Ostuni Renato Professore AssociatoMedicineBIO/17

POSIZIONI PROFESSIONALI

2015-ora      Group Leader, Unità di Genomica del Sistema Immunitario Innato
San Raffaele-Telethon Institute for Gene Therapy (SR-Tiget)

FORMAZIONE

2008-2010  Ph.D. in Immunologia - Medicina Traslazionale e     Molecolare (DIMET), Università di Milano-Bicocca, Milano, Italia

2005-2007  Laurea Specialistica in Biotecnologie Industriali (110/110 e lode)
Università di Milano-Bicocca, Milano, Italia

2002-2005  Laurea Triennale in Biotecnologie (110/110 e lode)
Università di Milano-Bicocca, Milano, Italia

POSIZIONI PRECEDENTI

2011-2015   Postdoctoral Fellow, laboratorio di Gioacchino Natoli
Istituto Europeo di Oncologia (IEO), Milano, Italia

06/2012   Postdoctoral Fellow (visiting), laboratorio di Ido Am
Weizmann Institute of Science, Rehovot, Israele

2008-2010  PhD Student, laboratorio di Francesca Granucci e Ivan Zan            Università di Milano-Bicocca, Milano, Italia.

PREMI e RICONOSCIMENTI

2019   Alessandro Moretta Young Investigator Award, Aegean Conferences, Rhodes

2018   Young Investigator Award, European Macrophage and Dendritic Cell Society

2017   European Research Council (ERC) Starting Grant (X-TAM, 759532)

2017   LaboSpace Prize, Italian Society of Immunology and Allergology (SIICA)

2013   Bioeconomy Rome Award, CNCCS Consortium

2012    European Molecular Biology Organization (EMBO) Short-Term Fellowship

2011-2015 European Union FP7th Structured International Post Doc (SIPOD) Fellowship

2008-2010   National PhD Fellowship, Italian Ministry of Health and Research

ATTIVITÀ di INSEGNAMENTO

2019-ora    Istologia (International Medical Doctor Program)                            Università Vita-Salute San Raffaele, Milano, Italia

2015-ora    Esercitazioni pratiche di Istologia    Lezioni per il corso di ‘Cell Therapy’ (Laurea Specialistica in Biotecnologie) -  Università Vita-Salute San Raffaele, Milano, Italia

2013, 2015   Lezioni per il corso di ‘Genomics’ (Ph.D. Program in Molecular Oncology)  IFOM-IEO Campus, Milano, Italia

2010-2012      Esercitazioni pratiche di Immunologia (Laura Triennale in Biotecnologie)

Lezioni per il corso di Immunologia Molecolare (L. Specialistica in Biotecnologie)  Università di Milano-Bicocca, Milano, Italia

ATTIVITÀ PROFESSIONALI, INCARICHI e COMMISSIONI

2018-ora  Membro del Comitato Tecnico-Sanitario del Ministero della Salute - Sezione Ricerca Sanitaria e Giovani Ricercatori

2019-ora  Coordinatore del Comitato Organizzatore del Retreat di Ospedale San Raffaele

2017-2019    Membro del Comitato Organizzatore del Retreat di Ospedale San Raffaele

2017-2019    Membro del Comitato Organizzatore del Retreat di SR-Tiget

2015-2018     Associate Editor di Frontiers in Immunology

2014-ora    Reviewer indipendente per Nature Immunology, Blood, Cell Reports, Journal of Leukocyte Biology, European Journal of Immunology, Nucleic Acid Research, PLOS ONE. Rewiever indipendent per Grant e Fellowship sottomessi al Ministero della Salute (Italia), Wellcome Trust (UK), Swiss Cancer League (CH), European Research Council (ERC)

2015-ora    European Society of Gene and Cell Therapy (ESGCT), Italian Society of Immunology and Allergology (SIICA)

FINANZIAMENTI

2019-2026    5x1000 Program, AIRC - Partner

2018-2023    Starting Grant #759532, European Research Council (ERC) - PI

2018-2023    My First AIRC Grant (MFAG) #20247, AIRC - PI

2018-2021    ‘Giovani Ricercatori’ Grant #2016-02362156, Italian MoH - PI

2017-2020    Infect-ERA Grant #126, ERA-NET - Partner

2016-2019    SR-Tiget Grant Award F04, Telethon Foundation - PI

2016-2019    ‘Giovani Ricercatori’ Grant #2015-0990, Cariplo Foundation - PIo Scientifico San Raffaele, Milano, Italia

FORMAZIONE

2008-2010   Ph.D. in Immunologia - Medicina Traslazionale e Molecolare (DIMET), Università di Milano-Bicocca, Milano, Italia

2005-2007   Laurea Specialistica in Biotecnologie Industriali (110/110 e lode) Università di Milano-Bicocca, Milano, Italia

2002-2005   Laurea Triennale in Biotecnologie (110/110 e lode) Università di Milano-Bicocca, Milano, Italia

POSIZIONI PRECEDENTI

2011-2015              Postdoctoral Fellow, laboratorio di Gioacchino Natoli

                               Istituto Europeo di Oncologia (IEO), Milano, Italia

06/2012                  Postdoctoral Fellow (visiting), laboratorio di Ido Amit

                               Weizmann Institute of Science, Rehovot, Israele

2008-2010              PhD Student, laboratorio di Francesca Granucci e Ivan Zanoni

                               Università di Milano-Bicocca, Milano, Italia.

PREMI e RICONOSCIMENTI

2019                       Alessandro Moretta Young Investigator Award, Aegean Conferences, Rhodes

2018                       Young Investigator Award, European Macrophage and Dendritic Cell Society

2017                       European Research Council (ERC) Starting Grant (X-TAM, 759532)

2017                       LaboSpace Prize, Italian Society of Immunology and Allergology (SIICA)

2013                       Bioeconomy Rome Award, CNCCS Consortium

2012                       European Molecular Biology Organization (EMBO) Short-Term Fellowship

2011-2015              European Union FP7th Structured International Post Doc (SIPOD) Fellowship

2008-2010              National PhD Fellowship, Italian Ministry of Health and Research

1.    Determinants, mechanisms, and functional outcomes of myeloid cell diversity in cancer
Caronni N, Montaldo E, Mezzanzanica L, Cilenti F, Genua M, Ostuni R.
Immunol Rev. 2021 Mar;300(1):220-236. doi: 10.1111/imr.12944.
2.    Co-option of Neutrophil Fates by Tissue Environments
Ballesteros I, Rubio-Ponce A, Genua M, Lusito E, Kwok I, Fernández-Calvo G, Khoyratty TE, van Grinsven E, González-Hernández S, Nicolás-Ávila JÁ, Vicanolo T, Maccataio A, Benguría A, Li JL, Adrover JM, Aroca-Crevillen A, Quintana JA, Martín-Salamanca S, Mayo F, Ascher S, Barbiera G, Soehnlein O, Gunzer M, Ginhoux F, Sánchez-Cabo F, Nistal-Villán E, Schulz C, Dopazo A, Reinhardt C, Udalova IA, Ng LG, Ostuni R, Hidalgo A.
Cell. 2020 Oct 20:S0092-8674(20)31309-X. doi: 10.1016/j.cell.2020.10.003.
3.    Tumor-derived prostaglandin E2 promotes p50 NF-kB-dependent differentiation of monocytic MDSCs.
Porta C, Consonni FM, Morlacchi S, Sangaletti S, Bleve A, Totaro MG, Larghi P, Rimoldi M, Tripodo C, Strauss L, Banfi S, Storto M, Pressiani T, Rimassa L, Tartari S, Ippolito A, Doni A, Soldà G, Duga S, Piccolo V, Ostuni R, Natoli G, Bronte V, Balzac F, Turco E, Hirsch E, Colombo MP, Sica A.
Cancer Res. 2020 Jul 1;80(13):2874-2888. doi: 10.1158/0008-5472.CAN-19-2843.
4.    Dynamics and genomic landscape of CD8+ T cells undergoing intrahepatic priming.
Bénéchet AP, De Simone G, Di Lucia P, Cilenti F, Barbiera G, Le Bert N, Fumagalli V, Lusito E, Moalli F, Bianchessi V, Andreata F, Zordan P, Bono E, Giustini L, Bonilla WV, Bleriot C, Kunasegaran K, Gonzalez-Aseguinolaza G, Pinschewer DD, Kennedy PTF, Naldini L, Kuka M, Ginhoux F, Cantore A, Bertoletti A, Ostuni R, Guidotti LG, Iannacone M. Co-last author
Nature. 2019 Oct 2. doi: 10.1038/s41586-019-1620-6.
5.    Adaptation and memory in immune responses.
Natoli G, Ostuni R. Co-corresponding author
Nat Immunol. 2019 Jul;20(7):783-792.
6.    Immune signature drives leukemia escape and relapse after hematopoietic cell transplantation.
Toffalori C, Zito L, Gambacorta V, Riba M, Oliveira G, Bucci G, Barcella M, Spinelli O, Greco R, Crucitti L, Cieri N, Noviello M, Manfredi F, Montaldo E, Ostuni R, Naldini M, Gentner B, Waterhouse M, Zeiser R, Finke J, Hanoun M, Beelen D, Gojo I, Luznik L, Onozawa M, Teshima T, Devillier R, Blaise D, Halkes C, Griffioen M, Carrabba M, Bernardi M, Peccatori J, Barlassina C, Stupka E, Lazarevic D, Tonon G, Rambaldi F, Cittaro D, Bonini C, Fleischhauer K, Ciceri F, Vago L.
Nat Med. 2019 Apr;25(4):603-611.
7.    Heterogeneity of neutrophils.
Ng LG, Ostuni R, Hidalgo A. Co-corresponding author
Nat Rev Immunol. 2019 Apr;19(4):255-265.
8.    Interferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens.
Escobar G, Barbarossa L, Barbiera G, Norelli M, Genua M, Ranghetti A, Plati T, Camisa B, Brombin C, Cittaro D, Annoni A, Bondanza A, Ostuni R, Gentner B, Naldini L.
Nat Commun. 2018 Jul 24;9(1):2896.
9.    Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells.
Norelli M, Camisa B, Barbiera G, Falcone L, Purevdorj A, Genua M, Sanvito F, Ponzoni M, Doglioni C, Cristofori P, Traversari C, Bordignon C, Ciceri F, Ostuni R, Bonini C, Casucci M, Bondanza A.
Nat Med. 2018 Jun;24(6):739-748.
10.    Opposing macrophage polarization programs show extensive epigenomic and transcriptional cross-talk.
Piccolo V, Curina A, Genua M, Ghisletti S, Simonatto M, Sabò A, Amati B, Ostuni R, Natoli G. Co-last and co-corresponding author
Nat Immunol. 2017 Mar 13.
11.    Inflammatory monocytes hinder antiviral B cell responses.
Sammicheli S, Kuka M, Di Lucia P, de Oya NJ, De Giovanni M, Fioravanti J, Cristofani C, Maganuco CG, Fallet B, Ganzer L, Sironi L, Mainetti M, Ostuni R, Larimore K, Greenberg PD, de la Torre JC, Guidotti LG, Iannacone M.
Sci Immunol. 2016 Oct 21;1(4). pii: eaah6789.
12.    Mutual epithelium-macrophage dependency in liver carcinogenesis mediated by ST18.
Ravà M, D'Andrea A, Doni M, Kress TR, Ostuni R, Bianchi V, Morelli MJ, Colin A, Ghisletti S, Nicoli P, Recordati C, Iascone M, Sonzogni A, D'Antiga L, Shukla R, Faulkner GJ, Natoli G, Campaner S, Amati B.
Hepatology. 2017 May;65(5):1708-1719.
13.    TNF-Mediated Restriction of Arginase 1 Expression in Myeloid Cells Triggers Type 2 NO Synthase Activity at the Site of Infection.
Schleicher U, Paduch K, Debus A, Obermeyer S, König T, Kling JC, Ribechini E, Dudziak D, Mougiakakos D, Murray PJ, Ostuni R, Körner H, Bogdan C.
Cell Rep. 2016 May 3;15(5):1062-75.
14.    Epigenetic regulation of neutrophil development and function.
Ostuni R, Natoli G, Cassatella MA, Tamassia N. Co-corresponding author
Semin Immunol. 2016 Apr;28(2):83-93.
15.    Macrophages and cancer: from mechanisms to therapeutic implications.
Ostuni R, Kratochvill F, Murray PJ, Natoli G. Co-corresponding author
Trends Immunol. 2015 Apr;36(4):229-39.
16.    A dual cis-regulatory code links IRF8 to constitutive and inducible gene expression in macrophages.
Mancino A, Termanini A, Barozzi I, Ghisletti S, Ostuni R, Prosperini E, Ozato K, Natoli G.
Genes Dev. 2015 Feb 15;29(4):394-408.

17.    Chromatin remodelling and autocrine TNFα are required for optimal interleukin-6 expression in activated human neutrophils.
Zimmermann M, Aguilera FB, Castellucci M, Rossato M, Costa S, Lunardi C, Ostuni R, Girolomoni G, Natoli G, Bazzoni F, Tamassia N, Cassatella MA.
Nat Commun. 2015 Jan 23;6:6061.
18.    Lineages, cell types and functional states: a genomic view.
Ostuni R, Natoli G. Co-corresponding author
Curr Opin Cell Biol. 2013 Dec;25(6):759-64.
19.    Cutting edge: An inactive chromatin configuration at the IL-10 locus in human neutrophils.
Tamassia N, Zimmermann M, Castellucci M, Ostuni R, Bruderek K, Schilling B, Brandau S, Bazzoni F, Natoli G, Cassatella MA.
J Immunol. 2013 Mar 1;190(5):1921-5.
20.    Latent enhancers activated by stimulation in differentiated cells.
Ostuni R, Piccolo V, Barozzi I, Polletti S, Termanini A, Bonifacio S, Curina A, Prosperini E, Ghisletti S, Natoli G. Co-corresponding author
Cell. 2013 Jan 17;152(1-2):157-71.
21.    The histone methyltransferase Wbp7 controls macrophage function through GPI glycolipid anchor synthesis.
Austenaa L, Barozzi I, Chronowska A, Termanini A, Ostuni R, Prosperini E, Stewart AF, Testa G, Natoli G.
Immunity. 2012 Apr 20;36(4):572-85.
22.    CD14 and NFAT mediate lipopolysaccharide-induced skin edema formation in mice.
Zanoni I, Ostuni R, Barresi S, Di Gioia M, Broggi A, Costa B, Marzi R, Granucci F. Co-first author
J Clin Invest. 2012 May;122(5):1747-57.
23.    Similarities and differences of innate immune responses elicited by smooth and rough LPS.
Zanoni I, Bodio C, Broggi A, Ostuni R, Caccia M, Collini M, Venkatesh A, Spreafico R, Capuano G, Granucci F.
Immunol Lett. 2012 Feb 29;142(1-2):41-7.
24.    CD14 controls the LPS-induced endocytosis of Toll-like receptor 4.
Zanoni I, Ostuni R, Marek LR, Barresi S, Barbalat R, Barton GM, Granucci F, Kagan JC.
Cell. 2011 Nov 11;147(4):868-80.
25.    Transcriptional control of macrophage diversity and specialization.
Ostuni R, Natoli G.
Eur J Immunol. 2011 Sep;41(9):2486-90.
26.    DC-ATLAS: a systems biology resource to dissect receptor specific signal transduction in dendritic cells.
Cavalieri D, Rivero D, Beltrame L, Buschow SI, Calura E, Rizzetto L, Gessani S, Gauzzi MC, Reith W, Baur A, Bonaiuti R, Brandizi M, De Filippo C, D'Oro U, Draghici S, Dunand-Sauthier I, Gatti E, Granucci F, Gündel M, Kramer M, Kuka M, Lanyi A, Melief CJ, van Montfoort N, Ostuni R, Pierre P, Popovici R, Rajnavolgyi E, Schierer S, Schuler G, Soumelis V, Splendiani A, Stefanini I, Torcia MG, Zanoni I, Zollinger R, Figdor CG, Austyn JM.
Immunome Res. 2010 Nov 19;6:10.
27.    Deciphering the complexity of Toll-like receptor signaling.
Ostuni R, Zanoni I, Granucci F.
Cell Mol Life Sci. 2010 Dec;67(24):4109-34.
28.    CD14 regulates the dendritic cell life cycle after LPS exposure through NFAT activation.
Zanoni I, Ostuni R, Capuano G, Collini M, Caccia M, Ronchi AE, Rocchetti M, Mingozzi F, Foti M, Chirico G, Costa B, Zaza A, Ricciardi-Castagnoli P, Granucci F.
Nature. 2009 Jul 9;460(7252):264-8.