Sassone Pagano Jenny RicercatoreMedicinaBIO/14 - Farmacologia

Biografia

Pubblicazioni

English version

Biografia

Scheda biografica Jenny Sassone

Nata ad Alessandria il 13/11/1976

Laurea con lode in Biotecnologie Farmaceutiche presso l’Università degli studi di Milano (Facoltà di Farmacia).

Specializzazione con lode in Genetica Medica presso l’Università degli studi di Milano (Facoltà di Medicina e Chirurgia).

 

Curriculum

Dal 2001 al 2004 ha svolto attività di ricerca in borsa di studio presso il Laboratorio di Neuroscienze dell’IRCCS Ospedale Maggiore Milano. Dal 2004 al 2014 è stata assistente di ricerca presso il Laboratorio di Neuroscienze dell’IRCCS Istituto Auxologico Italiano occupandosi di ricerca sui meccanismi molecolari responsabili della neurodegenerazione in malattia di Huntington e malattia di parkinson e di diagnostica molecolare sulle malattie da triplette. Dal 2014 al 2016 è stata assistente di ricerca presso l’IRCCS Istituto Neurologico Carlo Besta, dove si è occupata di ricerca sui meccanismi molecolari responsabili della neurodegenerazione in malattie del motoneurone e meccanismi molecolari responsabili del dolore neuropatico. Nel 2010 è’ stata visiting scientist presso il Department of Pharmacology, University of Alberta; nel 2016 visiting scientist presso il Dipartimento di Farmacologia, Università di Ferrara e presso il Dipartimento di Fisiopatologia Cellulare e Molecolare, Università degli Studi di Milano. Nel 2016 è stata insignita del Premio Telethon-Farmindustria per la ricerca in neuroscienze.

Da Marzo 2017 è ricercatore di ruolo in Farmacologia presso l’Università Vita-Salute San Raffaele.

 

Aree di Ricerca

Disfunzioni cellulari e molecolari presenti in Malattie Neurodegenerative, in particolare Malattia di Parkinson, Malattia di Huntington e Sclerosi Laterale Amiotrofica.

In particolare, i suoi studi sono focalizzati a comprendere le alterazioni sinaptiche presenti nelle fasi precoci di malattie neurodegenerative e mirati alla individuazione e validazione di nuovi bersagli farmacologici.

Pubblicazioni

  • Sassone J*, Serratto G, Valtorta F, Silani V, Passafaro M, Ciammola A. The synaptic function of parkin. Brain. 2017 Feb 23. doi: 10.1093/brain/awx006. [Epub ahead of print] PubMed PMID: 28335015. *corresponding author.

 

  • Kapetis D, Sassone J, Yang Y, Galbardi B, Xenakis MN, Westra RL, Szklarczyk R, Lindsey P, Faber CG, Gerrits M, Merkies IS, Dib-Hajj SD, Mantegazza M, Waxman SG, Lauria G; PROPANE Study Group.. Network topology of NaV1.7 mutations in sodium channel-related painful disorders. BMC Syst Biol. 2017 Feb 24;11(1):28. doi: 10.1186/s12918-016-0382-0. PubMed PMID: 28235406; PubMed Central PMCID: PMC5324268.

 

  • Filippo Martinelli-Boneschi, Marina Colombi, Marco Castori, Grazia Devigili, Roberto Eleopra, Rayaz, A. Malik, Marco Ritelli, Nicoletta Zoppi, Chiara Dordoni, Melissa Sorosina, Paola Grammatico, Hassan Fadavi, Monique M. Gerrits, Rowida Almomani, Catharina G. Faber, Ingemar S.J. Merkies, Daniela Toniolo for the INGI Network, Massimiliano Cocca, Claudio Doglioni, Stephen G. Waxman, Sulayman D. Dib-Hajj, Michela M. Taiana, Jenny Sassone, Raffaella Lombardi, Daniele Cazzato, Andrea Zauli, Silvia Santoro, Margherita Marchi and Giuseppe Lauria. COL6A5 Variants in Familial Neuropathic Chronic Itch. Brain. 2017 Jan 9. pii: aww343. doi: 10.1093/brain/aww343.

 

  • Bonati MT, Vanelli C, Sangalli D, Sina C, Giardino D, Sassone J, Girotti F, Silani V, Ciammola. Cerebral microbleeds in chromosome 22q11.2 deletion syndrome, a case report. J Neurol Sci. 2016 Sep 15;368:300-3. doi: 10.1016/j.jns.2016.07.044.

 

  • Michela Taiana, Jenny Sassone*, Giuseppe Lauria. Mutant SOD1 accumulation in sensory neurons does not associate with endoplasmic reticulum stress features: implications for differential vulnerability of sensory and motor neurons to SOD1 toxicity. Neurosci Lett. 2016 May 27;627:107-114. doi: 10.1016/j.neulet.2016.05.057. *corresponding author.

 

  • Jenny Sassone*, Michela Taiana, Raffaella Lombardi, Carla Porretta-Serrapiglia , Mattia Freschi, Silvia Bonanno, Stefania Marcuzzo, Francesca Caravello, Caterina Bendotti and Giuseppe Lauria*. ALS mouse model SOD1G93A displays early degeneration of sensory small fibers associated to accumulation of a neurotoxic splice variant of peripherin. Hum. Mol. Genet. first published online February 9, 2016 doi:10.1093/hmg/ddw035 *co-corresponding authors

 

  • Sassone F, Margulets V, Maraschi A, Rodighiero S, Passafaro M, Silani V, Ciammola A, Kirshenbaum LA, Sassone J*. Bcl-2/adenovirus E1B 19-kDa interacting protein (BNip3) has a key role in the mitochondrial dysfunction induced by mutant huntingtin. Hum Mol Genet. 2015 Nov 15;24(22):6530-9. doi: 10.1093/hmg/ddv362. Epub 2015 Sep 10. PubMed PMID: 26358776. *corresponding author

 

  • Solca F, Poletti B, Zago S, Crespi C, Sassone F, Lafronza A, Maraschi AM, Sassone J, Silani V, Ciammola A. Counterfactual Thinking Deficit in Huntington’s  Disease. PLoS One. 2015 Jun 12;10(6):e0126773. doi: 10.1371/journal.pone.0126773. eCollection 2015. PubMed PMID: 26070155; PubMed Central PMCID: PMC4466481.

 

  • Lauria G, Dacci P, Lombardi R, Cazzato D, Porretta-Serapiglia C, Taiana M, Sassone J, Dalla Bella E, Rinaldo S, Lettieri C, Eleopra R, Devigili G. Side and time variability of intraepidermal nerve fiber density. Neurology. 2015 Jun 9;84(23):2368-71. doi: 10.1212/WNL.0000000000001666. Epub 2015 May 13. PubMed PMID: 25972491.

 

  • Maraschi A, Ciammola A, Folci A, Sassone F, Ronzitti G, Cappelletti G, Silani V, Sato S, Hattori N, Mazzanti M, Chieregatti E, Mulle C, Passafaro M, Sassone J*. Parkin regulates kainate receptors by interacting with the GluK2 subunit. Nat Commun. 2014 Oct 15;5:5182. doi: 10.1038/ncomms6182. PubMed PMID: 25316086; PubMed Central PMCID: PMC4218952. *corresponding author

 

  • Taiana MM, Lombardi R, Porretta-Serapiglia C, Ciusani E, Oggioni N, Sassone J, Bianchi R, Lauria G. Neutralization of schwann cell-secreted VEGF is protective to in vitro and in vivo experimental diabetic neuropathy. PLoS One. 2014 Sep 30;9(9):e108403. doi: 10.1371/journal.pone.0108403. eCollection 2014. PubMed PMID: 25268360; PubMed Central PMCID: PMC4182455.

 

  • Folci A, Mapelli L, Sassone J, Prestori F, D’Angelo E, Bassani S, Passafaro M. Loss of hnRNP K impairs synaptic plasticity in hippocampal neurons. J Neurosci. 2014 Jul 2;34(27):9088-95. doi: 10.1523/JNEUROSCI.0303-14.2014. PubMed PMID: 24990929.

 

  • Sassone J*, Maraschi A, Sassone F, Silani V, Ciammola A. Defining the role of the Bcl-2 family proteins in Huntington’s disease. Cell Death Dis. 2013 Aug 15;4:e772. doi: 10.1038/cddis.2013.300. Review. PubMed PMID: 23949221; PubMed Central PMCID: PMC3763461. *corresponding author

 

  • Di Pardo A, Maglione V, Alpaugh M, Horkey M, Atwal RS, Sassone J, Ciammola A,  Steffan JS, Fouad K, Truant R, Sipione S. Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice. Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3528-33. doi: 10.1073/pnas.1114502109. Epub 2012 Feb 13. PubMed PMID: 22331905; PubMed Central  PMCID: PMC3295265.

 

  • Lunetta C, Serafini M, Prelle A, Magni P, Dozio E, Ruscica M, Sassone J, Colciago C, Moggio M, Corbo M, Silani V. Impaired expression of insulin-like growth factor-1 system in skeletal muscle of amyotrophic lateral sclerosis patients. Muscle Nerve. 2012 Feb;45(2):200-8. doi: 10.1002/mus.22288. PubMed PMID: 22246875; PubMed Central PMCID: PMC3306791.

 

  • Zuccato C, Marullo M, Vitali B, Tarditi A, Mariotti C, Valenza M, Lahiri N, Wild EJ, Sassone J, Ciammola A, Bachoud-Lèvi AC, Tabrizi SJ, Di Donato S, Cattaneo E. Brain-derived neurotrophic factor in patients with Huntington’s disease. PLoS One. 2011;6(8):e22966. doi: 10.1371/journal.pone.0022966. Epub 2011 Aug 12. PubMed PMID: 21857974; PubMed Central PMCID: PMC3155522.

 

  • Ciammola A, Sassone J, Poletti B, Mencacci N, Benti R, Silani V. Atypical Parkinsonism Revealing a Late Onset, Rigid and Akinetic Form of Huntington’s Disease. Case Rep Neurol Med. 2011;2011:696953. doi: 10.1155/2011/696953. Epub 2011 Sep 7. PubMed PMID: 22937345; PubMed Central PMCID: PMC3420516.

 

  • Piccolo G, Cortese A, Tavazzi E, Piccolo L, Sassone J, Ciammola A, Alfonsi E, Colombo I, Moggio M. Late onset oculopharyngeal muscular dystrophy with prominent neurogenic features and short GCG trinucleotide expansion. Muscle Nerve. 2011 Jan;43(1):141-2. doi: 10.1002/mus.21842. PubMed PMID: 21171103.

 

  • Ciammola A, Sassone J, Sciacco M, Mencacci NE, Ripolone M, Bizzi C, Colciago  C, Moggio M, Parati G, Silani V, Malfatto G. Low anaerobic threshold and increased skeletal muscle lactate production in subjects with Huntington’s disease. Mov Disord. 2011 Jan;26(1):130-7. doi: 10.1002/mds.23258. Epub 2010 Oct  7. PubMed PMID: 20931633; PubMed Central PMCID: PMC3081141.

 

  • Battaglia G, Cannella M, Riozzi B, Orobello S, Maat-Schieman ML, Aronica E, Busceti CL, Ciarmiello A, Alberti S, Amico E, Sassone J, Sipione S, Bruno V, Frati L, Nicoletti F, Squitieri F. Early defect of transforming growth factor β1  formation in Huntington’s disease. J Cell Mol Med. 2011 Mar;15(3):555-71. doi: 10.1111/j.1582-4934.2010.01011.x. PubMed PMID: 20082658; PubMed Central PMCID: PMC3922377.

 

  • Sassone J, Colciago C, Marchi P, Ascardi C, Alberti L, Di Pardo A, Zippel R,  Sipione S, Silani V, Ciammola A. Mutant Huntingtin induces activation of the Bcl-2/adenovirus E1B 19-kDa interacting protein (BNip3). Cell Death Dis. 2010;1:e7. doi: 10.1038/cddis.2009.6. PubMed PMID: 21364626; PubMed Central PMCID: PMC3032515.

 

  • Ciammola A, Sassone J, Colciago C, Mencacci NE, Poletti B, Ciarmiello A, Squitieri F, Silani V. Aripiprazole in the treatment of Huntington’s disease: a case series. Neuropsychiatr Dis Treat. 2009;5:1-4. Epub 2009 Apr 8. PubMed PMID:  19557093; PubMed Central PMCID: PMC2695210.

 

  • Chaturvedi RK, Adhihetty P, Shukla S, Hennessy T, Calingasan N, Yang L, Starkov A, Kiaei M, Cannella M, Sassone J, Ciammola A, Squitieri F, Beal MF. Impaired PGC-1alpha function in muscle in Huntington’s disease. Hum Mol Genet. 2009 Aug 15;18(16):3048-65. doi: 10.1093/hmg/ddp243. Epub 2009 May 21. PubMed PMID: 19460884; PubMed Central PMCID: PMC2733807.

 

  • Sassone J, Colciago C, Cislaghi G, Silani V, Ciammola A. Huntington’s disease: the current state of research with peripheral tissues. Exp Neurol. 2009  Oct;219(2):385-97. doi: 10.1016/j.expneurol.2009.05.012. Epub 2009 May 19. Review. PubMed PMID: 19460373.

 

  • Squitieri F, Cannella M, Simonelli M, Sassone J, Martino T, Venditti E, Ciammola A, Colonnese C, Frati L, Ciarmiello A. Distinct brain volume changes correlating with clinical stage, disease progression rate, mutation size, and age at onset prediction as early biomarkers of brain atrophy in Huntington’s disease. CNS Neurosci Ther. 2009 Winter;15(1):1-11. doi: 10.1111/j.1755-5949.2008.00068.x. PubMed PMID: 19228174.

 

  • Ciammola A, Sassone J, Cannella M, Calza S, Poletti B, Frati L, Squitieri F,  Silani V. Low brain-derived neurotrophic factor (BDNF) levels in serum of Huntington’s disease patients. Am J Med Genet B Neuropsychiatr Genet. 2007 Jun 5;144B(4):574-7. PubMed PMID: 17427191.

 

  • Lattuada D, Viganó P, Mangioni S, Sassone J, Di Francesco S, Vignali M, Di Blasio AM. Accumulation of retinoid X receptor-alpha in uterine leiomyomas is associated with a delayed ligand-dependent proteasome-mediated degradation and an alteration of its transcriptional activity. Mol Endocrinol. 2007 Mar;21(3):602-12. Epub 2006 Dec 14. PubMed PMID: 17170071.

 

  • Sassone J, Ciammola A, Tiloca C, Glionna M, Meola G, Mancinelli E, Silani V.  Apoptosis induced by proteasome inhibition in human myoblast cultures. Eur J Histochem. 2006 Apr-Jun;50(2):109-18. PubMed PMID: 16864121.

 

  • Ciammola A, Sassone J, Alberti L, Meola G, Mancinelli E, Russo MA, Squitieri  F, Silani V. Increased apoptosis, Huntingtin inclusions and altered differentiation in muscle cell cultures from Huntington’s disease subjects. Cell  Death Differ. 2006 Dec;13(12):2068-78. Epub 2006 May 26. PubMed PMID: 16729030.

 

  • Silani V, Fogh I, Ratti A, Sassone J, Ciammola A, Cova L. Stem cells in the treatment of amyotrophic lateral sclerosis (ALS). Amyotroph Lateral Scler Other Motor Neuron Disord. 2002 Dec;3(4):173-81. Review. PubMed PMID: 12710505.

English version

Biographical sketch Jenny Sassone

Born in Alessandria on 11/13/1976
Honors Degree in Pharmaceutical Biotechnology at the University of Milan (Faculty of Pharmacy).
Honors Degree in Medical Genetics at the University of Milan (Faculty of Medicine).

Curriculum
From 2001 to 2004, fellowship at the Laboratory of Neuroscience IRCCS Ospedale Maggiore Milan. From 2004 to 2014, research assistant at the Laboratory of Neuroscience Institute IRCCS Auxologico Italiano, dealing with research on molecular mechanisms of neurodegeneration in Huntington’s disease and Parkinson’s disease and molecular diagnostics on triplet diseases. From 2014 to 2016, research assistant at the IRCCS Carlo Besta Neurological Institute, where she was involved in research on the molecular mechanisms of neurodegeneration in motor neuron diseases and molecular mechanisms responsible for neuropathic pain. In 2010 she was a visiting scientist at the Department of Pharmacology, University of Alberta; in 2016 a visiting scientist at the Department of Pharmacology, University of Ferrara and at the Department of Cellular and Molecular Pathophysiology, University of Milan. In 2016 she was awarded the Telethon-Farmindustria Prize for research in neuroscience.
Since March 2017, assistant professor in Pharmacology at the Vita-Salute San Raffaele University.

Research Areas
Molecular and cellular dysfunctions underlying Neurodegenerative Diseases, in particular Parkinson’s disease, Huntington’s disease and Amyotrophic Lateral Sclerosis.
In particular, her studies aim at understanding the synaptic alterations present in the early stages of neurodegenerative diseases and aim at identifying and validating novel drug targets.

Il titolare del presente curriculum vitae, pubblicato online sul portale www.unisr.it, è garante in via esclusiva della correttezza e della veridicità dei dati e delle informazioni in esso riportate e del loro eventuale e puntuale aggiornamento. Egli è dunque il diretto ed unico responsabile dei contenuti indicati nei propri curricula.