Ghia Paolo Prospero Professore OrdinarioMedicineSSD MED/06 – Oncologia medica; SC 06/D3 – Malattie del sangue, oncologia e reumatologia; MSC 06/D – Clinica medica specialistica




Professor, Medical Oncology, Università Vita-Salute San Raffaele di Milano

Deputy-director, Division of Experimental Oncology, IRCCS Ospedale San Raffaele

Director, Strategic Research Program on Chronic Lymphocytic Leukemia, Division of Experimental Oncology, IRCCS Ospedale San Raffaele

Head, Research Unit on B Cell Neoplasia, Division of Experimental Oncology, IRCCS Ospedale San Raffaele

1984-1990 Medical School at the University of Torino, Italy. Summa cum laude Medical Degree M.D. Thesis “Study of the cytokines involved in the progression of multiple myeloma and Waldenstoem’s macroglobulinemia” (Tutor: Prof. Felice Gavosto)
1991-1994 Ph.D. program in “Human Oncology” at the University of Torino, Italy. Ph.D. Thesis: “B cell development: selecting events in the bone marrow” (Tutor: Prof Federico Caligaris-Cappio)
1998-2003 Internal Medicine Residency program, “San Luigi Gonzaga” University, Orbassano, Italy. Final Thesis: “Role of phenotypic and molecular markers in the prognosis of chronic lymphocytic leukemia (Tutor: Prof. Alberto Angeli)

1991-1993 PhD student (Human Oncology). Department of Biomedical Sciences and Human Oncology, University of Torino, Italy
1993-1996: Scientific Member Basel Institute for Immunology, Basel, Switzerland
1996-1998 Research Associate Department of Medicine, Harvard Medical School, Department of Adult Oncology, Dana-Farber Cancer Institute e Department of Medicine, Brigham and Women’s Hospital, Boston, USA
1998-2004 Assistant Professor in Internal Medicine Department of Oncological Sciences, University of Torino; Laboratory of Cancer Immunology, Institute for Cancer Research and Treatment, Candiolo, Italy
2005-2010 Assistant Professor in  Internal Medicine, Università Vita-Salute San Raffaele, Milano, Italy.
2010 – 2018 Associate Professor, Internal Medicine, Università Vita-Salute San Raffaele, Milano; Strategic Research Program on CLL, B Cell Neoplasia Unit, Division of Experimental Oncology, IRCCS Ospedale San Raffaele.

2018-2019 Professor, Internal Medicine, Università Vita-Salute San Raffaele, Milano; Strategic Research Program on CLL, B Cell Neoplasia Unit, Division of Experimental Oncology, IRCCS Ospedale San Raffele, Milano.

2019-today Professor, Medical Oncology, Università Vita-Salute San Raffaele, Milano; Strategic Research Program on CLL, B Cell Neoplasia Unit, Division of Experimental Oncology, IRCCS Ospedale San Raffele, Milano.

1995 Tutor at the EMBO Practical Course: “Lymphocyte development” – Institute for Immunology, Basel, Switzerland
1996–1998 Tutor of College students (Major: Biology), Harvard Medical School, Boston, USA
1999 Professor at the Advanced Courses in Molecular Medicine: “Novel Therapies for Human Cancer: the Future is Now” – Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal
1999–2004 Professor of Allergology and Clinical Immunology, Biotechnology Course, University of Torino Medical School
1999 – 2004 Professor of Allergology and Clinical Immunology, Resident program in Allergology and Clinical Immunology, University of Torino Medical School
2000 – 2004 Professor at the PhD program in Human Oncology, Department of Oncological Sciences, University of Torino
2003 Professor, International PhD program in Molecular Medicine, Università Vita-Salute San Raffaele, Milano
2004 – 2015 Professor, Molecular Oncology, Biotechnology Course, Università Vita-Salute San Raffaele, Milano
2006 – 2019 Professor, Internal Medicine, Nursing School, Università Vita-Salute San Raffaele, Milano
2007 – 2015 Professor, Lymphoproliferative disorders Course, Medical School, Università Vita-Salute San Raffaele, Milano
2005 – today Professor, Internal Medicine and Pneumology Residency Program, Medical School, Università Vita-Salute San Raffaele, Milano
2008 – 2014 Professor, PhD program in Translational and Molecular Medicine, DIMET, Università degli Studi di Milano Bicocca
2009 – today Co-Coordinator, PhD program in molecular Medicine, Basic and Applied Immunology and Oncology, Università Vita-Salute San Raffaele, Milano
2014 – 2019 Professor, Internal Medicine Course, International MD Program, Università Vita-Salute San Raffaele, Milano
2016 – today Professor, Oncology course, Italian MD program and Nursing Program, Università Vita-Salute San Raffaele, Milano

1998-2003 Assistant Professor of Internal Medicine: Attending physician at the Clinical Immunology and Allergology University Division, Ospedale Mauriziano “Umberto I”, Torino
2003-2004 Assistant Professor in Internal Medicine: Head of the Cancer Immunology University Unit, Institute for Cancer Research and Treatment, Candiolo, Italy. Clinical interest: molecular and phenotypic diagnosis of hematologic malignancies
2005-2015 Scientific coordinator: Lymphoid Malignancies Unit, Department of Oncology, IRCCS Ospedale San Raffaele, Milano
2016 – today Director, Strategic Research Program on CLL, Division of Experimental Oncology, IRCCS Ospedale San Raffaele, Milano

1997 – present American Society of Hematology, member
1997 – present American Association of Immunologists, member
2002 – present European Hematology Association, member
2002 – present Società Italiana di Immunologia, Immunologia Clinica e Allergologia, member
2006 – present Henry Kunkel Society, member
2006 – 2009 co-chairman of the Basic and Translational Research Committee of the European Research Initiative on CLL (ERIC)
2007 – today Società Italiana di Ematologia Sperimentale (SIES), member
2007 – 2009 Member of the Scientific Program Committee – Advisory Board (SPC-AB) of the European Hematology Association (EHA)
2007 – 2008 Co-organizer, II and III edition, “Young CLL Investigators Meeting” (London 2007; Cologne 2008)
2007 – today Member, Organizing and Scientific Committee of the Annual “Educational Workshop of Immunoglobulin Genes analysis in Chronic Lymphocytic Leukemia” (Uppsala, 2007; Paris, 2008; Thessaloniki 2009),
2008 – 2013 Member, Technical and Scientific Committee, Italian Association for Cancer Research (AIRC)
2009 – 2011 Member, Scientific Program Committee (SPC), European Hematology Association (EHA)
2009 – today Member, Executive Committee, European Research Initiative on CLL (ERIC),
2014 – today Member, WHO Clinical Advisory Committee for Lymphocytic and Histiocytic Malignancies (area: Chronic Lymphocytic Leukemia, MBL and PLL)
2015 – today President, European Research Initiative on CLL (ERIC)

2005 – 2013 Member of the editorial board of Leukemia
2008 – 2017 Member of the editorial board of Haematologica/The Hematology Journal
2009 – 2013 Section Editor (CLL and B cell disorders), Leukemia
2010 – 2013 Deputy Editor (Lymphomas and Chronic Lymphocytic Leukemia), Blood Cancer Journal (ISSN 2044-5385)
2014 – 2017 Section Editor (Chronic Lymphocytic Leukemia), Haematologica/The Hematology Journal (ISSN 0390-6078)
2018 – today Section Editor (Leucemia Linfatica Cronica), Hemasphere, the Official journal of the EHA (ISSN 2572-9241)

Reviewer for Acta Hematolologica, Blood, Hematologica/The Hematology Journal, Hematological Oncology, Journal of Leukocyte biology, Leukemia & Lymphoma
Abstract reviewer for EHA, ASH, iwCLL (International Workshop on CLL), ECI (European Congress of Immunology) meetings




  1. Furman RR, Sharman JP, Coutre SE, Cheson BD, Pagel JM, Hillmen P, Barrientos JC, Zelenetz AD, Kipps TJ, Flinn I, Ghia P, Eradat H, Ervin T, Lamanna N, Coiffier B, Pettitt AR, Ma S, Stilgenbauer S, Cramer P, Aiello M, Johnson DM, Miller LL, Li D, Jahn TM, Dansey RD, Hallek M, O’Brien SM. Idelalisib and Rituximab in Relapsed Chronic Lymphocytic Leukemia.

N Engl J Med. 2014 Jan 22. [Epub ahead of print]                                                         I.F. 51.658


  1. Rosenquist R, Davi F, Ghia P. The microenvironment in lymphomas – Dissecting the complex crosstalk between tumor cells and ‘by-stander’ cells.

Semin Cancer Biol. 2013 Dec 21. [Epub ahead of print]                                        I.F. 7.436


  1. Shim YK, Rachel JM, Ghia P, Boren J, Abbasi F, Dagklis A, Venable G, Kang J, Degheidy H, Plapp FV, Vogt RF, Menitove JE, Marti GE. Monoclonal B-cell lymphocytosis in healthy blood donors: an unexpectedly common finding.

Blood. 2013 Dec 17. [Epub ahead of print]                                                                  I.F. 9.060


  1. Vardi A, Agathangelidis A, Sutton LA, Chatzouli M, Scarfo L, Mansouri L, Douka V, Anagnostopoulos A, Darzentas N, Rosenquist R, Ghia P, Belessi C, Stamatopoulos K. IgG-switched CLL has a distinct immunogenetic signature from the common MD variant: ontogenetic implications.

Clin Cancer Res. 2014;20:323-330  doi: 10.1158/1078-0432                                  I.F. 7.837


  1. Scarfò L, Ghia P. Reprogramming cell death: bcl2 family inhibition in hematological malignancies. Immunol Lett. 2013 Oct 1. I.F. 2.337


  1. Karube K, Scarfò L, Campo E, Ghia P. Monoclonal B cell lymphocytosis and “in situ” lymphoma.

Semin Cancer Biol. 2013 Aug 30. [Epub ahead of print]                                        I.F. 7.436


  1. Sutton LA, Agathangelidis A, Belessi C, Darzentas N, Davi F, Ghia P, Rosenquist R, Stamatopoulos K. Antigen selection in B-cell lymphomas-Tracing the evidence.

Semin Cancer Biol. 2013;23:399-409                                                                I.F. 7.436


  1. Martins LR, Lúcio P, Melão A, Antunes I, Cardoso BA, Stansfield R, Bertilaccio MT, Ghia P, Drygin D, Silva MG, Barata JT. Activity of the clinical-stage CK2-specific inhibitor CX-4945 against chronic lymphocytic leukemia.

Leukemia. 2014;28:179-182                                                                           I.F. 10.164


  1. Acquati F, Lualdi M, Bertilaccio S, Monti L, Turconi G, Fabbri M, Grimaldi A, Anselmo A, Inforzato A, Collotta A, Cimetti L, Riva C, Gribaldo L, Ghia P, Taramelli R. Loss of function of Ribonuclease T2, an ancient and phylogenetically conserved RNase, plays a crucial role in ovarian tumorigenesis.

Proc Natl Acad Sci U S A. 2013 May 14;110(20):8140-5                              I.F. 9.737


  1. Papakonstantinou N, Ntoufa S, Chartomatsidou E, Papadopoulos G, Hatzigeorgiou A, Anagnostopoulos A, Chlichlia K, Ghia P, Muzio M, Belessi C, Stamatopoulos K. Differential microRNA profiles and their functional implications in different immunogenetic subsets of chronic lymphocytic leucemia

Mol Med. 2013;19:115-23                                                                     I.F. 4.469


  1. Vardi A, Dagklis A, Scarfò L, Jelinek D, Newton D, Bennett F, Almeida J, Rodriguez-Caballero A, Allgood S, Lanasa M, Cortelezzi A, Orlandi E, Veronese S, Montillo M, Rawstron A, Shanafelt T, Orfao A, Stamatopoulos K, Ghia P. Immunogenetics shows that not all MBL are equal: the larger the clone the more similar to CLL.

Blood. 2013;121:4521-4528                                                                            I.F. 9.060


  1. Scarfò L, Fazi C, Ghia P. MBL Versus CLL: How Important Is the Distinction?

Hematol Oncol Clin North Am. 2013;27:251-265                                        I.F. 2.084


  1. Strefford JC, Sutton LA, Baliakas P, Agathangelidis A, Malcíková J, Plevova K, Scarfó L, Davis Z, Stalika E, Cortese D, Cahill N, Pedersen LB, di Celle PF, Tzenou T, Geisler C, Panagiotidis P, Langerak AW, Chiorazzi N, Pospisilova S, Oscier D, Davi F, Belessi C, Mansouri L, Ghia P*, Stamatopoulos K, Rosenquist R. Distinct patterns of novel gene mutations in poor-prognostic stereotyped subsets of chronic lymphocytic leukemia: the case of SF3B1 and subset #2. *joint senior author

Leukemia. 2013 Nov;27(11):2196-9                                                                 I.F. 10.164


  1. Apollonio B, Scielzo C, Bertilaccio MT, Ten Hacken E, Scarfò L, Ranghetti P, Stevenson F, Packham G, Ghia P*, Muzio M, Caligaris-Cappio F. Targeting B cell anergy in chronic lymphocytic leukemia. *Corresponding author

Blood. 2013 May 9;121(19):3879-88                                                                 I.F. 9.060


  1. Ten Hacken E, Scielzo C, Bertilaccio MT, Scarfò L, Apollonio B, Barbaglio F, Stamatopoulos K, Ponzoni M, Ghia P*, Caligaris-Cappio F. Targeting the LYN/HS1 signaling axis in chronic lymphocytic leukemia. *Corresponding author

Blood. 2013 Mar 21;121(12):2264-73.                                                              I.F. 9.060


  1. Ghia P. A look into the future: can minimal residual disease guide therapy and predict prognosis in chronic lymphocytic leukemia?

Hematology Am Soc Hematol Educ Program. 2012;2012:97-104


  1. Fonte E, Apollonio B, Scarfò L, Ranghetti P, Fazi C, Ghia P, Caligaris-Cappio F, Muzio M. In Vitro Sensitivity of CLL Cells to Fludarabine May Be Modulated by the Stimulation of Toll-like Receptors.

Clin Cancer Res. 2013;19:367-379                                                          I.F. 7.837


  1. Ponzoni M, Kanellis G, Pouliou E, Baliakas P, Scarfò L, Ferreri AJ, Doglioni C, Bikos V, Dagklis A, Anagnostopoulos A, Ghia P, Stamatopoulos K, Papadaki T. Bone Marrow Histopathology in the Diagnostic Evaluation of Splenic Marginal-zone and Splenic Diffuse Red Pulp Small B-cell Lymphoma: A Reliable Substitute for Spleen Histopathology?

Am J Surg Pathol. 2012;36:1609-18                                                                 I.F. 4.868


  1. Rawstron AC, Böttcher S, Letestu R, Villamor N, Fazi C, Kartsios H, de Tute RM, Shingles J, Ritgen M, Moreno C, Lin K, Pettitt AR, Kneba M, Montserrat E, Cymbalista F, Hallek M, Hillmen P, Ghia P. Improving efficiency and sensitivity: European Research Initiative in CLL (ERIC) update on the international harmonised approach for flow cytometric residual disease monitoring in CLL.

Leukemia. 2013; 27:142-149                                                                          I.F. 10.164


  1. Bertilaccio MT, Scielzo C, Simonetti G, Hacken ET, Apollonio B, Ghia P*, Caligaris-Cappio F. Xenograft models of chronic lymphocytic leukemia: problems, pitfalls and future directions. *Corresponding author

Leukemia. 2013;27:534-540                                                                           I.F.10.164


  1. Bikos V, Stalika E, Baliakas P, Darzentas N, Davis Z, Traverse-Glehen A, Dagklis A, Kanellis G, Anagnostopoulos A, Tsaftaris A, Ponzoni M, Berger F, Felman P, Ghia P, Papadaki T, Oscier D, Belessi C, Stamatopoulos K. Selection of antigen receptors in splenic marginal-zone lymphoma: further support from the analysis of the immunoglobulin light-chain gene repertoire.

Leukemia. 2012; 26:2567-2569                                                                       I.F. 10.164


  1. Franiak-Pietryga I, Maciejewski H, Wolowiec D, Salagacka A, Blonski JZ, Janus A, Kotkowska A, Wawrzyniak E, Ghia P, Mirowski M, Robak T, Korycka-Wolowiec A. Changes in the apoptotic gene expression profile in CLL patients treated with rituximab combined with cladribine and cyclophosphamide-preliminary results.

Leuk Res. 2012;36:1134-1140                                                                         I.F. 2.764


  1. Santoni de Sio FR, Massacand J, Barde I, Offner S, Corsinotti A, Kapopoulou A, Bojkowska K, Dagklis A, Fernandez M, Ghia P, Thomas JH, Pinschewer D, Harris N, Trono D. KAP1 regulates gene networks controlling mouse B-lymphoid cell differentiation and function.

Blood. 2012;119:4675-4685                                                                   I.F. 9.060


  1. Ntoufa S, Vardi A, Papakonstantinou N, Anagnostopoulos A, Aleporou-Marinou V, Belessi C, Ghia P, Caligaris-Cappio F, Muzio M, Stamatopoulos K. Distinct Innate Immunity Pathways to Activation and Tolerance in Subgroups of Chronic Lymphocytic Leukemia with Distinct Immunoglobulin Receptors.

Mol Med. 2012;18:1281-1291                                                                          I.F. 4.469


  1. Shinawi T, Hill V, Dagklis A, Baliakas P, Stamatopoulos K, Agathanggelou A, Stankovic T, Maher ER, Ghia P, Latif F. KIBRA gene methylation is associated with unfavorable biological prognostic parameters in chronic lymphocytic leukemia.

Epigenetics. 2012;7:211-215                                                                           I.F. 4.920


  1. Ghia P*, Caligaris-Cappio F. Monoclonal B-cell lymphocytosis (MBL): right track or red herring? *corresponding author

Blood. 2012;119:4358-4362                                                                   I.F. 9.060


  1. Agathangelidis A, Darzentas N, Hadzidimitriou A, Brochet X, Murray F, Yan XJ, Davis Z, van Gastel-Mol EJ, Tresoldi C, Chu CC, Cahill N, Giudicelli V, Tichy B, Pedersen LB, Foroni L, Bonello L, Janus A, Smedby K, Anagnostopoulos A, Merle-Beral H, Laoutaris N, Juliusson G, di Celle PF, Pospisilova S, Jurlander J, Geisler C, Tsaftaris A, Lefranc MP, Langerak AW, Oscier DG, Chiorazzi N, Belessi C, Davi F, Rosenquist R, Ghia P*, Stamatopoulos K. Stereotyped B-cell receptors in one third of chronic lymphocytic leukemia: towards a molecular classification with implications for targeted therapeutic interventions. *corresponding author

Blood. 2012;119:4467-4475                                                                   I.F. 9.060


  1. Pospisilova S, Gonzalez D, Malcikova J, Trbusek M, Rossi D, Kater AP, Cymbalista F, Eichhorst B, Hallek M, Döhner H, Hillmen P, van Oers M, Gribben J, Ghia P, Montserrat E, Stilgenbauer S, Zenz T. ERIC recommendations on TP53 mutation analysis in Chronic Lymphocytic Leukemia.

Leukemia. 2012;26:1458-1461                                                                        I.F. 10.164


  1. Scarfò L, Zibellini S, Tedeschi A, Maura F, Neri A, Bertazzoni P, Sarina B, Nalli G, Motta M, Rossini F, Cortelezzi A, Montillo M, Orlandi E, Ghia P. Impact of B-cell count and imaging screening in cMBL: any need to revise the current guidelines?

Leukemia. 2012;26:1703-1707                                                                        I.F. 10.164


  1. Dolcetti R, Serraino D, Dognini G, Govi S, Crocchiolo R, Ghia P, Pasini E, Ponzoni M, Talamini R, De Paoli P, Doglioni C, Ferreri AJ. Exposure to animals and increased risk of marginal zone B-cell lymphomas of the ocular adnexae.

Br J Cancer. 2012;106:966-969                                                                       I.F. 5.082


  1. Bikos V, Darzentas N, Hadzidimitriou A, Davis Z, Hockley S, Traverse-Glehen A, Algara P, Santoro A, Gonzalez D, Mollejo M, Dagklis A, Gangemi F, Bosler DS, Bourikas G, Anagnostopoulos A, Tsaftaris A, Iannitto E, Ponzoni M, Felman P, Berger F, Belessi C, Ghia P, Papadaki T, Dogan A, Degano M, Matutes E, Piris MA, Oscier D, Stamatopoulos K. Over 30% of patients with splenic marginal zone lymphoma express the same immunoglobulin heavy variable gene: ontogenetic implications.

Leukemia. 2012;26:1638-1646                                                                        I.F. 10,164


  1. Kostareli E, Gounari M, Janus A, Murray F, Brochet X, Giudicelli V, Pospisilova S, Oscier D, Foroni L, di Celle PF, Tichy B, Pedersen LB, Jurlander J, Ponzoni M, Kouvatsi A, Anagnostopoulos A, Thompson K, Darzentas N, Lefranc MP, Belessi C, Rosenquist R, Davi F, Ghia P*, Stamatopoulos K. Antigen receptor stereotypy across B-cell lymphoproliferations: the case of IGHV4-59/IGKV3-20 receptors with rheumatoid factor activity. * corresponding author and joint senior author

Leukemia. 2012;26:1127-1131                                                                       I.F. 10.164


  1. Dagklis A, Ponzoni M, Govi S, Cangi MG, Pasini E, Charlotte F, Vino A, Doglioni C, Davì F, Lossos IS, Ntountas I, Papadaki T, Dolcetti R, Ferreri AJ, Stamatopoulos K, Ghia P. Immunoglobulin gene repertoire in ocular adnexal lymphomas: hints on the nature of the antigenic stimulation.

Leukemia. 2012;26:814-821                                                                           I.F. 10.164


  1. Fazi C, Scarfò L, Pecciarini L, Cottini F, Dagklis A, Janus A, Talarico A, Scielzo C, Sala C, Toniolo D, Caligaris-Cappio F, Ghia P. General population low-count CLL-like MBL persist over time without clinical progression, though carrying the same cytogenetic abnormalities of CLL.

Blood. 2011;118:6618-6625                                                                   I.F. 9.060


  1. Ghia P. Another piece of the puzzle: is there a “nodal” monoclonal B-cell lymphocytosis?

Haematologica. 2011;96:1089-1091.

Il titolare del presente curriculum vitae, pubblicato online sul portale, è garante in via esclusiva della correttezza e della veridicità dei dati e delle informazioni in esso riportate e del loro eventuale e puntuale aggiornamento. Egli è dunque il diretto ed unico responsabile dei contenuti indicati nei propri curricula.