Panina Paola Professore associatoMedicineMED/50 – Scienze e tecniche mediche applicate
Biography
Publications
Biography
Education
Ph.D., Cellular and Molecular Biotechnologies, Università degli Studi di Brescia
Post-graduate Specialisation, Microbiology, Università degli Studi di Parma, summa cum laude
Master Degree, Biological Sciences, Università degli Studi di Parma, summa cum laude
Professional activities
2018 - present
Universita’ Vita-Salute San Raffaele.
Associate Professor, Applied Medical Technical Sciences, Faculty of Medicine
2011 - 2018
Universita’ Vita-Salute San Raffaele.
Adjunct Professor, Applied Biology, Faculty of Medicine
2005 - 2009
Universita’ Vita-Salute San Raffaele.
Adjunct Professor, Physiology, Faculty of Medicine
2019 - present
Division of Neuroscience, Ospedale San Raffaele
Scientist
2010 - 2018
Division of Genetics and Cell Biology, Ospedale San Raffaele
Scientist
2002 - 2009
Bioxell SpA, Milano
Co-founder and Director of Preclinical Research
1992 - 2001
Roche Milano Ricerche, Milano
Scientist
1991 - 1992
CNRS-LGME INSERM-U184, Strasbourg, F
Visiting Scientist
1988 - 1990
Basel Institute for Immunology, Basel, CH
Member
Other activities
Interfaculty Centre for Gender Studies, Università Vita-Salute San Raffaele: Member of the Scientific Board.
Supervisory committee for equal opportunities, worker welfare and non-discrimination (CUG), Università Vita-Salute San Raffaele: Faculty of Medicine contact.
Scientific Interest
My current scientific interest is the elucidation of the pathogenic mechanisms of immune-mediated central nervous system disorders. The expertise in cell biology and immunology adds up to a vast experience in discovery, validation and development of novel therapeutic agents for inflammatory disorders. Research challenges are adressed within qualified international networks. I am co-author of more than 80 scientific publications, >9000 citations, h-index: 42 (source: Scopus, March 2021).
Publications
Most relevant publications
Murtaj V, Belloli S, Di Grigoli G, Pannese M, Ballarini E, Rodriguez-Menendez V, Marmiroli P, Cappelli A, Masiello V, Monterisi C, Bellelli G, Panina-Bordignon P, Moresco RM (2019) Age and Sex Influence the Neuro-inflammatory Response to a Peripheral Acute LPS Challenge. Front Aging Neurosci. 11:299.
Pagani I, Ghezzi S, Ulisse A, Rubio A, Turrini F, Garavaglia E, Candiani M, Castilletti C, Ippolito G, Poli G, Broccoli V, Panina-Bordignon P*, Vicenzi* E. (2017) Human Endometrial Stromal Cells Are Highly Permissive to Productive Infection by Zika Virus. Sci Rep. 7:44286. (*co-last/corresponding authors)
Sanchez AM, Quattrone F, Pannese M, Ulisse A, Candiani M, Diaz-Alonso J, Velasco G, Panina-Bordignon P. (2017) The cannabinoid receptor CB1 contributes to the development of ectopic lesions in a mouse model of endometriosis. Hum Reprod. 32(1):175.
Belloli, S., Pannese, M., Buonsanti, C., ...Moresco, R.M., Panina-Bordignon, P. (2017) Early upregulation of 18-kDa translocator protein in response to acute neurodegenerative damage in TREM2-deficient mice. Neurobiology of Aging 53:159.
Ruiz A, Rockfield S, Taran N, Haller E, Engelman RW, Flores I, Panina-Bordignon P, Nanjundan M. (2016) Effect of hydroxychloroquine and characterization of autophagy in a mouse model of endometriosis. Cell Death Dis. 7:e2059.
Sanchez AM, Viganò P, Quattrone F, Pagliardini L, Papaleo E, Candiani M, Panina-Bordignon P. (2014) The WNT/β-catenin signaling pathway and expression of survival promoting genes in luteinized granulosa cells: endometriosis as a paradigm for a dysregulated apoptosis pathway. Fertil Steril. 2014 101(6):1688.
Amodio G, Mugione A, Sanchez AM, Viganò P, Candiani M, Somigliana E, Roncarolo MG, Panina-Bordignon P*, Gregori S*. (2013) HLA-G expressing DC-10 and CD4(+) T cells accumulate in human decidua during pregnancy. Hum Immunol. 74(4):406. (*co-last/corresponding authors)
Mariani M, Viganò P, Gentilini D, Camisa B, Caporizzo E, Di Lucia P, Monno A, Candiani M, Somigliana E, Panina-Bordignon P. (2012) The selective vitamin D receptor agonist, elocalcitol, reduces endometriosis development in a mouse model by inhibiting peritoneal inflammation. Hum Reprod. 27(7):2010.
Stefano L, Racchetti G, Bianco F, Passini N, Gupta RS, Panina Bordignon P, Meldolesi J. (2009) The surface-exposed chaperone, Hsp60, is an agonist of the microglial TREM2 receptor. J Neurochem. 110(1):284.
Piccio L, Buonsanti C, Cella M, Tassi I, Schmidt RE, Fenoglio C, Rinker J 2nd, Naismith RT, Panina-Bordignon P, Passini N, Galimberti D, Scarpini E, Colonna M, Cross AH. (2008) Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation. Brain 131(Pt 11):3081.
Piccio L, Buonsanti C, Mariani M, Cella M, Gilfillan S, Cross AH, Colonna M, Panina-Bordignon P. (2007) Blockade of TREM-2 exacerbates experimental autoimmune encephalomyelitis. Eur J Immunol. 37(5):1290.
Prada I, Ongania GN, Buonsanti C, Panina-Bordignon P, Meldolesi J. (2006) Triggering receptor expressed in myeloid cells 2 (TREM2) trafficking in microglial cells: continuous shuttling to and from the plasma membrane regulated by cell stimulation. Neuroscience. 140(4):1139.
Grenningloh R, Gho A, di Lucia P, Klaus M, Bollag W, Ho IC, Sinigaglia F, Panina-Bordignon P. (2006) Cutting Edge: Inhibition of the retinoid X receptor (RXR) blocks T helper 2 differentiation and prevents allergic lung inflammation. J. Immunol. ;176(9):5161.
Sessa G, Podini P, Mariani M, Meroni A, Spreafico R, Sinigaglia F, Colonna M, Panina P, Meldolesi J. (2004) Distribution and signaling of TREM2/DAP12, the receptor system mutated in human polycystic lipomembraneous osteodysplasia with sclerosing leukoencephalopathy dementia. Eur J Neurosci. 20(10):2617.
Somigliana E, Viganò P, Rossi G, Carinelli S, Vignali M, Panina-Bordignon P. (1999) Endometrial ability to implant in ectopic sites can be prevented by interleukin-12 in a murine model of endometriosis. Hum Reprod. 14(12):2944.
D'Ambrosio D, Cippitelli M, Cocciolo MG, Mazzeo D, Di Lucia P, Lang R, Sinigaglia F, Panina-Bordignon P. (1998) Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3 Involvement of NF-kappaB downregulation in transcriptional repression of the p40 gene. J Clin Invest. 101(1):252.
Panina-Bordignon P, Lang R, van Endert PM, Benazzi E, Felix AM, Pastore RM, Spinas GA, Sinigaglia F. (1995) Cytotoxic T cells specific for glutamic acid decarboxylase in autoimmune diabetes. J Exp Med.181(5):1923.
Panina-Bordignon P, Fu XT, Lanzavecchia A, Karr RW. (1992) Identification of HLA-DR alpha chain residues critical for binding of the toxic shock syndrome toxin superantigen. J Exp Med. 176(6):1779.
Panina-Bordignon P, Corradin G, Roosnek E, Sette A, Lanzavecchia A. (1991) Recognition by class II alloreactive T cells of processed determinants from human serum proteins. Science. 252(5012):1548.
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