Gene and Cell Therapy

Laboratories 2024/2025 - Gene and Cell Therapy

Please find below the list of the Supervisors (with a link to their CV) and their PhD Projects proposed for the academic year 2024/2025 for the curriculum in Gene and Cell Therapy.

The list includes the project based fellowships and below the free projects among which the candidates, who passed the first evaluation phase, must express their preference as indicated in the Call for Applications.

9 PROJECTS-BASED FELLOWSHIPS:

PROJECT-BASED FELLOWSHIP GCT1: ANNONI ANDREA

Unit: Immune Core Unit– IRCCS Ospedale San Raffaele

GCT1: Engineering Thymic Selection to Control the Development of Alloreactive T Cells to promote acceptance of allogeneic transplantation

PROJECT-BASED FELLOWSHIP GCT2: APRILE ANNAMARIA

Unit: Gene transfer into stem cells Unit, San Raffaele Telethon Institute for Gene Therapy (SR-Tiget) – IRCCS Ospedale San Raffaele

GCT2: Targeting the hematopoietic stem cell niche to improve gene therapy for hemoglobinopathies

PROJECT-BASED FELLOWSHIP GCT3: CANTORE ALESSIO

Unit: Liver gene therapy – The San Raffaele Telethon Institute for Gene Therapy (SR-Tiget) – IRCCS Ospedale San Raffaele

GCT3: Dissecting hepatocyte heterogeneity in liver growth to improve in vivo gene therapy

PROJECT-BASED FELLOWSHIP GCT4: CESANA DANIELA

Unit: San Raffaele Telethon Institute for Gene Therapy, Safety of Gene therapy and insertional mutagenesis Unit – IRCCS Ospedale San Raffaele

GCT4: cell-free DNA as an early molecular response biomarker of CAR-T cell activity and efficacy

PROJECT-BASED FELLOWSHIP GCT5: DITADI ANDREA

Unit: Human hematopoietic development and disease modeling Unit – IRCCS Ospedale San Raffaele

GCT5: Gene expression dynamics of blood cell emegence

PROJECT-BASED FELLOWSHIP GCT6: OSTUNI RENATO

Unit: Genomics of the innate immune system Unit– IRCCS Ospedale San Raffaele

GCT6: Epigenetic regulators of inflammatory responses

PROJECT-BASED FELLOWSHIP GCT7: CASUCCI MONICA

Unit: Immunoterapie Innovative – IRCCS Ospedale San Raffaele

GCT7: Optimizing the therapeutic index of CD44v6 CAR T cells

PROJECT-BASED FELLOWSHIP GCT8: CRIPPA STEFANIA

Unit: Pathogenesis and therapy of primary immunodeficiencies Unit Telethon Institute for Gene Therapy– IRCCS Ospedale San Raffaele

Funded in the context of EU funds – NextGeneration EU- pursuant to DM 630/2024

GCT8: Pre-clinical development of HSPC-GT for Morquio syndrome

PROJECT-BASED FELLOWSHIP GCT9: BONINI CHIARA

Unit: Experimental Hematology Unit – IRCCS Ospedale San Raffaele

Funded in the context of EU funds – NextGeneration EU- pursuant to DM 630/2024

GCT9: Uncover and overcome senescence and dysfunction of genetically engineered T lymphocytes for cancer immunotherapy

BALESTRIERI CHIARA

Unit: Experimental Hematology Unit e Center for Omics Sciences

Unraveling Mechanisms and Targeting Liver Metastasis in Pancreatic Cancer: Insights into the Metastatic Microenvironment

BROCCOLI VANIA

Unit: Stem cells and neurogenesis

Isolating and validating new engineered AAV vectors for efficient brain transduction and efficacious gene therapy in a Rett disease mouse model

COLASANTE GAIA

Unit: Stem cells and neurogenesis

Investigating and enhancing the trafficking of Nav1.1 channel to set a gene therapy for Dravet Syndrome

COLTELLA NADIA

Unit: Targeted cancer Gene Therapy Unit 

Targeted delivery of orthogonal cytokines to safely improve CAR-T function within the tumor microenvironment of solid tumors

DI MICCO RAFFAELLA

Unit: SR-TIGET Group Leader, Senescence in Stem Cell Aging, Differentiation and Cancer

Studying the inetrplay between senescent cancer cells and the immune micronvironment in acute myeloid leukemia

FERRARI SAMUELE

Unit: Gene transfer technologies and new gene therapy strategies

Addressing the Unknowns of VEXAS syndrome by Single-cell Multiomic Clonal Tracking and Targeted Genome Editing

OMER ATTYA

Unit: Gene transfer technologies and new gene therapy strategies

Mobilization and Antibody-Mediated Conditioning: A Dual Approach to Maximize Chemotherapy-free Hematopoietic Stem Cell Therapy

SQUADRITO MARIO LEONARDO

Unit: Targeted cancer gene therapy

In vivo genetic engineering of liver metastases to modulate immune circuits