Ostuni Renato Professore AssociatoMedicineBIO/17
Biografia
Publications
Biografia
POSIZIONI PROFESSIONALI
2015-ora Group Leader, Unità di Genomica del Sistema Immunitario Innato
San Raffaele-Telethon Institute for Gene Therapy (SR-Tiget)
FORMAZIONE
2008-2010 Ph.D. in Immunologia - Medicina Traslazionale e Molecolare (DIMET), Università di Milano-Bicocca, Milano, Italia
2005-2007 Laurea Specialistica in Biotecnologie Industriali (110/110 e lode)
Università di Milano-Bicocca, Milano, Italia
2002-2005 Laurea Triennale in Biotecnologie (110/110 e lode)
Università di Milano-Bicocca, Milano, Italia
POSIZIONI PRECEDENTI
2011-2015 Postdoctoral Fellow, laboratorio di Gioacchino Natoli
Istituto Europeo di Oncologia (IEO), Milano, Italia
06/2012 Postdoctoral Fellow (visiting), laboratorio di Ido Am
Weizmann Institute of Science, Rehovot, Israele
2008-2010 PhD Student, laboratorio di Francesca Granucci e Ivan Zan Università di Milano-Bicocca, Milano, Italia.
PREMI e RICONOSCIMENTI
2019 Alessandro Moretta Young Investigator Award, Aegean Conferences, Rhodes
2018 Young Investigator Award, European Macrophage and Dendritic Cell Society
2017 European Research Council (ERC) Starting Grant (X-TAM, 759532)
2017 LaboSpace Prize, Italian Society of Immunology and Allergology (SIICA)
2013 Bioeconomy Rome Award, CNCCS Consortium
2012 European Molecular Biology Organization (EMBO) Short-Term Fellowship
2011-2015 European Union FP7th Structured International Post Doc (SIPOD) Fellowship
2008-2010 National PhD Fellowship, Italian Ministry of Health and Research
ATTIVITÀ di INSEGNAMENTO
2019-ora Istologia (International Medical Doctor Program) Università Vita-Salute San Raffaele, Milano, Italia
2015-ora Esercitazioni pratiche di Istologia Lezioni per il corso di ‘Cell Therapy’ (Laurea Specialistica in Biotecnologie) - Università Vita-Salute San Raffaele, Milano, Italia
2013, 2015 Lezioni per il corso di ‘Genomics’ (Ph.D. Program in Molecular Oncology) IFOM-IEO Campus, Milano, Italia
2010-2012 Esercitazioni pratiche di Immunologia (Laura Triennale in Biotecnologie)
Lezioni per il corso di Immunologia Molecolare (L. Specialistica in Biotecnologie) Università di Milano-Bicocca, Milano, Italia
ATTIVITÀ PROFESSIONALI, INCARICHI e COMMISSIONI
2018-ora Membro del Comitato Tecnico-Sanitario del Ministero della Salute - Sezione Ricerca Sanitaria e Giovani Ricercatori
2019-ora Coordinatore del Comitato Organizzatore del Retreat di Ospedale San Raffaele
2017-2019 Membro del Comitato Organizzatore del Retreat di Ospedale San Raffaele
2017-2019 Membro del Comitato Organizzatore del Retreat di SR-Tiget
2015-2018 Associate Editor di Frontiers in Immunology
2014-ora Reviewer indipendente per Nature Immunology, Blood, Cell Reports, Journal of Leukocyte Biology, European Journal of Immunology, Nucleic Acid Research, PLOS ONE. Rewiever indipendent per Grant e Fellowship sottomessi al Ministero della Salute (Italia), Wellcome Trust (UK), Swiss Cancer League (CH), European Research Council (ERC)
2015-ora European Society of Gene and Cell Therapy (ESGCT), Italian Society of Immunology and Allergology (SIICA)
FINANZIAMENTI
2019-2026 5x1000 Program, AIRC - Partner
2018-2023 Starting Grant #759532, European Research Council (ERC) - PI
2018-2023 My First AIRC Grant (MFAG) #20247, AIRC - PI
2018-2021 ‘Giovani Ricercatori’ Grant #2016-02362156, Italian MoH - PI
2017-2020 Infect-ERA Grant #126, ERA-NET - Partner
2016-2019 SR-Tiget Grant Award F04, Telethon Foundation - PI
2016-2019 ‘Giovani Ricercatori’ Grant #2015-0990, Cariplo Foundation - PIo Scientifico San Raffaele, Milano, Italia
FORMAZIONE
2008-2010 Ph.D. in Immunologia - Medicina Traslazionale e Molecolare (DIMET), Università di Milano-Bicocca, Milano, Italia
2005-2007 Laurea Specialistica in Biotecnologie Industriali (110/110 e lode) Università di Milano-Bicocca, Milano, Italia
2002-2005 Laurea Triennale in Biotecnologie (110/110 e lode) Università di Milano-Bicocca, Milano, Italia
POSIZIONI PRECEDENTI
2011-2015 Postdoctoral Fellow, laboratorio di Gioacchino Natoli
Istituto Europeo di Oncologia (IEO), Milano, Italia
06/2012 Postdoctoral Fellow (visiting), laboratorio di Ido Amit
Weizmann Institute of Science, Rehovot, Israele
2008-2010 PhD Student, laboratorio di Francesca Granucci e Ivan Zanoni
Università di Milano-Bicocca, Milano, Italia.
PREMI e RICONOSCIMENTI
2019 Alessandro Moretta Young Investigator Award, Aegean Conferences, Rhodes
2018 Young Investigator Award, European Macrophage and Dendritic Cell Society
2017 European Research Council (ERC) Starting Grant (X-TAM, 759532)
2017 LaboSpace Prize, Italian Society of Immunology and Allergology (SIICA)
2013 Bioeconomy Rome Award, CNCCS Consortium
2012 European Molecular Biology Organization (EMBO) Short-Term Fellowship
2011-2015 European Union FP7th Structured International Post Doc (SIPOD) Fellowship
2008-2010 National PhD Fellowship, Italian Ministry of Health and Research
Publications
1. Determinants, mechanisms, and functional outcomes of myeloid cell diversity in cancer
Caronni N, Montaldo E, Mezzanzanica L, Cilenti F, Genua M, Ostuni R.
Immunol Rev. 2021 Mar;300(1):220-236. doi: 10.1111/imr.12944.
2. Co-option of Neutrophil Fates by Tissue Environments
Ballesteros I, Rubio-Ponce A, Genua M, Lusito E, Kwok I, Fernández-Calvo G, Khoyratty TE, van Grinsven E, González-Hernández S, Nicolás-Ávila JÁ, Vicanolo T, Maccataio A, Benguría A, Li JL, Adrover JM, Aroca-Crevillen A, Quintana JA, Martín-Salamanca S, Mayo F, Ascher S, Barbiera G, Soehnlein O, Gunzer M, Ginhoux F, Sánchez-Cabo F, Nistal-Villán E, Schulz C, Dopazo A, Reinhardt C, Udalova IA, Ng LG, Ostuni R, Hidalgo A.
Cell. 2020 Oct 20:S0092-8674(20)31309-X. doi: 10.1016/j.cell.2020.10.003.
3. Tumor-derived prostaglandin E2 promotes p50 NF-kB-dependent differentiation of monocytic MDSCs.
Porta C, Consonni FM, Morlacchi S, Sangaletti S, Bleve A, Totaro MG, Larghi P, Rimoldi M, Tripodo C, Strauss L, Banfi S, Storto M, Pressiani T, Rimassa L, Tartari S, Ippolito A, Doni A, Soldà G, Duga S, Piccolo V, Ostuni R, Natoli G, Bronte V, Balzac F, Turco E, Hirsch E, Colombo MP, Sica A.
Cancer Res. 2020 Jul 1;80(13):2874-2888. doi: 10.1158/0008-5472.CAN-19-2843.
4. Dynamics and genomic landscape of CD8+ T cells undergoing intrahepatic priming.
Bénéchet AP, De Simone G, Di Lucia P, Cilenti F, Barbiera G, Le Bert N, Fumagalli V, Lusito E, Moalli F, Bianchessi V, Andreata F, Zordan P, Bono E, Giustini L, Bonilla WV, Bleriot C, Kunasegaran K, Gonzalez-Aseguinolaza G, Pinschewer DD, Kennedy PTF, Naldini L, Kuka M, Ginhoux F, Cantore A, Bertoletti A, Ostuni R, Guidotti LG, Iannacone M. Co-last author
Nature. 2019 Oct 2. doi: 10.1038/s41586-019-1620-6.
5. Adaptation and memory in immune responses.
Natoli G, Ostuni R. Co-corresponding author
Nat Immunol. 2019 Jul;20(7):783-792.
6. Immune signature drives leukemia escape and relapse after hematopoietic cell transplantation.
Toffalori C, Zito L, Gambacorta V, Riba M, Oliveira G, Bucci G, Barcella M, Spinelli O, Greco R, Crucitti L, Cieri N, Noviello M, Manfredi F, Montaldo E, Ostuni R, Naldini M, Gentner B, Waterhouse M, Zeiser R, Finke J, Hanoun M, Beelen D, Gojo I, Luznik L, Onozawa M, Teshima T, Devillier R, Blaise D, Halkes C, Griffioen M, Carrabba M, Bernardi M, Peccatori J, Barlassina C, Stupka E, Lazarevic D, Tonon G, Rambaldi F, Cittaro D, Bonini C, Fleischhauer K, Ciceri F, Vago L.
Nat Med. 2019 Apr;25(4):603-611.
7. Heterogeneity of neutrophils.
Ng LG, Ostuni R, Hidalgo A. Co-corresponding author
Nat Rev Immunol. 2019 Apr;19(4):255-265.
8. Interferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens.
Escobar G, Barbarossa L, Barbiera G, Norelli M, Genua M, Ranghetti A, Plati T, Camisa B, Brombin C, Cittaro D, Annoni A, Bondanza A, Ostuni R, Gentner B, Naldini L.
Nat Commun. 2018 Jul 24;9(1):2896.
9. Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells.
Norelli M, Camisa B, Barbiera G, Falcone L, Purevdorj A, Genua M, Sanvito F, Ponzoni M, Doglioni C, Cristofori P, Traversari C, Bordignon C, Ciceri F, Ostuni R, Bonini C, Casucci M, Bondanza A.
Nat Med. 2018 Jun;24(6):739-748.
10. Opposing macrophage polarization programs show extensive epigenomic and transcriptional cross-talk.
Piccolo V, Curina A, Genua M, Ghisletti S, Simonatto M, Sabò A, Amati B, Ostuni R, Natoli G. Co-last and co-corresponding author
Nat Immunol. 2017 Mar 13.
11. Inflammatory monocytes hinder antiviral B cell responses.
Sammicheli S, Kuka M, Di Lucia P, de Oya NJ, De Giovanni M, Fioravanti J, Cristofani C, Maganuco CG, Fallet B, Ganzer L, Sironi L, Mainetti M, Ostuni R, Larimore K, Greenberg PD, de la Torre JC, Guidotti LG, Iannacone M.
Sci Immunol. 2016 Oct 21;1(4). pii: eaah6789.
12. Mutual epithelium-macrophage dependency in liver carcinogenesis mediated by ST18.
Ravà M, D'Andrea A, Doni M, Kress TR, Ostuni R, Bianchi V, Morelli MJ, Colin A, Ghisletti S, Nicoli P, Recordati C, Iascone M, Sonzogni A, D'Antiga L, Shukla R, Faulkner GJ, Natoli G, Campaner S, Amati B.
Hepatology. 2017 May;65(5):1708-1719.
13. TNF-Mediated Restriction of Arginase 1 Expression in Myeloid Cells Triggers Type 2 NO Synthase Activity at the Site of Infection.
Schleicher U, Paduch K, Debus A, Obermeyer S, König T, Kling JC, Ribechini E, Dudziak D, Mougiakakos D, Murray PJ, Ostuni R, Körner H, Bogdan C.
Cell Rep. 2016 May 3;15(5):1062-75.
14. Epigenetic regulation of neutrophil development and function.
Ostuni R, Natoli G, Cassatella MA, Tamassia N. Co-corresponding author
Semin Immunol. 2016 Apr;28(2):83-93.
15. Macrophages and cancer: from mechanisms to therapeutic implications.
Ostuni R, Kratochvill F, Murray PJ, Natoli G. Co-corresponding author
Trends Immunol. 2015 Apr;36(4):229-39.
16. A dual cis-regulatory code links IRF8 to constitutive and inducible gene expression in macrophages.
Mancino A, Termanini A, Barozzi I, Ghisletti S, Ostuni R, Prosperini E, Ozato K, Natoli G.
Genes Dev. 2015 Feb 15;29(4):394-408.
17. Chromatin remodelling and autocrine TNFα are required for optimal interleukin-6 expression in activated human neutrophils.
Zimmermann M, Aguilera FB, Castellucci M, Rossato M, Costa S, Lunardi C, Ostuni R, Girolomoni G, Natoli G, Bazzoni F, Tamassia N, Cassatella MA.
Nat Commun. 2015 Jan 23;6:6061.
18. Lineages, cell types and functional states: a genomic view.
Ostuni R, Natoli G. Co-corresponding author
Curr Opin Cell Biol. 2013 Dec;25(6):759-64.
19. Cutting edge: An inactive chromatin configuration at the IL-10 locus in human neutrophils.
Tamassia N, Zimmermann M, Castellucci M, Ostuni R, Bruderek K, Schilling B, Brandau S, Bazzoni F, Natoli G, Cassatella MA.
J Immunol. 2013 Mar 1;190(5):1921-5.
20. Latent enhancers activated by stimulation in differentiated cells.
Ostuni R, Piccolo V, Barozzi I, Polletti S, Termanini A, Bonifacio S, Curina A, Prosperini E, Ghisletti S, Natoli G. Co-corresponding author
Cell. 2013 Jan 17;152(1-2):157-71.
21. The histone methyltransferase Wbp7 controls macrophage function through GPI glycolipid anchor synthesis.
Austenaa L, Barozzi I, Chronowska A, Termanini A, Ostuni R, Prosperini E, Stewart AF, Testa G, Natoli G.
Immunity. 2012 Apr 20;36(4):572-85.
22. CD14 and NFAT mediate lipopolysaccharide-induced skin edema formation in mice.
Zanoni I, Ostuni R, Barresi S, Di Gioia M, Broggi A, Costa B, Marzi R, Granucci F. Co-first author
J Clin Invest. 2012 May;122(5):1747-57.
23. Similarities and differences of innate immune responses elicited by smooth and rough LPS.
Zanoni I, Bodio C, Broggi A, Ostuni R, Caccia M, Collini M, Venkatesh A, Spreafico R, Capuano G, Granucci F.
Immunol Lett. 2012 Feb 29;142(1-2):41-7.
24. CD14 controls the LPS-induced endocytosis of Toll-like receptor 4.
Zanoni I, Ostuni R, Marek LR, Barresi S, Barbalat R, Barton GM, Granucci F, Kagan JC.
Cell. 2011 Nov 11;147(4):868-80.
25. Transcriptional control of macrophage diversity and specialization.
Ostuni R, Natoli G.
Eur J Immunol. 2011 Sep;41(9):2486-90.
26. DC-ATLAS: a systems biology resource to dissect receptor specific signal transduction in dendritic cells.
Cavalieri D, Rivero D, Beltrame L, Buschow SI, Calura E, Rizzetto L, Gessani S, Gauzzi MC, Reith W, Baur A, Bonaiuti R, Brandizi M, De Filippo C, D'Oro U, Draghici S, Dunand-Sauthier I, Gatti E, Granucci F, Gündel M, Kramer M, Kuka M, Lanyi A, Melief CJ, van Montfoort N, Ostuni R, Pierre P, Popovici R, Rajnavolgyi E, Schierer S, Schuler G, Soumelis V, Splendiani A, Stefanini I, Torcia MG, Zanoni I, Zollinger R, Figdor CG, Austyn JM.
Immunome Res. 2010 Nov 19;6:10.
27. Deciphering the complexity of Toll-like receptor signaling.
Ostuni R, Zanoni I, Granucci F.
Cell Mol Life Sci. 2010 Dec;67(24):4109-34.
28. CD14 regulates the dendritic cell life cycle after LPS exposure through NFAT activation.
Zanoni I, Ostuni R, Capuano G, Collini M, Caccia M, Ronchi AE, Rocchetti M, Mingozzi F, Foti M, Chirico G, Costa B, Zaza A, Ricciardi-Castagnoli P, Granucci F.
Nature. 2009 Jul 9;460(7252):264-8.
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