Laboratories 2020/2021 - Cellular and Molecular Biology

Please find below the list of the Directors of Studies (with a link to their CV) and their PhD Projects proposed for the academic year 2021/2022 for the curriculum in Cellular and Molecular Biology.

AGRESTI ALESSANDRA

Unit: In Vivo Chromatin and Transcription

Mechanisms of Haematopoietic Stem and Progenitor Cells mobilization from bone marrow: HMGB1, CXCL12, CXCR4 and Diflunisal

BOLETTA ALESSANDRA

Unit: Molecular Basis of Cystic Kidney Disorders

Characterization of the mitochondrial alterations in autosomal dominant polycystic kidney disease

BOLINO ALESSANDRA

Unit: Human Inherited Neuropathies Unit

Pharmacological modulation of myelin synthesis and cytoskeletal remodeling as a therapeutic strategy for CMT4B neuropathies with aberrant myelin

BRAGONZI ALESSANDRA

Unit: Infection and Cystic Fibrosis

New allelic combinations in cystic fibrosis models to define disease mechanisms and causes of phenotypic variation

CARDACI SIMONE

Unit: Cancer Metabolism

Project 1: Studying metabolic alterations in inflammation-driven tumours Project 2: Identifying metabolic vulnerabilities imposed by the loss of tumour suppressor genes in solid tumours

CAVALLI GIULIO

Age-related diseases

Role of trained immunity in the pathogenesis of Still’s disease

CENCI SIMONE

Unit: Age Related Diseases

ComBAT aging: exploring the biological bases of the exceptional longevity of bats

CIONI JEAN MICHEL

Unit: RNA biology of the Neuron

Decipher endosomal function in regulating mitochondrial proteome in neurons

COLASANTE GAIA

Unit: Stem Cell and Neurogenesis

Targeting altered proteostasis in cellular and mouse models of AFG3L2-related cerebellar ataxias

D'ANTONIO MAURIZIO

Unit: Biology of Myelin

Modulation of the Unfolded Protein Response (UPR) for therapeutic intervention in demyelinating Charcot-Marie-Tooth neuropathies

DE CURTIS IVAN

Unit: Cell adhesion

Kinase-controlled biomolecular condensates regulating cell migration and invasion.

GABELLINI DAVIDE

Unit: Gene Expression and Muscular Dystrophy

Project 1: Transcriptional regulation of anti-tumor immunity Project 2: Safety and efficacy of a possible therapeutic treatment for FSHD muscular dystrophy

MALTECCA FRANCESCA

Unit: Mitochondrial dysfunctions in neurodegeneration

Targeting altered proteostasis in cellular and mouse models of AFG3L2-related cerebellar ataxias

MILAN ENRICO

Unit: Age Related Diseases

Harnessing antibody production against plasma cell dyscrasias

MONDINO ANNA

Unit: Lymphocyte Activation

Empowering TCR/CAR engineered T cells against pancreatic liver

MUSCO GIOVANNA

Unit: Biomolecular NMR

Pharmacological targeting of NSD2 PHDvCHCH domain: a therapeutic approach against Multiple Myeloma

NAI ANTONELLA

Unit: Regulation of Iron Metabolism

TFR2: A novel modulator of erythropoietin activity and cell metabolism

PEDROTTI SIMONA

Unit: Gene expression and Muscular Dystrophy

Epigenetic in the pathogenesis and treatment of diabetes

RAMPOLDI LUCA

Unit: Molecular Genetics of Renal Disorders

Molecular bases of the association of common uromodulin variants with risk of chronic kidney disease and hypertension

SCIELZO CRISTINA

Unit: Malignant B cells Biology and 3D modelling

The role of HS1 protein in haematopoietic cells in lymphoid tissues

SITIA ROBERTO

Unit: Protein Transport and Secretion, DGCB

Signals and mechanisms that integrate organellar reshaping during cell differentiation

VENEREAU EMILIE

Unit: Tissue Regeneration & Homeostasis

Development of innovative therapeutic strategies for muscular dystrophies

ZAMBRANO SAMUEL

Unit: Chromatin Dynamics

Project 1: Single-cell and tissue dynamics of liver inflammation Project 2: Role of nuclear physical properties and dynamics in myogenesis

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