Sitia Roberto Professore ordinarioMedicinaBIO/11

Breve narrativa

Dopo la laurea in Medicina e Chirurgia e la specializzazione in Ematologia all’Università di Genova, il Prof. Sitia ha lavorato a lungo negli USA, presso il Memorial Sloan Kettering Cancer Center a New York e nel Regno Unito, presso il Laboratory of Molecular Biology del Medical Research Council a Cambridge, e l’Istituto Scientifico Tumori di Genova. Arrivato al San Raffaele nel1990, ha partecipato alla fondazione del Dipartimento di Biologia e Tecnologia (DiBiT) e dell’Università Vita Salute San Raffaele. Ha presieduto il Corso di Laurea in Medicina (2005-2008) e diretto la Divisione di Genetica e Biologia Cellulare (2008-2014). Membro dell’EMBO dal 1992, si è sempre battuto per lo sviluppo delle scienze biomediche a livello italiano, europeo ed internazionale, partecipando alla fondazione dell’European Network of Immunology Institutes (ENII) e dell’European Life Sciences Organization (ELSO). Ha tenuto corsi universitari in Giappone (Tokyo Univ.) e Australia (New South Wales Univ.) e seminari e conferenze nei 5 continenti. Autore di oltre 170 pubblicazioni citate più di 10,000, è considerato un leader internazionale nella secrezione proteica e nella biosintesi degli anticorpi. Molti suoi allievi occupano posizioni prestigiose in Italia e all’estero. Pionieristici sono stati i suoi contributi sui meccanismi di controllo di qualità della sintesi proteica e sui meccanismi che regolano omeostasi e signaling redox nelle cellule umane. Attualmente insegna Biologia Molecolare e dirige il laboratorio di Trasporto e Secrezione delle Proteine.

Professore di Biologia Molecolare

ORCID ID                               000-0001-7026-4152

Scopus Author ID     35498375100

Researcher ID                       AAB-5005-2019

Educazione

1971 Maturità classica. Liceo A D’Oria, Genova

1977 Laurea in Medicina Università di Genova

1980 Specializzazione in Ematologia Università di Genova

Cariche attuali e precedenti

2000-oggi       Professor of Molecular Biology, Università Vita Salute San Raffaele. Milan

1990-oggi  Group leader, San Raffaele Scientific Institute, Milan, IT

2008-14           Director, Division of Genetics and Cell Biology, Ospedale San Raffaele

2008                Visiting professor, Institut Curie, Paris (FR)

2006                Visiting professor, Tokyo University (Japan)

2005-07           President of the School of Medicine, Università Vita Salute San Raffaele. Milan

1999                Visiting professor, New South Wales University (Australia)

1998-07           Deputy Director, Dept. Functional Genomics & Molecular Biology, Ospedale San Raffaele

1987-90           Associate Professor, Immunogenetics, National Cancer Center, Genoa

1986-87           Visiting Investigator, MRC Laboratory of Molecular Biology, Cambridge, UK

1982-86           Assistant Professor, Molecular Biology, National Cancer Center, Genoa,

1980-82           Assistant Professor, Immunology and Transplantation, University of Genoa, IT

1978-79           PostDoc, Immunochemistry, Memorial Sloan Kettering Cancer Center, New York USA

Premi e riconoscimenti

European Molecular Biology Organisation (EMBO), 1992

Founder and Steering Committee (1991-8), European Network of Immunology Institute,

Founder and Steering Committee (1998-2006) of European Life Science Organisation (ELSO)

Italian Immunology Cooperation Group (GCI). Member and Steering Committee

Italian Association Cell & Developmental Biology (ABCD) Member and Steering Committee

American Society of Cell Biology (ASCB)

American Society of Biochemistry and Molecular Biology (ASBMB)

Attività Editoriali e Divulgative

Editor, The EMBO Journal (1998-present); Antioxidant Redox Signaling (2010-present); Scientific reports (2014-present); EMBO Reports (1998-2010); J.Biol. Chem (2001-2006); PathoGenetics (2008-2011); KOS a magazine merging science, medicine and culture (1998-2008)

Membro del Consiglio Scientifico dell’Enciclopedia Italiana Treccani (1994-8)

Membro        (2002-2004) e Chair (2004-2007) dell’ EMBO Science and Society Committee

Referee per i maggiori giornali scientifici in Biologia Cellulare e Molecolare e Immunologia (Nature, Science, Cell, Immunity, PNAS eLife etc).

Consulente: European Commission; ERC; Academy of Finland; MRC and Welcome Trust (UK); Austrian Research Minister, FWF; Israeli Science Foundation; Spanish Minister of Science and Education; NIH (US); Swiss Science Foundation (CH); ANR (FR); Italian Ministries of Health and University-Research; CNR, Telethon (IT)

Fondatore (2004) e organizzatore (2004-0ggi) di Bergamo Scienza

 Organizzazione di congressi e corsi

- Chair of the ENII-ESF Conference: Physiology of Antigen Presentation, 1991 Como (IT)

- Co-Chair, ENII Conference, 1991 Les Embiez (FR)

- Chair: ENII Conference, 1992 Les Embiez (FR)

- Chair of the Italian Cell and Molecular Biology Meeting, 1993 Milano (IT)

- Co-Chair of the ELSO meeting, 2000 Geneva (CH)

- Co-Chair of the ELSO meeting, 2002 Nice (FR)

- Chair of the ELSO Meeting, 2007 Dresden (D)

- Co-Chair of the II Gordon Conf., Thiol-based Redox Regulation and Signalling, 2008 Lucca  (IT)

- Chair of the III Gordon Conference, Thiol-based Redox Regulation and Signalling, 2010 Lucca (IT)

- Co-Chair of the ETH Conference Quality Control: Folding and Degradation of Proteins in the ER, 2011

- Co-Chair, ER & Redox Club Meeting, 2015 Venice (IT)

- Co-Chair, EMBO conference Thiol-based redox switches in life science Sant Feliu de Guixols 2018 (SP)

- Chair EMBO conference Thiol-based redox switches in life science 2019

 

Sitia R, Rubartelli A. 2020 Evolution, role in inflammation, and redox control of leaderless secretory proteins. J Biol Chem. 295:7799-7811

Bestetti S, Galli M, Sorrentino I, Pinton P, Rimessi A, Sitia R, Medraño-Fernandez I§. 2020 Human aquaporin-11 guarantees efficient transport of H2O2 across the endoplasmic reticulum membrane. Redox Biol. 2020 Jan; 28:101326. § joint last authors

Sicari D, Chatzijoannou A, Koutsandreas T, Sitia R, Chevet E. 2020 Role of the early secretory pathway in SARS-CoV-2 infection. J Cell Biol. 219(9) § joint last authors

Vitale M, Bakunts A, Orsi A, Lari F, Tadè L, Danieli A, Rato C, Valetti C, Sitia R, Raimondi A, Christianson JC, van Anken E. 2019 Inadequate BiP availability defines endoplasmic reticulum stress. E-life. Mar 14;8. pii: e41168.

Watanabe S, Amagai Y, Sannino S, Tempio T, Anelli T, Harayama M, Masui S, Sorrentino I, Yamada M, Sitia R§, Inaba K§. 2019 Nature Comm. 10:603. § joint last authors

Semino C, Carta S, Gattorno M, Sitia R§, Rubartelli A§. 2018 Progressive waves of IL-1β release by primary human monocytes via sequential activation of vesicular and gasdermin D-mediated secretory pathways. Cell Death Dis. 9:1088. § joint last authors

Bestetti S. Medraño-Fernandez I, Galli M, Ghitti M, Bienert GP, Musco G, Orsi A, Rubartelli A and Sitia R, 2018 A persulfidation-based mechanism controls aquaporin-8 conductance Science Adv. 4:eaar5770

Bakunts A, Orsi A, Vitale M, Cattaneo A, Lari F, Tadè L, Sitia R, Raimondi A, Bachi A, van Anken E. 2017 Ratiometric sensing of BiP-client versus BiP levels by the unfolded protein response determines its signaling amplitude. E-life e27518. doi: 10.7554/eLife.27518

Pasalic D, Weber B, Giannone C, Anelli T, Müller R, Fagioli C, Felkl M, John C, Mossuto MF, Becker CFW, Sitia R§, Buchner J§. 2017 Proc Natl Acad Sci U S A 114:E8575-E8584 § joint last authors

Pengo N, Scolari M, Oliva L, Milan E, Mainoldi F, Raimondi A, Fagioli C, Merlini A, Mariani E, Pasqualetto E,

  Orfanelli U, Ponzoni M, Sitia R, Casola S, Cenci S. 2013 Plasma cells require autophagy for sustainable   immunoglobulin production. Nature Immunol.14:298

Vavassori S, Cortini M. Masui S, Sannino S. Anelli T. Caserta I, Fagioli C, Mossuto MF, Fornili A. van Anken E, Degano M, Inaba K and Sitia R. 2013 A pH-regulated quality control cycle for surveillance of secretory protein assembly.  Molecular Cell 50:783-92.

Anelli T, Ceppi S, Bergamelli L, Cortini M, Masciarelli S, Valetti C and Sitia R. 2007 Sequential steps and checkpoints in the early exocytic compartment during secretory IgM biogenesis. EMBO J. 26, 4177-88

Cenci S, Mezghrani A, Cascio P, Bianchi G, Cerruti F, Fra AM, Lelouard H, Masciarelli S, Mattioli L, Oliva L, Orsi A, Pasqualetto E, Pierre P, Ruffato E, Tagliavacca L and Sitia R. 2006 Progressively impaired proteasomal capacity during terminal plasma cell differentiation. EMBO J, 25, 1104-1113.

Sitia R, Braakman I. 2003 Quality control in the endoplasmic reticulum protein factory. Nature 426:891-4.

Anelli T, Alessio M, Bachi A, Bergamelli L, Bertoli G, Camerini S, Mezghrani A, Ruffato E, Simmen T, Sitia R. 2003 Thiol-mediated protein retention in the endoplasmic reticulum: the role of ERp44. EMBO J. 22,5015-22

VanAnken E, Romijn EP, Maggioni C, Mezghrani A, Sitia R§, Braakman I§, and Heck AJR§ 2003 Sequential waves of functionally related proteins are expressed when B cells prepare for antibody secretion. Immunity 18, 243-53. § joint last authors

Rubartelli A, Cozzolino F, Talio M, Sitia R. 1990. A novel secretory pathway for interleukin-1 beta, a protein lacking a signal sequence. EMBO J. 9:1503-10.

Sitia R, Neuberger MS, Alberini C, Bet P, Fra AM, Valetti C, Williams G and Milstein C. 1990. Developmental regulation of IgM secretion: the role of the carboxy-terminal cysteine. Cell 60, 781-790.

Sitia R, Neuberger MS, and Milstein C. 1987. Regulation of membrane IgM expression in secretory B cells. EMBO J 6, 3969-77.  

Sitia R. Corte G, Ferrarini M and Bargellesi A. 1977 Lymphocyte membrane immunoglobulins: similarities between human IgD and mouse IgD-like molecules Eur. J. Immunol. 7:503-7.