Rovere Querini Patrizia Professore associatoMedicineMED/09

Director of the School of Specialization in Allergy and Clinical Immunology

Coordinator of the Autoimmunity and Gender Medicine Unit, Department of Internal Medicine, San Raffaele Hospital, Milan.

 

Biographic Sketch

Born in Milan on March 11, 1969. Three children.

 

Curriculum of Studies and Training

Degree cum laude in Medicine and Surgery, University of Milan on July 29, 1994.

PhD, Open University, London May 22, 2000.

Specialization cum laude in Allergy and Clinical Immunology, San Raffaele University, October 5, 2002.

Post-doc 1995-1997, Centre d’Immunologie INSERM-CNRS de Marseille-Luminy, Marseille, France.

 

Clinical and Research Activities

Medical Researcher, San Raffaele Hospital: 2003-2013.

Head of the Autoimmunity and Pregnancy Unit, San Raffaele Hospital: 2003-present.

 

Honors

1988 and 1995 “A. Origlia ” Study Award, awarded by the Italian Union of Merchants, Milan.

1998 Roche Prize for Research in Immunology, awarded by the Italian Society of Immunology.

1999 Cecilia Cioffrese Award for cancer research, awarded by the Fondazione Carlo Erba.

2000: Research Award of the Italian Society of Internal Medicine and Aventis Foundation.

2011: Vice-Chair (with Nathalie Franc, The Scripps Research Institute), Gordon Research Conference “Apoptotic Cell Recognition & Clearance: Death and Damage in Development and Disease” July 17-22, 2011 Bates College in Lewiston, ME

2013: Chair (with Nathalie Franc, The Scripps Research Institute), Gordon Research Conference “Apoptotic Cell Recognition & Clearance” June 23-28, 2013 University of New England, Biddeford, ME

1993-present: Active Member of the Italian Society of Immunology, Clinical Immunology and Allergology.

Review Editor for Frontiers in Immunology in 2010. Guest Associate Editor for Antioxidants & Redox Signaling (2013). Associate Faculty Member for F1000 (Faculty of 1000) since 2011. Editorial Advisory Board of the Open Autoimmunity Journal since 2008. Ad hoc reviewer for several international journals including: American Journal of Reproductive Immunology, American Journal of Pathology, Apoptosis, Arthritis and Rheumatology, Cell Death and Differentiation, Clinical and Experimental Immunology, Human Reproduction , Immunology , Journal of Immunology , Journal of Leukocyte Biology, Human Gene Therapy, Journal of Autoimmunity, Journal of Immunology, Molecular and Cellular Biology.

Is part of the panel of auditors of the research projects at the University of Padua.

 

Main research interests

Role of cell death in the pathogenesis of systemic vasculitis and connective tissue diseases, with particular reference to the common complications associated with pregnancy and pathology of gender.

 

Role of innate immunity in injury and tissue repair.

 

She has published 140 articles in extenso in international scientific journals (total impact factor> 900). The works have been cited over 5800 times since 1996 (data from the bibliographic citation database Scopus multidisciplinary and updated to January 2014): Scopus “h” index: 40.

 

Recent Publications (2011-2014)

1: Zordan P, Rigamonti E, Freudenberg K, Conti V, Azzoni E, Rovere-Querini P, Brunelli S. Macrophages commit postnatal endothelium-derived progenitors to angiogenesis and restrict endothelial to mesenchymal transition during muscle

regeneration. Cell Death Dis. 2014 Jan 30;5:e1031.

 

2: Maugeri N, Rovere-Querini P, Baldini M, Baldissera E, Sabbadini MG, Bianchi ME, Manfredi AA. Oxidative Stress Elicits Platelet/Leukocyte Inflammatory Interactions via HMGB1: A Candidate for Microvessel Injury in Sytemic Sclerosis. Antioxid Redox Signal. 2014 Jan 17.

 

3: Rovere-Querini P, Clementi E, Brunelli S. Nitric oxide and muscle repair: Multiple actions converging on therapeutic efficacy. Eur J Pharmacol. 2013 Nov 20. pii: S0014-2999(13)00853-4.

 

4: Ramirez GA, Maugeri N, Sabbadini MG, Rovere-Querini P, Manfredi AA. Intravascular immunity as a key to systemic vasculitis: a work in progress, gaining momentum. Clin Exp Immunol. 2013 Oct 15.

 

5: Bozzolo EP, Ramirez GA, Bonavida G, Lanzani C, Scotti R, Dell’antonio G, Baldissera E, Canti V, Manfredi AA, Rovere-Querini P, Sabbadini MG. Efficacy and toxicity of treatments for nephritis in a series of consecutive lupus patients. Autoimmunity. 2013 Dec;46(8):537-46.

 

6: Esposito A, Campana L, Palmisano A, De Cobelli F, Canu T, Santarella F, Colantoni C, Monno A, Vezzoli M, Pezzetti G, Manfredi AA, Rovere-Querini P, Del Maschio A. Magnetic resonance imaging at 7T reveals common events in age-related sarcopenia and in the homeostatic response to muscle sterile injury. PLoS One. 2013;8(3):e59308.

 

7: Maugeri N, Cattaneo M, Rovere-Querini P, Manfredi AA. Platelet clearance by circulating leukocytes: A rare event or a determinant of the “immune continuum”? Platelets. 2013 Feb 12.

 

8: Capobianco A, Rovere-Querini P. Endometriosis, a disease of the macrophage. Front Immunol. 2013 Jan 28;4:9.

 

9: Rigamonti E, Touvier T, Clementi E, Manfredi AA, Brunelli S, Rovere-Querini P. Requirement of inducible nitric oxide synthase for skeletal muscle regeneration after acute damage. J Immunol. 2013 Feb 15;190(4):1767-77.

 

 

10: Mekinian A, Lachassinne E, Nicaise-Roland P, Carbillon L, Motta M, Vicaut E, Boinot C, Avcin T, Letoumelin P, De Carolis S, Rovere-Querini P, Lambert M, Derenne S, Pourrat O, Stirnemann J, Chollet-Martin S, Biasini-Rebaioli C, Rovelli R, Lojacono A, Ambrozic A, Botta A, Benbara A, Pierre F, Allegri F, Nuzzo M, Hatron PY, Tincani A, Fain O, Aurousseau MH, Boffa MC. European registry of

babies born to mothers with antiphospholipid syndrome. Ann Rheum Dis. 2013 Feb;72(2):217-22.

 

11: De Palma C, Morisi F, Cheli S, Pambianco S, Cappello V, Vezzoli M, Rovere-Querini P, Moggio M, Ripolone M, Francolini M, Sandri M, Clementi E. Autophagy as a new therapeutic target in Duchenne muscular dystrophy. Cell Death Dis. 2012 Nov 15;3:e418.

 

12: Ariel A, Maridonneau-Parini I, Rovere-Querini P, Levine JS, Mühl H. Macrophages in inflammation and its resolution. Front Immunol. 2012 Nov 1;3:324.

 

13: Maugeri N, Franchini S, Campana L, Baldini M, Ramirez GA, Sabbadini MG, Rovere-Querini P, Manfredi AA. Circulating platelets as a source of the damage-associated molecular pattern HMGB1 in patients with systemic sclerosis. Autoimmunity. 2012 Dec;45(8):584-7.

 

14: Maugeri N, Rovere-Querini P, Evangelista V, Godino C, Demetrio M, Baldini M, Figini F, Coppi G, Slavich M, Camera M, Bartorelli A, Marenzi G, Campana L, Baldissera E, Sabbadini MG, Cianflone D, Tremoli E, D’Angelo A, Manfredi AA, Maseri A. An intense and short-lasting burst of neutrophil activation

differentiates early acute myocardial infarction from systemic inflammatory syndromes. PLoS One. 2012;7(6):e39484.

 

15: Ramirez GA, Franchini S, Rovere-Querini P, Sabbadini MG, Manfredi AA, Maugeri N. The role of platelets in the pathogenesis of systemic sclerosis. Front Immunol. 2012 Jun 18;3:160.

 

16: Canti V, Maggio L, Ramirez GA, Locatelli A, Cozzolino S, Ramoni V, Ruffatti A, Tonello M, Valsecchi L, Rosa S, Inversetti A, Manfredi AA, Sabbadini MG, Castiglioni MT, Rovere-Querini P. Hypertension negatively affects the pregnancy outcome in patients with antiphospholipid syndrome. Lupus. 2012 Jun;21(7):810-2.

 

17: Alijotas-Reig J, Ferrer-Oliveras R; EUROAPS Study Group. The European Registry on Obstetric Antiphospholipid Syndrome (EUROAPS): a preliminary first year report. Lupus. 2012 Jun;21(7):766-8.

 

18: Bosurgi L, Corna G, Vezzoli M, Touvier T, Cossu G, Manfredi AA, Brunelli S, Rovere-Querini P. Transplanted mesoangioblasts require macrophage IL-10 for survival in a mouse model of muscle injury. J Immunol. 2012 Jun 15;188(12):6267-77.

 

19: Maugeri N, Baldini M, Ramirez GA, Rovere-Querini P, Manfredi AA. Platelet-leukocyte deregulated interactions foster sterile inflammation and tissue damage in immune-mediated vessel diseases. Thromb Res. 2012 Mar;129(3):267-73.

 

20: Taraborelli M, Ramoni V, Brucato A, Airò P, Bajocchi G, Bellisai F, Biasi D, Blagojevic J, Canti V, Caporali R, Caramaschi P, Chiarolanza I, Codullo V, Cozzi F, Cuomo G, Cutolo M, De Santis M, De Vita S, Di Poi E, Doria A, Faggioli P, Favaro M, Ferraccioli G, Ferri C, Foti R, Gerosa A, Gerosa M, Giacuzzo S, Giani L, Giuggioli D, Imazio M, Iudici M, Iuliano A, Leonardi R, Limonta M, Lojacono A,

Lubatti C, Matucci-Cerinic M, Mazzone A, Meroni M, Meroni PL, Mosca M, Motta M, Muscarà M, Nava S, Padovan M, Pagani G, Paolazzi G, Peccatori S, Ravagnani V, Riccieri V, Rosato E, Rovere-Querini P, Salsano F, Santaniello A, Scorza R, Tani

C, Valentini G, Valesini G, Vanoli M, Vigone B, Zeni S, Tincani A; IMPRESS Investigators. Brief report: successful pregnancies but a higher risk of preterm births in patients with systemic sclerosis: an Italian multicenter study. Arthritis Rheum. 2012 Jun;64(6):1970-7.

 

21: Baldini M, Maugeri N, Ramirez GA, Giacomassi C, Castiglioni A,

Prieto-González S, Corbera-Bellalta M, Comite GD, Papa I, Dell’antonio G, Ammirati E, Cuccovillo I, Vecchio V, Mantovani A, Rovere-Querini P, Sabbadini MG, Cid MC, Manfredi AA. Selective up-regulation of the soluble pattern-recognition receptor pentraxin 3 and of vascular endothelial growth factor in giant cell arteritis: relevance for recent optic nerve ischemia. Arthritis Rheum. 2012 Mar;64(3):854-65.

 

22: Canti V, Castiglioni MT, Rosa S, Franchini S, Sabbadini MG, Manfredi AA, Rovere-Querini P. Pregnancy outcomes in patients with systemic autoimmunity. Autoimmunity. 2012 Mar;45(2):169-75.

 

23: Cottone L, Valtorta S, Capobianco A, Belloli S, Rovere-Querini P, Fazio F, Manfredi AA, Moresco RM. Evaluation of the role of tumor-associated macrophages in an experimental model of peritoneal carcinomatosis using (18)F-FDG PET. J Nucl Med. 2011 Nov;52(11):1770-7.

 

24: Capobianco A, Monno A, Cottone L, Venneri MA, Biziato D, Di Puppo F, Ferrari S, De Palma M, Manfredi AA, Rovere-Querini P. Proangiogenic Tie2(+) macrophages infiltrate human and murine endometriotic lesions and dictate their growth in a mouse model of the disease. Am J Pathol. 2011 Nov;179(5):2651-9.

 

25: Maugeri N, Malato S, Femia EA, Pugliano M, Campana L, Lunghi F, Rovere-Querini P, Lussana F, Podda G, Cattaneo M, Ciceri F, Manfredi AA. Clearance of circulating activated platelets in polycythemia vera and essential thrombocythemia. Blood. 2011 Sep 22;118(12):3359-66.

 

26: Maugeri N, Rovere-Querini P, Slavich M, Coppi G, Doni A, Bottazzi B, Garlanda C, Cianflone D, Maseri A, Mantovani A, Manfredi AA. Early and transient release of leukocyte pentraxin 3 during acute myocardial infarction. J Immunol. 2011 Jul 15;187(2):970-9.

 

27: Ruffatti A, Tonello M, Visentin MS, Bontadi A, Hoxha A, De Carolis S, Botta A, Salvi S, Nuzzo M, Rovere-Querini P, Canti V, Mosca M, Mitic G, Bertero MT, Pengo V, Boffa MC, Tincani A. Risk factors for pregnancy failure in patients with anti-phospholipid syndrome treated with conventional therapies: a multicentre,

case-control study. Rheumatology (Oxford). 2011 Sep;50(9):1684-9.

 

28: Pagani A, Nai A, Corna G, Bosurgi L, Rovere-Querini P, Camaschella C, Silvestri L. Low hepcidin accounts for the proinflammatory status associated with iron deficiency. Blood. 2011 Jul 21;118(3):736-46.

 

29: Vezzoli M, Castellani P, Corna G, Castiglioni A, Bosurgi L, Monno A, Brunelli S, Manfredi AA, Rubartelli A, Rovere-Querini P. High-mobility group box 1 release and redox regulation accompany regeneration and remodeling of skeletal muscle. Antioxid Redox Signal. 2011 Oct 15;15(8):2161-74.

 

30: Bosurgi L, Manfredi AA, Rovere-Querini P. Macrophages in injured skeletal muscle: a perpetuum mobile causing and limiting fibrosis, prompting or restricting resolution and regeneration. Front Immunol. 2011 Nov 16;2:62.

 

31: Castiglioni A, Canti V, Rovere-Querini P, Manfredi AA. High-mobility group box 1 (HMGB1) as a master regulator of innate immunity. Cell Tissue Res. 2011 Jan;343(1):189-99.