Regoni Maria Ricercatore tempo determinato tipo aMedicineBIO/14

Born in Lovere (BG) on 30/01/1988.

2017: PhD in Molecular Genetics, Biotechnology and Experimental Medicine at the University of Brescia (Faculty of Medicine).

2012: Honors Degree in Medical Biotechnology at the University of Brescia (Faculty of Medicine).

2010: Bachelor’s Degree in Biotechnologies (Faculty of Medicine).

 

Curriculum
From 2017 to 2023 postdoctoral fellow at the Laboratory of Neuropsychopharmacology (Division of Neuroscience) Vita-Salute San Raffaele University of Milan, studying cellular dysfunctions and molecular mechanisms underlying neurodegeneration and pathogenesis in mouse models of Juvenile Parkinsonism (ARJP) to identify new targets for neuroprotective approaches.

In 2018 she was a visiting scientist at the Department of Pharmacology, University of Ferrara.

Since March 2023, she holds the position of assistant professor of Pharmacology (SSD/BIO-14) at the Vita-Salute San Raffaele University.

 

Research Areas

Cellular dysfunctions and molecular mechanisms underlying neurodegeneration to identify new molecular targets for pharmacological strategies aimed at neuroprotection. In particular, the research activity aims at understanding synaptic alterations, molecular mechanisms of neurotransmission and their imbalances in neurological diseases. Specifically, her studies aim at studying the role of glutamatergic receptors in Autosomal Recessive Juvenile Parkinsonism (ARJP) caused by mutations in the PARK2 gene, and at validating the kainate receptor as a new potential target in the neuroprotective therapy of ARJP.

 

Teaching Experiences

2023-present: Assistant Professor in Pharmacology (SSD/BIO-14), Vita-Salute San Raffaele University.

2020-2022: Lecturer in Pharmacology (Bachelor’s Degree in Nursing, Master's Degree in Nursing and Midwifery, Bachelor’s Degree in Biotechnology Research in Medicine, Master's Degree in Medicine and Surgery, at the Vita-Salute San Raffaele University, Faculty of Medicine).

 

Unique identifiers

SCOPUS AUTHOR ID: 56168647500

ORCID ID: 0000-0002-7162-7447

WEB OF SCIENCE RESEARCHER ID: AAN-4376-2020

Goerttler T, Zanetti L, Regoni M, Egger K, Kellner E, Deuschl C, Kleinschnitz C, Sassone J, and Klebe S. Adult-onset Alexander disease: new causal mutation in the GFAP gene. Neurol Genet. 2022 May 20;8(3):e681. doi: 10.1212/NXG.0000000000000681. eCollection 2022 Jun.PMID: 35620133

 

Zanetti L*, Regoni M*, Ratti E, Valtorta F, Sassone J. Presynaptic AMPA Receptors in Health and Disease. Cells. 2021 Aug 31;10(9):2260. doi: 10.3390/cells10092260. *Equal contribution to this work

 

Cattaneo S, Regoni M, Sassone J, Taverna S. Cell-attached and Whole-cell Patch-clamp Recordings of Dopamine Neurons in the Substantia Nigra Pars Compacta of Mouse Brain Slices. Bio Protoc. 2021 Aug 5;11(15):e4109. doi: 10.21769/BioProtoc.4109. eCollection 2021 Aug 5.

(JCI year of publication: 0.22; Number of citations: 1)

 

Bastioli G*, Regoni M*, Cazzaniga F, De Luca CMG, Bistaffa E, Zanetti L, Moda F, Valtorta F, Sassone J. Animal Models of Autosomal Recessive Parkinsonism. Biomedicines. 2021 Jul 13;9(7):812. doi: 10.3390/biomedicines9070812. *Equal contribution to this work

(IF year of publication: 4.757; Number of citations: 3)

 

Regoni M, Zanetti L, Comai S, Mercatelli D, Novello S, Albanese F, Croci L, Consalez GG, Ciammola A, Valtorta F, Morari M, Sassone J. Early dysfunction of substantia nigra dopamine neurons in the parkinq311x mouse. Biomedicines. 2021 May 5;9(5):514. doi: 10.3390/biomedicines9050514.

(IF year of publication: 4.757; Number of citations: 4)

 

Sassone J, Reale C, Dati G, Regoni M, Pellecchia MT, Garavaglia B. The Role of VPS35 in the Pathobiology of Parkinson's Disease. Cell Mol Neurobiol. 2021 Mar;41(2):199-227. doi: 10.1007/s10571-020-00849-8. Epub 2020 Apr 22.

(IF year of publication: 4.231; Number of citations: 17)

 

Regoni M, Cattaneo S, Mercatelli D, Novello S, Passoni A, Bagnati R, Davoli E, Croci L, Consalez GG, Albanese F, Zanetti L, Passafaro M, Serratto GM, Di Fonzo A, Valtorta F, Ciammola A, Taverna S, Morari M, Sassone J. Pharmacological antagonism of kainate receptor rescues dysfunction and loss of dopamine neurons in a mouse model of human parkin-induced toxicity. Cell Death Dis. 2020 Nov 10;11(11):963. doi: 10.1038/s41419-020-03172-8.

 

Maranta F, Cianfanelli L, Regoni M, Cianflone D. Cardiologist and Diabetologist crosstalk in the era of cardiovascular outcome trials of novel glucose-lowering drugs. Int J Cardiol Heart Vasc. 2018 Oct 24;21:80-86. doi: 10.1016/j.ijcha.2018.10.001. eCollection 2018 Dec.

(JCI year of publication: 0.3; Number of citations: 6)

 

Truman-Rosentsvit M, Berenbaum D, Spektor L, Cohen LA, Belizowsky-Moshe S, Lifshitz L, Ma J, Li W, Kesselman E, Abutbul-Ionita I, Danino D, Gutierrez L, Li H, Li K, Lou H, Regoni M, Poli M, Glaser F, Rouault TA, Meyron-Holtz EG. Ferritin is secreted via 2 distinct nonclassical vesicular pathways. Blood. 2018 Jan 18;131(3):342-352. doi: 10.1182/blood-2017-02-768580. Epub 2017 Oct 26.

 

Maccarinelli F, Regoni M, Carmona F, Poli M, Meyron-Holtz EG, Arosio P. Mitochondrial ferritin deficiency reduces male fertility in mice. Reprod Fertil Dev. 2017 Sep;29(10):2005-2010. doi: 10.1071/RD16348.

 

Maccarinelli F, Carmona F, Regoni M, Arosio P. Photoacoustic molecular imaging for in vivo liver iron quantitation. J Biomed Opt. 2016 May 31;21(5):56008. doi: 10.1117/1.JBO.21.5.056008.

 

Ruzzenenti P, Asperti M, Mitola S, Crescini E, Maccarinelli F, Gryzik M, Regoni M, Finazzi D, Arosio P, Poli M. The Ferritin-Heavy-Polypeptide-Like-17 (FTHL17) gene encodes a ferritin with low stability and no ferroxidase activity and with a partial nuclear localization. Biochim Biophys Acta. 2015 Jun;1850(6):1267-73. doi: 10.1016/j.bbagen.2015.02.016. Epub 2015 Mar 5.

 

Maccarinelli F, Gammella E, Asperti M, Regoni M, Biasiotto G, Turco E, Altruda F, Lonardi S, Cornaghi L, Donetti E, Recalcati S, Poli M, Finazzi D, Arosio P, Cairo G. Mice lacking mitochondrial ferritin are more sensitive to doxorubicin-mediated cardiotoxicity. J Mol Med (Berl). 2014 Aug;92(8):859-69. doi: 10.1007/s00109-014-1147-0. Epub 2014 Apr 13.

(IF year of publication: 5.107; Number of citations: 40)

 

Poli M, Asperti M, Ruzzenenti P, Regoni M, Arosio P. Hepcidin antagonists for potential treatments of disorders with hepcidin excess. Front Pharmacol. 2014 Apr 28;5:86. doi: 10.3389/fphar.2014.00086. eCollection 2014.