Benedetti Francesco Professore associatoPsychologyMED/25 - Psichiatria

Since 2018          Associate Professor of Psychiatry, University Vita-Salute San Raffaele, Milano

2017                      Italian National Scientific Qualification for Full Professor of Psychiatry

2014                     Italian National Scientific Qualification for Associate Professor of Psychiatry

Since 2009          Director of the Psychiatry and Clinical Psychobiology Unit, Scientific Institute Ospedale San Raffaele, Milano

2005                      Diplomate in Psychiatry, summa cum laude, University Vita-Salute San Raffaele

2003 –2018       Adjunct Professor, School of Medicine & School of Psychology, University Vita-Salute San Raffaele.

Since 2002          Area Coordinator (scientific research – psychiatric branch), Ospedale San Raffaele

1996 – 2001        Staff Psychiatrist, Ospedale San Raffaele, Milano

1995                     Diplomate in Clinical Psychology, summa cum laude, University of Milano

1993 – 1994        Italian Army (military obligation), Medical Lieutenant, Arma dei Carabinieri

1992 – 1993        Post-doctoral fellow, Medical Psychology, Institute of Psychology, University of Milan

1991                     M.D. degree, summa cum laude, University of Modena

1985 – 1991        Studies in Medicine, University of Modena. Pre-doctoral research fellow, Institute of Human Physiology

 

Research fields

My research focus is in the field of translational and reverse-translational research in psychiatry and clinical psychobiology, with the following major areas:

– Brain imaging of psychopathology, psychiatric diseases, and therapeutics

– Psychiatric genetics, with a particular enphasis on imaging genetics

– Chronobiology and chronotherapeutics

– Neurobiology of mood disorders, schizophrenia, anxiety disorders

– Developmental clinical psychobiology (consequences of early adverse experience, interactions of stress and dispositional factors)

– Neuroinflammation in psychiatric conditions

Venti articoli, e un libro

Benedetti F, Poletti S, Hoogenboezem TA, Locatelli C, de Wit H, Wijkhuijs AJM, Colombo C, Drexhage HA (2017) Higher baseline pro-inflammatory cytokines mark poor antidepressant response in bipolar disorder. Journal of Clinical Psychiatry, 78(8):e986-e993

 

ENIGMA-OCD Working-Group (2018) Cortical abnormalities associated with pediatric and adult obsessive-compulsive disorder. American Journal of Psychiatry, 175(5):453-462.

 

Benedetti F, Melloni EMT, Dallaspezia S, Bollettini I,  Locatelli C, Poletti S, Colombo C (2017) Night sleep influences white matter microstructure in bipolar depression. Journal of Affective Disorders, 218:380-387.

 

Mazza E, Poletti S, Bollettini I, Locatelli C, Falini A, Colombo C, Benedetti F (2017) Body mass index associates with white matter microstructure in bipolar depression. Bipolar Disorders, 19(2):116-127.

 

Benedetti F, Poletti S,  Hoogenboezem TA, Mazza E, Ambrée O, de Wit H, Wijkhuijs AJM, Locatelli C, Bollettini I, Colombo C, Arolt V, Drexhage HA (2016) Inflammatory cytokines influence measures of white matter integrity in Bipolar Disorder. Journal of Affective Disorders, 202:1-9.

 

Canali P, Sarasso S, Rosanova M,  Casarotto S, Sferrazza-Papa G,  Gosseries O, Fecchio M,  Massimini M, Cavallaro M, Smeraldi E, Colombo C, Benedetti F. (2015) Shared reduction of oscillatory natural frequencies in bipolar disorder, major depressive disorder and schizophrenia. Journal of Affective Disorders, 184:111-5

 

Benedetti F, Poletti S,  Radaelli D, Locatelli C, Pirovano A, Lorenzi C, Vai B, Bollettini I,  Falini A, Smeraldi E, Colombo C (2015) Lithium and GSK3-b promoter gene variants influence cortical grey matter volumes in bipolar disorder. Psychopharmacology, 232(7):1325-36.

 

Benedetti F, Bollettini I, Radaelli D, Poletti S, Locatelli C, Falini A, Smeraldi E, Colombo C (2014) Adverse childhood experiences influence white matter microstructure in patients with bipolar disorder. Psychological Medicine, 44:3069–3082

 

Benedetti F, Riccaboni R, Locatelli C, Poletti S, Dallaspezia S, Colombo C (2014) Rapid treatment response of suicidal symptoms to lithium, sleep deprivation, and light therapy (chronotherapeutics) in drug-resistant bipolar depression.  Journal of Clinical Psychiatry, 75(2):133-140

 

Benedetti F, Riccaboni R, Poletti S, Radaelli D, Locatelli C, Lorenzi C, Pirovano A,  Smeraldi E, Colombo C (2014) The serotonin transporter genotype modulates the relationship between early stress and adult suicidality in bipolar disorder. Bipolar Disorders, 16:857–866.

 

Canali P, Sferrazza Papa G, Casali AG, Fecchio M, Pigorini A, Schiena G, Smeraldi E, Colombo C, Benedetti F (2014) Changes of cortical excitability as markers of antidepressant response in bipolar depression.  Bipolar Disorders, 16:809–819

 

Benedetti F, Bollettini I, Barberi I, Radaelli D, Poletti S, Locatelli C, Pirovano A,  Lorenzi C, Colombo C, Smeraldi E (2013) Lithium and GSK3-b promoter gene variants influence white matter microstructure in bipolar disorder. Neuropsychopharmacology, 38(2):313-27

 

Benedetti F, Ping-Hong Yeh, Bellani M, Radaelli D, Nicoletti MA, Poletti S, Falini A, Dallaspezia S,  Colombo C, Scotti G, Smeraldi E, Soares JC, Brambilla P (2011) Disruption of white matter integrity in bipolar depression as a possible structural marker of illness. Biological Psychiatry, 69(4):309-17.

 

Benedetti F, Absinta M, Rocca M, Radaelli D, Poletti S, Bernasconi A, Dallaspezia S, Pagani E, Falini A, Colombo C,  Comi G, Smeraldi E (2011) Tract-specific white matter structural disruption in patients with bipolar disorder. Bipolar Disorders, 13(4):414-424

 

Benedetti F, Bernasconi A, Bosia M, Cavallaro R, Dallaspezia S, Falini A, Poletti S,  Radaelli D, Riccaboni R, Scotti G, Smeraldi E (2009) Functional and structural brain correlates of theory of mind and empathy deficits in schizophrenia. Schizophrenia Research, 114(1-3):154-60

 

Benedetti F, Bernasconi A, Blasi V, Cadioli M, Colombo C, Falini A, Lorenzi C, Radaelli D, Scotti G, Smeraldi E (2007) Neural and genetic correlates of antidepressant response to sleep deprivation: a fMRI study of moral valence decision in bipolar depression. Archives of General Psychiatry, 64:179-87

 

Benedetti F, Barbini B, Cigala Fulgosi M, Colombo C, Dallaspezia S, Pontiggia A,  Smeraldi E (2005) Combined total sleep deprivation and light therapy in the treatment of drug-resistant bipolar depression: Acute response and long-term remission rates. Journal of Clinical Psychiatry, 66(12):1535-1540.

 

Benedetti F, Colombo C, Serretti A, Lorenzi C, Pontiggia A, Barbini B,  Smeraldi E (2003)  Antidepressant effects of light therapy combined with sleep deprivation are influenced by a functional polymorphism within the promoter of the serotonin transporter gene. Biological Psychiatry, 54(7):687-692

 

Benedetti F, Serretti A, Colombo C, Campori E, Barbini B, Di Bella D, Smeraldi E. (1999) Influence of a functional polymorphism within the promoter of the serotonin transporter gene on the effects of total sleep deprivation in bipolar depression. American Journal of Psychiatry, 156(9):1450-1452

 

Smeraldi E, Zanardi R, Benedetti F, Di Bella D, Perez J, Catalano M (1998) Polymorphism within the promoter of the serotonin transporter gene and antidepressant efficacy of fluvoxamine. Molecular Psychiatry, 3(6):508-511

 

Wirz-Justice A, Benedetti F, Terman M (2013) Chronotherapeutics for affective disorders. A clinician’s manual for light and wake therapy. 2nd edition. Karger, Basel.