Martino Gianvito Professore ordinarioMedicineBIO/13

Biography

Publications

Biography

Gianvito Martino (Bergamo, 1962) received his Medical Degree in 1987 from the Univ. of Pavia(Italy)and completed his residency in Neurology in 1991. In 1990, he was a Visiting Scientist at the Dept. of Neurology of the Karolinska Institute (Sweden) and, from 1991 to 1992, he held the position of Research Associate at the Dept. of Neurology of the Univ. of Chicago (Chicago, IL, USA). From 1992 to 2008, he worked first as Senior Scientist and then as Director of the Neuroimmunology Unit of the San Raffaele Scientific Inst. in Milan (Italy) where he acted as Director of the Neuroscience Division (2008-2016). From 2016, he is Scientific Director of the San Raffaele Scientific Institute. He is full professor of Experimental Biology at the San Raffaele Vita-Salute Univ. in Milan and he was appointed Honorary Professor at Queen Mary Univ. of London from 2009 to 2017. He has been the Scientific Secretary (1998-2003) and the President (2009-2012) of the Italian Neuroimmunology Society (AINI). He is the founder and the Scientific Coordinator of the European School of Neuroimmunology (ESNI) and of the Global Schools of Neuroimmunology (GSNI). Within the International Society for Neuroimmunology (ISNI), he served as advisory board member (2002-2010), Vice President (2010-2012) and President (2012-2014). He has been a member of the scientific committee and reviewing panel of ECTRIMS, FISM, MSIF, INSERM; UK MS Society, Wellcome Trust's Peer Review College. From 2017 to 2019 he has been the President of the scientific council of the Fondazione Regionale per la Ricerca Biomedica (FRRB).  From 2015 he serves as Panel Member of the European Research Council (ERC).

He has co-authored more than 250 original articles and book chapters. His scientific interests range from the elucidation of the pathogenic mechanisms of immune-mediated central nervous system disorders to the development of gene and stem cell-based therapies for the treatment of these disorders.

 

 

Publications

PLUCHINO S, QUATTRINI A, BRAMBILLA E, GRITTI A, SALANI G, DINA G, GALLI R, BERGAMI A, FURLAN R, DELCARRO U, AMADIO S, COMI G, VESCOVI AL, MARTINO G. Injection of adult neurospheres induce clinical recovery in a chronic model of multiple sclerosis. Nature 2003;422:688-694.

MARTINO G. How the brain repairs itself: perspectives for new therapeutic strategies for inflammatory and degenerative CNS disorders. Lancet Neurol. 2004;3:372-378.

PLUCHINO S, ZANOTTI L, ROSSI B, BRAMBILLA E, OTTOBONI L, SALANI G, MARTINELLO M, CATTALINI A, BERGAMI A, FURLAN R, COMI G, CONSTANTIN G, MARTINO G. Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism. Nature 2005;436:266-271.

MARTINO G, PLUCHINO S. The therapeutic potential of neural stem cells. Nat. Rev. Neurosci. 2006;7:395-406.

ZIV Y, AVIDAN H, PLUCHINO S, MARTINO G, SCHWARTZ M. Synergy between immune cells and adult stem/progenitor cells promote functional recovery from spinal cord injury. Proc. Natl. Acad. Sci. USA 2006;103:13174-13179.

FURLAN R, BERGAMI A, BRAMBILLA E, 2007- E, DE SIMONI MG, CAMPAGNOLI M, MARCONI P, COMI G, MARTINO G. HSV-1-mediated IL-1 receptor antagonist gene therapy ameliorates MOG35-55 induced experimental autoimmune encephalomyelitis in C57BL/6 mice. Gene Ther. 2007;14:93-98.

PLUCHINO S, MUZIO L, IMITOLA J, DELEIDI M, ALFARO-CERVELLO C, SALANI G, PORCHERI C, BRAMBILLA E, BERGAMASCHI A, GARCIA-VERDUGO JM, COMI G, KHOURY SJ*, MARTINO G*. Chronic inflammation induces a non cell-autonomous dysfunction of the endogenous brain stem cell compartment. Brain 2008;131:2564-2578 (*equally contributed).

BUTTI E, BERGAMI A, RECCHIA A, BRAMBILLA E, DEL CARRO U, AMADIO S, CATTALINI A, STORNAIUOLO A, COMI G, PLUCHINO S, MAVILIO F, MARTINO G, FURLAN R. IL-4 gene delivery to the CNS recruits regulatory T cells and induces clinical recovery in mouse models of multiple sclerosis. Gene Ther. 2008;15:504-515.

CENTONE D*, MUZIO L*, ROSSI S, CAVASINNI F, DE CHIARA V, BERGAMI A, MUSELLA A, MARCELLO D’AMELIO M, CAVALLUCCI V, MARTORANA A, BERGAMASCHI A, CONCIONI MT, DIAMANTINI A, BUTTI E, COMI G, BERNARDI G, CECCONI F, BATTISTINI L, FURLAN R, MARTINO G. Inflammation triggers synaptic alteration and degeneration in experimental autoimmune encephalomyelitis. J. Neurosci. 2009;29:3442-3452 (*equally contributed).

BACIGALUPPI M*, PLUCHINO S*, KILIC E, PERUZZOTTI-JAMETTI L, KILIC U, SALANI G, BRAMBILLA E, COMI G, MARTINO G*, HERMANN DM*. Delayed post-ischemic neuroprotection following systemic neural stem cell transplantation involves multiple mechanisms. Brain 2009;132:2239-2251 (*equally contributed).

SHECHTER R, LONDON A, VAROL C, CUSIMANO M, RAPOSO C, ROLLS A, PLUCHINO S, MARTINO G, JUNG S, SCHWARTZ M. Infiltrating blood-borne monocytes display an anti-inflammatory role in supporting recovery from spinal cord injury. PLoS Med. 2009;6:e1000113.

PLUCHINO S*, GRITTI A*, BLAZER E, AMADIO S, BRAMBILLA E, BORSELLINO G, COSSETTI C, DEL CARRO U, COMI G, ‘T HART B, VESCOVI A, MARTINO G. Human neural stem cells ameliorate autoimmune encephalomyelitis in non human primates. Ann. Neurol. 2009;66:343-354 (*equally contributed).

MARTINO G, FRANKLIN RJ, VAN EVERCOOREN AB, KERR DA, the Stem Cells in Multiple Sclerosis (STEMS) Consensus Group. Stem cell transplantation in multiple sclerosis: current status and future prospects. Nat. Rev. Neurol. 2010;6:247-255.

MARTINO G, PLUCHINO S, BONFANTI L, SCHWARTZ M. Brain regeneration in physiology and pathology: the immune signature driving therapeutic plasticity of neural stem cells. Physiol. Rev. 2011;91:1281-1304.

BUTTI E, BACIGALUPPI M, ROSSI S, CAMBIAGHI M, BARI M, CEBRIAN SILLA A, BRAMBILLA E, MUSELLA A, DE CEGLIA R, TENEUD L, DE CHIARA V, D’ADAMO P, GARCIA-VERDUGO JM, COMI G, MUZIO L, QUATTRINI A, LEOCANI L, MACCARRONE M, CENTONZE D, MARTINO G. Subventricular zone neural progenitors protect striatal neurons from glutamatergic excitoxicity. Brain 2012;115:3320-3335.

KOKAIA Z*, MARTINO G*, SCHWARTZ M*, LINDVALL O. Cross-talk between neural stem cells and immune cells: the key to better brain repair? Nat. Neurosci. 2012;15:1078-1087 (*equally contributed).

BUTTI E*, BACIGALUPPI M*, ROSSI S, CAMBIAGHI M, BARI M, CEBRIAN SILLA A, BRAMBILLA E, MUSELLA A, DE CEGLIA R, TENEUD L, DE CHIARA V, D’ADAMO P, GARCIA-VERDUGO JM, COMI G, MUZIO L, QUATTRINI A, LEOCANI L, MACCARRONE M, CENTONZE D, MARTINO G. Subventricular zone neural progenitors protect striatal neurons from glutamatergic excitoxicity. Brain 2012;115:3320-3335 (*equally contributed).

NIGRO A, MENON R, BERGAMASCHI A, CLOVIS Y, BALDI A, DE PIETRI TONELLI D, COMI G, FARINA C, MARTINO G*, MUZIO L*. MiR-30 and miR-181d control radial glia cell proliferation via HtrA1 modulation. Cell Death Dis. 2012;3:e360 (*equally contributed).

PERUZZOTTI-JAMETTI L*, CAMBIAGHI M*, BACIGALUPPI M, GALLIZIOLI M, GAUDE E, CURSI M, MARI S, SANDRONE S, TENEUD L, COMI G, MUSCO G, MARTINO G*, LEOCANI L*. Cathodal tDCS prevents neuronal damage in the very acute phase of ischemic stroke. Stroke 2013;44:3166-3174 (*equally contributed).

LATERZA C, MERLINI A, DE FEO D, RUFFINI F, MENON R, ONORATI M, FREDRICKX E, MUZIO L, LOMBARDO A, COMI G, QUATTRINI A, TAVEGGI AC, FARINA C, CATTANEO E, MARTINO G. iPSC-derived neural precursors exert a neuroprotective role in immune-mediated demyelination via the secretion of leukemia inhibitory factor. Nat. Commun. 2013;4:2597.

SANDRONE A, BACIGALUPPI M, GALLONI MR, CAPPA SF, MORO A, CATANI M, FILIPPI M, MONTI MM, PERANI D*, MARTINO G*. Weighing brain activity with the balance: Angelo Mosso’s original manuscripts come to light. Brain 2014;137:621-633 (*equally contributed).

MARTINO G, BUTTI E, BACIGALUPPI M. Neurogenesis or non-neurogenesis: this is the question. J. Clin. Invest. 2014;124:970-973.

ONORATI M*, CASTIGLIONI V*, BIASCI D**, CESANA E**, MENON R**, VUONO R, TALPO F, GOYA RL, LYONS P, BULFAMANTE GP, MUZIO L, MARTINO G, TOSELLI M, FARINA C, BARKER RA, BIELLA G, CATTANEO E. Molecular and functional definition of the developing human striatum. Nat. Neurosci. 2014;17:1804-1815 (*,**equally contributed).

ARNÒ B, GRASSIVARO F, ROSSI C, BERGAMASCHI A, GRETER M, FAVARO R, COMI G, BECHER B, MARTINO G*, MUZIO L*. Neural progenitors cells orchestrate microglia migration and positioning into the developing cortex. Nat. Comm. 2014;5:5611 (*equally contributed).

MOZAFARI S, LATERZA C, ROUSSEL D, BACHELIN C, MARTEYN A, DEBOUX C, MARTINO G, BARON-VAN EVERCOOREN A. Skin-derived neural precursors competitively generate functional myelin in adult demyelinated mice. J. Clin. Inv. 2015;125:3642-3656.

BACIGALUPPI M, RUSSO G*, PERUZZOTTI-JAMETTI L*, ROSSI S, SANDRONE S, GALLIZIOLI M, DE CEGLIA R, BUTTI E, STUDER V, COLOMBO E, REITMEIR R, MOTTA C, MUZIO L, COMI G, FARINA C, LETTERIO POLITI LS, INVERNIZZI RW, HERMANN DM*, CENTONZE D*, MARTINO G. Neural stem cell transplantation promotes post-ischemic neuronal plasticity by regulating the expression of glutamate transporters. J. Neurosci. 2016;36:10529-10544 (*equally contributed).

 

DE FEO D, MERLINI A, BRAMBILLA E, OTTOBONI L, LATERZA C, MENON R, SRINIVASAN S, FARINA C, MANTEIGA JMG, BUTTI E, BACIGALUPPI M, COMI G, GRETER M, MARTINO G. Neural precursor cell-secreted TGF-β2 redirects inflammatory monocyte-derived cells in CNS autoimmunity. J. Clin. Inv. 2017;127:3937-3953 [Epub ahead of print on September 25, 2017]

 

ROSSI C, CUSIMANO M, ZAMBITO M, FINARDI A, CAPOTONDO A, GARCIA-MANTEIGA JM, COMI G, FURLAN R, MARTINO G*, MUZIO L*. IL-4 modulates microglia homeostasis and attenuates the early slowly progressive phase of Amyotrophic Lateral Sclerosis. Cell Death Dis. 2018;9:250 (*equally contributed).

 

CUSIMANO M, BRAMBILLA E, CAPOTONDO A, DE FEO D, TOMASSO A, COMI G, MUZIO L*, MARTINO G*. Selective killing of spinal cord neural stem cells impairs locomotor recovery in a mouse model of spinal cord injury. J. Neuroinflamm. 2018;15:58 (*equally contributed).

 

BECHER J, SIMULA L, VOLPE E, PROCACCINI C, LA ROCCA C, D’ACUNZO P, CIANFANELLI V, STRAPPAZZON F, CARUANA I, NAZIO F, WEBER G, GIGANTINO V, BOTTI G, CICCOSANTI F, BORSELLINO G, CAMPELLO S, MANDOLESI G, DE BARDI M, FIMIA GM, D’AMELIO M, RUFFINI F, FURLAN R, CENTONZE D, MARTINO G, BRAGHETTA P, CHRISAM M, BONALDO P, MATARESE G, LOCATELLI F, BATTISTINI L, CECCONI F. AMBRA1 controls regulatory T-cell differentiation and homeostasis upstream of the FOXO3-FOXP3 axis. Dev. Cell 2018;47:592-607.

 

 

 

 

 

CORADA M, ORSENIGO F, PARAMESHWAR BHAT G, CONZE LL, BREVIARIO F, CUNHA SI, CLAESSON-WELSH L, BEZNOUSSENKO GV, MIRONOV AA, BACIGALUPPI M, MARTINO G, PITULESCU ME, ADAMS RH, MAGNUSSON P, DEJANA E. Fine tuning of Sox17 and canonical Wnt coordinates the permeability properties of the blood-brain barrier. Circ. Res. 2019;124:511-525.

 

BUTTI E, BACIGALUPPI M, CHAABANE L, RUFFINI F, BRAMBILLA E, BERERA G, MONTONATI C, QUATTRINI A, MARTINO G. Neural stem cells of the subventricular zone contribute to neuroprotection of the corpus callosum after cuprizone-induced demyelination. J. Neurosci. 2019;39:5481-5492 [Epub ahead of print on May 28, 2019].

 

GRASSIVARO F, MENON R, ACQUAVIVA M, OTTOBONI L, RUFFINI F, BERGAMASCHI A, MUZIO M, FARINA C*, MARTINO G*. Convergence between microglia and peripheral macrophages phenotypes during development and neuroinflammation. J. Neurosci. 2020;40 (4):784-795 [Epub ahead of print on Dec. 9, 2019] (*co-correspondence)

 

Viggiano D, Wagner C, Martino G, Nedergaard M, Zoccali C, Unwin R, Capasso G. Mechanisms of cognitive dysfunction in CKD. Nat. Rev. Nephrol. 2020 [Epub ahead of print on March 31] https://doi.org/10.1038/s41581-020-0266-9

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