Bonini Chiara Professore ordinarioMedicine
Biography
Biography
Born in Padova (Italy), August 21, 1969. Italian citizen. Married, two children.
Languages spoken: Italian (mother tongue), English (fluently).
Education and Professional Experience
1994: MD, summa cum laude, University of Milano Medical School, Milan (Italy)
1994-1998: Board in Hematology, summa cum laude, University of Pavia, (Italy)
1998-2000: Post-doctoral training in Immunology, Greenberg’s Lab, Fred Hutchinson Cancer Research Center, Seattle, WA
1991-1994: Undergraduate student, Experimental Hematology, San Raffaele Scientific Institute (OSR), Milano, Italy
1993: Undergraduate student, Bone Marrow Transplantation Unit, MSKCC, New York
1994-1998: PI of the clinical trial ” Transfer of the HSV-tk gene into donor peripheral blood lymphocytes for in vivo modulation of donor anti-tumor immunity after allogeneic bone marrow transplantation.”
1995-1997: Medical fellow, Bone Marrow Transplant Unit, OSR Milano, Italy
1996-1998: Post-doctoral fellow, TIGET (Telethon Institute for Gene Therapy), DIBIT, OSR
1998-2000: Post-doctoral fellow, Program in Immunology, FHCRC Seattle.
1998-2004: Hematologist, Bone Marrow Transplant Unit, OSR (leave of absence 1998-2000).
2000-2008: Group Leader, Experimental Hematology Unit, OSR.
2001-2007: PI of the multicentric clinical trial TK007, sponsored by Molmed s.p.a.
2008- currently: Head of the Experimental Hematology Unit, OSR.
2010- currently: Co-PI of the multicentric TK008 randomized phase III clinical trial.
2014- currently: Deputy Director Division of Immunology, Transplantation and Infectious Diseases, OSR
2015- currently: Professor, Università Vita-Salute San Raffaele, School of Medicine, Milan, Italy.
Scientific Service
Elected Member: Member of the Board of the European Society of Gene and Cell Therapy (ESGCT) (2005-2011); Member of Cancer Gene Therapy Committees of the American Society of Gene and Cell Therapy (ASGCT) and of ESGCT (2009-currently); Presidential Scientific Committee XVIII Annual ESGCT Congress Milan, Oct 22-25 (2010); Member of the ASGCT Board of Directors (2011-2014); Chairman of the ASGCT Cancer Committee (2012-2014); Chairman of the Cell Therapy and Immunobiology Working Party (CTIWP) of EBMT (2014-currently); Member of the Board of the European School of Hematology (ESH) (2014-currently); Member of the Strategic Research Committee, European Hematology Association (EHA) (2015-currently); President of the 1st EBMT-CTIWP Scientific Symposium: For transplantation to Gene Therapy: the cellular Therapy Evolution (11-13 Nov, 2015); Member of ASH Awards Committee (2018-2021). Member of ASH, ASGCT, ESGCT, SIE, SIES, NIBIT, EHA, EBMT
Editorial boards: Associate Editor Journal of Gene Medicine (2009-2015).
Member of the Editorial Board of Frontiers in Immunology (2011-currently). Associate Editor, Human Gene Therapy, Human Gene Therapy Methods, Editorial Board Molecular Therapy (2011-2014); Associate Editor, Human Gene Therapy Clinical Development Gene Therapy Committee (2012-2014); Member of the Editorial Board of Molecular Therapy, Molecular Therapy: Methods and Clinical Development (2013-currently).
Reviewer for: Nature Medicine, Nature Biotechnology, Nature Communications, Science Translational Medicine, Blood, Journal of Clinical Investigation, Cancer Research, Human Gene Therapy, The Journal of Gene Medicine, Bone Marrow Transplantation, Human Immunology, Molecular Therapy, Cytotherapy, Experimental Hematology, Hematologica, Hematological Oncology, Oncotarget, Journal of Immunology.
Grant Reviewer for European research Council (ERC), INSERM (FR), French National Cancer Institute (INCA, FR), The Netherland organization for Health Research and Development (ZonMw-NL) Cancer Research (UK) Innovation and Technology Fund (China),AICR (UK) Leukemia Research (UK), MIUR (IT), Association Francaise contre le Myopathies (AFM, FR), Research Promotion Foundation (Cyprus), IHU-Strarsbourg, Leukemia, Lymphoma Research (UK), Foundation against Cancer (Belgium), Fundació la Marató de TV3 (Spain), Fondation contre le cancer (Belgium), Dutch cancer Society (NL) , Agencie Nationale del la Recherche (FR).
Member of Expert Review Panels, French National Cancer Institute (INCA), Paris (2010-currently)
Teaching activities:
2001-2015 Assistant Professor in Hematology, Università Vita-Salute San Raffaele (Uni-SR), Milano.
2004-2015 Assistant Professor, Faculty of Medicine, “Speciality School of Hematology”, “School of Biotechnology, Uni-SR.
Since 2004 Supervisor and examiner of PhD Students (International PhD Program in Cellular and Molecular Medicine, PhD Open University Program, Università Vita-Salute San Raffaele, Milano and other Universities throughout Europe).
2014-2016: Member of the Pedagogic Committee, School of Medicine, Uni-SR.
2014-2016: Member of the Board of the PhD Program in Molecular Medicine, Uni-SR.
Since 2015 Full Professor, Faculty of Medicine, Università Vita-Salute San Raffaele, Milano.
Honors: Cancer Research Institute Fellowship, NY, USA (1999-2001). Young Investigator Award. American Society of Gene Therapy (2005). Young Investigator Award. Fondazione Berlucchi (2006). Grant MIUR-IDEAS, for top 8% ranked by the European Research Council(ERC). (2009).Team Science Recognition Award (iSBTC, now SITC) (2010). Van Bekkum Award. European Society of Bone Marrow Transplantation (EBMT) (2012). Van Rood Award. European Federation of Immunogenetics (EFI) (2012). Jon Van Rood Award. Immunobiology Working Party EBMT (2013). Basic Science Award, EBMT (2014). Melvin Jones Fellow for Humanitarian Services, Lions International (2016). Van Bekkum Award. (EBMT) (2016). Basic Science Award (EBMT) (2017).
Scientific Production
103 papers in international scientific journals, 7 contributions to books. Cumulative citation index (SCOPUS) of 6151. Scopus “h” index: 36. Inventor of 6 international patents.
Invited speaker to more than 100 International Meetings, Workshops and Universities.
Most significant publications 2007-2017:
- Kaneko S, Mastaglio S, Bondanza A, Punzoni M, Sanvito F, Aldrighetti A, Radrizzani M, La Seta-Catamancio S, Provasi E, Mondino A, Nagasawa T, Fleischhauer K, Russo V, Traversari C, Ciceri F, Bordignon C and Bonini C. IL-7 and IL-15 allow the generation of suicide gene-modified alloreactive self-renewing central memory human T lymphocytes. Blood 2009 Jan 29;113(5):1006-15.
- Ciceri F, Bonini C, (FC, CB, equal contribution), Lupo Stanghellini MT, Bondanza A, Traversari C, Salomoni M, Turchetto L, Colombi S, Bernardi M, Peccatori J, Pescarollo A, Servida P, Magnani Z, Perna SK, Valtolina V, Crippa F, Callegaro L, Spoldi E, Crocchiolo R, Fleischhauer K, Ponzoni M, Vago L, Rossini S, Santoro A, Todisco A, Apperley J, Olavarria E, Slavin S, Weissinger EM, Ganser A, Stadler M, Yannaki E, Fassas A, Anagnostopoulos A, Bregni M, Gallo Stampino C, Bruzzi P, and Bordignon C. Infusion of suicide gene-engineered donor lymphocytes after family haploidentical hemopoietic transplantation for leukemia: the TK007 phase I/II trial. Lancet Oncol. 2009 May;10(5):489-500. Epub 2009 Apr 1.
Editorial: “Immune reconstitution after HLA mismatched haemopoietic stem-cell transplantation.” Ringdén O, Karlsson H, Omazic B. Lancet Oncol. 2009 May;10(5):440.
3.Vago L, Perna SK, Zanussi M, Mazzi B, Barlassina C, Lupo-Stanghellini MT, Perrelli NF, Cosentino C, Torri F, Angius A, Forno B, Casucci M, Bernardi M, Peccatori J, Corti C, Bondanza A, Ferrari M, Rossini S, Roncarolo MG, Bordignon C, Bonini C, Ciceri F, Fleischhauer K. Loss of mismatched HLA in leukemia after stem-cell transplantation. N Engl J Med. 2009 Jul 30;361(5):478-88.
Editorial: “Genetic Trickery — Escape of Leukemia from Immune Attack” John Barrett, M.D., and Bruce R. Blazar, M.D. N Engl J Med. 2009 Jul 30;361(5):424-25.
- Provasi E, Genovese P, Lombardo A, Magnani Z, Liu PQ, Reik A, Chu V, Paschon DE, Zhang L, Kuball J, Camisa B, Bondanza A, Casorati G, Ponzoni M, Ciceri F, Bordignon C, Greenberg PD, Holmes MC, Gregory PD, Naldini L, Bonini C. Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer. Nature Medicine 2012 May;18(5):807-15. doi: 10.1038/nm.2700.
Editorial:“Research Highlights: Zinc-finger nucleases hone tumor cell therapy. Jason Kreisberg Nature Biotechnology 30, 411 (2012) doi:10.1038/nbt.2227 Van Bekkum Award 2012, EBMT
Van Rood Award 2012, EFI
- Cieri N, Camisa B, Cocchiarella F, Forcato M, Oliveira G, Provasi E, Bondanza A, Bordignon C, Peccatori J, Ciceri F, Lupo-Stanghellini MT, Mavilio F, Mondino A, Bicciato S, Recchia A, Bonini C. IL-7 and IL-15 instruct the generation of human memory stem T cells from naïve precursors. Blood. 2013 Jan 24;121(4):573-84. doi: 10.1182/blood-2012-05-431718.
Editorial: ” Inside Blood: Gattinoni L, Restifo NP. Moving T memory stem cells to the clinic. Blood 2013 121:567”.
6.Genovese P, Schiroli G, Escobar G, Di Tomaso T, Firrito C, Calabria A, Moi D, Mazzieri R, Bonini C, Holmes MC, Gregory PD, van der Burg M, Gentner B, Montini E, Lombardo A, Naldini L. Targeted Genome Editing in Human Repopulating Hematopoietic Stem Cells. Nature. 2014 Jun 12;510(7504):235-40. doi: 10.1038/nature13420. Epub 2014 May 28.
7.N. Cieri, G. Oliveira, R. Greco, M. Forcato, C. Taccioli, B. Cianciotti, V. Valtolina, M. Noviello, L. Vago, A. Bondanza, F. Lunghi, S. Marktel, L. Bellio, C. Bordignon, S. Bicciato, J. Peccatori, F. Ciceri, and C. Bonini. Generation of human memory stem T cells upon haploidentical T-replete hematopoietic stem cell transplantation. Blood 2015 Apr 30;125(18):2865-74. Mar 3. pii: blood-2014-11-608539. [Epub ahead of print]
- G. Oliveira, E.Ruggiero, M.T. Lupo Stanghellini, N. Cieri, M. D’Agostino, R. Fronza, C. Lulay, F. Dionisio, S. Mastaglio, R. Greco, J.Peccatori, A. Aiuti, A. Ambrosi, L. Biasco, A. Bondanza, A. Lambiase, C. Traversari, L. Vago, C. Von Kalle, M.Schmidt, C. Bordignon, F. Ciceri, C. Bonini. Tracking genetically engineered lymphocytes long-term reveals the dynamics of T-cell immunological memory. Sci Transl Med. 2015 Dec 9;7(317):317ra198. doi: 10.1126/scitranslmed.aac8265.
Research Highlights: Lingering T cells. Nature Reviews Immunology Published online 25 Jan. 2016; doi:10.1038/nri.2016.14
- Gattinoni L, Speiser DE, Lichterfeld, M, Bonini C. T memory stem cells in health and disease: new insights and therapeutic opportunities. Nat Med. 2017 Jan 6;23(1):18-27. doi: 10.1038/nm.4241. Review.
- Mastaglio S, Genovese P, Magnani Z, Ruggiero E, Landoni E, Camisa B, Schiroli G, Provasi E, Lombardo A, Reik A, Cieri N, Rocchi M, Oliveira G, Escobar G, Casucci M, Gentner B, Spinelli A, Mondino A, Bondanza A, Vago L, Ponzoni P, Ciceri F, Holmes M, Naldini L, and Bonini C. NY-ESO-1 TCR single edited central memory and memory stem T cells to treat multiple myeloma without inducing GvHD. Blood. 2017 Jun 21. pii: blood-2016-08-732636. doi: 10.1182/blood-2016-08-732636. [Epub ahead of print]
- Nimitha RM, Baumgartner F, Braun L, et al., Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD mutant leukemia cells. Nature Medicine In press.
- Prestipino A, Emhardt AJ, Aumann K, et al., Oncogenic JAK2 causes PD-L1 expression mediating immune-escape in myeloproliferative neoplasms. Science Translational Medicine. In press
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