Poli Guido Professore ordinarioMedicineMED/04

PERSONAL INFORMATION

Citizenship Italian

Place and date of birth Verona, Italy, October 9, 1957.

Marital Status Married, two sons

 

EDUCATION

1976 High School (Scientific Lyceum).

1982 Medical Doctor degree, University of Ferrara, Italy; final marks: 110/110 e lode (Summa cum Laude).

1985 Specialist in Oncology, University of Ferrara, Italy; final marks: 70/70 lode (Summa cum Laude).

1985 Specialist in Pharmacological Research, Lombardy Region, “Mario Negri” Institute for Pharmacological Research, Milano, Italy.

 

PROFESSIONAL EXPERIENCE

Jan-June 1983

Internship, Division of General Medicine, Public Hospital of Quistello (Mantova), USSL 48, Italy.

Sept 1983-Sept 1986

Research Fellow, Laboratory of Human Immunology (Head: Dr. Alberto Mantovani), “Mario Negri” Institute for Pharmacological Research, Milano, Italy.

Oct 1987-Oct 1993

Laboratory of Immunoregulation (Head: Dr. Anthony S. Fauci), NIAID, NIH, Bethesda, MD, USA. Final position: Visiting Scientist.

Since Nov 1993

Head, AIDS Immunopathogenesis Unit, San Raffaele Scientific Institute, Milano, Italy.

Dec 2002-Dec 2015

Associate Professor of Pathology, Vita-Salute San Raffaele University, Milano, Italy.

Since Jan 2016

Full Professor of Pathology, Vita-Salute San Raffaele University, Milano, Italy.

LANGUAGE               

ITALIAN                  Mother tongue

ENGLISH                 Spoken (fluent), written

AWARDS                   

1992            NIH Award of Merit.

1999            European Society for Clinical Investigation (formerly Mac Foster) Award.

OTHER ACTIVITIES             

SINCE 2004

Past and Current Associate Editor for: The Journal of Immunology, AIDS, PlosOne.

Co-Chair, Subgroup “Immunological mechanisms and compartments involved”, “TOWARDS AN HIV CURE”: GLOBAL SCIENTIFIC STRATEGY International Working Group (Chair: Francoise Barré-Sinoussi. Institut Pasteur, Paris, France. (http://www.iasociety.org/What-we-do/Towards-an-HIV-Cure/Activities/2012-International-Scientific-Working-Group)

International Networks

Since 2011     Italy Vice-Director, Global Viral Network, (Chair: Robert C. Gallo, Institute of Human Virology, Baltimore, MD, USA – http://gvn.org/

Since 2012    Member, Towards an HIV Cure: Industry Collaboration

(http://www.iasociety.org/What-we-do/Towards-an-HIV-Cure/Activities/Working-Groups)

 

BIBLIOGRAPHY

(1985-2015)

10 KEY PUBLICATIONS                  

1989

577. Poli, J. Orenstein, A. Kinter, T.M. Folks, & A.S. Fauci. Interferon alpha but not AZT suppresses HIV expression in chronically infected cell lines.  Science, 244: 575-577.

1990

158. Poli, P. Bressler, A.L. Kinter, E. Duh, W.C. Timmer, A. Rabson,  J.S. Justement, S. Stanley, & A.S. Fauci.  Interleukin-6 induces HIV expression in chronically infected monocytic cells alone and in synergy with TNF-a by transcriptional and post-transcriptional mechanisms. J. Exp. Med., 172: 151-158.

1991

597. Poli, A.L. Kinter, J.S. Justement, P.Bressler, J.H. Kehrl, & A.S. Fauci. Transforming growth factor-ß (TGF-ß) suppresses human immunodeficiency virus expression and replication in infected cells of the monocyte/macrophage lineage. J. Exp. Med., 173: 589-597.

1999

1999. Bovolenta, L. Camorali, A.L. Lorini, S. Ghezzi, E. Vicenzi, A. Lazzarin, & G. Poli. Constitutive activation of STATs upon in vivo HIV infection. Blood, 94: 4202-4209, 1999.

2003

4. Poli & C. Bordignon. Unplugging the T cell receptor. Nature Immunol., 4:943-4.

2009

1709. Alfano, S.A. Mariani, C. Elia, R. Pardi, F. Blasi, & G. Poli. Ligand-engaged urokinase-type plasminogen activator receptor (uPAR) and the CD11b/CD18 (Mac1) integrin inhibit late events of HIV expression in monocytic cells. Blood, 113:1699-1709.

2009

6246. Cassol, C. Rizzi, L. Cassetta, M. Alfano, & G. Poli. M1 and M2a polarization of human monocyte-derived macrophages inhibits HIV-1 replication by distinct mechanisms. J. Immunol. 182: 6237-6246.

2012

1. Guergnon, C. Dalmasso, P. Broet, L. Meyer, S.J. Westrop, N. Imami, E. Vicenzi, G. Morsica,
2. Tinelli, B. Zanone Poma, C. Goujard, V. Potard, F.M. Gotch, C. Casoli, A. Cossarizza, F.

Macciardi, P. Debré, J.F. Delfraissy, M. Galli, B. Autran, D. Costagliola,

1. Poli, I. Theodorou, & A. Riva *GISHEAL Consortium. Both Class-I and Class-III MHC genetic subregions contribute to natural long-term non progression in HIV infection.
2. Infect. Dis., 205:718-724, 2012.

2013

1. Saba, M. Origoni, G. Taccagni, D. Ferrari, C. Doglioni, A. Nava, A. Lisco, J.-C. Grivel,
2. Margolis, & G. Poli. Productive HIV-1 infection of human cervical tissue ex vivo is associated with the secretory phase of the menstrual cycle. Mucosal Immunol, 6:1081-90, 2013.

2015

1. Graziano, M. Desdouits, L. Garzetti, P. Podini, M. Alfano, A. Rubartelli,
2. Furlan. P. Benaroch & G. Poli. Extracellular ATP induces the rapid release of HIV-1 from virus containing compartments of human macrophages. Proc. Natl. Acad. Sci. (USA), 112:E3265-73, 2015.

10 Pubblicazioni di rilievo

1989

577. Poli, J. Orenstein, A. Kinter, T.M. Folks, & A.S. Fauci. Interferon alpha but not AZT suppresses HIV expression in chronically infected cell lines.  Science, 244: 575-577.

1990

158. Poli, P. Bressler, A.L. Kinter, E. Duh, W.C. Timmer, A. Rabson,  J.S. Justement, S. Stanley, & A.S. Fauci.  Interleukin-6 induces HIV expression in chronically infected monocytic cells alone and in synergy with TNF-a by transcriptional and post-transcriptional mechanisms. J. Exp. Med., 172: 151-158.

1991

597. Poli, A.L. Kinter, J.S. Justement, P.Bressler, J.H. Kehrl, & A.S. Fauci. Transforming growth factor-ß (TGF-ß) suppresses human immunodeficiency virus expression and replication in infected cells of the monocyte/macrophage lineage. J. Exp. Med., 173: 589-597.

1999

1999. Bovolenta, L. Camorali, A.L. Lorini, S. Ghezzi, E. Vicenzi, A. Lazzarin, & G. Poli. Constitutive activation of STATs upon in vivo HIV infection. Blood, 94: 4202-4209, 1999.

2003

4. Poli & C. Bordignon. Unplugging the T cell receptor. Nature Immunol., 4:943-4.

2009

1709. Alfano, S.A. Mariani, C. Elia, R. Pardi, F. Blasi, & G. Poli. Ligand-engaged urokinase-type plasminogen activator receptor (uPAR) and the CD11b/CD18 (Mac1) integrin inhibit late events of HIV expression in monocytic cells. Blood, 113:1699-1709.

2009

6246. Cassol, C. Rizzi, L. Cassetta, M. Alfano, & G. Poli. M1 and M2a polarization of human monocyte-derived macrophages inhibits HIV-1 replication by distinct mechanisms. J. Immunol. 182: 6237-6246.

2012

1. Guergnon, C. Dalmasso, P. Broet, L. Meyer, S.J. Westrop, N. Imami, E. Vicenzi, G. Morsica,
2. Tinelli, B. Zanone Poma, C. Goujard, V. Potard, F.M. Gotch, C. Casoli, A. Cossarizza, F.

Macciardi, P. Debré, J.F. Delfraissy, M. Galli, B. Autran, D. Costagliola,

1. Poli, I. Theodorou, & A. Riva *GISHEAL Consortium. Both Class-I and Class-III MHC genetic subregions contribute to natural long-term non progression in HIV infection.
2. Infect. Dis., 205:718-724, 2012.

2013

1. Saba, M. Origoni, G. Taccagni, D. Ferrari, C. Doglioni, A. Nava, A. Lisco, J.-C. Grivel,
2. Margolis, & G. Poli. Productive HIV-1 infection of human cervical tissue ex vivo is associated with the secretory phase of the menstrual cycle. Mucosal Immunol, 6:1081-90, 2013.

2015

1. Graziano, M. Desdouits, L. Garzetti, P. Podini, M. Alfano, A. Rubartelli,
2. Furlan. P. Benaroch & G. Poli. Extracellular ATP induces the rapid release of HIV-1 from virus containing compartments of human macrophages. Proc. Natl. Acad. Sci. (USA), 112:E3265-73, 2015.