Palmieri Michela Ricercatore tempo determinato tipo aMedicine

 

Dr. Michela Palmieri is a Researcher (RTDA) at Vita-Salute San Raffaele University, and Project Leader at Division of Neuroscience at San Raffaele Hospital. Her research activity is focused on understanding the autophagy function during brain development in health and disease, with particular focus at defining potential therapeutic strategy that could revert the symptoms associated with Rett syndrome (RTT), a devastating neurodevelopmental disorder that mainly affects females.

 

Education:

2010    PhD in Medical Genetics, Seconda Universita’ degli Studi di Napoli, at Telethon Institute of Genetics and Medicine (TIGEM), Naples (IT).

2006    Master Degree in Biology, (110/110 cum laude), Seconda Universita’ degli Studi di  Napoli, Caserta (IT).

2004    Bachelor Degree in Biological Sciences, (110/110 cum laude), Seconda Universita’ degli Studi di Napoli, Caserta (IT).

 

Professional Experiences:

2022-present   Researcher (RTDA), Faculty of Medicine and Surgery, Vita-Salute San  Raffaele University, Milan (IT).

2019-present   Project Leader, Division of Neuroscience, San Raffaele Hospital, Milan

2016-2019      Postdoctoral Fellow, Division of Neuroscience, San Raffaele Hospital, Milan  

2010-2016      Postdoctoral Fellow, Human and Molecular Genetics Department, Baylor College of Medicine, Houston (TX).

2007-2010      PhD student, Telethon Institute of Genetics and Medicine (TIGEM), Naples

 

Prizes and Honors

2022    PNRR Young Research MSCA (Minister of University and Research, IT)

2019    Young Researcher - Ricerca Finalizzata (Minister of Health, IT)

2018    Marie Skłodowska-Curie Individual Fellowship – Horizon 2020 (European         Commission)  

2016    Best Poster at Gordon Research Conference on Autophagy in Stress, Development and   Disease, Ventura (CA).

 

Additional Activities

2021- present  Reviewer Editor in Cellular Neuropathology.

 

Major Fields of Interests

Lysosomal-autophagy signaling pathways in neurobiology and neurological disorders.

Additional Information:

ORCID ID: 0000-0001-9373-1133

Researcher ID: H-4292-2016

Google scholar

Linkedin

 

Frasca A, Spiombi E, Palmieri Michela, Albizzati E, Valente M, Bergo A, Leva B, Kilstrup-Nielsen C, Bianchi F, Di Cunto F, Landsberger N. MECP2 mutations affect ciliogenesis: a novel perspective for Rett syndrome and related disorders. EMBO Mol Med. 2020 Jun8; 12(6): e10270. 

 

Gandaglia A, Brivio E, Carli S, Palmieri M, Bedogni F, Stefanelli G, Bergo A, Leva B, Cattaneo C, Pizzamiglio L, Cicerone M, Bianchi V, Kilstrup-Nielsen C, D’Annessa I, Di Marino D, D’Adamo P, Antonucci F, Frasca A and Landsberger N. A novel Mecp2 Y120D knock-in model displays similar behavioral traits but distinct molecular features compared to the Mecp2-null mouse implying precision medicine for the treatment of Rett syndrome. Mol Neurobiol. 2018 Nov 6 doi: 10.1007/s12035-018-1412-2.

 

di Ronza A, Bajaj L, Sharma J, Sanagasetti D, Lotfi P, Adamski CJ, Collette J, Palmieri M, Amawi A, Popp L, Chang KT, Meschini MC, Leung HE, Segatori L, Simonati A, Sifers RN, Santorelli FM and Sardiello M. CLN8 is an endoplasmic reticulum cargo receptor that regulates lysosome biogenesis. Nat Cell Biol. 2018 Dec;20(12):1370-1377.

 

Pal R, Palmieri M, Chaudhury A, Klisch TJ, di Ronza A, Neilson J, Rodney GG and Sardiello M. Src regulates amino acid-mediated mTORC1 activation by disrupting GATOR1-Rag GTPase interaction. Nat Commun. 2018 Oct 19;9(1):4351.

 

Palmieri M, Pal R and Sardiello M. AKT modulates the autophagy-lysosome pathway via TFEB. Cell Cycle. 2017 Jul 3;16:1237-1238.

 

Palmieri M, Pal R, Nelvagal HR, Lotfi P, Stinnett GR, Seymour ML, Chaudhury A, Bajaj L, Bremner L, Saleem U, Tse DY, Sanagasetti D, Wu SM, Neilson JR, Pereira FA, Pautler RG, Rodney GG, Cooper JD and Sardiello M. mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases. Nat Commun. 2017 Feb 6;8:14338.

 

Pal R, Bajaj L, Sharma J, Palmieri M, di  Ronza A, Lotfi P, Sardiello  M and  Rodney GG. NADPH oxidase promotes Parkinsonian phenotypes by impairing autophagic flux in an mTORC1-independent fashion in a cellular model of Parkinson’s disease. Sci Rep. 2016 Mar 10;6:22866.

 

Wong CO, Palmieri M, Li J, Akhmedov D, Chao Y, Broadhead GT, Zhu MX, Berdeaux R, Collins CA, Sardiello M and Venkatachalam K. Diminished MTORC1-Dependent JNK-Activation Underlies the Neurodevelopmental Defects Associated with Lysosomal Dysfunction. Cell Rep. 2015 Sep 29;12(12):2009-20.

 

Polito VA, Li H, Martini-Stoica H, Wang B, Yang L, Xu Y, Swartzlander D, Palmieri M, di Ronza A, Lee V, Sardiello M, Ballabio A and Zheng H. Selective clearance of aberrant Tau proteins and rescue of neurotoxicity by transcription factor EB. EMBO Mol Med. 2014 Sep 6(9):1142–1160.

 

Pal R, Palmieri M, Loehr JA, Li S, Abo-Zahrah R, Monroe TO, Thakur PB, Sardiello M and Rodney GG. Src-dependent impairment of autophagy by oxidative stress in a mouse model of Duchenne muscular dystrophy. Nat Commun. 2014 Jul 16;5:4425.

 

Pal R., Monroe T.O., Palmieri M., Sardiello M. and Rodney G.G. Rotenone induces neurotoxicity through Rac1-dependent activation of NADPH oxidase in SHSY-5Y cells. FEBS Lett. 2014 Jan 31;588(3):472-481.

 

Medina DL, Fraldi A, Bouche V, Annunziata F, Mansueto G, Spampanato C, Pignata A, Martina JA, Sardiello M, Palmieri M, Polischuk R, Puertollano R and Ballabio A. Transcriptional activation of lysosomal exocytosis promotes cellular clearance. Dev Cell.  2011 Sep 13;21(3):421-30.

 

Palmieri M, Impey D, Kang H, di Ronza A, Pelz C, Sardiello M and Ballabio A. Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways. Hum Mol Genet. 2011 Oct 1;20(19):3852-66.

 

Sardiello M, Palmieri M, di Ronza A, Medina DL, Valenza M, Gennarino VA, Di Malta C, Donaudy F, Embrione V, Polishchuk RS, Banfi S, Parenti G, Cattaneo E and Ballabio A. A gene network regulating lysosomal biogenesis and function. Science 2009 Jul 24;325(5939):473-7.