Codazzi Franca Professore associatoMedicineBIO/09

Education

1997: PhD in Pharmacology and Toxicology, School of Medicine, University of Milan

1992: Master’s degree in Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Milan

Professional experiences

2018-today: Associate Professor of Physiology, School of Medicine, San Raffaele University

2013-2018: Assistant Professor of Physiology, School of Medicine, San Raffaele University

2000-2013: Assistant Researcher, Scientific Institute San Raffaele

1998-1999: Post-doctoral Associate, Cell Biology Department, Duke University Medical Center, Durham, NC, USA

1996-1998: Post-doctoral Fellow, Scientific Institute San Raffaele

1992-1996: Doctoral Fellow, Scientific Institute San Raffaele and University of Milan

 

Research fields

The main areas of research are in the field of neuroscience, with particular interest in the study of synaptic activity as well as of the mechanisms for calcium and iron handling in neurons and glial cells, both in physiological and pathological conditions. Calcium and iron are indeed essential to neuronal activity, but they can both contribute to neurotoxic processes and neurodegenerative diseases. This is the case, for example, in Friedreich's ataxia, characterized by iron mishandling and by the consequent oxidative stress.

Advanced techniques of fluorescence microscopy, cellular and molecular biology approaches and neuronal and glial in vitro models (obtained from primary murine cultures or derived from human iPSC) are used to study pathophysiological mechanisms in the CNS, thus opening the possibility to new therapeutic approaches.

 

Pubblicazioni (dal 1999)

Tulli S, Del Bondio A, Baderna V, Mazza D, Codazzi F, Pierson TM, Ambrosi A, Nolte D, Goizet C, Toro C, Baets J, Deconinck T, DeJonghe P, Mandich P, Casari G, Maltecca F. Pathogenic variants in the AFG3L2 proteolytic domain cause SCA28 through haploinsufficiency and proteostatic stress-driven OMA1 activation. J Med Genet. Mar 25. [Epub ahead of print] 2019

 

Vannocci T, Notario Manzano R, Beccalli O, Bettegazzi B, Grohovaz F, Cinque G, de Riso A, Quaroni L, Codazzi F, Pastore A. Adding a temporal dimension to the study of Friedreich's ataxia: the effect of frataxin overexpression in a human cell model. Dis Model Mech. Jun 25;11(6). 2018

 

Bettegazzi B, Bellani S, Roncon P, Guarnieri FC, Bertero A, Codazzi F, Valtorta F, Simonato M, Grohovaz F, Zacchetti D. eIF4B phosphorylation at Ser504 links synaptic activity with protein translation in physiology and pathology. Sci Rep. Sep 5;7(1):10563. 2017

 

Codazzi F, Hu A, Rai M, Salerno Scarzella F, Mangiameli E, Pelizzoni I, Grohovaz F, Pandolfo M. Friedreich ataxia induced pluripotent stem cell-derived neurons show a cellular phenotype that is corrected by a benzamide HDAC inhibitor. Hum Mol Genet. 25(22):4847-4855, 2016

 

Codazzi F, Pelizzoni I, Zacchetti D, Grohovaz F. Iron entry in neurons and astrocytes: a link with synaptic activity. Frontiers in Molecular Neuroscience 3: 8-18, 2015

 

Maccarinelli F, Pagani A, Cozzi A, Codazzi F, Di Giacomo G, Capoccia S, Rapino S, Finazzi D, Politi LS, Cirulli F, Giorgio M, Cremona O, Levi S, Grohovaz F. A novel neuroferritinopathy mouse model (FTL 498InsTC) shows progressive brain iron dysregulation, morphological signs of early neurodegeneration and motor coordination deficits. Neurobiology of Disease 81:119-33, 2015

 

Maltecca F, Baseggio E, Consolato F, Mazza D, Podini P, Young SM Jr, Drago I, Bahr BA, Puliti A, Codazzi F, Quattrini A, Casari G. Purkinje neuron Ca2+ influx reduction rescues ataxia in SCA28 model. J Clin Invest. J Clin Invest. 125(1):263-74, 2015

 

Lazzaro M, Bettegazzi B, Barbariga M, Codazzi F, Zacchetti D, Alessio M. Ceruloplasmin potentiates nitric oxide synthase activity and cytokine secretion in activated microglia. J Neuroinflammation. 11(1):164, 2014

 

Macco R, Pelizzoni I, Consonni A, Vitali I, Giacalone G, Martinelli Boneschi F, Codazzi F, Grohovaz F, Zacchetti D. Astrocytes acquire resistance to iron-dependent oxidative stress upon proinflammatory activation. J Neuroinflammation. 10:130, 2013

 

Pelizzoni I, Zacchetti D, Campanella A, Grohovaz F, Codazzi F. Iron uptake in quiescent and inflammation-activated astrocytes: a potentially neuroprotective control of iron burden. Biochim Biophys Acta. 1832(8):1326-33, 2013

 

Pelizzoni I, Zacchetti D, Smith CP, Grohovaz F, Codazzi F. Expression of divalent metal transporter 1 in primary hippocampal neurons: reconsidering its role in non-transferrin-bound iron influx. J Neurochem. 120:269-78, 2012

 

Olivieri S, Conti A, Iannaccone S, Cannistraci CV, Campanella A, Barbariga M, Codazzi F, Pelizzoni I, Magnani G, Pesca M, Franciotta D, Cappa SF, Alessio M. Ceruloplasmin oxidation, a feature of Parkinson's disease CSF, inhibits ferroxidase activity and promotes cellular iron retention. J Neurosci. 31:18568-772011, 2011

 

Consonni A, Morara S, Codazzi F, Grohovaz F, Zacchetti D. Inhibition of lipopolysaccharide-induced microglia activation by calcitonin gene related peptide and adrenomedullin. Mol Cell Neurosci, 48:151-60, 2011

 

Pelizzoni I, Macco R, Morini MF, Zacchetti D, Grohovaz F, and Codazzi F. Iron handling in hippocampal neurons: activity-dependent iron entry and mitochondria-mediated neurotoxicity. Aging Cell 10:172-83, 2011

 

Bettegazzi B, Mihailovich M, Di Cesare A, Consonni A, Macco R, Pelizzoni I, Codazzi F, Grohovaz F and Zacchetti D β-secretase Activity in Rat Astrocytes: Translational Block of BACE1 and Modulation of BACE2 Expression. Eur. J. Neurosci,.33:236-43, 2011

 

D’Antoni S, Zambusi L, Codazzi F, Zacchetti D, Grohovaz F, Provini L, Catania MV, Morara S. Calcitonin Gene-Related Peptide (CGRP) stimulates Purkinje cell dendrite growth in culture. Neurochemical Research  35:2135-43, 2010

 

Pelizzoni I, Macco M, Zacchetti D, Grohovaz F, Codazzi F. Iron and calcium in central nervous system: a close relationship in health and sickness. Biochem. Soc. Trans., 36:1309-12, 2008

 

Chiulli N, Codazzi F, Di Cesare A, Gravaghi C, Zacchetti D, Grohovaz F. Sphingosylphosphocholine effects on cultured astrocytes reveal mechanisms potentially involved in neurotoxicity in Niemann-Pick type A disease. Eur. J. Neurosci., 26(4):875-81, 2007

 

Codazzi F, Di Cesare A, Chiulli N, Albanese A, Meyer T, Zacchetti D, Grohovaz F. Synergistic control of protein kinase Cgamma activity by ionotropic and metabotropic glutamate receptor inputs in hippocampal neurons. J Neurosci., 26(13):3404-11, 2006

 

Negri L, Lattanzi R, Giannini E, Colucci MA, Mignogna G, Barra D, Grohovaz F, Codazzi F, Kaiser A, Kreil G, Melchiorri P. Biological activities of Bv8 analogues.  Br J Pharmacol., 146(5):625-32, 2005

 

Vangelista L, Soprana E, Cesco-Gaspere M, Mandiola P, Di Lullo G, Fucci RN, Codazzi F, Palini A, Paganelli G, Burrone OR, Siccardi AG. Membrane IgE binds and activates Fc epsilon RI in an antigen-independent manner. J Immunol., 174(9):5602-11, 2005

 

Pietri Tonelli D, Mihailovich M, Di Cesare A, Codazzi F, Grohovaz F, Zacchetti D.  Translational regulation of BACE-1 expression in neuronal and non-neuronal cells. Nucleic Acids Research, 32: 1808-1817, 2004

 

Codazzi F, Teruel MN, Meyer T. Control of astrocyte Ca2+ oscillations and waves by oscillating translocation and activation of protein kinase C. Curr. Biol., 11: 1089-1097, 2001.

 

Haugh JM, Codazzi F, Teruel M, Meyer T. Spatial sensing in fibroblasts mediated by 3' phosphoinositide. J. Cell Biol., 151: 1269-1279, 2000

 

Improta-Brears, T, Whorton AR, Codazzi F, York J.D, Meyer T, McDonnell PD. Estrogen-induced activation of mitogen-activated protein kinase requires mobilization of intracellular calcium. Proc Natl. Acad. Sci., USA 96:4686-4691, 1999

 

Bertuzzi F, Davalli AM, Nano R, Socci C, Codazzi F, Fesce R, Di Carlo V, Pozza G, Grohovaz F. Mechanisms of Coordination of Ca2+ Signals in Pancreatic Islet Cells. Diabetes, 48: 1971-1978, 1999