Di Resta Chiara Ricercatore tempo determinato tipo bMedicineMED/05




Doctor Chiara Di Resta obtained a degree in Biological Sciences (2005) and the PhD in Translational and Molecular Medicine (2008) at the University of Milano-Bicocca (Italy). Then, she obtained a Specialization in Clinical Pathology (2016) at the University of Pavia (Italy). She holds the position of Researcher (rtd) at Vita-Salute San Raffaele University since 2015, carrying out teaching activities in the field of clinical laboratory medicine. Since 2016, she is a member of the Specialization School in Clinical Pathology and Clinical Biochemistry at UniSR and she holds the role of supervisor or co-supervisor in several students’ thesis works.


Her main research activity is focused on the application of molecular medicine for the study of inherited diseases.  In particular, the main purpose of her studies is the characterization of the molecular basis of the genetic cardiac forms, which are still unknown. Indeed, the most advanced molecular techniques and new sequencing approaches of the post-genomic era offer the possibility of identifying new causative genes and novel mutations. So, her main laboratory activities are therefore characterized by close collaboration with clinicians in molecular and translational research projects. Her work has been published in relevant scientific journals.

Moreover, she has contributed to the field of Personalized Medicine, participating in the activities of the dedicated working group (WG-PLM) of the European Federation of Laboratory Medicine (EFLM).



2016: Specialization in Clinical Pathology; University of Pavia, Italy 

Thesis project published: Hum Mol Genet. 2015 Oct 15;24(20):5828-35

2008: Ph.D. in Traslational and Molecular Medicine (DIMET); University of Milano-Bicocca, Milan, Italy

Thesis project published: Eur J Pharmacol. 2010 Sep 15;643(1):13-20

2005: Degree in Biological Sciences (5 years); University of Milano-Bicocca, Milan, Milan, Italy

Thesis project published: Am J Hum Genet. 2006 Aug;79(2):342-50

2000: Diploma of High School (Classical Lyceum "Ettore Majorana”, Desio, Italy)

Unique identifiers

ORCID ID: 0000-0003-2880-6631

Scopus Author ID: 36157555900

Participation in Editorial Boards of Scientific Journals

From 2022: Topic editor for the Special Issue: “Whole Genome Sequencing for Rare Diseases” in Frontiers in Medicine (ISSN: 2296-858X; IF: 5.05)


From 2021: Guest editor for the Special Issue “Advance in Genomics of Rare Genetic Diseases”, Section of Molecular

Genetics, in Biomolecules (ISSN 2218-273X; IF: 6.06)  


From 2019:  Review Editor for Genetics of Common and Rare Diseases for Frontiers in Genetics (eISSN: 1664-8021;

Impact Factor 2020: 4.7)  


From 2019: Review Editor for Genetics of Common and Rare Diseases for Frontiers in Pediatrics (eISNN: 2296-2360; Impact Factor 2020: 3.569)



2021–today:    Member of the EFLM Academy (European Federation of Clinical Chemistry and Laboratory Medicine)

2019 - today: Member of Task Force Young Scientists of the IFCC (International Federation of Clinical Biochemistry)

2013 - 2018: Young Scientist Member of the European Working Group on Personalized Laboratory Medicine of the             European Federation of clinical chemistry and laboratory medicine (EFLM).

2011– today:   Member of the Italian Network of Laminopathies (NIL)

(Update january 2023)


  1. Tomaiuolo R, Restelli U, Faggiano FC, Di Resta C, Al Bitar Nehme S, Giuliani F, Derrico P, Ricciardi W, Banfi G, Ritrovato M. Health technology assessment to employ COVID-19 serological tests as companion diagnostics in the vaccination campaign against SARS-CoV-2.

Clin Chem Lab Med. 2022 Jun 24;60(9):1463-1477.

doi: 10.1515/cclm-2022-0262. PMID: 35749147.

  1. Tomaiuolo R, Di Resta C, Viganò M, Banfi G, Russo C, Linardos G, Ranno S, Perno CF, Giuffrida F. Six months SARS-CoV-2 serology in a cohort of mRNA vaccinated subjects over 90 years old.

Sci Rep. 2022 Jul 20;12(1):12446.

doi: 10.1038/s41598-022-15148-z. PMID: 35858893; PMCID: PMC9298708.

  1. Di Resta C, Berg J, Villatore A, Maia M, Pili G, Fioravanti F, Tomaiuolo R, Sala S, Benedetti S, Peretto G. Concealed Substrates in Brugada Syndrome: Isolated Channelopathy or Associated Cardiomyopathy?

Genes (Basel). 2022 Sep 28;13(10):1755.

doi: 10.3390/genes13101755. PMID: 36292641; PMCID: PMC9602309.

  1. Ferrari D, Ambrosi A, Di Resta C, Tomaiuolo R, Locatelli M, Banfi G. Evaluation of antibody titer kinetics and SARS-CoV-2 infections in a large cohort of healthcare professionals ten months after administration of the BNT162b2 vaccine. J Immunol Methods. 2022 Jun 2:113293.

doi: 10.1016/j.jim.2022.113293. PMID: 35660546.

  1. Guicciardi NA, De Bonis M, Di Resta C, Ascione G, Alfieri O, Maisano F, Vergara P. Genetic background of mitral valve prolapse.

Rev Cardiovasc Med. 2022 Mar 12;23(3):96.

doi: 10.31083/j.rcm2303096. PMID: 35345263.

  1. Veneruso I, Di Resta C, Tomaiuolo R, D'Argenio V. Current Updates on Expanded Carrier Screening: New Insights in the Omics Era. Medicina (Kaunas). 2022;58(3):455. Published 2022 Mar 21.


  1. Colombini A, Viganò M, Tomaiuolo R, Di Resta C, Corea F, Sabetta E, Ferrari D, De Vecchi E, Maria Spanò S, Banfi G. Exploratory assessment of serological tests to determine antibody titer against SARS-CoV-2: Appropriateness and limits. J Clin Lab Anal. 2022 May;36(5):e24363.

doi: 10.1002/jcla.24363. Epub 2022 Mar 25. PMID: 35334493; PMCID: PMC9102736.

  1. Carobene A, Sabetta E, Monteverde E, Locatelli M, Banfi G, Di Resta C, Guerranti R, Vidali M, Campagner A, Cabitza F. Machine Learning based on laboratory medicine test results in diagnosis and prognosis for COVID-19 patients: A systematic review. Biochimica Clinica; 45(4) 348-364.

doi: 10.19186/BC_2021.046. ISSN: 0393-0564

  1. Ferrari D, Clementi N, Criscuolo E, Ambrosi A, Corea F, Di Resta C, Tomaiuolo R, Mancini N, Locatelli M, Plebani M, Banfi G. Antibody Titer Kinetics and SARS-CoV-2 Infections Six Months after Administration with the BNT162b2 Vaccine. Vaccines (Basel). 2021 Nov 19;9(11):1357.

doi: 10.3390/vaccines9111357. PMID: 34835288; PMCID: PMC8620373. ISSN: 2076-393X

  1. Ferrari D, Mangia A, Spanò MS, Zaffarano L, Viganò M, Di Resta C, Locatelli M, Ciceri F, De Vecchi E. Quantitative serological evaluation as a valuable tool in the COVID-19 vaccination campaign. Clin Chem Lab Med. 2021 Oct 7;59(12):2019-2026.

      doi: 10.1515/cclm-2021-0364. PMID: 34614550. ISSN: 1437-6621

  1. Vecchi VM, Spreafico M, Brix A, Santoni A, Sala S, Pistocchi A, Marozzi A, Di Resta C. Generation of a Triadin KnockOut Syndrome Zebrafish Model. Int J Mol Sci. 2021 Sep 8;22(18):9720.

      doi: 10.3390/ijms22189720. PMID: 34575879; PMCID: PMC8471218. ISSN: 1661-6596

  1. Ferrari D, Clementi N, Spanò SM, Albitar-Nehme S, Ranno S, Colombini A, Criscuolo E, Di Resta C, Tomaiuolo R, Viganó M, Mancini N, De Vecchi E, Locatelli M, Mangia A, Perno CF, Banfi G. Harmonization of six quantitative SARS-CoV-2 serological assays using sera of vaccinated subjects. Clin Chim Acta. 2021 Nov;522:144-151.

      doi: 10.1016/j.cca.2021.08.024. Epub 2021 Aug 20. PMID: 34425105; PMCID: PMC8378065. ISSN: 0009-8981

  1. Banfi F, Rubio A, Zaghi M, Massimino L, Fagnocchi G, Bellini E, Luoni M, Cancellieri C, Bagliani A, Di Resta C, Maffezzini C, Ianielli A, Ferrari M, Piazza R, Mologni L, Broccoli V, Sessa A. SETBP1 accumulation induces P53 inhibition and genotoxic stress in neural progenitors underlying neurodegeneration in Schinzel-Giedion syndrome. Nat Commun. 2021 Jun 30;12(1):4050.

      doi: 10.1038/s41467-021-24391-3. PMID: 34193871; PMCID: PMC8245514. ISSN: 2041-1723

  1. Ferrari D, Di Resta C, Tomaiuolo R, Sabetta E, Pontillo M, Motta A, Locatelli M. Long-term antibody persistence and exceptional vaccination response on previously SARS-CoV-2 infected subjects. Vaccine. 2021 Jul 13;39(31):4256-4260.

      doi: 10.1016/j.vaccine.2021.06.020. Epub 2021 Jun 12. PMID: 34147292; PMCID: PMC8196312. ISSN: 0264-410X

  1. Di Resta C, Ferrari D, Viganò M, Moro M, Sabetta E, Minerva M, Ambrosio A, Locatelli M, Tomaiuolo R. The Gender Impact Assessment among Healthcare Workers in the SARS-CoV-2 Vaccination-An Analysis of Serological Response and Side Effects. Vaccines (Basel). 2021 May 18;9(5):522.

      doi: 10.3390/vaccines9050522. PMID: 34070196; PMCID: PMC8158485. ISSN: 2076-393X

  1. Ferrari D, Carobene A, Campagner A, Cabitza F, Sabetta E, Ceriotti D, Di Resta C, Locatelli M. Evidence of significant difference in key COVID-19 biomarkers during the Italian lockdown strategy. A retrospective study on patients admitted to a hospital emergency department in Northern Italy. Acta Biomed. 2020 Nov 10;91(4):e2020156.

      doi: 10.23750/abm.v91i4.10371. PMID: 33525206; PMCID: PMC7927476. ISSN: 0392-4203

  1. Peretto G, Barzaghi F, Cicalese MP, Di Resta C, Slavich M, Benedetti S, Giangiobbe S, Rizzo S, Palmisano A, Esposito A, De Cobelli F, Gulletta S, Basso C, Casari G, Aiuti A, Della Bella P, Sala S. Immunosuppressive therapy in childhood-onset arrhythmogenic inflammatory cardiomyopathy. Pacing Clin Electrophysiol. 2021 Mar;44(3):552-556.

      doi: 10.1111/pace.14153. Epub 2021 Jan 18. PMID: 33372694. ISSN: 0147-8389

  1. Ciconte G, Monasky MM, Santinelli V, Micaglio E, Vicedomini G, Anastasia L, Negro G, Borrelli V, Giannelli L, Santini F, de Innocentiis C, Rondine R, Locati ET, Bernardini A, Mazza BC, Mecarocci V, Ćalović Ž, Ghiroldi A, D'Imperio S, Benedetti S, Di Resta C, Rivolta I, Casari G, Petretto E, Pappone C. Brugada syndrome genetics is associated with phenotype severity. Eur Heart J. 2021 Mar 14;42(11):1082-1090. 

      doi: 10.1093/eurheartj/ehaa942. PMID: 33221895; PMCID: PMC7955973. ISSN: 0195-668X

  1. Cabitza F, Campagner A, Ferrari D, Di Resta C, Ceriotti D, Sabetta E, Colombini A, De Vecchi E, Banfi G, Locatelli M, Carobene A. Development, evaluation, and validation of machine learning models for COVID-19 detection based on routine blood tests. Clin Chem Lab Med. 2021 Oct 21;59(2):421-431.

doi: 10.1515/cclm-2020-1294. PMID: 33079698. ISSN: 1437-6621

  1. Peretto G, Barison A, Forleo C, Di Resta C, Esposito A, Aquaro GD, Scardapane A, Palmisano A, Emdin M, Resta N, Santoni A, Guaricci AI, Santobuono VE, Pepe M, Favale S, Ferrari M, Benedetti S, Della Bella P, Sala S. Late gadolinium enhancement role in arrhythmic risk stratification of patients with LMNA cardiomyopathy: results from a long-term follow-up multicentre study. Europace. 2020 Dec 23;22(12):1864-1872.

      doi: 10.1093/europace/euaa171. PMID: 32995851. ISSN: 1099-5129

  1. Di Resta C, Pipitone GB, Carrera P, Ferrari M. Current scenario of the genetic testing for rare neurological disorders exploiting next generation sequencing. Neural Regen Res. 2021 Mar;16(3):475-481.

      doi: 10.4103/1673-5374.293135. PMID: 32985468; PMCID: PMC7996035. ISSN: 1673-5374

  1. Monasky MM, Micaglio E, Ciconte G, Borrelli V, Giannelli L, Vicedomini G, Ghiroldi A, Anastasia L, Locati ET, Benedetti S, Di Resta C, Casari G, Pappone C. Novel SCN5A p.V1429M Variant Segregation in a Family with Brugada Syndrome. Int J Mol Sci. 2020 Aug 17;21(16):5902.

      doi: 10.3390/ijms21165902. PMID: 32824506; PMCID: PMC7460631. ISSN: 1661-6596

  1. Longo F, Benedetti S, Zambon AA, Sora MGN, Di Resta C, De Ritis D, Quattrini A, Maltecca F, Ferrari M, Previtali SC. Impaired turnover of hyperfused mitochondria in severe axonal neuropathy due to a novel DRP1 mutation. Hum Mol Genet. 2020 Jan 15;29(2):177-188.

      doi: 10.1093/hmg/ddz211. PMID: 31868880. ISSN: 0964-6906

  1. Micaglio E, Monasky MM, Resta N, Bagnulo R, Ciconte G, Giannelli L, Locati ET, Vicedomini G, Borrelli V, Ghiroldi A, Anastasia L, Benedetti S, Di Resta C, Ferrari M, Pappone C. Novel SCN5Ap.W697X Nonsense Mutation Segregation in a Family with Brugada Syndrome. Int J Mol Sci. 2019 Oct 4;20(19):4920.

      doi: 10.3390/ijms20194920. PMID: 31590245; PMCID: PMC6801452. ISSN: 1661-6596

  1. Di Resta C, Ferrari M. Genetic testing in neurology exploiting next generation sequencing: state of art. Neural Regen Res. 2020 Feb;15(2):265-266.

      doi: 10.4103/1673-5374.265554. Erratum in: Neural Regen Res. 2020 Aug;15(8):1559. PMID: 31552897; PMCID: PMC6905334. ISSN: 1673-5374

  1. Peretto G, Di Resta C, Perversi J, Forleo C, Maggi L, Politano L, Barison A, Previtali SC, Carboni N, Brun F, Pegoraro E, D'Amico A, Rodolico C, Magri F, Manzi RC, Palladino A, Isola F, Gigli L, Mongini TE, Semplicini C, Calore C, Ricci G, Comi GP, Ruggiero L, Bertini E, Bonomo P, Nigro G, Resta N, Emdin M, Favale S, Siciliano G, Santoro L, Sinagra G, Limongelli G, Ambrosi A, Ferrari M, Golzio PG, Bella PD, Benedetti S, Sala S; Italian Network for Laminopathies (NIL). Cardiac and Neuromuscular Features of Patients With LMNA-Related Cardiomyopathy. Ann Intern Med. 2019 Oct 1;171(7):458-463.

      doi: 10.7326/M18-2768. Epub 2019 Sep 3. PMID: 31476771. ISSN: 0003-4819

  1. Rossi D, Gigli L, Gamberucci A, Bordoni R, Pietrelli A, Lorenzini S, Pierantozzi E, Peretto G, De Bellis G, Della Bella P, Ferrari M, Sorrentino V, Benedetti S, Sala S, Di Resta C. A novel homozygous mutation in the TRDN gene causes a severe form of pediatric malignant ventricular arrhythmia. Heart Rhythm. 2020 Feb;17(2):296-304.

      doi: 10.1016/j.hrthm.2019.08.018. Epub 2019 Aug 19. PMID: 31437535. ISSN: 1547-5271

Il titolare del presente curriculum vitae, pubblicato online sul portale www.unisr.it, è garante in via esclusiva della correttezza e della veridicità dei dati e delle informazioni in esso riportate e del loro eventuale e puntuale aggiornamento. Egli è dunque il diretto ed unico responsabile dei contenuti indicati nei propri curricula.