022 PNRR Young Research MSCA (Minister of University and Research, IT)
2019 Young Researcher - Ricerca Finalizzata (Minister of Health, IT)
2018 Marie Skłodowska-Curie Individual Fellowship – Horizon 2020 (European Commission)
2016 Best Poster at Gordon Research Conference on Autophagy in Stress, Development and Disease, Ventura (CA).
Additional Activities
2021- present Reviewer Editor in Cellular Neuropathology.
Major Fields of Interests
Lysosomal-autophagy signaling pathways in neurobiology and neurological disorders.
Additional Information:
ORCID ID: 0000-0001-9373-1133
Researcher ID: H-4292-2016
Publications
Frasca A, Spiombi E, Palmieri Michela, Albizzati E, Valente M, Bergo A, Leva B, Kilstrup-Nielsen C, Bianchi F, Di Cunto F, Landsberger N. MECP2 mutations affect ciliogenesis: a novel perspective for Rett syndrome and related disorders. EMBO Mol Med. 2020 Jun8; 12(6): e10270.
Gandaglia A, Brivio E, Carli S, Palmieri M, Bedogni F, Stefanelli G, Bergo A, Leva B, Cattaneo C, Pizzamiglio L, Cicerone M, Bianchi V, Kilstrup-Nielsen C, D’Annessa I, Di Marino D, D’Adamo P, Antonucci F, Frasca A and Landsberger N. A novel Mecp2 Y120D knock-in model displays similar behavioral traits but distinct molecular features compared to the Mecp2-null mouse implying precision medicine for the treatment of Rett syndrome. Mol Neurobiol. 2018 Nov 6 doi: 10.1007/s12035-018-1412-2.
di Ronza A, Bajaj L, Sharma J, Sanagasetti D, Lotfi P, Adamski CJ, Collette J, Palmieri M, Amawi A, Popp L, Chang KT, Meschini MC, Leung HE, Segatori L, Simonati A, Sifers RN, Santorelli FM and Sardiello M. CLN8 is an endoplasmic reticulum cargo receptor that regulates lysosome biogenesis. Nat Cell Biol. 2018 Dec;20(12):1370-1377.
Pal R, Palmieri M, Chaudhury A, Klisch TJ, di Ronza A, Neilson J, Rodney GG and Sardiello M. Src regulates amino acid-mediated mTORC1 activation by disrupting GATOR1-Rag GTPase interaction. Nat Commun. 2018 Oct 19;9(1):4351.
Palmieri M, Pal R and Sardiello M. AKT modulates the autophagy-lysosome pathway via TFEB. Cell Cycle. 2017 Jul 3;16:1237-1238.
Palmieri M, Pal R, Nelvagal HR, Lotfi P, Stinnett GR, Seymour ML, Chaudhury A, Bajaj L, Bremner L, Saleem U, Tse DY, Sanagasetti D, Wu SM, Neilson JR, Pereira FA, Pautler RG, Rodney GG, Cooper JD and Sardiello M. mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases. Nat Commun. 2017 Feb 6;8:14338.
Pal R, Bajaj L, Sharma J, Palmieri M, di Ronza A, Lotfi P, Sardiello M and Rodney GG. NADPH oxidase promotes Parkinsonian phenotypes by impairing autophagic flux in an mTORC1-independent fashion in a cellular model of Parkinson’s disease. Sci Rep. 2016 Mar 10;6:22866.
Wong CO, Palmieri M, Li J, Akhmedov D, Chao Y, Broadhead GT, Zhu MX, Berdeaux R, Collins CA, Sardiello M and Venkatachalam K. Diminished MTORC1-Dependent JNK-Activation Underlies the Neurodevelopmental Defects Associated with Lysosomal Dysfunction. Cell Rep. 2015 Sep 29;12(12):2009-20.
Polito VA, Li H, Martini-Stoica H, Wang B, Yang L, Xu Y, Swartzlander D, Palmieri M, di Ronza A, Lee V, Sardiello M, Ballabio A and Zheng H. Selective clearance of aberrant Tau proteins and rescue of neurotoxicity by transcription factor EB. EMBO Mol Med. 2014 Sep 6(9):1142–1160.
Pal R, Palmieri M, Loehr JA, Li S, Abo-Zahrah R, Monroe TO, Thakur PB, Sardiello M and Rodney GG. Src-dependent impairment of autophagy by oxidative stress in a mouse model of Duchenne muscular dystrophy. Nat Commun. 2014 Jul 16;5:4425.
Pal R., Monroe T.O., Palmieri M., Sardiello M. and Rodney G.G. Rotenone induces neurotoxicity through Rac1-dependent activation of NADPH oxidase in SHSY-5Y cells. FEBS Lett. 2014 Jan 31;588(3):472-481.
Medina DL, Fraldi A, Bouche V, Annunziata F, Mansueto G, Spampanato C, Pignata A, Martina JA, Sardiello M, Palmieri M, Polischuk R, Puertollano R and Ballabio A. Transcriptional activation of lysosomal exocytosis promotes cellular clearance. Dev Cell. 2011 Sep 13;21(3):421-30.
Palmieri M, Impey D, Kang H, di Ronza A, Pelz C, Sardiello M and Ballabio A. Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways. Hum Mol Genet. 2011 Oct 1;20(19):3852-66.
Sardiello M, Palmieri M, di Ronza A, Medina DL, Valenza M, Gennarino VA, Di Malta C, Donaudy F, Embrione V, Polishchuk RS, Banfi S, Parenti G, Cattaneo E and Ballabio A. A gene network regulating lysosomal biogenesis and function. Science 2009 Jul 24;325(5939):473-7.
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