Tonon Giovanni Professore OrdinarioMedicineMed/50

Biography

Publications

Biography

Dr. Giovanni Tonon is the Director for Omics Sciences, and of the Functional Genomics of Cancer Unit at the San Raffaele Scientific Institute in Milan, Italy. He has a long-standing interest in the identification of genes and pathways associated with diseases, in particular cancer, through genomic and bioinformatic approaches, and in the development of new technologies.

EDUCATION

 

1997 - 2002

Ph.D. in Clinical Methodology, University of Milan, Italy (full marks).

 

1992 - 1996

Resident, University of Milan, II School of Hematology, Italy. Final test full marks (70/70 cum laude).

 

1992

Doctor in Medicine, University of Padua, Italy (110/110 cum laude).

 

1989

Music Professor of piano, "B. Marcello" Conservatory, Venice, Italy.

 

1985

Classical Baccalaureate, Liceo Tito Livio, Padua, Italy (60/60 full marks).

 

PROFESSIONAL BACKGROUND

 

2016 – present

Director, Center for Omics Sciences, San Raffaele Scientific Institute, Milan, Italy.

 

2008 – present

Unit Head, Functional Genomics of Cancer Unit, San Raffaele Scientific Institute, Milan, Italy.

 

2003 – 2008

Instructor in Medicine (2004 – 2008) and Research Associate (2003-2004), Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA. Mentor: Dr. Ronald A. DePinho.

 

1998 – 2003

Research Fellow (2001 - 2003) and Visiting Fellow (1998 - 2001), Genetics Branch, National Cancer Institute, Bethesda, MD. Mentor: Dr. Ilan R. Kirsch.

 

1996 – 1998

Visiting scientist, Platelet Biology Department, American Red Cross, Rockville, MD. Mentor: Dr. Graham A. Jamieson.

 

1992 – 1996

Resident, University of Milan, Hemophilia and Thrombosis Center, Milan, Italy. Mentor: Dr. Pier Mannuccio Mannucci.

 

1991 – 1992

Internship, University Hospital, Cardiology Unit, Padua, Italy. Mentors: Dr. S. Dalla Volta, Padua University, and Dr. Malliani, Milan University.

 

 

TEACHING

 

 

2018

Indications and Used of Genetic Tests in Urology, Residents in Urology

San Raffaele Vita-Salute University, Milan.

2017

Epigenetics and Cancer, PhD Course on Epigenetic Mechanisms of Disease

Milan University, Milan.

2011 - present

How to read the scientific literature and write a thesis (~ 16 hr/year)

San Raffaele Vita-Salute University, Milan.

2009 – present

Gene expression/bioinformatics (~12 hr/year)

San Raffaele Vita-Salute University, Milan.

2008 - 2016

Molecular Oncology (~20 hr/year)

San Raffaele Vita-Salute University, Milan.

 

AWARDS AND HONORS

 

 

2006 - 2009

Leukemia and Lymphoma Society, Special Fellow Award.

 

2006

International Myeloma Foundation, Brian D. Novis Research Award.

 

2004 - 2006

Multiple Myeloma SPORE Career Development Award.

 

1998 – 2001

National Institutes of Health Post-Doctoral Traineeship Award.

 

1997

Foundation “A.Bianchi Bonomi” Scholarship.

 

         

 

PATENTS

 

Co-inventor in 7 Italian, US and International patents, issued or pending.

 

 

 

Patent number

Issue Date

Title

 

 

 

GB2101656.3

5/02/2021

Engineered Transposase And Uses Thereof

102020000009442

29/04/2020

Piastra micro-droplet.

15/562,961

September 29, 2017

STK4 inhibitors for treatment of hematological malignancies.

14/440,744

August 24, 2017

Novel Targets in Multiple Myeloma and Other Disorders.

8,211,634

July 3, 2012

Compositions, Kits, and Methods for Identification, Assessment, Prevention, and Therapy of Cancer.

8,168,602

May 1, 2012

Compositions, Kits, and Methods for Identification, Assessment, Prevention, and Therapy of Cancer.

7,214,488

July 3, 2002

Detection of MECT1-MAML2 Fusion Products.

 

(Agg. mar. 2022)

Publications

(last 4 years)

Tedesco M, Giannese F, Lazarević D, Giansanti V, Rosano D, Monzani S,

Catalano I, Grassi E, Zanella ER, Botrugno OA, Morelli L, Panina Bordignon P,

Caravagna G, Bertotti A, Martino G, Aldrighetti L, Pasqualato S, Trusolino L,

Cittaro D, Tonon G. Chromatin Velocity reveals epigenetic dynamics by single-

cell profiling of heterochromatin and euchromatin. Nat Biotechnol. 2021, in press.

doi: 10.1038/s41587-021-01031-1. PMID: 34635836.

            Featured in Research Highlights in Nature. Reviews of Genetics, 2021; 22:748 and in Nature Methods, 2021; 18:1448.

 

Alfano M, Tascini AS, Pederzoli F, Locatelli I, Nebuloni M, Giannese F,

Garcia-Manteiga JM, Tonon G, Amodio G, Gregori S, Agresti A, Montorsi F, Salonia

A. Aging, inflammation and DNA damage in the somatic testicular niche with

idiopathic germ cell aplasia. Nat Commun. 2021;12(1):5205.

 

Santoliquido BM, Frenquelli M, Contadini C, Bestetti S, Gaviraghi M, Barbieri

E, De Antoni A, Albarello L, Amabile A, Gardini A, Lombardo A, Doglioni C,

Provero P, Soddu S, Cittaro D, Tonon G. Deletion of a pseudogene within a

fragile site triggers the oncogenic expression of the mitotic CCSER1 gene. Life

Sci Alliance. 2021; 4(8):e202101019.

 

Fan F, Malvestiti S, Vallet S, Lind J, Garcia-Manteiga JM, Morelli E, Jiang

Q, Seckinger A, Hose D, Goldschmidt H, Stadlbauer A, Sun C, Mei H, Pecherstorfer

M, Bakiri L, Wagner EF, Tonon G, Sattler M, Hu Y, Tassone P, Jaeger D, Podar K.

JunB is a key regulator of multiple myeloma bone marrow angiogenesis. Leukemia. 2021; 35(12):3509-3525.

 

Palmisano A, Scotti GM, Ippolito D, Morelli MJ, Vignale D, Gandola D, Sironi

S, De Cobelli F, Ferrante L, Spessot M, Tonon G, Tacchetti C, Esposito A. Chest

CT in the emergency department for suspected COVID-19 pneumonia. Radiol Med.

2021;126(3):498-502.

 

Tonon G. The winding road toward the myeloma mouse. Blood. 2021;137(1):7-8.

 

Frenquelli M, Tonon G. WNT Signaling in Hematological Malignancies. Front Oncol. 2020; 10:615190.

 

Palmisano A, Scotti GM, Ippolito D, Morelli MJ, Vignale D, Gandola D, Sironi S, De Cobelli F, Ferrante L, Spessot M, Tonon G, Tacchetti C, Esposito A. Chest CT in the emergency department for suspected COVID-19 pneumonia. Radiol Med. 2021: 1;126(3):498–502.

 

Gaviraghi M, Rabellino A, Andolfo A, Brand M, Brombin C, Bagnato P, De Feudis G, Raimondi A, Locatelli A, Tosoni D, Mazza D, Gianni L, Tonon G, Yarden Y, Tacchetti C, Daniele T. Direct stimulation of ERBB2 highlights a novel cytostatic signaling pathway driven by the receptor Thr701 phosphorylation. Sci Rep. 2020;10(1):16906.

 

Manfrini N, Mancino M, Miluzio A, Oliveto S, Balestra M, Calamita P, Alfieri R, Rossi RL, Sassoè-Pognetto M, Salio C, Cuomo A, Bonaldi T, Manfredi M, Marengo E, Ranzato E, Martinotti S, Cittaro D, Tonon G, Biffo S. FAM46C and FNDC3A are multiple myeloma tumor suppressors that act in concert to impair clearing of protein aggregates and autophagy. Cancer Res. 2020; 80(21):4693-4706.

 

Mannucci A, Zuppardo RA, Crippa S, Carrera P, Patricelli MG, Russo Raucci A, Calabrese F, Lazarevic D, Giannese F, Tonon G, Ferrari M, Testoni PA, Cavestro GM.

MSH6 gene pathogenic variant identified in familial pancreatic cancer in the absence of colon cancer. Eur J Gastroenterol Hepatol. 2020; 32(3):345-349.

 

Riba M, Sala C, Toniolo D, Tonon G. Big Data in Medicine, the Present and Hopefully the Future. Front Med (Lausanne). 2019; 6:263.

 

Botrugno OA, Bianchessi S, Zambroni D, Frenquelli M, Belloni D, Bongiovanni L, Girlanda S, Di Terlizzi S, Ferrarini M, Ferrero E, Ponzoni M, Marcatti M, Tonon G. ATR addiction in multiple myeloma: synthetic lethal approaches exploiting established therapies. Haematologica. 2020; 105(10):2440-2447.

 

Gaviraghi M, Vivori C, Tonon G. How Cancer Exploits Ribosomal RNA Biogenesis: A Journey beyond the Boundaries of rRNA Transcription. Cells. 2019; 8(9):1098.

 

Tocci P, Cianfrocca R, Di Castro V, Rosanò L, Sacconi A, Donzelli S, Bonfiglio S, Bucci G, Vizza E, Ferrandina G, Scambia G, Tonon G, Blandino G, Bagnato A. β-arrestin1/YAP/mutant p53 complexes orchestrate the endothelin A receptor signaling in high-grade serous ovarian cancer. Nat Commun. 2019; 10(1):3196.

 

Frenquelli M, Caridi N, Antonini E, Storti F, Viganò V, Gaviraghi M, Occhionorelli M, Bianchessi S, Bongiovanni L, Spinelli A, Marcatti M, Belloni D, Ferrero E, Karki S, Brambilla P, Martinelli-Boneschi F, Colla S, Ponzoni M, DePinho RA, Tonon G. The WNT receptor ROR2 drives the interaction of multiple myeloma cells with the microenvironment through AKT activation. Leukemia. 2019; 34(1):257-270.

 

Toffalori C, Zito L, Gambacorta V, Riba M, Oliveira G, Bucci G, Barcella M, Spinelli O, Greco R, Crucitti L, Cieri N, Noviello M, Manfredi F, Montaldo E, Ostuni R, Naldini MM, Gentner B, Waterhouse M, Zeiser R, Finke J, Hanoun M, Beelen DW, Gojo I, Luznik L, Onozawa M, Teshima T, Devillier R, Blaise D, Halkes CJM, Griffioen M, Carrabba MG, Bernardi M, Peccatori J, Barlassina C, Stupka E, Lazarevic D, Tonon G, Rambaldi A, Cittaro D, Bonini C, Fleischhauer K, Ciceri F, Vago L. Immune signature drives leukemia escape and relapse after hematopoietic cell transplantation. Nat Med. 2019; 25(4):603-611.

 

Calcinotto A, Brevi A, Chesi M, Ferrarese R, Garcia Perez L, Grioni M, Kumar S, Garbitt VM, Sharik ME, Henderson KJ, Tonon G, Tomura M, Miwa Y, Esplugues E, Flavell RA, Huber S, Canducci F, Rajkumar VS, Bergsagel PL, Bellone M. Microbiota-driven interleukin-17-producing cells and eosinophils synergize to accelerate multiple myeloma progression. Nat Commun. 2018; 9(1):4832.

 

Gaviraghi M, Vivori C, Pareja Sanchez Y, Invernizzi F, Cattaneo A, Santoliquido BM, Frenquelli M, Segalla S, Bachi A, Doglioni C, Pelechano V, Cittaro D, Tonon G. Tumor suppressor PNRC1 blocks rRNA maturation by recruiting the decapping complex to the nucleolus. EMBO J. 2018; 3;37(23).

 

Cavestro GM, Mannucci A, Zuppardo RA, Di Leo M, Stoffel E, Tonon G. Early onset sporadic colorectal cancer: Worrisome trends and oncogenic features. Dig Liver Dis. 2018; 50(6):521-532.

 

Agathangelidis A, Ljungström V, Scarfò L, Fazi C, Gounari M, Pandzic T, Sutton LA, Stamatopoulos K, Tonon G, Rosenquist R, Ghia P. Highly similar genomic landscapes in monoclonal B-cell lymphocytosis and ultra-stable chronic lymphocytic leukemia with low frequency of driver mutations. Haematologica. 2018; 103(5):865-873.

 

Belloni D, Heltai S, Ponzoni M, Villa A, Vergani B, Pecciarini L, Marcatti M, Girlanda S, Tonon G, Ciceri F, Caligaris-Cappio F, Ferrarini M, Ferrero E. Modeling Multiple Myeloma-Bone Marrow interactions and response to drugs in a 3D surrogate microenvironment. Haematologica. 2018; 103(4):707-716.

(Agg. mar. 2022)

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